He aha ʻo Iloprost: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau kūikawā ʻo Iloprost e kōkua ana i ka wehe ʻana i nā kīʻaha koko i loko o kou mau māmā ke lilo lākou i mea haiki loa. He mana synthetic ia o kahi mea maoli a kou kino e hana ai i kapa ʻia ʻo prostacyclin, e mālama ana i ke kahe ʻana o ke koko ma waena o kou mau aʻa.

Hoʻohana nui ʻia kēia lāʻau lapaʻau i hoʻokomo ʻia i loko o ka ea e mālama ai i ka pulmonary arterial hypertension (PAH), kahi maʻi koʻikoʻi kahi e lilo ai ke koko i loko o kou mau aʻa māmā i mea kiʻekiʻe loa. Ke hanu ʻoe i ka iloprost ma o kahi nebulizer kūikawā, hele pololei ia i ka hana e hoʻomaha ai i kēlā mau kīʻaha koko paʻa, e maʻalahi ai i kou puʻuwai ke pauma i ke koko ma waena o kou mau māmā.

No ke aha e hoʻohana ʻia ai ʻo Iloprost?

Hoʻomaʻamaʻa ʻo Iloprost i ka pulmonary arterial hypertension, kahi maʻi kahi e lilo ai nā aʻa liʻiliʻi i loko o kou mau māmā i mānoanoa a haiki. ʻO kēia ka mea e hana nui ai kou puʻuwai e pauma i ke koko ma waena o kou mau māmā, hiki ke alakaʻi i ka puʻuwai inā ʻaʻole i mālama ʻia.

Ua ʻae ʻia ka lāʻau lapaʻau no ka poʻe me PAH i loaʻa nā hōʻailona maʻalahi a koʻikoʻi. Hiki i kāu kauka ke kuhikuhi iā ia inā ʻoe e ʻike nei i ka pōkole o ka hanu, ka ʻeha o ka umauma, a i ʻole ka luhi e kaupalena ana i kāu mau hana i kēlā me kēia lā. He mea kōkua nui ia no ka poʻe i pane ʻole maikaʻi i nā lāʻau lapaʻau PAH ʻē aʻe.

I kekahi manawa hoʻohana nā kauka i ka iloprost no nā hihia koʻikoʻi o ka maʻi o Raynaud, kahi e paʻa ai nā kīʻaha koko i kou mau manamana lima a me nā manamana wāwae i ka pane ʻana i ke anuanu a i ʻole ke kaumaha. I nā hihia kakaʻikahi, hiki ke kuhikuhi ʻia no kekahi mau ʻano o nā koko koko i loko o nā māmā, ʻoiai ʻaʻole kēia ka mea nui e hoʻohana ai.

Pehea e hana ai ʻo Iloprost?

Hana ʻo Iloprost ma ka hoʻohālike ʻana i ka prostacyclin, kahi mea maoli ikaika e hana ai kou kino e mālama i nā kīʻaha koko i hoʻomaha a hāmama. Ke hanu ʻoe i ka lāʻau lapaʻau, hele pololei ia i nā kīʻaha koko liʻiliʻi i loko o kou mau māmā kahi e pono ai.

I laila, haʻi ʻo iloprost i nā cell muscle maʻemaʻe i loko o nā paia o kou mau kīʻaha koko e hoʻomaha a ākea. ʻO kēia hana, i kapa ʻia ʻo vasodilation, hoʻemi koke i ke kaomi i loko o kou mau ʻaʻa māmā. Kōkua nō hoʻi ka lāʻau lapaʻau i ka pale ʻana i ka hana ʻana o nā koko koko a hoʻemi i ka mumū i loko o nā paia o nā kīʻaha koko.

E noʻonoʻo e like me ka wehe ʻana i kahi paipu māla i ālaina ʻia - ke ākea ke ala, kahe ka wai me ka maʻalahi. Ua manaʻo ʻia ʻo Iloprost he lāʻau lapaʻau ikaika waena e hāʻawi ana i ke kōkua i kuhikuhi ʻia ma kahi e loaʻa ai ka pilikia, ma mua o ka hoʻopilikia ʻana i kāu ʻōnaehana holoʻokoʻa.

