He aha ʻo Guselkumab: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Guselkumab e kōkua ana i ka mālama ʻana i kekahi mau maʻi autoimmune ma ka hoʻopaʻa ʻana i nā ʻāpana kikoʻī o kāu ʻōnaehana pale. No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo interleukin-23 inhibitors, e hana ana ma ka pale ʻana i nā protein e hoʻoulu ai i ka mumū i loko o kou kino.

Hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano he injection ma lalo o kou ʻili, e like me ke ʻano o ka poʻe me ka maʻi diabetes e hāʻawi iā lākou iho i nā pana insulin. E kauoha maʻamau kāu kauka iā guselkumab ke hana ʻole nā ​​lāʻau lapaʻau ʻē aʻe a i ʻole ke pono ʻoe i kahi ala i manaʻo ʻia e mālama i kou maʻi.

No ke aha i hoʻohana ʻia ai ʻo Guselkumab?

Hoʻohana nui ʻia ʻo Guselkumab e mālama i ka psoriasis plaque mai ka maʻi a hiki i ke koʻikoʻi i nā pākeke. ʻO ka psoriasis plaque kahi maʻi ʻili mau e hoʻoulu ai i nā ʻāpana mānoanoa a me ka unahi e hana ma kou ʻili, pinepine ma kou mau kuʻekuʻe, nā kuli, ke poʻo, a me ke kua.

Ua ʻae ʻia kēia lāʻau lapaʻau e mālama i ka psoriatic arthritis, kahi maʻi e pili ana ka psoriasis i kou mau hono, e hoʻoulu ana i ka ʻeha, ka ʻoʻoleʻo, a me ka pehu. Loaʻa i kekahi poʻe ka psoriasis ʻili a me nā pilikia hui, a ʻo nā mea ʻē aʻe paha he mau hōʻailona hui wale nō.

Hiki i kāu kauka ke noʻonoʻo iā guselkumab inā ua hoʻāʻo ʻoe i nā lāʻau lapaʻau topical, light therapy, a i ʻole nā ​​lāʻau lapaʻau ʻē aʻe me ka loaʻa ʻole o ke kōkua āu e pono ai. He mea kōkua nui ia no ka poʻe nona ka psoriasis e uhi ana i kahi ʻāpana nui o ko lākou kino a i ʻole e pili nui ana i ko lākou ola.

Pehea e hana ai ʻo Guselkumab?

Hana ʻo Guselkumab ma ka pale ʻana i kahi protein i kapa ʻia ʻo interleukin-23 (IL-23) i loko o kāu ʻōnaehana pale. Kōkua maʻamau kēia protein i ka hoʻopili ʻana i ka pane pale o kou kino, akā i nā maʻi autoimmune e like me ka psoriasis, lilo ia i mea hana nui a hoʻoulu i ka mumū nui.

E manaʻo e like me ka IL-23 he ʻelele e haʻi ana i kāu mau pūnaewele pale e hana i ka mumū. Ke kāohi ʻo guselkumab i kēia ʻelele, hoʻēmi ia i nā hōʻailona mumū e hana ai i nā hōʻailona psoriasis. Kōkua kēia i ka hoʻolohi ʻana i ka ulu wikiwiki ʻana o nā pūnaewele ʻili e hana ana i kēlā mau pā mānoanoa a me ka unahi.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia, ʻo ia hoʻi, e kālele ana ia i kekahi ʻāpana o ka ʻōnaehana pale ma mua o ka hoʻopau ʻana i kāu pane pale holoʻokoʻa. Hiki i kēia ala i manaʻo ʻia ke ʻoi aku ka maikaʻi a hiki ke hana i nā hopena ʻaoʻao liʻiliʻi ma mua o kekahi mau lāʻau lapaʻau e hoʻopau ana i ka pale.

Pehea wau e lawe ai iā Guselkumab?

Hāʻawi ʻia ʻo Guselkumab ma ke ʻano he injection ma lalo o ka ʻili, maʻamau i kou ʻūhā, ka lima luna, a i ʻole ka ʻōpū. E aʻo kāu mea mālama ola iā ʻoe pehea e hāʻawi ai iā ʻoe iho i kēia mau injections ma ka home, a i ʻole hiki i kahi lālā o ka ʻohana ke aʻo e kōkua iā ʻoe.

ʻO ka maʻamau hoʻomaka he 100 mg i hāʻawi ʻia i nā pule 0 a me 4, a laila i kēlā me kēia 8 pule ma hope o kēlā. E hoʻoholo kāu kauka i ka papa manawa kūpono no kou kūlana. He mea nui e pili i kēia papa manawa inā ʻoe e hoʻomaka ana e maikaʻi, no ka mea, kōkua ka kūlike i ka mālama ʻana i ka pono o ka lāʻau.

