Ibrutinib (ma ka waha)
Nā mea hōʻailona e loaʻa ana
Imbruvica
E pili ana i kēia lāʻau
Hoʻohana ʻia ka Ibrutinib no ka mālama ʻana i ka leukemia lymphocytic maʻi mau loa (CLL)/lymphoma lymphocytic liʻiliʻi (SLL), ka leukemia lymphocytic maʻi mau loa (CLL)/lymphoma lymphocytic liʻiliʻi (SLL) i nā mea maʻi me ka 17p deletion, a me ka Waldenström macroglobulinemia (WM). Hoʻohana ʻia nō hoʻi ia no ka mālama ʻana i ka maʻi graft-versus-host maʻi mau loa (cGHVD) ma hope o hoʻokahi a ʻoi aku paha mau lāʻau lapaʻau ʻaʻole i hana. Hoʻopilikia ia i ka ulu ʻana o nā cell kanesa, kahi e luku ʻia ai i ka hopena e ke kino. He lāʻau antineoplastic (lāʻau kanesa) ka Ibrutinib. Loaʻa wale kēia lāʻau me ke kauoha a kāu kauka. Loaʻa kēia huahana ma nā ʻano dosage e like me kēia:
Ma mua o ka hoʻohana ʻana i kēia lāʻau
I ka hoʻoholo ʻana e hoʻohana i kahi lāʻau lapaʻau, pono e kaulike ke kaumaha o ka lawe ʻana i ka lāʻau lapaʻau me ka pono e hana ai. He hoʻoholo kēia āu a me kāu kauka e hana ai. No kēia lāʻau lapaʻau, pono e noʻonoʻo i kēia mau mea: E haʻi aku i kāu kauka inā ua loaʻa iā ʻoe kekahi hopena maʻamau ʻole a i ʻole ka maʻi ʻiliʻili i kēia lāʻau lapaʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe. E haʻi pū aku i kāu limahana mālama ola inā loaʻa iā ʻoe nā ʻano ʻē aʻe o nā maʻi ʻiliʻili, e like me nā meaʻai, nā kala, nā mea mālama, a i ʻole nā holoholona. No nā huahana kūʻai ʻole ʻia, e heluhelu pono i ka lepili a i ʻole nā mea hoʻohui pūʻolo. ʻAʻohe mau haʻawina kūpono i hana ʻia ma ka pilina o ka makahiki i nā hopena o ka ibrutinib e mālama ai i ka maʻi graft-versus-host maʻi (cGHVD) i nā keiki ʻoi aku ka liʻiliʻi ma mua o 1 makahiki a e mālama ai i ka leukemia lymphocytic maʻi (CLL)/lymphoma lymphocytic liʻiliʻi (SLL), leukemia lymphocytic maʻi (CLL)/leukemia lymphocytic liʻiliʻi (SLL) me ka 17p deletion, a me ka Waldenström macroglobulinemia (WM) i nā keiki. ʻAʻohe palekana a me ka pono i hoʻokumu ʻia. ʻAʻohe mau haʻawina kūpono i hana ʻia a hiki i kēia lā i hōʻike ʻole i nā pilikia geriatric-kūikawā e kaupalena ai i ka pono o ka ibrutinib i nā ʻelemakule. Eia naʻe, ʻoi aku ka nui o nā poʻe ʻelemakule i nā hopena makemake ʻole (e laʻa, anemia, pneumonia, nā pilikia koko, ke koko kiʻekiʻe, nā pilikia rhythm naʻau), kahi e pono ai ke akahele i nā mea maʻi e loaʻa ana i ka ibrutinib. ʻAʻohe mau haʻawina lawa i nā wāhine no ka hoʻoholo ʻana i ka pilikia o ka pēpē i ka wā e hoʻohana ana i kēia lāʻau lapaʻau i ka wā e hānai ai. E kaulike i nā pono hiki ke loaʻa me nā pilikia hiki ke loaʻa ma mua o ka lawe ʻana i kēia lāʻau lapaʻau i ka wā e hānai ai. ʻOiai ʻaʻole pono e hoʻohana pū ʻia kekahi mau lāʻau lapaʻau, i nā hihia ʻē aʻe, hiki ke hoʻohana pū ʻia ʻelua mau lāʻau lapaʻau ʻokoʻa ʻoiai inā hiki ke loaʻa kahi pilina. I kēia mau hihia, makemake paha kāu kauka e hoʻololi i ka nui, a i ʻole nā mea akahele ʻē aʻe paha e pono ai. I ka wā e lawe ana ʻoe i kēia lāʻau lapaʻau, he mea nui loa ia i kāu limahana mālama ola e ʻike inā ke lawe nei ʻoe i kekahi o nā lāʻau lapaʻau i helu ʻia ma lalo nei. Ua koho ʻia nā pilina aʻe ma muli o ko lākou koʻikoʻi hiki ke loaʻa a ʻaʻole pono nā mea āpau. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe. Hiki i kāu kauka ke hoʻoholo ʻaʻole e mālama iā ʻoe me kēia lāʻau lapaʻau a hoʻololi paha i kekahi o nā lāʻau lapaʻau ʻē aʻe āu e lawe nei. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe, akā hiki ke koi ʻia i kekahi mau hihia. