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He lāʻau lapaʻau maʻi maʻi ʻo Idelalisib e kōkua ana i ka hakakā ʻana i kekahi mau ʻano maʻi maʻi koko ma ka pale ʻana i nā protein kikoʻī e pono ai nā sela maʻi e ola a ulu. Hana kēia lāʻau lapaʻau waha ma ke ʻano he lāʻau lapaʻau pololei, ʻo ia hoʻi ua hoʻolālā ʻia e hoʻouka i nā sela maʻi ma ke hoʻāʻo ʻana e mālama i nā sela olakino mai ka pōʻino.
Inā ua kau ʻia ʻo idelalisib iā ʻoe a i ʻole kekahi āu e mālama ai, nui paha kāu mau nīnau e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai. He hōʻailona kēia lāʻau lapaʻau i kahi holomua nui i ka mālama ʻana i ka maʻi maʻi, e hāʻawi ana i ka manaʻolana no ka poʻe me nā ʻano lymphomas a me leukemia i ʻole e pane maikaʻi i ka chemotherapy kuʻuna.
He ʻano lāʻau maʻi maʻi ʻo Idelalisib i kapa ʻia he kinase inhibitor āu e lawe ai ma ka waha ma ke ʻano he papa. Hana ia ma ka pale ʻana i kahi protein kikoʻī i kapa ʻia ʻo PI3K delta, a nā sela maʻi e hoʻohana ai e hoʻonui a laha i kou kino.
No kahi papa hou o nā lāʻau lapaʻau maʻi maʻi i kapa ʻia he lāʻau lapaʻau i manaʻo ʻia kēia lāʻau lapaʻau. ʻAʻole like me ka chemotherapy kuʻuna e pili ana i nā sela like ʻole i kou kino, ua hoʻolālā ʻia ʻo idelalisib e kālele pono i nā mīkini e hoʻohana ai nā sela maʻi koko e ola ai. E noʻonoʻo iā ia he mea hana pololei e manaʻo ana e hoʻopau i ka ulu ʻana o ka maʻi maʻi me ka hiki ke hana i nā hopena ʻaoʻao liʻiliʻi ma mua o nā lāʻau lapaʻau ākea.
Ua hoʻomohala ʻia ka lāʻau lapaʻau ma o nā makahiki o ka noiʻi ʻana i ke ʻano o ka hana ʻana o kekahi mau maʻi maʻi koko ma ka pae molekala. Ua ʻike nā ʻepekema he nui kēia mau maʻi maʻi e hilinaʻi nui ana i ke ala protein PI3K delta, e lilo ana ia i mea kūpono no ka mālama ʻana.
Ua ʻae ʻia ʻo Idelalisib no ka mālama ʻana i kekahi mau ʻano maʻi koko, ʻo ia hoʻi ka leukemia lymphocytic maʻi (CLL) a me nā ʻano kikoʻī o ka lymphoma non-Hodgkin. E kauoha maʻamau kāu kauka i kēia lāʻau lapaʻau ke hana ʻole nā lāʻau lapaʻau ʻē aʻe a i ʻole ua hoʻi mai kāu maʻi maʻi ma hope o ka mālama ʻana.
ʻO nā maʻi maʻamau i mālama ʻia me ka idelalisib e pili ana i ka leukemia lymphocytic maʻi i hui pū ʻia me ka rituximab, follicular B-cell non-Hodgkin's lymphoma, a me ka lymphoma lymphocytic liʻiliʻi. He mau maʻi maʻi kēia e pili ana i kāu mau keʻokeʻo keʻokeʻo, he ʻāpana o kāu ʻōnaehana pale.
Hiki i kāu oncologist ke noʻonoʻo i ka idelalisib no ka lymphoma i hoʻihoʻi ʻia a i ʻole refractory, ʻo ia hoʻi ua hoʻi mai kāu maʻi maʻi ma hope o ka mālama ʻana a i ʻole ʻaʻole i pane i nā lāʻau lapaʻau ʻē aʻe. Hāʻawi kēia lāʻau i kahi koho ke hiki ʻole nā ʻano chemotherapy kuʻuna a i ʻole pono no kāu kūlana.
