He aha ka Idecabtagene Vicleucel: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Idecabtagene vicleucel kahi lapaʻau maʻi maʻi e hoʻohana ana i kāu mau pūnaewele immune ponoʻī e hakakā i ka myeloma nui. ʻO kēia ʻano hana hou, i ʻike ʻia hoʻi ʻo ide-cel a i ʻole ma kona inoa inoa ʻo Abecma, he holomua nui i ka mālama maʻi maʻi pilikino.

E noʻonoʻo e like me ka hāʻawi ʻana i kāu ʻōnaehana immune i kahi hoʻomaikaʻi ikaika. ʻO kāu mau T-cell (nā koa o kāu ʻōnaehana immune) i hōʻiliʻili ʻia, hoʻololi ʻia i ka genetic i loko o kahi hale hana e ʻike maikaʻi a hoʻouka i nā pūnaewele maʻi maʻi, a laila hoʻokomo ʻia i loko o kou kino e hakakā i ka maʻi mai loko mai.

He aha ka Idecabtagene Vicleucel?

ʻO Idecabtagene vicleucel kahi ʻano o ka CAR-T cell therapy i hoʻolālā ʻia no ka myeloma nui. ʻO CAR-T ke kū nei no ka

ʻO ka myeloma nui he maʻi ʻaʻai e pili ana i nā pūnaewele plasma i loko o kou iwi iwi. ʻO kēia nā pūnaewele e hana ana i nā antibodies e hakakā i nā maʻi. Ke lilo lākou i mea maʻi ʻaʻai, hoʻonui lākou me ka ʻole o ka mana a hoʻopau i nā pūnaewele koko olakino.

Hiki i kāu kauka ke ʻōlelo aku i kēia lapaʻau inā ua hoʻāʻo mua ʻoe i nā hui like ʻole o nā lapaʻau myeloma nui maʻamau. ʻO kēia mau mea e pili ana i nā lāʻau lapaʻau e like me lenalidomide, pomalidomide, bortezomib, carfilzomib, daratumumab, a i ʻole ka hoʻololi ʻana i ke kelepona stem, a ua hoʻi mai kāu maʻi ʻaʻai a ʻaʻole paha e pane pono.

Pehea e hana ai ʻo Idecabtagene Vicleucel?

Hana ʻo Idecabtagene vicleucel ma ka hoʻololi ʻana i kāu ʻōnaehana pale i kahi ikaika hakakā maʻi ʻaʻai. Ua manaʻo ʻia kēia lapaʻau he mea ikaika loa i ka honua o nā lapaʻau maʻi ʻaʻai, e hōʻike ana i kekahi o nā ala holomua loa i loaʻa iā mākou.

Hoʻomaka ke kaʻina hana i ka wā e hōʻiliʻili ʻia ai kāu T-cells a hoʻolālā ʻia e hana i nā mea hoʻokipa kūikawā e hiki ke ʻike i kahi protein i kapa ʻia ʻo BCMA. Loaʻa i ka hapa nui o nā pūnaewele myeloma nui ka nui o BCMA ma ko lākou ʻili, e lilo ana lākou i mau pahuhopu kūpono no kēia mau pūnaewele pale i hoʻololi ʻia.

Ke hoʻokomo hou ʻia i loko o kou kino, hoʻonui kēia mau T-cells i hoʻomaikaʻi ʻia a lilo i pūʻali koa o nā mea hakakā maʻi ʻaʻai. E hele lākou i kou kahe koko a me ka iwi iwi, e ʻimi a luku i nā pūnaewele myeloma. ʻO ka nani o kēia ala e hoʻohana ana i ka ʻōnaehana pale kūlohelohe o kou kino, me nā hiki ke kuhikuhi maikaʻi.