Pehea wau e lawe ai iā Iloprost?

Pono e hoʻokomo ʻia ʻo Iloprost me ka hoʻohana ʻana i kahi mea nebulizer kūikawā e hāʻawi ai kāu hui mālama ola a e aʻo iā ʻoe e hoʻohana pono. E lawe maʻamau ʻoe i 6 a 9 mau manawa i ka lā, e hoʻokaʻawale ana i nā mea ma kahi o 2 a 3 mau hola i ka wā o kou mau hola ala.

He 5 a 15 mau minuke e hoʻopau ai i kēlā me kēia kau inhalation. E hanu maʻamau ʻoe ma ka waha nebulizer i ka wā e hoʻololi ai ka mīkini i ka lāʻau wai i loko o ka noe maikaʻi e hiki ai i loko o kou mau māmā. He mea nui e noho pololei i ka wā o ka mālama ʻana a hanu mālie a hohonu.

Hiki iā ʻoe ke lawe iā iloprost me ka ʻole o ka meaʻai, akā ʻike ka nui o nā kānaka he maʻalahi ke hoʻonohonoho me nā meaʻai no ka mea e lawe pinepine ana ʻoe i ka lā. E hōʻoia e hoʻomaʻemaʻe i kāu lako nebulizer ma hope o kēlā me kēia hoʻohana e like me nā ʻōlelo a ka mea hana e pale ai i nā maʻi.

Mai hoʻohui i ka iloprost me nā lāʻau lapaʻau ʻē aʻe i loko o ka nebulizer hoʻokahi ke ʻole i kuhikuhi ʻia e kāu kauka. E mālama i nā vials i wehe ʻole ʻia i loko o ka pahu hau, akā e ʻae iā lākou e hiki i ka mahana o ka lumi ma mua o ka hoʻohana.

Pehea ka lōʻihi e lawe ai au iā Iloprost?

Pono ka hapa nui o nā kānaka me ka pulmonary arterial hypertension e lawe i ka iloprost i ka wā lōʻihi e mālama pono i ko lākou maʻi. He maʻi maʻi ʻo PAH e koi ana i ka mālama mau ʻana e mālama i nā hōʻailona i kaohi ʻia a pale i ka maʻi mai ka ʻino.

E nānā kāu kauka i kou pane ʻana i ka lāʻau lapaʻau ma o nā nānā maʻamau, me nā hoʻokolohua e ana ana i ka maikaʻi o ka hana ʻana o kou puʻuwai a me nā māmā. Inā kōkua ʻo iloprost iā ʻoe e ʻoi aku ka maikaʻi a hōʻike nā hopena o kāu hoʻokolohua i ka maikaʻi, e hoʻomau paha ʻoe i ka lawe ʻana iā ia no ka manawa pau ʻole.

Pono paha kekahi poʻe e hoʻololi i nā lāʻau lapaʻau like ʻole a i ʻole e hoʻohui i nā lāʻau lapaʻau ʻē aʻe i ka wā e loli ai ko lākou maʻi. Mai hooki koke i ka lawe ʻana iā iloprost me ka ʻole e kamaʻilio mua me kāu kauka, no ka mea, hiki i kēia ke hoʻihoʻi koke i kāu mau hōʻailona a hiki ke alakaʻi i nā pilikia weliweli.

He aha nā hopena ʻaoʻao o Iloprost?

E like me nā lāʻau lapaʻau a pau, hiki i ka iloprost ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia ke hoʻoponopono lākou i ke ʻano lapaʻau. ʻO nā hopena ʻaoʻao maʻamau e pili ana i nā hopena wehe ʻana i nā kīʻaha koko o ka lāʻau lapaʻau ma kou kino.