Hana ʻo Idelalisib ma ka pale ʻana i kahi enzyme kikoʻī i kapa ʻia ʻo PI3K delta e pono ai nā cell cancer e ola, ulu, a hoʻonui. Hana kēia protein e like me ka hoʻololi e haʻi ana i nā cell cancer e hoʻomau i ka māhele a me ka laha ʻana i kou kino.
Ke pale ʻo idelalisib i kēia hoʻololi, ʻoki ʻo ia i nā hōʻailona ola nui e hilinaʻi ai nā cell cancer. Me ka ʻole o kēia mau hōʻailona, hoʻomaka nā cell cancer e make maoli ma o ke kaʻina hana i kapa ʻia ʻo apoptosis. ʻO kēia ala i manaʻo ʻia e hiki ai i ka lāʻau lapaʻau ke kūpono i kekahi mau ʻano maʻi koko me ka hoʻoulu ʻana i nā hopena ʻaoʻao liʻiliʻi ma mua o nā lāʻau lapaʻau e pili ana i nā cell e māhele wikiwiki ana.
Ma ke ʻano he lāʻau lapaʻau maʻi maʻi ikaika, hiki i ka idelalisib ke hana i nā hopena nui i ka hakakā ʻana i nā maʻi koko, akā pono ia i ka nānā pono ʻana e kāu hui mālama ola. Hoʻomaka maʻamau ka lāʻau lapaʻau i loko o kekahi mau pule, ʻoiai e hiki ke lawe i kekahi mau mahina e ʻike i nā pōmaikaʻi piha e pili ana i ka hōʻemi ʻana i nā helu cell cancer a me ka hoʻomaikaʻi ʻana i nā hōʻailona.
Pono ʻoe e lawe i ka idelalisib e like me ke kauoha a kāu kauka, maʻamau ʻelua manawa i ka lā me ka ʻole o ka meaʻai. Pono e moni ʻia nā papa holoʻokoʻa me ke aniani wai, a ʻaʻole pono ʻoe e ʻoki, wāwahi, a nau paha iā lākou no ka mea hiki ke hoʻopilikia i ke ʻano o ka lawe ʻana o ka lāʻau.
ʻO ka lawe ʻana i ka idelalisib me ka meaʻai hiki ke kōkua i ka hōʻemi ʻana i ka ʻōpū, ʻoiai ʻaʻole pono ia no ka hana pono ʻana o ka lāʻau. Hiki iā ʻoe ke lawe me kahi mea ʻai māmā a i ʻole ka ʻai inā ʻoe e ʻike he maʻalahi ia ma kou ʻōpū. E hoʻāʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā e mālama i nā pae paʻa o ka lāʻau i loko o kāu ʻōnaehana.
Inā ʻoe e lawe ana i nā lāʻau ʻē aʻe, e kūkākūkā i ka manawa me kāu mea mālama ola no ka mea hiki i kekahi mau lāʻau ke launa pū me ka idelalisib. Hiki i kāu kauka ke ʻōlelo e lawe i kekahi mau lāʻau i nā manawa like ʻole o ka lā e pale aku i nā pilina e hiki ke hoʻopilikia i ka maikaʻi o ka hana ʻana o kekahi lāʻau.
E hoʻomau ʻoe i ka lawe ʻana i ka idelalisib no ka lōʻihi e kōkua ana i ka mālama ʻana i kāu maʻi kanesa a ke ʻae maikaʻi nei ʻoe iā ia. ʻAʻole like me kekahi mau lāʻau āu e lawe ai no kekahi manawa, mālama pinepine ʻia nā lāʻau lapaʻau maʻi kanesa e like me ka idelalisib i ka wā lōʻihi e like me ka mālama ʻana.
