He aha ʻo Ibrutinib: Nā Hoʻohana, Nā Kumu, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i hoʻopaʻa ʻia ʻo Ibrutinib e hana ana ma ka pale ʻana i nā protein kikoʻī e kōkua ana i kekahi mau maʻi maʻi koko e ulu a laha. No kēia lāʻau lapaʻau waha i kahi papa o nā lāʻau i kapa ʻia ʻo BTK inhibitors, ʻo ia hoʻi, e kālele ana i kahi protein i kapa ʻia ʻo Bruton's tyrosine kinase e pono ai nā maʻi maʻi e ola. Hiki i kāu kauka ke kuhikuhi iā ibrutinib inā loaʻa iā ʻoe kekahi mau ʻano maʻi maʻi koko e like me ka maʻi lymphocytic leukemia a i ʻole mantle cell lymphoma.

He aha ʻo Ibrutinib?

He lāʻau lapaʻau maʻi maʻi pololei ʻo Ibrutinib e kālele ana i nā maʻi maʻi maʻi me ka waiho ʻana i ka hapa nui o nā cell olakino. Hana ia ma ka pale ʻana i kahi ala protein e hoʻohana ai nā cell maʻi e ulu, hoʻonui, a pale i ka make ʻana o nā cell maʻamau. E noʻonoʻo e like me ka hoʻopau ʻana i kahi kuapo e pono ai nā cell maʻi e noho ola.

Lawe ʻia kēia lāʻau lapaʻau ma ke ʻano he capsules a i ʻole nā ​​papa ma ka waha, e maʻalahi ai ma mua o ka chemotherapy kuʻuna e koi ana i nā infusions IV. Ua hoʻomohala ʻia ka lāʻau lapaʻau ma o nā makahiki o ka noiʻi ʻana i ka hoʻomaopopo ʻana i ke ʻano o kekahi mau maʻi maʻi koko ma ka pae molekala.

No ke aha e hoʻohana ʻia ai ʻo Ibrutinib?

Hoʻomaʻamaʻa ʻo Ibrutinib i kekahi mau ʻano maʻi maʻi koko, ʻo ia hoʻi ka poʻe e pili ana i kāu ʻōnaehana lymphatic. E hoʻoholo kāu oncologist inā kūpono kēia lāʻau lapaʻau no kāu ʻano maʻi kikoʻī a me ke kūlana.

ʻO nā kūlana nui e kōkua ai ʻo ibrutinib i ka mālama ʻana, ʻo ia:

• Chronic lymphocytic leukemia (CLL) - he maʻi maʻi koko e ulu ana e pili ana i nā cell keʻokeʻo koko
• Small lymphocytic lymphoma (SLL) - pili pili loa i ka CLL akā pili nui i nā lymph nodes
• Mantle cell lymphoma - he ʻano o ka non-Hodgkin's lymphoma
• Marginal zone lymphoma - kekahi ʻano o ka lymphoma e ulu ana
• Waldenstrom's macroglobulinemia - he ʻano maʻi maʻi koko

E noʻonoʻo nō hoʻi kāu kauka inā ua hoʻāʻo ʻoe i nā lāʻau lapaʻau ʻē aʻe ma mua a pehea i pane mai ai kāu maʻi kanesa. Loaʻa i kekahi poʻe ka ibrutinib ma ke ʻano he lāʻau lapaʻau mua, aʻo nā poʻe ʻē aʻe e hoʻohana ia mea ma hope o ka hana ʻole ʻana o nā lāʻau lapaʻau ʻē aʻe e like me ka mea i manaʻo ʻia.

Pehea e Hana ai ʻo Ibrutinib?

Ua manaʻo ʻia ʻo Ibrutinib he lāʻau lapaʻau ikaika a i manaʻo ʻia e hana ʻokoʻa mai ka chemotherapy kuʻuna. Ma kahi o ka hoʻouka ʻana i nā cell e mahele wikiwiki ana, e ālai pono ia i ka protein BTK e hilinaʻi ai kekahi mau cell maʻi kanesa no ke ola.

Ke hiki ʻole i nā cell maʻi kanesa ke hoʻohana i kēia ala protein, e nāwaliwali lākou a make maoli i ka hopena. ʻO kēia ala i manaʻo ʻia e hana pinepine i nā hopena ʻaoʻao liʻiliʻi ma mua o nā lāʻau chemotherapy ākea no ka mea e koho nui ana i nā cell e pili ana.