ʻO ka mea e ikaika ai kēia lapaʻau, ʻo ia ka hiki ke hāʻawi i ka pale lōʻihi. Hiki i kekahi o kēia mau T-cells i hoʻololi ʻia ke noho i loko o kou kino no nā mahina a i ʻole nā makahiki, e hoʻomau ana i ka nānā ʻana i nā pūnaewele maʻi ʻaʻai e hoʻi mai ana.

Pehea wau e lawe ai iā Idecabtagene Vicleucel?

ʻAʻole he mea e lawe ai ʻo Idecabtagene vicleucel ma ka home e like me ka pila a i ʻole ka pahu. He hana paʻakikī kēia, he nui nā ʻanuʻu e pono ai ka hoʻoponopono ma waena ou a me kāu hui lapaʻau ma kahi kikowaena maʻi maʻi kūikawā.

Hoʻomaka ka huakaʻi me ka leukapheresis, he hana e hōʻiliʻili ʻia ai kāu mau T-cell ma o ke kaʻina hana e like me ka hāʻawi ʻana i nā platelets. E hoʻopili ʻia ʻoe i kahi mīkini e hoʻokaʻawale i kāu mau T-cell mai kou koko, ʻoiai e hoʻihoʻi ana i ke koena o kāu mau mea koko iā ʻoe. He 3-6 hola ka lōʻihi o kēia a ua ʻae maikaʻi ʻia.

ʻOiai e hana ʻia ana kāu mau cell i loko o ka hale hana (e lawe ana ma kahi o 4 pule), e loaʻa iā ʻoe ka mea i kapa ʻia he lymphodepleting chemotherapy. ʻO ka mea maʻamau, e loaʻa ana ka fludarabine a me ka cyclophosphamide ma o ka IV no ʻekolu lā. Kōkua kēia ʻanuʻu i ka hoʻomaʻemaʻe ʻana i kahi i loko o kāu ʻōnaehana pale no ka hana pono ʻana o nā cell CAR-T hou.

I ka lā infusion, e loaʻa iā ʻoe kāu mau cell CAR-T pilikino ma o ka IV, e like me ka loaʻa ʻana o ka hoʻoili koko. He mea wikiwiki ka infusion maoli, maʻamau e lawe ana ma lalo o hoʻokahi hola. Eia naʻe, pono ʻoe e noho kokoke i ke kikowaena lapaʻau no ka liʻiliʻi o ʻehā pule ma hope no ka nānā pono ʻana.

Pehea ka lōʻihi e lawe ai au i ka Idecabtagene Vicleucel?

Hāʻawi ʻia ʻo Idecabtagene vicleucel ma ke ʻano he lapaʻau hoʻokahi, ʻaʻole he lāʻau lapaʻau e like me ka chemotherapy kuʻuna. Ke hoʻokomo ʻia kāu mau T-cell i hoʻololi ʻia, ua hoʻolālā ʻia lākou e hoʻomau i ka hana i loko o kou kino no ka manawa lōʻihi.

ʻO ka hana lapaʻau mua e pili ana i 6-8 pule mai ka hoʻomaka ʻana a hiki i ka hopena. Aia kēia i ka manawa no ka hōʻiliʻili ʻana i nā cell, ka hana ʻana, ka chemotherapy hoʻomākaukau, a me ka infusion ponoʻī. Eia naʻe, hiki ke lōʻihi ka hopena o ka lapaʻau.

Hiki paha i kāu mau T-cell i hoʻololi ʻia ke noho ikaika i loko o kou kino no nā mahina a i ʻole nā makahiki ma hope o ka hoʻokomo ʻana. Hoʻomau kekahi poʻe maʻi i ka pōmaikaʻi mai kēia lapaʻau hoʻokahi no nā wā lōʻihi, ʻoiai ʻokoʻa loa nā pane pilikino. E nānā pono kāu hui lapaʻau iā ʻoe me nā hoʻokolohua koko maʻamau a me nā haʻawina kiʻi e nānā i ka maikaʻi o ka hana ʻana o ka lapaʻau.