Eia nā hopena ʻaoʻao āu e ʻike ai, e hoʻomaka ana me nā mea maʻamau e pili ana i ka nui o nā kānaka:

• ʻEha i ka iwi ā a i ʻole ka ʻeha ʻiʻo - Hana ʻia kēia no ka mea e pili ana ʻo iloprost i ke kahe koko i kou mau ʻiʻo ā i ka wā e nau ai
• ʻEha poʻo - Maʻamau ka maʻalahi a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau
• ʻUlaʻula a i ʻole ka manaʻo mehana - Hiki ke wela kou maka a me kou umauma i ka wā e hoʻonui ai nā kīʻaha koko
• Nausea a i ʻole ka ʻōpū huhū - ʻO ka lawe ʻana i ka lāʻau lapaʻau me ka meaʻai i kekahi manawa e kōkua
• ʻAmi a i ʻole ka māmā - ʻOi loa i ka wā e kū koke ai
• ʻU a i ʻole ka huhū ʻana o ka ʻāʻī - Mai ke kaʻina hana inhalation ponoʻī

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao maʻamau a pinepine e lilo i mea liʻiliʻi i ka wā e hoʻomau ai ʻoe i ka lapaʻau. Eia naʻe, pono ʻoe e hoʻokaʻaʻike i kāu kauka inā lilo lākou i mea koʻikoʻi a i ʻole e keakea i kāu mau hana i kēlā me kēia lā.

Hiki ke hana ʻia nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi, a pono ʻoe e ʻimi i ka lāʻau lapaʻau inā ʻike ʻoe i kekahi o kēia mau mea:

• Hāʻule nui o ke koko - Ke hana nei i ka nāwaliwali, ka wili nui, a i ʻole ka huikau
• Puʻuwai wikiwiki a i ʻole ʻole - Hiki i kou puʻuwai ke hei a i ʻole e lele i nā kuʻi
• ʻEha umauma - ʻAʻole like me kāu mau hōʻailona PAH maʻamau
• Nā pilikia hanu nui - Hoʻonui ka pōkole o ka hanu a i ʻole ka hū
• Nā hōʻailona o ka maʻi maʻi māmā - ʻĀwela, sputum kala, a i ʻole ka ʻū nui

ʻO nā pilikia laha ʻole akā koʻikoʻi paha e pili ana i nā hopena maʻi maʻi nui, nā pilikia koko nui, a i ʻole nā hāʻule weliweli i ke koko e koi ai i ka mālama olakino koke. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike i nā hōʻailona ʻōlelo aʻo a ʻimi koke i ke kōkua inā loaʻa lākou.

ʻO wai ka mea ʻaʻole pono e lawe iā Iloprost?

ʻAʻole palekana ʻo Iloprost no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻAʻole kūpono paha ka poʻe me kekahi mau maʻi puʻuwai a i ʻole ka poʻe e lawe ana i nā lāʻau lapaʻau kikoʻī no kēia lapaʻau.

ʻAʻole pono ʻoe e lawe iā iloprost inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• Maʻi puʻuwai nui - Me ka puʻuwai i hala koke, angina paʻa ʻole, a i ʻole nā pilikia puʻuwai nui
• Koko haʻahaʻa loa - Hiki i ka Iloprost ke hoʻohaʻahaʻa hou i ke koko
• Nā maʻi koko ikaika - Hiki i ka lāʻau lapaʻau ke hoʻonui i ka pilikia o ke koko
• Maʻi ate nui - ʻAʻole paha e hana pono kou kino i ka lāʻau lapaʻau
• ʻIke ʻia ka maʻi maʻi i ka iloprost a i ʻole nā lāʻau lapaʻau like - Me nā lāʻau prostacyclin ʻē aʻe

E akahele nō hoʻi kāu kauka i ke kau ʻana iā iloprost inā loaʻa iā ʻoe nā pilikia kīkī, hāpai a hānai paha, a i ʻole e lawe ana i nā mea lahilahi koko. Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka iloprost, ʻo ia hoʻi nā mea e hoʻohaʻahaʻa ana i ke koko.

Hiki i nā kānaka ma luna o 65 makahiki ke pono i ka nānā kūikawā no ka mea, ʻoi aku ka nui o ka loaʻa ʻana o nā hopena ʻaoʻao. E haʻi mau i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei ma mua o ka hoʻomaka ʻana i ka iloprost.