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua. Hiki i ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe ke hoʻonui i ka pilikia o kekahi mau hopena ʻaoʻao, akā ʻo ka hoʻohana ʻana i nā lāʻau lapaʻau ʻelua paha ka mālama maikaʻi loa no ʻoe. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua. ʻAʻole pono e hoʻohana ʻia kekahi mau lāʻau lapaʻau i ka wā a i ʻole kokoke i ka wā e ʻai ai i ka meaʻai a i ʻole ka ʻai ʻana i kekahi mau ʻano meaʻai ʻoiai hiki ke loaʻa nā pilina. Hiki i ka hoʻohana ʻana i ka waiʻona a i ʻole ka paka me kekahi mau lāʻau lapaʻau ke hoʻokumu pū i nā pilina. Ua koho ʻia nā pilina aʻe ma muli o ko lākou koʻikoʻi hiki ke loaʻa a ʻaʻole pono nā mea āpau. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā mea aʻe, akā hiki ke hiki ʻole ke pale ʻia i kekahi mau hihia. Inā hoʻohana pū ʻia, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i kēia lāʻau lapaʻau, a i ʻole e hāʻawi iā ʻoe i nā ʻōlelo kuhikuhi kūikawā e pili ana i ka hoʻohana ʻana i ka meaʻai, ka waiʻona, a i ʻole ka paka. Hiki i ke alo o nā pilikia olakino ʻē aʻe ke hoʻopilikia i ka hoʻohana ʻana i kēia lāʻau lapaʻau. E hōʻoia e haʻi aku i kāu kauka inā loaʻa iā ʻoe nā pilikia olakino ʻē aʻe, ʻoiai:
Pehea e hoʻohana ai i kēia lāʻau
E lawe pono i kēia lāʻau e like me ke kauoha a kāu kauka. Mai lawe nui aku, mai lawe pinepine aku, a mai lawe lōʻihi aku ma mua o ka kauoha a kāu kauka. Hiki mai kēia lāʻau me kahi pepa ʻike no nā mea maʻi a me nā ʻōlelo aʻo no nā mea maʻi. E heluhelu a hahai pono i kēia mau ʻōlelo aʻo. E nīnau i kāu kauka inā he nīnau kāu. E lawe i kēia lāʻau i ka manawa hoʻokahi i kēlā me kēia lā. E ʻai i ka kapu a i ʻole ka papahele holoʻokoʻa me kahi aniani wai. Mai wehe, ʻānai, haki, a ʻai paha. E ana i ka lāʻau wai waha me ka syringe ana ʻana i ka waha i hāʻawi ʻia. E inu i ka wai nui i kēlā me kēia lā e kōkua ai i ka pale ʻana i ka nele wai i hana ʻia e ka maʻi ʻōpū. Mai inu i ka wai grepufruta a ʻai paha i ka grepufruta a i ʻole nā ʻalani Seville me kēia lāʻau. E ʻokoʻa ka nui o kēia lāʻau no nā mea maʻi like ʻole. E hahai i nā kauoha a kāu kauka a i ʻole nā kuhikuhi ma ka lepili. Hoʻokomo wale nā ʻike ma lalo nei i nā nui awelika o kēia lāʻau. Inā ʻokoʻa kāu nui, mai hoʻololi inā ʻaʻole i haʻi aku kāu kauka iā ʻoe e hana pēlā. ʻO ka nui o ka lāʻau āu e lawe ai e hilinaʻi ana i ka ikaika o ka lāʻau. Eia kekahi, ʻo ka nui o nā nui āu e lawe ai i kēlā me kēia lā, ka manawa i ʻae ʻia ma waena o nā nui, a me ka lōʻihi o ka manawa āu e lawe ai i ka lāʻau e hilinaʻi ana i ka pilikia olakino āu e hoʻohana nei i ka lāʻau. Inā nalowale ʻoe i kahi nui o kēia lāʻau, e lawe koke iā ia. Eia naʻe, inā kokoke ka manawa no kāu nui aʻe, e haʻalele i ka nui i nalowale a hoʻi i kāu papa hana hoʻohana maʻamau. Mai pāpālua i nā nui. E lawe wale i ka nui i nalowale inā ʻo ia ka lā hoʻokahi me ka nui i hoʻonohonoho ʻia. E mālama i ka lāʻau i loko o kahi pahu pani ʻia ma ka mahana o ka lumi, mamao aku i ka wela, ka pulu, a me ka mālamalama pololei. E mālama mai ka hau. E mālama mamao aku i nā keiki. Mai mālama i ka lāʻau i hala ka lā a i ʻole ka lāʻau ʻaʻole pono hou. E nīnau i kāu limahana olakino pehea ʻoe e hoʻolei ai i kekahi lāʻau āu ʻaʻole e hoʻohana. E hoʻolei i kekahi wai wai ʻaʻole i hoʻohana ʻia 60 mau lā ma hope o ka wehe ʻana i ka hue.
Hōʻole: He kahua ʻike olakino ʻo ʻAukake a ʻaʻole hōʻike kāna mau pane i ka ʻōlelo aʻoaʻo lapaʻau. E kūkākūkā mau me kahi ʻoihana lapaʻau laikini kokoke iā ʻoe ma mua o ka hana ʻana i nā hoʻololi.
Hana ʻia i India, no ka honua