Noho ka lāʻau lapaʻau i loko o kāu ʻōnaehana no kahi o 24 mau hola, ʻo ia ke kumu e lawe ai ʻoe i hoʻokahi manawa i ka lā. He mau pule a i ʻole mau mahina e ʻike i nā hopena piha i ka wā e hoʻomaʻemaʻe mālie ai kou kino i nā cell maʻi kanesa i hoʻopilikia ʻia.

Pehea e Lawe ai au i ka Ibrutinib?

E lawe i ka ibrutinib e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā i ka manawa like i kēlā me kēia lā. Hiki iā ʻoe ke lawe me ka ʻai a i ʻole me ka ʻole o ka ʻai, akā e hoʻāʻo e kūlike me kāu hana maʻamau e kōkua i ka mālama ʻana i nā pae paʻa i loko o kou koko.

E ale i nā capsules a i ʻole nā papa holoʻokoʻa me ke aniani wai piha. Mai ʻoki, wāwahi, a nau paha iā lākou no ka mea hiki i kēia ke hoʻopilikia i ke ʻano o ka lawe ʻia ʻana o ka lāʻau lapaʻau a hiki ke hoʻonui i nā hopena ʻaoʻao.

Inā ʻoe e lawe ana i ke ʻano capsule, e mālama mālie iā lākou no ka mea hiki iā lākou ke paʻa pū kekahi manawa. E mālama i kāu lāʻau lapaʻau i ka mahana wela o ka lumi mai ka wai a me ka wela. Manaʻo kekahi poʻe he mea kōkua ke hoʻonohonoho i ka alarm i kēlā me kēia lā e hoʻomanaʻo i kā lākou mahele.

Pehea ka lōʻihi e lawe ai au i ka Ibrutinib?

He nui ka poʻe e lawe ana i ka ibrutinib no nā mahina a i ʻole nā makahiki, ma muli o ka maikaʻi o kāna hana a me ka maikaʻi o kou hoʻomanawanui ʻana. ʻAʻole like me kekahi mau lapaʻau maʻi maʻi i loaʻa kahi lā pau, hoʻomau pinepine ʻia ka ibrutinib inā e kōkua ana i ka mālama ʻana i kāu maʻi maʻi me ka ʻole o ka hana ʻana i nā hopena ʻaoʻao hiki ʻole ke mālama.

E nānā kāu kauka i kāu pane ma o nā hoʻokolohua koko maʻamau a me nā nānā ʻana. Lawe kekahi poʻe i ka ibrutinib no kekahi mau makahiki, a ʻo nā mea ʻē aʻe e hoʻololi i nā lapaʻau like ʻole inā pono.

Mai hooki koke i ka lawe ʻana i ka ibrutinib me ka ʻole e kamaʻilio mua me kāu hui mālama ola. E alakaʻi kāu kauka iā ʻoe ma nā loli i kāu hoʻolālā lapaʻau a kōkua i ka hōʻoia ʻana i kou palekana i ke kaʻina hana.

He aha nā hopena ʻaoʻao o Ibrutinib?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka ibrutinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao, a e hana pū kāu hui mālama ola me ʻoe e hōʻemi i nā pilikia.

ʻO nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Pāpaʻa - pinepine ka hopena ʻaoʻao pinepine, maʻamau ka maʻalahi a i ʻole ka waena
• Luhi a me ka luhi maʻalahi ma mua o ka maʻamau
• Nausea a me ka pilikia o ka ʻōpū
• ʻO ka ʻeha maʻalahi ma mua o ka maʻamau
• ʻEha ʻiʻo a me nā hui
• ʻO ka ʻili ʻili a i ʻole ka ʻū
• Poʻo
• ʻO ka wili a i ʻole ka manaʻo māmā

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā pule mua. Hiki i kāu kauka ke hōʻike i nā ala e mālama ai iā lākou, e like me nā lāʻau lapaʻau ma luna o ka pāʻani a i ʻole nā loli meaʻai.

ʻAʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, akā pono lākou i ka lāʻau lapaʻau koke. Pākuʻi ʻia kēia:

• Ke kahe ʻana o ke koko a i ʻole ka ʻeha ʻana i maʻa ʻole a ʻaʻole e pau
• Nā hōʻailona o ka maʻi e like me ke kuni, nā anu, a i ʻole ka ʻūlū mau
• Ka maʻi pāhoehoe nui e alakaʻi ana i ka maloʻo
• Ka ʻeha o ka umauma a i ʻole ka puʻuwai ʻole
• Nā hopena ʻili nui a i ʻole ka ʻōpala
• Ka melemele ʻana o ka ʻili a i ʻole nā maka

E kelepona koke i kāu hui mālama ola inā ʻike ʻoe i kekahi o kēia mau hōʻailona koʻikoʻi. Hiki iā lākou ke kōkua i ka hoʻoholo inā pono ʻoe i ka mālama koke ʻana a i ʻole inā hiki i nā hoʻoponopono i kāu lapaʻau ke kōkua.