E nānā kāu kauka i kāu pane ʻana i ka lāʻau ma o nā hoʻokolohua koko maʻamau a me nā haʻawina kiʻi. Inā pane maikaʻi kāu maʻi kanesa a ʻaʻole ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi, hiki iā ʻoe ke hoʻomau i ka lawe ʻana i ka idelalisib no nā mahina a i ʻole nā makahiki. ʻO ka pahuhopu ka mālama ʻana i kāu maʻi kanesa i ka wā e mālama ana i kou maikaʻi o ke ola.
Eia naʻe, inā e hoʻomohala ʻoe i nā hopena ʻaoʻao koʻikoʻi a i ʻole inā e pau kāu maʻi kanesa i ka pane ʻana i ka lāʻau, hiki i kāu kauka ke ʻōlelo e hooki i ka idelalisib a hoʻololi i kahi ala lapaʻau ʻē aʻe. Hana mau ʻia kēia mau hoʻoholo me ka akahele, e kau ana i nā pōmaikaʻi o ka mālama ʻana i ka hoʻomau ʻana i nā pilikia a i ʻole nā hopena ʻaoʻao āu e ʻike nei.
E like me nā lāʻau lapaʻau maʻi 'aʻai a pau, hiki i ka idelalisib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole e ʻike nā kānaka a pau iā lākou. ʻO nā hopena ʻaoʻao maʻamau ka mea e hiki ke mālama ʻia me ka nānā pono ʻana a me ke kākoʻo mai kāu hui mālama ola.
Hiki i ka hoʻomaopopo ʻana i ka mea e manaʻo ai ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e noi ai i ke kōkua. Eia nā hopena ʻaoʻao āu e ʻike ai, i hoʻonohonoho ʻia mai ka mea maʻamau a hiki i ka mea liʻiliʻi:
ʻO nā hopena ʻaoʻao maʻamau e ʻike ai ka nui o nā kānaka:
Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka manawa a me ke kākoʻo. Hiki i kāu hui mālama ola ke hāʻawi i nā lāʻau lapaʻau a me nā hoʻolālā e kōkua i ka mālama ʻana i kēia mau hōʻailona a mālama iā ʻoe i ka ʻoluʻolu i ka wā o ka lāʻau lapaʻau.
ʻO nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e pono ai ka lāʻau lapaʻau koke:
ʻOiai ʻaʻole maʻamau kēia mau hopena ʻaoʻao koʻikoʻi, pono lākou i ka lāʻau lapaʻau wikiwiki. E nānā pono kāu hui mālama ola iā ʻoe ma o nā nānā maʻamau a me nā hoʻokolohua koko e hopu i nā pilikia i ka wā mua.
Nā hopena ʻaoʻao kakaʻikahi akā hiki ke hoʻoweliweli i ke ola, e komo pū ana me:
Hōʻike kēia mau pilikia kakaʻikahi i ke kumu e koʻikoʻi ai ka nānā mau ʻana i ka wā o ka lāʻau idelalisib. Ua aʻo ʻia kāu hui oncology e ʻike i nā hōʻailona mua a hana wikiwiki inā pono.
ʻAʻole kūpono ʻo Idelalisib no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka kau ʻana i kēia lāʻau. Hiki i kekahi mau maʻi olakino a i ʻole nā kūlana ke palekana ʻole a i ʻole ka liʻiliʻi o ka idelalisib.
Pono kāu kauka e ʻike e pili ana i kāu mau maʻi olakino a me nā lāʻau lapaʻau e hoʻoholo ai inā kūpono ʻo idelalisib iā ʻoe. Eia nā kumu nui e hiki ʻole ai ke ʻōlelo ʻia kēia lāʻau:
ʻO nā maʻi olakino e pale ai iā ʻoe mai ka lawe ʻana iā idelalisib e komo pū ana me:
Inā loaʻa iā ʻoe kekahi o kēia mau maʻi, pono paha kāu kauka e mālama mua iā lākou a i ʻole e koho i kahi lāʻau lapaʻau maʻi ʻaʻai ʻē aʻe i ʻoi aku ka palekana no kāu kūlana.