Inā pau ka hana pono ʻana o ka lapaʻau i ka manawa, hiki i kāu kauka ke kūkākūkā i nā koho ʻē aʻe, akā ʻaʻole maʻamau ka hana hou ʻana i ka lāʻau lapaʻau CAR-T cell me nā protocols o kēia manawa.

He aha nā hopena ʻaoʻao o Idecabtagene Vicleucel?

E like me nā lāʻau lapaʻau maʻi maʻi ikaika a pau, hiki i ka idecabtagene vicleucel ke hana i nā hopena ʻaoʻao, a ʻo kekahi o ia mau mea he koʻikoʻi. Eia naʻe, ua ʻike nui kāu hui lapaʻau i ka mālama ʻana i kēia mau hopena a e nānā pono iā ʻoe i ka wā o kāu lapaʻau.

Hiki i ka hoʻomaopopo ʻana i ka mea e manaʻo ai ke kōkua iā ʻoe e mākaukau a emi ka hopohopo e pili ana i ke kaʻina hana. E hele kākou i nā hopena ʻaoʻao, e hoʻomaka ana me nā mea maʻamau a laila e kūkākūkā ana i nā mea liʻiliʻi akā ʻoi aku ka koʻikoʻi.

Nā hopena ʻaoʻao maʻamau

ʻO ka hapa nui o nā maʻi e ʻike i kekahi degere o ka luhi a me ka nāwaliwali i nā pule ma hope o ka lapaʻau. Hiki nō hoʻi iā ʻoe ke ʻike i nā hōʻailona e like me ka maʻi flu, me ke kuni, nā anu, a me nā ʻeha kino. Hana ʻia kēia mau mea no ka mea e hana ikaika ana kāu ʻōnaehana pale e hakakā i ka maʻi maʻi.

• Luhi a me ka nāwaliwali e hiki ke mau i nā pule he nui
• Ke kuni a me nā anu, ʻoi loa i ka pule mua ma hope o ka hoʻokomo ʻana
• Nausea a me ka emi ʻana o ka ʻai
• Nā poʻo a me ka noʻonoʻo
• Nā helu koko haʻahaʻa, hiki ke hoʻonui i ka pilikia o ka maʻi
• ʻEha ʻiʻo a me nā hui
• Pāpaʻa a i ʻole ka paʻa ʻana

Hiki ke mālama ʻia kēia mau hōʻailona me ka mālama kākoʻo a maʻa mau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lapaʻau. E hāʻawi kāu hui lapaʻau i nā lāʻau lapaʻau a me nā hoʻolālā e kōkua iā ʻoe e ʻoluʻolu.

Nā hopena ʻaoʻao koʻikoʻi

ʻElua mau hopena ʻaoʻao koʻikoʻi e pono ai ka mālama olakino koke: ka maʻi hoʻokuʻu cytokine (CRS) a me nā mea ʻona neurologic. ʻOiai he mea weliweli kēia mau mea, ua mākaukau kāu hui lapaʻau e ʻike a mālama koke iā lākou.

Hana ʻia ka maʻi hoʻokuʻu cytokine ke hoʻokuʻu nā T-cell i hoʻāla ʻia i nā mea mumū nui i kapa ʻia ʻo cytokines. E noʻonoʻo e like me ka ʻōnaehana pale o kou kino e hauʻoli nui ana i ka hakakā ʻana i ka maʻi maʻi. Hiki i nā hōʻailona ke komo i ke kuni kiʻekiʻe, ke koko haʻahaʻa, ka pilikia o ka hanu ʻana, a me ka manaʻo ʻana ʻaʻole maikaʻi.

Hiki i nā hopena ʻaoʻao neurologic ke komo i ka huikau, ka pilikia o ka ʻōlelo ʻana, nā haʻalulu, a i ʻole nā hopu ʻana. Hana ʻia kēia mau mea no ka mea hiki i nā pūnaewele pale i hoʻāla ʻia ke hoʻopilikia i ka ʻōnaehana nerve. ʻO ka hapa nui o nā hōʻailona neurologic he manawa pōkole a hoʻoponopono me ka mālama kūpono.