Hiki iā ʻoe ke lawe iā guselkumab me ka ʻole o ka meaʻai no ka mea ua hoʻokomo ʻia ma mua o ka lawe ʻia ʻana e ka waha. E mālama i ka lāʻau lapaʻau i loko o kāu pahu hau, akā e ʻae iā ia e hiki i ka mahana o ka lumi ma mua o ka hoʻokomo ʻana iā ia e ʻoluʻolu ai ka injection.

Ma mua o kēlā me kēia injection, holoi pono i kou mau lima a hoʻomaʻemaʻe i ka pūnaewele injection me kahi swab waiʻona. E hoʻololi i kāu mau pūnaewele injection e pale ai i ka huhū, a mai hoʻokomo i nā wahi kahi e palupalu ai kou ʻili, ʻeha, a i ʻole i hoʻopilikia ʻia e ka psoriasis.

Pehea ka lōʻihi e lawe ai au iā Guselkumab?

ʻO Guselkumab ka mea maʻamau he lapaʻau lōʻihi no nā maʻi maʻi e like me ka psoriasis a me ka psoriatic arthritis. Pono ka hapa nui o nā kānaka e hoʻomau i ka lawe ʻana iā ia no ka manawa pau ʻole e mālama i ko lākou hoʻomaikaʻi ʻana, no ka mea, ʻaʻole i loaʻa i kēia mau maʻi kahi lāʻau lapaʻau mau.

Hiki paha iā ʻoe ke ʻike i ka hoʻomaikaʻi ʻana i kou ʻili i loko o nā pule mua, akā hiki ke lawe i 16 pule e ʻike i nā pōmaikaʻi piha. ʻIke kekahi poʻe i ka hoʻomaʻemaʻe nui ʻana o kā lākou mau pā psoriasis i loko o 2-3 mau mahina o ka hoʻomaka ʻana i ka lāʻau.

E nānā kāu kauka i kāu holomua ma o nā manawa maʻamau a hiki ke hoʻoponopono i kāu hoʻolālā lapaʻau ma muli o ka maikaʻi o kāu pane ʻana. Inā ʻoe e hooki i ka lawe ʻana i ka guselkumab, e hoʻi hou ana kāu mau hōʻailona, ​​pinepine i loko o kekahi mau mahina.

He aha nā hopena ʻaoʻao o Guselkumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka guselkumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a loaʻa nā hopena ma ke kahua injection. Eia ka mea āu e ʻike ai:

• ʻUlaʻula, pehu, a i ʻole ka ʻeha maʻalahi kahi e hoʻokomo ai ʻoe i ka lāʻau
• Nā maʻi hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā poʻo e maʻalahi a me ka manawa
• Luhi a i ʻole ka luhi ma mua o ka maʻamau
• ʻEha hui, ʻoi loa i nā pule mua o ka lāʻau
• Pāpaʻa a i ʻole ka ʻōpū maʻalahi

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Eia naʻe, pono ʻoe e hoʻokaʻaʻike i kāu kauka inā e hoʻomau lākou a lilo paha i mea hoʻonāukiuki.

Hiki ke hana ʻia nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau no ka mea e pili ana ka guselkumab i kāu ʻōnaehana pale. ʻOiai he kakaikahi kēia, he mea nui e ʻike iā lākou:

• Nā maʻi koʻikoʻi e koi ai i ka haukapila
• Hoʻāla hou ʻana i nā maʻi dormant e like me ka maʻi tuberculosis a i ʻole hepatitis B
• Nā hopena maʻi maʻi me ka ʻōpala, ka ʻūlū, a i ʻole ka pilikia o ka hanu
• Nā hōʻailona maʻi ʻōpū inflammatory e like me ka maʻi maʻi mau a i ʻole ka ʻeha o ka ʻōpū
• Nā loli maʻamau i kou ʻili a i ʻole nā ​​ulu hou

Inā loaʻa iā ʻoe ke kuni, ka ʻū mau, nā hōʻailona e like me ka maʻi flu, a i ʻole nā hōʻailona o ka maʻi, e hoʻokaʻaʻike koke i kāu mea mālama ola. Hiki i kēia mau mea ke hōʻike i ka pono o kāu ʻōnaehana pale i ka nānā.

ʻO wai ka mea pono ʻole e lawe iā Guselkumab?

ʻAʻole kūpono ʻo Guselkumab no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻAʻole pono ka poʻe me nā maʻi e hoʻomaka i kēia lāʻau a hiki i ka wā e mālama ʻia ai kā lākou maʻi.