ʻO nā kūlana kūikawā e koi ana i ka mālama hou ʻana e komo pū ana me:
E hana pū kāu hui mālama ola me ʻoe e hoʻoponopono i kēia mau hopohopo a e hoʻoholo i ke ala lapaʻau palekana loa no kāu kūlana pilikino.
Kūʻai ʻia ʻo Idelalisib ma lalo o ka inoa brand Zydelig, i hana ʻia e Gilead Sciences. ʻO kēia wale nō ka mana inoa brand i loaʻa i kēia manawa, no ka mea, aia nō ka lāʻau lapaʻau ma lalo o ka pale patent.
Ke kiʻi ʻoe i kāu kauoha, e ʻike ʻoe iā "Zydelig" ma ka hue me ka inoa generic "idelalisib." E pili ana nā inoa ʻelua i ka lāʻau lapaʻau like, akā hiki i kāu ʻinikua a i ʻole ka lāʻau lapaʻau ke hoʻohana i kekahi inoa ke kūkākūkā ʻana i kāu kauoha.
No ka mea he lāʻau lapaʻau maʻi maʻi kūikawā kēia, loaʻa pinepine ia ma o nā lāʻau lapaʻau kūikawā i loaʻa ka ʻike i ka mālama ʻana i nā lāʻau oncology. E kōkua kāu hui mālama ola i ka hoʻonohonoho ʻana i ka loaʻa ʻana o kāu kauoha ma o ka lāʻau lapaʻau kūpono.
Nui nā koho lapaʻau i manaʻo ʻia no ka mālama ʻana i nā maʻi koko e like me nā mea i mālama ʻia me idelalisib. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ʻo idelalisib iā ʻoe a i ʻole inā ʻaʻole pane maikaʻi kāu maʻi maʻi i ka lapaʻau.
Hana nā lāʻau lapaʻau ʻē aʻe ma o nā ʻano hana like ʻole akā manaʻo e hoʻokō i nā hopena like i ka mālama ʻana i nā maʻi koko. Eia kekahi mau koho e kūkākūkā ai kāu oncologist:
ʻO nā koho lapaʻau i manaʻo ʻia e komo pū ana:
E noʻonoʻo kāu kauka i nā mea e like me ke ʻano o kāu maʻi ʻaʻai, nā lāʻau i hala, ke olakino holoʻokoʻa, a me nā hopena ʻaoʻao e hiki ke loaʻa i ka wā e ʻōlelo ai i ka mea maikaʻi loa no kou kūlana.
ʻO nā ala lapaʻau kuʻuna i hiki ke noʻonoʻo ʻia e komo pū ana me:
Aia ke koho ma waena o kēia mau mea ʻē aʻe i nā mea he nui, a e kōkua kāu hui oncology iā ʻoe e hoʻomaopopo i nā pono a me nā pōʻino o kēlā me kēia koho no kou kūlana.
He mau lāʻau lapaʻau i manaʻo ʻia ʻo Idelalisib a me ibrutinib no nā maʻi koko, akā hana lākou ma nā ʻano hana like ʻole a ʻoi aku ka maikaʻi no nā maʻi like ʻole. ʻAʻole ʻoi aku ka maikaʻi o kekahi lāʻau lapaʻau ma mua o kekahi – pili ke koho i ke ʻano o kāu maʻi ʻaʻai, ke kūlana olakino, a me ka mōʻaukala lapaʻau.
Ke ālai nei ʻo Ibrutinib (Imbruvica) i kahi protein i kapa ʻia ʻo BTK, aʻo idelalisib e ālai ana i ka PI3K delta. Hiki i nā ala ʻelua ke maikaʻi, akā hiki iā lākou ke hana maikaʻi no nā ʻano maʻi koko like ʻole a i ʻole i nā kūlana lapaʻau like ʻole. E noʻonoʻo kāu oncologist i kāu hihia i ka wā e ʻōlelo ai i ka lāʻau lapaʻau e ʻoi aku ka maikaʻi.