Nā hopena ʻaoʻao laha ʻole akā koʻikoʻi

Hiki i kekahi poʻe maʻi ke hoʻomohala i nā helu koko haʻahaʻa lōʻihi, hiki ke hoʻonui i ka pilikia o nā maʻi, ke kahe ʻana, a i ʻole ka anemia. I nā hihia laha ʻole, hiki i nā maʻi ke hoʻomohala i nā maʻi maʻi lua i nā makahiki ma hope o ka mālama ʻana, ʻoiai he haʻahaʻa loa kēia pilikia.

Aia kekahi manawa liʻiliʻi o ka hoʻomohala ʻana i ka mea i kapa ʻia ʻo ka maʻi lysis tumor, kahi e wāwahi koke ai nā pūnaewele maʻi maʻi i ko lākou mau mea i loko o ke kahe koko ʻoi aku ka wikiwiki ma mua o ka hiki i kou mau puʻupaʻa ke hana iā lākou. He hōʻailona maoli kēia e hana ana ka lāʻau lapaʻau, akā pono ia i ka nānā pono ʻana a me ka mālama ʻana.

E kūkākūkā kāu hui lapaʻau i kēia mau mea a pau me ʻoe ma nā kikoʻī a e hōʻoia e maopopo iā ʻoe nā hōʻailona ʻōlelo aʻo e nānā ai. E hoʻomanaʻo, hiki ke mālama ʻia nā hopena ʻaoʻao koʻikoʻi ke hopu ʻia i ka wā mua, ʻo ia ke kumu he mea nui ka nānā pono ʻana.

ʻO wai ka mea pono ʻole e lawe iā Idecabtagene Vicleucel?

ʻAʻole nā mea a pau i loaʻa i ka myeloma nui he moho no idecabtagene vicleucel. E loiloi pono kāu hui lapaʻau i kou olakino holoʻokoʻa a me ka mōʻaukala lapaʻau e hoʻoholo ai inā kūpono kēia lapaʻau iā ʻoe.

ʻAʻole ʻōlelo ʻia kēia lapaʻau inā loaʻa iā ʻoe kekahi mau maʻi maʻi, ʻoi aku hoʻi nā maʻi viral koʻikoʻi e like me ka HIV, hepatitis B, a i ʻole hepatitis C i mālama ʻole ʻia. Pono e lawa ka ikaika o kāu ʻōnaehana pale e mālama ai i ke kaʻina hana lapaʻau, a hiki i nā maʻi maʻi ke hoʻopilikia i ka hoʻōla.

ʻAʻole paha he moho maikaʻi nā poʻe me kekahi mau maʻi puʻuwai, nā maʻi māmā, a i ʻole nā pilikia o ka puʻupaʻa, no ka mea, pono e hana maikaʻi kēia mau ʻōkana e mālama i ke koʻikoʻi o ka lapaʻau. E hana kāu kauka i nā hoʻokolohua piha, me nā hoʻokolohua hana puʻuwai a me nā haʻawina hana māmā, e hōʻoia i ke olakino lawa ʻoe no ke kaʻina hana.

Inā he mōʻaukala kou o nā maʻi autoimmune koʻikoʻi, ʻaʻole kūpono paha kēia lapaʻau iā ʻoe. Mai ka wā e hoʻonui ai ka CAR-T therapy i kāu ʻōnaehana pale, hiki iā ia ke hoʻonui i nā kūlana autoimmune kahi i hana nui ai kāu ʻōnaehana pale.