Nā inoa inoa o Iloprost

Loaʻa ka Iloprost ma lalo o nā inoa inoa like ʻole ma muli o kou wahi a me ka hoʻohuihui kikoʻī. Ma ʻAmelika Hui Pū ʻIa, ʻo ka inoa inoa maʻamau ʻo Ventavis, ʻo ia ke ʻano i hoʻokomo ʻia i hoʻohana ʻia no ka pulmonary arterial hypertension.

ʻO nā inoa inoa ʻē aʻe āu e hālāwai ai, ʻo ia ka Ilomedin, i hoʻohana ʻia ma kekahi mau ʻāina no ka lawelawe ʻana i loko o ka vein. Loaʻa paha i kekahi mau wahi nā inoa inoa hou a i ʻole nā mana generic. Hiki i kāu kauka lāʻau ke kōkua iā ʻoe e ʻike i ka inoa inoa a i ʻole ka hoʻohuihui āu e loaʻa nei.

Ma waho aʻe o ka inoa inoa, ua like ka mea hana ikaika, akā ʻokoʻa paha ke ʻano o ka hāʻawi ʻana a me ka nui. E hoʻohana mau i ka huahana pololei i kauoha ʻia e kāu kauka a mai hoʻololi ma waena o nā inoa inoa like ʻole me ka ʻole o ke alakaʻi olakino.

Nā koho ʻē aʻe o Iloprost

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i ka pulmonary arterial hypertension inā ʻaʻole kūpono ka iloprost iā ʻoe a i ʻole ʻaʻole e hana pono ana. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe ma muli o kou kūlana kikoʻī a me ke ʻano o kou pane ʻana i ka lāʻau lapaʻau.

ʻO nā lāʻau lapaʻau ʻē aʻe i hoʻokumu ʻia i ka prostacyclin, ʻo ia ka epoprostenol (Flolan), i hāʻawi ʻia ma o ka hoʻokomo ʻana i ka IV mau, a me ka treprostinil (Remodulin), hiki ke hāʻawi ʻia ma ke ʻano he injection ma lalo o ka ʻili, ma o ka IV, a i ʻole ma ke ʻano he lāʻau lapaʻau i hoʻokomo ʻia. Hana like kēia mau mea me ka iloprost akā he mau papa hana ʻokoʻa a me nā ʻaoʻao hopena.

ʻO nā ʻano like ʻole o nā lāʻau lapaʻau PAH e komo pū ana me nā mea hoʻokūkū endothelin receptor e like me bosentan (Tracleer) a me ambrisentan (Letairis), e hana ana ma ka pale ʻana i nā mea e hoʻopaʻa ai i nā kīʻaha koko. ʻO nā mea hoʻopaʻa phosphodiesterase-5 e like me sildenafil (Revatio) a me tadalafil (Adcirca) e kōkua i nā kīʻaha koko e hoʻomaha ma o kahi ʻano hana ʻokoʻa.

ʻO nā lāʻau lapaʻau hou e like me riociguat (Adempas) e hana ana ma kahi ala ʻē aʻe e kōkua i nā kīʻaha koko e noho hāmama. Nui ka poʻe me PAH e pau ana i ka lawe ʻana i nā hui pū ʻana o kēia mau lāʻau lapaʻau e loaʻa ai nā hopena maikaʻi loa.

Ua ʻoi aku ka maikaʻi o Iloprost ma mua o Epoprostenol?

ʻO Iloprost a me epoprostenol nā lāʻau lapaʻau prostacyclin e hana like ana e mālama i ka PAH, akā he mau ʻokoʻa nui ko lākou e kūpono ai kēlā me kēia no nā poʻe like ʻole. ʻAʻole ʻoi aku ka maikaʻi o kekahi - pili ka koho i kou nohona, nā maʻi olakino ʻē aʻe, a me ke ʻano o kou pane ʻana i ka lāʻau lapaʻau.

ʻO ka pōmaikaʻi nui o Iloprost he mea maʻalahi mai ka mea e hanu ai ʻoe i kekahi mau manawa i ka lā ma mua o ka loaʻa ʻana o ka infusion IV mau. ʻO ia hoʻi, ʻaʻole pono ʻoe i kahi catheter mau a i ʻole ka pauma lawe lima, e hōʻemi nui ana i ka pilikia o nā maʻi koʻikoʻi a hāʻawi iā ʻoe i ke kūʻokoʻa hou aʻe i kāu mau hana i kēlā me kēia lā.