ʻO wai ka mea pono ʻole e lawe iā Ibrutinib?

ʻAʻole palekana ʻo Ibrutinib no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. Hiki i kekahi mau maʻi olakino a i ʻole nā lāʻau lapaʻau ke hoʻemi i ka palekana a i ʻole ka maikaʻi o ka ibrutinib iā ʻoe.

E ʻōlelo paha kāu kauka i kahi lapaʻau ʻē aʻe inā loaʻa iā ʻoe:

• Nā pilikia ate nui a i ʻole ka hepatitis ikaika
• He moʻolelo o nā maʻi kahe koko koʻikoʻi
• Nā pilikia o ka puʻuwai
• Nā maʻi ikaika a koʻikoʻi
• Hāpai a i ʻole nā hoʻolālā e hāpai

Pono nō hoʻi ʻoe i ka nānā ʻana kūikawā inā ʻoe e lawe i nā mea lahilahi koko, he moʻolelo o nā pilikia o ka puʻuwai, a i ʻole e lawe i kekahi mau lāʻau lapaʻau ʻē aʻe. E nānā kāu kauka i kāu mau lāʻau lapaʻau i kēia manawa e nānā i nā pilina e hiki ke hōʻino.

ʻAʻole ia e pale iā ʻoe mai ka lawe ʻana iā ibrutinib, akā hiki i kāu kauka ke hoʻomaka me kahi mahele haʻahaʻa a i ʻole e nānā pono iā ʻoe e hōʻoia i kou palekana.

Nā inoa inoa ʻo Ibrutinib

Loaʻa ʻo Ibrutinib ma lalo o ka inoa inoa ʻo Imbruvica, ʻo ia ka mana i kauoha pinepine ʻia. Aia i loko o kēia mana inoa inoa ka mea hana like me ka ibrutinib generic akā he mau mea hana ʻole like ʻole.

Hiki i kāu hale kūʻai lāʻau lapaʻau ke pani i ka ibrutinib generic no ka mana inoa inoa, hiki ke kōkua i ka hoʻemi ʻana i nā kumukūʻai. Hana like nā mana ʻelua a loaʻa nā hopena like no ka mālama ʻana i kāu maʻi kanesa.

Nā koho ʻē aʻe o Ibrutinib

Nui nā lāʻau lapaʻau ʻē aʻe e hana like me ka ibrutinib a i ʻole e mālama i nā ʻano maʻi maʻi koko like. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole ʻo ibrutinib ke koho maikaʻi loa no kou kūlana.

ʻO nā mea pale BTK ʻē aʻe e komo pū ana me acalabrutinib (Calquence) a me zanubrutinib (Brukinsa). Hana kēia mau lāʻau lapaʻau hou i nā ala like akā he ʻokoʻa paha nā hopena ʻaoʻao a i ʻole he kūpono no kekahi mau ʻano maʻi maʻi.

ʻO nā hui chemotherapy kuʻuna, nā lāʻau lapaʻau i manaʻo ʻia, a me nā lāʻau immunotherapy e like me ka CAR-T cell therapy paha he mau koho nō hoʻi e pili ana i kāu ʻano maʻi maʻi a me ke olakino holoʻokoʻa. E kōkua kāu oncologist e hoʻoholo i ke ʻano o ka mālama ʻana i kūpono loa no kou kūlana kūʻokoʻa.

Ua ʻoi aku ka maikaʻi o Ibrutinib ma mua o Rituximab?

Hana ʻo Ibrutinib a me rituximab ma nā ʻano like ʻole, no laila ʻaʻole maʻalahi ka hoʻohālikelike ʻana iā lākou. ʻO Rituximab kahi monoclonal antibody e kuhikuhi ana i kahi protein ʻokoʻa (CD20) ma nā cell cancer, ʻoiai ʻo ibrutinib e ālai i ke ala protein BTK.