ʻAʻole pono nā wahine hāpai a i ʻole nā wahine e hānai ana i ka waiū e loaʻa kēia lapaʻau, no ka mea, ʻaʻole ʻike ʻia nā hopena i nā pēpē e ulu ana. Eia kekahi, pono nā kāne a me nā wahine e hoʻohana i ka mana hānau maikaʻi i ka wā o ka lapaʻau a no kekahi manawa ma hope.

Inoa Brand Idecabtagene Vicleucel

Hoʻolaha ʻia ʻo Idecabtagene vicleucel ma lalo o ka inoa brand Abecma. ʻO kēia inoa brand ka mea āu e ʻike ai ma nā pepa haukapila a me nā palapala ʻinikua, ʻoiai e kuhikuhi paha kāu hui lapaʻau iā ia ma nā inoa like ʻole.

Hiki nō hoʻi iā ʻoe ke lohe iā ia i kapa ʻia ʻo

Hana ʻia ʻo Abecma e Bristol Myers Squibb me ka hui pū ʻana me bluebird bio. He mea nui e hoʻomaopopo he lapaʻau kūikawā loa kēia i loaʻa wale nō ma nā kikowaena lapaʻau i hōʻoia ʻia me ka ʻike kūikawā i ka lāʻau lapaʻau CAR-T cell.

Nā koho ʻē aʻe o Idecabtagene Vicleucel

Inā ʻaʻole kūpono ʻo idecabtagene vicleucel iā ʻoe, a i ʻole ke ʻimi nei ʻoe i nā koho āpau, aia kekahi mau lapaʻau ʻē aʻe no ka myeloma nui i hoʻihoʻi ʻia. E kōkua kāu kauka iā ʻoe e hoʻomaopopo i ka mea kūpono loa no kou kūlana.

ʻO Ciltacabtagene autoleucel (Carvykti) kekahi lāʻau lapaʻau CAR-T cell e manaʻo ana i ka protein BCMA like akā hoʻohana i kahi ala ʻokoʻa iki. Ua ʻae ʻia nō hoʻi no nā maʻi myeloma nui i hoʻāʻo i nā lapaʻau mua he nui, a manaʻo kekahi mau haʻawina he pono paha ia i nā maʻi i loaʻa mua i nā lāʻau lapaʻau CAR-T ʻē aʻe.

Hōʻike nā mea hoʻopili T-cell bispecific i kahi ala hou. Aia kēia mau lāʻau lapaʻau e like me teclistamab (Tecvayli) a me elranatamab (Elrexfio), e kōkua ana e hoʻopili pololei i kāu mau T-cell i nā sela maʻi ʻaʻole pono ka hoʻololi genetic. Hāʻawi ʻia kēia mau lapaʻau ma ke ʻano he injections a hiki ke lawelawe ʻia i nā wahi outpatient.

He mea nui nō hoʻi nā lāʻau lapaʻau hui kuʻuna. Hiki i kēia ke komo i nā hui hou o nā lāʻau immunomodulatory, nā mea pale proteasome, a me nā antibodies monoclonal ʻaʻole i komo i kāu mau lapaʻau mua.

No kekahi mau maʻi, hiki ke noʻonoʻo ʻia kahi transplant cell stem lua, ʻoiai inā loaʻa iā ʻoe kahi pane maikaʻi i kāu transplant mua a ua hala kekahi mau makahiki mai ia lapaʻau. Loaʻa mau nā hoʻokolohua lapaʻau e noiʻi ana i nā ala hou loa a hiki ke hāʻawi i ke komo ʻana i nā lapaʻau kiʻekiʻe.

Ua ʻoi aku ka maikaʻi o Idecabtagene Vicleucel ma mua o Ciltacabtagene Autoleucel?

He mea maikaʻi loa nā lāʻau lapaʻau CAR-T cell ʻo idecabtagene vicleucel (Abecma) a me ciltacabtagene autoleucel (Carvykti) no ka maʻi myeloma lehulehu, akā he mau ʻokoʻa ko lākou e hiki ai ke kūpono kekahi i kāu kūlana ma mua o kekahi.