Pono ʻoe e haʻi i kāu kauka inā he moʻolelo kou o ka maʻi tuberculosis, hepatitis B a i ʻole C, a i ʻole nā maʻi maʻi ʻē aʻe. Hiki i kēia mau maʻi ke hana hou i ka wā e hoʻololi ʻia ai kāu ʻōnaehana pale e guselkumab.

Pono nā wahine hāpai a i ʻole e hānai ana i ka waiū e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola. ʻOiai he ʻikepili palena ʻia ma guselkumab i ka wā hāpai, hiki i kāu kauka ke kōkua iā ʻoe e kaupaona i nā pōmaikaʻi e kūʻē i nā pilikia hiki.

Pono ka poʻe i loaʻa i nā lāʻau lapaʻau ola i kēia manawa e kali ma mua o ka hoʻomaka ʻana iā guselkumab. Eia kekahi, pono ʻoe e pale i nā lāʻau lapaʻau ola i ka wā e lawe ana i kēia lāʻau, ʻoiai ua palekana ka hapa nui o nā lāʻau lapaʻau maʻamau.

Nā inoa inoa o Guselkumab

Loaʻa ʻo Guselkumab ma lalo o ka inoa inoa ʻo Tremfya. ʻO kēia wale nō ka inoa inoa i loaʻa no kēia lāʻau i ka hapa nui o nā ʻāina.

Ke kiʻi ʻoe i kāu kauoha, e ʻike ʻoe iā "Tremfya" ma ka pūʻolo a me ka lepili. Hele mai ka lāʻau lapaʻau i nā syringes i hoʻopiha mua ʻia a i ʻole nā peni auto-injector, e maʻalahi ai ka hāʻawi ʻana iā ʻoe iho i nā injections ma ka home.

Nā koho ʻē aʻe o Guselkumab

Inā ʻaʻole kūpono ʻo guselkumab iā ʻoe, hiki i kekahi mau lāʻau lapaʻau ʻē aʻe ke mālama i ka psoriasis a me ka psoriatic arthritis. Hiki i kāu kauka ke noʻonoʻo i nā lāʻau lapaʻau olaola ʻē aʻe e hana ana ma nā ʻano like akā e kuhikuhi ana i nā ʻāpana like ʻole o ka ʻōnaehana pale.

ʻO nā mea pale IL-23 ʻē aʻe e komo pū ana me risankizumab (Skyrizi) a me tildrakizumab (Ilumya). Hana like kēia mau lāʻau lapaʻau me guselkumab akā he mau papa hana ʻokoʻa paha a i ʻole nā hopena ʻaoʻao e kūpono paha i kāu mau pono.

ʻO nā mea pale TNF e like me adalimumab (Humira), etanercept (Enbrel), a me infliximab (Remicade) he papa ʻē aʻe o nā lāʻau lapaʻau olaola e hiki ke maikaʻi no ka psoriasis a me ka psoriatic arthritis. Ua loaʻa kēia mau mea no ka manawa lōʻihi a loaʻa nā ʻikepili palekana nui.

ʻO nā mea pale IL-17 e like me secukinumab (Cosentyx) a me ixekizumab (Taltz) e hōʻike ana i kahi ala i manaʻo ʻia. E noʻonoʻo kāu kauka i nā mea e like me kāu mau hōʻailona kikoʻī, nā kūlana olakino ʻē aʻe, a me ka ʻinikua i ke koho ʻana i ke koho maikaʻi loa.

Ua ʻoi aku ka maikaʻi o Guselkumab ma mua o Adalimumab?

He mau lapaʻau maikaʻi ʻo Guselkumab a me adalimumab no ka psoriasis a me ka psoriatic arthritis, akā hana lākou i nā mea like ʻole a ʻoi aku paha ka maikaʻi no nā poʻe like ʻole. Hoʻopaʻa ʻo Guselkumab iā IL-23, ʻoiai ʻo adalimumab e ālai i ka TNF-alpha, ʻo ia nā protein mumū nui.

Hōʻike nā haʻawina lapaʻau e ʻoi aku ka maikaʻi o guselkumab no ka psoriasis ʻili, me kekahi poʻe e loaʻa ana ka ʻili maʻemaʻe i hoʻohālikelike ʻia me adalimumab. Eia naʻe, ua loaʻa ʻo adalimumab no ka manawa lōʻihi a loaʻa nā ʻikepili nui e pili ana i ka palekana a me ka pono i ka wā lōʻihi.

He ʻokoʻa nui nā papa hana. Hāʻawi ʻia ʻo Guselkumab i kēlā me kēia 8 pule ma hope o nā mahele mua, ʻoiai hāʻawi ʻia ʻo adalimumab i kēlā me kēia pule ʻē aʻe. Makemake kekahi poʻe i ka liʻiliʻi o ka hāʻawi ʻana o guselkumab.