Ma ke ʻano o nā hopena ʻē aʻe, hiki i nā lāʻau lapaʻau ʻelua ke hana i nā hopena nui, akā ʻokoʻa nā hopena ʻē aʻe. ʻOi aku ka maʻamau o ka Ibrutinib i ka hana ʻana i nā pilikia o ka puʻuwai a me nā pilikia o ke koko, ʻoiai ʻo idelalisib e hana pinepine i ka maʻi maʻi nui a me nā pilikia o ke ake. E noʻonoʻo kāu kauka i nā mea pilikia no kēia mau hopena ʻē aʻe i ka wā e hana ai i nā ʻōlelo aʻoaʻo lapaʻau.
Ua hōʻike nā haʻawina lapaʻau hiki i nā lāʻau lapaʻau ʻelua ke lilo i mea maikaʻi i ka mālama ʻana i nā maʻi maʻi koko i hoʻi hou a i ʻole refractory. Eia naʻe, hiki i kekahi poʻe maʻi ke pane maikaʻi i kekahi lāʻau lapaʻau ma mua o kekahi, a hiki i kekahi ke ʻae i kekahi lāʻau lapaʻau ma mua o kekahi ma muli o kā lākou ʻikepili olakino.
Pono ʻo Idelalisib i ka noʻonoʻo pono inā he pilikia ate kāu, no ka mea, hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana ate a ua hana ʻia ma o ke ake. Pono kāu kauka e loiloi i kou olakino ate ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a nānā pono iā ia i ka wā o ka lāʻau lapaʻau.
Inā he mau pilikia ate liʻiliʻi kāu, hiki i kāu kauka ke kuhikuhi iā idelalisib akā e ʻōlelo paha i ka nānā pinepine ʻana a me ka haʻahaʻa haʻahaʻa. Eia naʻe, inā he maʻi ate koʻikoʻi a i ʻole ka hāʻule ʻana o ke ake, ʻaʻole palekana paha ʻo idelalisib iā ʻoe, a e ʻōlelo paha kāu kauka i nā lāʻau lapaʻau ʻē aʻe.
ʻO nā hoʻokolohua koko maʻamau e nānā i ka hana ate he ʻāpana maʻamau o ka lāʻau lapaʻau idelalisib no nā maʻi a pau, me ka nānā ʻole inā he pilikia ate mua ko lākou. Kōkua kēia nānā ʻana i ka hopu ʻana i nā hopena ʻē aʻe e pili ana i ke ake i ka wā mua i hiki ke hoʻoponopono koke ʻia.
Inā ua lawe ʻoe i ka idelalisib i ʻoi aku ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa, ʻoiai inā ʻaʻole ʻoe e maʻi koke. ʻO ka lawe ʻana i ka lāʻau lapaʻau nui loa hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi nā pilikia o ke ake a me ka maʻi maʻi nui.
Mai hoʻāʻo e hoʻoponopono i ka lāʻau keu ma ka haʻalele ʻana i kāu lāʻau i hoʻonohonoho ʻia e hiki mai ana, no ka mea, hiki i kēia ke hoʻopilikia i ka hana maikaʻi ʻana o ka lāʻau. Akā, e hahai i nā ʻōlelo a kāu kauka e pili ana i ke ʻano e hoʻomau ai me kāu papa hana maʻamau.
E mālama i ka manawa āu e lawe ai i kāu lāʻau lapaʻau e kōkua ai i ka pale ʻana i nā lāʻau nui ʻole. ʻO ka hoʻohana ʻana i ka mea hoʻonohonoho pila a i ʻole ka hoʻonohonoho ʻana i nā mea hoʻomanaʻo kelepona hiki ke kōkua iā ʻoe e hoʻomanaʻo inā ua lawe mua ʻoe i kāu lāʻau no ka lā.
Inā ua hala ʻoe i kahi lāʻau o idelalisib, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole ua kokoke ka manawa no kāu lāʻau i hoʻonohonoho ʻia e hiki mai ana. Ma ia hihia, e haʻalele i ka lāʻau i hala a e hoʻomau me kāu papa hana maʻamau – mai lawe i ʻelua lāʻau i ka manawa hoʻokahi e hoʻoponopono ai i ka mea i hala.