Hoʻohana ʻo Ciltacabtagene autoleucel i kahi hoʻolālā CAR ʻokoʻa e kuhikuhi ana i ʻelua mau ʻāpana o ka protein BCMA ma kahi o hoʻokahi, e hiki ai ke ʻoi aku ka maikaʻi i ka ʻike ʻana a me ka hoʻouka ʻana i nā sela maʻi. Hōʻike kekahi mau hoʻokolohua lapaʻau e hiki ke hana i nā pane hohonu a paʻa i kekahi mau maʻi.

Eia naʻe, ua loaʻa ʻo idecabtagene vicleucel no ka lōʻihi a ʻoi aku ka nui o ka ʻike maoli ma hope ona. ʻO ia hoʻi, ʻoi aku ka nui o ka ʻikepili o nā kauka e pili ana i nā hopena lōʻihi a ua ʻike nui lākou i ka mālama ʻana i kāna mau hopena ʻaoʻao. Ua hoʻokumu maikaʻi ʻia ke kaʻina hana hana no ide-cel, i kekahi manawa hiki ke manaʻo i nā manawa kali pōkole.

Ua like loa nā ʻaoʻao hopena ma waena o nā lāʻau lapaʻau ʻelua, akā hōʻike kekahi mau haʻawina i nā ʻokoʻa liʻiliʻi i nā helu o kekahi mau pilikia. E noʻonoʻo kāu hui lapaʻau i nā mea e like me kāu mau lāʻau lapaʻau mua, ke kūlana olakino o kēia manawa, a me ka wikiwiki e pono ai ʻoe e hoʻomaka i ka lāʻau lapaʻau i ke kōkua ʻana iā ʻoe e koho ma waena o lākou.

Ma mua o ka maopopo ʻana o kekahi i ka

E hana pū ana kāu kauka cardiologist a me oncologist e loiloi i ka hana o kou puʻuwai ma mua o ka mālama ʻana. ʻO ka mea maʻamau, e komo ana kēia i ka echocardiogram a i ʻole MUGA scan e ana i ka maikaʻi o ka puʻuwai e pauma i ke koko. Inā pilikia nui ka hana o kou puʻuwai, hiki i kāu hui lapaʻau ke ʻōlelo aku e hoʻomaikaʻi mua i ke olakino o kou puʻuwai a i ʻole e noʻonoʻo i nā lāʻau lapaʻau ʻē aʻe.

I ka wā o ka mālama ʻana, e loaʻa iā ʻoe ka nānā hou ʻana no nā pilikia e pili ana i ka puʻuwai. ʻO ka lono maikaʻi, ʻo ka hapa nui o nā hopena ʻaoʻao e pili ana i ka puʻuwai mai ka lāʻau lapaʻau CAR-T he manawa pōkole a hiki ke mālama ʻia ke ʻike mua ʻia. He nui ka ʻike o kāu hui lapaʻau i ka mālama ʻana i nā maʻi me nā maʻi puʻuwai like ʻole e loaʻa ana kēia lāʻau lapaʻau.

He aha kaʻu e hana ai inā hoʻohana au i ka nui o Idecabtagene Vicleucel?

ʻAʻole hiki ke hana kēia kūlana no ka mea, hāʻawi ʻia ʻo idecabtagene vicleucel i nā kikowaena lapaʻau kūikawā e nā poʻe loea i aʻo ʻia. Hoʻohālikelike ʻia ka mahele ma muli o ke kaumaha o kou kino a me ka helu o nā cell CAR-T i hana kūikawā ʻia no ʻoe.

ʻAʻole like me nā lāʻau lapaʻau āu e lawe ai ma ka home, hāʻawi ʻia kēia lāʻau lapaʻau ma o ke kaʻina hana infusion i mālama pono ʻia. Nui nā loiloi palekana i kahi e hōʻoia ai e loaʻa iā ʻoe ka nui kūpono. Hōʻoia kāu hui lapaʻau i kou ʻike a me ka mahele kūpono i nā manawa he nui ma mua a i ka wā o ka infusion.