ʻO Epoprostenol, ma kekahi ʻaoʻao, hāʻawi i ka lāʻau lapaʻau mau a ʻoi aku ka maikaʻi no ka poʻe me PAH koʻikoʻi loa. Eia naʻe, pono ia i kahi catheter laina waena mau a me kahi pauma infusion mau, e hoʻonui ana i ka pilikia o nā maʻi e hoʻoweliweli ana i ke ola a me nā pilikia.

E noʻonoʻo kāu kauka i nā mea e like me ke koʻikoʻi o kāu PAH, kou hiki ke mālama i nā mea lapaʻau paʻakikī, kou pilikia i ka maʻi, a me kāu mau makemake pilikino i ke koho ʻana ma waena o kēia mau lāʻau lapaʻau. Hoʻomaka kekahi poʻe me iloprost a hoʻololi i epoprostenol inā ʻoi aku ko lākou maʻi, aʻo nā mea ʻē aʻe e hoʻohana pū i nā lāʻau lapaʻau ʻelua.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Iloprost

He palekana ʻo Iloprost no ka poʻe me ka maʻi puʻuwai?

Pono e loiloi pono ʻia ʻo Iloprost i ka poʻe me ka maʻi puʻuwai no ka mea hiki iā ia ke hoʻopilikia i ke koko a me ka puʻuwai. Pono kāu kaukaʻi puʻuwai e loiloi inā ʻoi aku ka maikaʻi ma mua o nā pilikia no kou maʻi puʻuwai.

Hiki i ka poʻe me ka maʻi puʻuwai paʻa ke hoʻohana palekana iā iloprost me ka nānā pono ʻana, akā ʻaʻole hiki i ka poʻe me ka angina paʻa ʻole, nā puʻuwai puʻuwai hou, a i ʻole nā pilikia o ka puʻuwai koʻikoʻi ke hoʻohana i kēia lāʻau. Makemake paha kāu kauka e hana i nā hoʻokolohua puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau a nānā pono iā ʻoe ma hope.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Iloprost?

Inā lawe hewa ʻoe i kahi lāʻau iloprost hou, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau. ʻO ka lawe ʻana i ka nui hiki ke hoʻohaʻahaʻa i ke koko, nā ʻeha poʻo nui, ka nausea, a i ʻole ka maʻi.

Mai ho'āʻo e

E loiloi mau kāu kauka inā ʻo ka iloprost ka lāʻau lapaʻau maikaʻi loa nāu a hiki iā ia ke hoʻoponopono i kāu mau lāʻau lapaʻau ma muli o ke ʻano o kāu pane ʻana. Inā pono ʻoe e hooki i ka iloprost, e hoʻololi paha kāu kauka iā ʻoe i kekahi lāʻau lapaʻau PAH ʻē aʻe ma mua o ka hooki ʻana i nā lāʻau lapaʻau a pau.

Hiki iaʻu ke hele i ka wā e lawe ana i ka Iloprost?

ʻAe, hiki iā ʻoe ke hele i ka wā e lawe ana i ka iloprost, akā pono ia i ka hoʻolālā mua ʻana e hōʻoia i ka lawa o kāu lāʻau lapaʻau a hiki iā ʻoe ke mālama i kāu papa hana. Pono ʻoe e lawe i kāu lako nebulizer a me nā lako lāʻau lapaʻau keu inā loaʻa nā lohi.

I ka lele ʻana, e lawe i kāu iloprost a me ka nebulizer i loko o kāu ʻeke lima me kahi leka mai kāu kauka e wehewehe ana i kāu pono olakino no nā lako. E hoʻokaʻaʻike i kāu mokulele ma mua e pili ana i ka hele ʻana me nā mea lapaʻau. No ka huakaʻi honua, e noiʻi inā he kānāwai kāu lāʻau lapaʻau ma kou ʻāina e hele nei a lawe i nā lako keu inā loaʻa nā pilikia.