Inā ʻaʻole ʻoe maopopo e pili ana i ka manawa, e kelepona i kāu mea mālama ola a i ʻole ka mea kūʻai lāʻau lapaʻau no ke alakaʻi. Hiki iā lākou ke kōkua iā ʻoe e hoʻoholo i ke ala maikaʻi loa e pili ana i ka nui o ka manawa i hala mai kāu lāʻau i hala.
No ke kōkua ʻana i ka hoʻomanaʻo ʻana i kāu mau lāʻau, e hoʻāʻo e lawe i ka idelalisib i nā manawa like i kēlā me kēia lā a e noʻonoʻo e hoʻohana i nā mea hoʻomanaʻo e like me nā ʻala kelepona a i ʻole nā mea hoʻonohonoho pila. ʻO ka kūlike i ka manawa e kōkua ai i ka mālama ʻana i nā pae paʻa o ka lāʻau i loko o kāu ʻōnaehana.
ʻAʻole pono ʻoe e hooki i ka lawe ʻana i ka idelalisib me ka ʻole e kūkākūkā mua me kāu oncologist, ʻoiai inā ʻoe e manaʻo maikaʻi a i ʻole e ʻike i nā hopena ʻaoʻao. ʻO ka hooki ʻana i ka mālama ʻana i ka maʻi kanesa hiki ke ʻae i kāu maʻi kanesa e ulu a laha hou, e paʻakikī paha i ka mālama ʻana i ka wā e hiki mai ana.
E loiloi mau kāu kauka i ka maikaʻi o ka hana ʻana o ka lāʻau a me ka maikaʻi o kou ʻae ʻana iā ia. Hiki iā lākou ke ʻōlelo e hooki i ka idelalisib inā e holomua ana kāu maʻi maʻi ʻoiai ke mālama ʻia, inā e loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi ʻaʻole hiki ke mālama ʻia, a i ʻole inā loaʻa kahi koho lapaʻau maikaʻi aʻe.
Inā hopohopo ʻoe e pili ana i nā hopena ʻaoʻao a i ʻole he mau nīnau kāu e pili ana i kāu hoʻolālā lapaʻau, e kūkākūkā ākea me kāu hui mālama ola. Hiki iā lākou ke hoʻoponopono i kāu mahele, hoʻohui i nā lāʻau lapaʻau kākoʻo, a i ʻole e hana i nā loli ʻē aʻe e kōkua iā ʻoe e hoʻomau i ka mālama ʻana me ka palekana a me ka ʻoluʻolu.
Hiki i ka Idelalisib ke launa pū me nā lāʻau lapaʻau ʻē aʻe, no laila he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau, nā lāʻau lapaʻau i kūʻai ʻia, a me nā mea hoʻohui āu e lawe nei. Hiki i kekahi mau pilina ke koʻikoʻi a pono paha i nā hoʻoponopono ʻana i ka mahele a i ʻole nā lāʻau lapaʻau ʻē aʻe.
Hiki i kekahi mau lāʻau lapaʻau ke hoʻonui i nā pae o ka idelalisib i loko o kou koko, e alakaʻi ana i nā hopena ʻaoʻao hou aku, ʻoiai ʻo nā mea ʻē aʻe e hōʻemi i kona pono. E nānā kāu kauka lapaʻau a me ke kauka i kāu mau lāʻau lapaʻau a pau e ʻike i nā pilina kūpono a hana i nā ʻōlelo paipai kūpono.
E nānā mau me kāu mea mālama ola ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou, me nā lāʻau lapaʻau i kūʻai ʻia a me nā mea kanu lāʻau, ʻoiai e lawe ana i ka idelalisib. Hiki i nā huahana i ʻike ʻia he mea ʻole ke launa pū me nā lāʻau lapaʻau maʻi ma nā ala i manaʻo ʻole ʻia.