Inā he hopohopo kāu e pili ana i kāu lāʻau lapaʻau a i ʻole e ʻike i nā hōʻailona i manaʻo ʻole ʻia ma hope o ka loaʻa ʻana o ka lāʻau lapaʻau CAR-T, e hoʻokaʻaʻike koke i kāu hui lapaʻau. Loaʻa lākou 24/7 e pane i nā nīnau a i ʻole nā hopohopo āu e loaʻa ai i ka wā o kāu lāʻau lapaʻau a me ka manawa hoʻōla.

He aha kaʻu e hana ai inā e hala au i kahi mahele o Idecabtagene Vicleucel?

Hāʻawi ʻia ʻo Idecabtagene vicleucel ma ke ʻano he infusion hoʻokahi, no laila ʻaʻole pili ka hala ʻana i kahi mahele ma ke ʻano kuʻuna. Eia naʻe, aia nā ʻāpana o ke kaʻina hana lapaʻau kahi e koʻikoʻi ai ka manawa, e like me ka chemotherapy hoʻomākaukau a i ʻole ka lā infusion i hoʻonohonoho ʻia.

Inā ʻaʻole hiki iā ʻoe ke loaʻa i kāu chemotherapy hoʻomākaukau e like me ka mea i hoʻonohonoho ʻia, e hana pū kāu hui lapaʻau me ʻoe e hoʻonohonoho hou iā ia. Hoʻolālā ʻia ka manawa ma waena o ka chemotherapy hoʻomākaukau a me ka hoʻokomo ʻana i ka cell CAR-T e hoʻomaikaʻi i ka pono o ka lāʻau lapaʻau.

Inā pono ʻoe e hoʻopaneʻe i kāu hoʻokomo ʻana i ka cell CAR-T no kekahi kumu, hiki ke mālama ʻia kēia. Hiki ke mālama palekana ʻia kāu mau cell pilikino no kekahi manawa i kou hoʻoponopono ʻana i nā pilikia olakino a i ʻole nā hopohopo ʻē aʻe i kū mai. E hoʻonohonoho kāu hui lapaʻau i ka manawa hou e hōʻoia i ka hopena maikaʻi loa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Idecabtagene Vicleucel?

No ka mea, hāʻawi ʻia ʻo idecabtagene vicleucel ma ke ʻano he lāʻau lapaʻau hoʻokahi ma mua o ka lāʻau lapaʻau e hoʻomau nei, ʻaʻohe wahi hoʻoholo kahi e

Inā hoʻi mai kāu myeloma lehulehu ma hope o ka pane mua ʻana i ka lāʻau lapaʻau CAR-T, e loiloi kāu hui lapaʻau i kekahi mau mea e hoʻoholo ai i nā hana maikaʻi loa e hiki mai ana. Hiki i kēia ke komo i nā lāʻau lapaʻau CAR-T ʻē aʻe, nā antibodies bispecific, nā hui chemotherapy kuʻuna, a i ʻole nā hoʻokolohua lapaʻau e noiʻi ana i nā ala hou.

Hiki i kekahi poʻe maʻi nona ka maʻi e hoʻi mai ma hope o ka lāʻau lapaʻau CAR-T ke lilo i mau moho no kahi ʻano lapaʻau CAR-T ʻokoʻa, e like me ka ciltacabtagene autoleucel, ʻoiai inā he pane maikaʻi kā lākou i ka wā mua. E noʻonoʻo kāu hui lapaʻau i kou olakino holoʻokoʻa, pehea ka lōʻihi o ka hana ʻana o ka lāʻau lapaʻau mua, a me nā koho ʻē aʻe i loaʻa i ka wā e hoʻolālā ai i kāu mau hana e hiki mai ana.