Nui ka poʻe e loaʻa ana i nā lāʻau lapaʻau ʻelua i hui pū ʻia ma ke ʻano he hui pū. Hōʻike nā haʻawina no kekahi mau ʻano maʻi maʻi koko, ʻo ka hoʻohana ʻana i ka ibrutinib me ka rituximab hiki ke ʻoi aku ka maikaʻi ma mua o ka hoʻohana ʻana i kekahi lāʻau.

E noʻonoʻo kāu kauka i nā mea e like me kāu ʻano maʻi maʻi, nā lāʻau lapaʻau i hala, ke olakino holoʻokoʻa, a me nā makemake pilikino i ka wā e hoʻoholo ai ma waena o kēia mau koho. ʻO ka mea e hana maikaʻi loa e ʻokoʻa mai kēlā me kēia kanaka e pili ana i kā lākou kūlana olakino kūʻokoʻa.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Ibrutinib

He palekana anei ʻo Ibrutinib no ka maʻi puʻuwai?

Hiki i ka poʻe me ka maʻi puʻuwai ke lawe pinepine i ka ibrutinib, akā pono lākou i ka nānā ʻana. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai, ʻoi aku hoʻi i ka poʻe i loaʻa mua nā pilikia o ka puʻuwai.

E hana pū ana kāu kauka naʻau a me ka oncologist e hoʻoholo inā palekana ka ibrutinib iā ʻoe. Hiki iā lākou ke ʻōlelo i ka nānā ʻana i ka naʻau maʻamau ma o nā EKG a i ʻole nā hoʻokolohua ʻē aʻe e hōʻoia i ka olakino o kou naʻau i ka wā o ka mālama ʻana.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Ibrutinib?

E kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make inā lawe ʻoe i ka nui o ka ibrutinib ma mua o ka mea i kuhikuhi ʻia. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi e like me ke kahe nui ʻana a i ʻole nā pilikia o ka naʻau.

Mai hoʻāʻo e hoʻoponopono i ka mahele keu ma ka haʻalele ʻana i nā mahele e hiki mai ana. Akā, e hahai i ke alakaʻi a kāu kauka e pili ana i ka manawa e hoʻomaka hou ai i kāu papa hana maʻamau. E mālama i ka hue lāʻau i ka wā e kelepona ai i hiki iā ʻoe ke hāʻawi i ka ʻike kikoʻī e pili ana i ka nui āu i lawe ai.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Ibrutinib?

Inā haʻalele ʻoe i kahi mahele a ua hala ma lalo o 12 mau hola mai kou manawa maʻamau, e lawe koke iā ia ke hoʻomanaʻo ʻoe. Inā ua hala ma mua o 12 mau hola, e lele i ka mahele i haʻalele ʻia a lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i haʻalele ʻia. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole o ka hāʻawi ʻana i ka pōmaikaʻi hou. E noʻonoʻo e hoʻonohonoho i kahi alarm i kēlā me kēia lā a i ʻole e hoʻohana i kahi mea hoʻonohonoho pill e kōkua iā ʻoe e hoʻomanaʻo i kāu lāʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Ibrutinib?

E hooki wale i ka lawe ʻana i ka ibrutinib ke haʻi kāu kauka iā ʻoe he palekana ke hana pēlā. Hana maʻamau kēia inā ʻaʻole e pane hou ana kāu maʻi kanesa i ka lāʻau, inā e ʻike ana ʻoe i nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā e hoʻololi ana ʻoe i kahi lapaʻau ʻē aʻe.

E nānā kāu kauka i kāu hana koko a me nā scans i kēlā me kēia manawa e hoʻoholo ai i ka maikaʻi o ka hana ʻana o ka lāʻau. E kūkākūkā lākou i nā loli i kāu hoʻolālā lapaʻau me ʻoe ma mua e hiki ai iā ʻoe ke hoʻomākaukau no ka hoʻololi.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Ibrutinib?

He mea maikaʻi ka pale ʻana i ka waiʻona a i ʻole ka inu ʻana i nā mea liʻiliʻi wale nō i ka wā e lawe ana i ka ibrutinib. Hiki i ka waiʻona ke hoʻonui i kou pilikia o ke kahe ʻana o ke koko a hiki ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka ʻūlū a i ʻole ka ʻōpū.

E kamaʻilio me kāu kauka e pili ana inā he mea maikaʻi paha ka inu ʻana i ka waiʻona i kekahi manawa, me ka liʻiliʻi, no kou kūlana kikoʻī. Hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kou olakino holoʻokoʻa a me ka maikaʻi o kou ʻae ʻana i ka lāʻau.