E noʻonoʻo kāu kauka i kāu kūlana kikoʻī, nā pilikia olakino ʻē aʻe, nā lapaʻau mua, a me nā makemake pilikino i ka wā e hoʻoholo ai i ka lāʻau lapaʻau e hana maikaʻi ai iā ʻoe. Hiki ke ʻokoʻa ka mea e hana maikaʻi ai mai kēlā me kēia kanaka.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Guselkumab

Ua palekana ʻo Guselkumab no ka poʻe me ka maʻi puʻuwai?

Me he mea lā he palekana ʻo Guselkumab no ka poʻe me ka maʻi puʻuwai, a ke hōʻike nei kekahi mau haʻawina he mau pōmaikaʻi cardiovascular paha. ʻAʻole like me kekahi mau lāʻau lapaʻau psoriasis ʻē aʻe, ʻaʻole ʻike ʻia ʻo guselkumab e hoʻonui i ka pilikia o nā pilikia o ka puʻuwai.

Eia naʻe, pono ʻoe e kūkākūkā i kou maʻi puʻuwai me kāu kauka ma mua o ka hoʻomaka ʻana i ka guselkumab. Hiki iā lākou ke makemake e nānā pono iā ʻoe a i ʻole e hoʻopili me kāu cardiologist e hōʻoia i ka kūpono o ka lāʻau lapaʻau no kou kūlana.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Guselkumab?

Inā ʻoe e hoʻokomo hewa i ka guselkumab ma mua o ka mea i kauoha ʻia, mai hopohopo. E hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole ka mea kūʻai lāʻau lapaʻau e kūkākūkā i ka mea i hana ʻia a loaʻa ke alakaʻi i nā hana aʻe.

ʻOiai ʻaʻohe antidote kikoʻī no ka overdose guselkumab, makemake paha kāu kauka e nānā pono iā ʻoe no nā hopena ʻaoʻao, ʻoi aku hoʻi nā hōʻailona o ka maʻi a i ʻole ka hoʻopaʻa ʻana i ka ʻōnaehana pale. E mālama i ka pūʻolo lāʻau lapaʻau me ʻoe ke kelepona ʻoe i hiki iā ʻoe ke hāʻawi i ka ʻike pololei e pili ana i ka nui āu i lawe ai.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Guselkumab?

Inā ua hala ʻoe i kahi mahele o guselkumab, e lawe koke iā ia ke hoʻomanaʻo ʻoe, a laila e hoʻomau me kāu papa manawa maʻamau. Mai pāpālua i nā mahele a i ʻole e hoʻāʻo e hana i ka injection i hala ma ka lawe ʻana i ka lāʻau lapaʻau keu.

E hoʻokaʻaʻike i kāu mea mālama ola inā ʻaʻole ʻoe maopopo e pili ana i ka manawa, ʻoiai inā ua hala kekahi mau pule mai kāu mahele i hala. Hiki iā lākou ke kōkua iā ʻoe e ʻike i ke ala maikaʻi loa e hoʻi ai i ke ala me kāu papa hana lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Guselkumab?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana i ka guselkumab me ka ʻole e kūkākūkā mua i kāu mea mālama ola. No ka mea he mau maʻi maʻi ka psoriasis a me ka psoriatic arthritis, ʻo ka hooki ʻana i ka lāʻau lapaʻau e hoʻihoʻi mai i kāu mau hōʻailona.

Hiki i kāu kauka ke noʻonoʻo e hooki a hoʻololi paha i kāu lapaʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, inā ʻaʻole maikaʻi ka pane ʻana o kou maʻi, a i ʻole inā e komo ana kāu psoriasis i ka remission lōʻihi. Eia naʻe, pono e hana mau ʻia kēia mau hoʻoholo me kāu hui mālama ola.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Guselkumab?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau maʻamau i ka wā e lawe ana iā guselkumab, akā pono ʻoe e pale i nā lāʻau lapaʻau ola. Aia kēia i nā lāʻau lapaʻau e like me ka lāʻau lapaʻau flu nasal spray, ka lāʻau lapaʻau MMR, a me ka lāʻau lapaʻau shingles ola.

E kamaʻilio me kāu kauka ma mua o ka loaʻa ʻana o kekahi lāʻau lapaʻau e hōʻoia i ka palekana. Hiki iā lākou ke ʻōlelo e loaʻa i kekahi mau lāʻau lapaʻau ma mua o ka hoʻomaka ʻana iā guselkumab, a i ʻole e hoʻonohonoho lākou me kāu mau mea mālama ola ʻē aʻe e hōʻoia i ka manawa kūpono o nā lāʻau lapaʻau.