He aha ka Imetelstat: Nā Hoʻohana, Ka Laʻau, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻaʻai kūikawā ʻo Imetelstat e kuhikuhi ana i kahi enzyme kikoʻī i kapa ʻia ʻo telomerase e kōkua i ka mālama ʻana i kekahi mau maʻi maʻi koko. Hana kēia lapaʻau intravenous ma ka pale ʻana i nā sela maʻi mai ka mālama ʻana i ko lākou hiki ke māhele a hoʻonui pau ʻole, ʻo ia kekahi o nā hiʻohiʻona nui e lilo ai nā sela maʻi i mea weliweli.

Inā ua kau ʻia ʻo imetelstat iā ʻoe a i ʻole kekahi mea aloha, e hana ana paha ʻoe me kahi maʻi koko kakaʻikahi akā koʻikoʻi. ʻOiai he holomua nui kēia lāʻau lapaʻau i ka mālama ʻana i ka maʻi ʻaʻai, he mea maʻamau ke loaʻa nā nīnau e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai i ka wā o ka mālama ʻana.

He aha ka Imetelstat?

He lāʻau lapaʻau maʻi ʻaʻai i manaʻo ʻia ʻo Imetelstat e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo telomerase inhibitors. Ua hoʻolālā ʻia e mālama i nā maʻi myelodysplastic (MDS) a me myelofibrosis, ʻo ia nā ʻano maʻi koko a me ka iwi iwi e pili ana i ke ʻano o kou kino e hana ai i nā sela koko olakino.

E noʻonoʻo iā imetelstat ma ke ʻano he mea hana pololei e kuhikuhi ana i kahi nāwaliwali kikoʻī i nā sela maʻi. Loaʻa i nā sela olakino maʻamau nā palena maoli i ka nui o nā manawa e hiki ai iā lākou ke māhele, akā ua loaʻa i nā sela maʻi nā ala e pale ai i kēia mau palena. Kōkua ʻo Imetelstat i ka hoʻihoʻi ʻana i kēlā mau palena maoli ma ka pale ʻana i ka enzyme e hiki ai i nā sela maʻi ke hoʻomau i ka māhele pau ʻole.

Hāʻawi ʻia kēia lāʻau lapaʻau ma o ka IV infusion, ʻo ia hoʻi, hāʻawi pololei ʻia i loko o kou kahe koko ma o ka vein. Hāʻawi ʻia ka lapaʻau ma kahi haukapila a i ʻole kahi kikowaena lapaʻau maʻi ʻaʻai kūikawā kahi e hiki ai i nā poʻe loea lapaʻau ke nānā pono iā ʻoe i ke kaʻina hana.

No ke aha e hoʻohana ʻia ai ʻo Imetelstat?

Hoʻohana nui ʻia ʻo Imetelstat no ka mālama ʻana i nā pākeke me nā maʻi myelodysplastic (MDS) haʻahaʻa pilikia i loaʻa nā ʻano genetic kikoʻī a ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe. He pūʻulu nā MDS o nā maʻi koko kahi e hana ʻole ai kou iwi iwi i nā keʻena koko olakino lawa, e alakaʻi ana i nā pilikia me ka anemia, nā maʻi, a me ke kahe ʻana.

Hiki i kāu kauka ke noʻonoʻo i ka imetelstat no kekahi mau ʻano o ka myelofibrosis, kahi maʻi e kūkulu ai ka ʻiʻo ʻōpala i loko o kou iwi iwi a keakea i ka hana ʻana o nā keʻena koko maʻamau. I kēia mau hihia, hiki i ka imetelstat ke kōkua i ka hoʻolohi ʻana i ka holomua o ka maʻi a hoʻomaikaʻi i kou maikaʻi o ke ola.

Hoʻopaʻa ʻia ka lāʻau lapaʻau no nā maʻi i hoʻāʻo i nā lāʻau lapaʻau maʻamau ʻē aʻe me ka holomua ʻole. E hana kāu hui mālama ola i nā hoʻokolohua genetic kikoʻī e hoʻoholo ai inā e pane ana kāu ʻano maʻi maʻi i ka imetelstat, no ka mea, ʻaʻole nā maʻi koko a pau i ka hana telomerase e manaʻo nei kēia lāʻau.

Pehea e hana ai ʻo Imetelstat?

Hana ʻo Imetelstat ma ka manaʻo ʻana i ka telomerase, kahi enzyme e hana e like me ka pāpale pale ma nā wēlau o nā chromosomes. I loko o nā keʻena olakino, ua kaupalena ʻia ka hana telomerase, ʻo ia hoʻi hiki i nā keʻena ke mahele i kekahi helu o nā manawa ma mua o ka make maoli ʻana. Akā naʻe, loaʻa pinepine i nā keʻena maʻi maʻi ka hana telomerase kiʻekiʻe, e ʻae ana iā lākou e mahele mau.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia he ikaika ma mua o ka chemotherapy kuʻuna. Hoʻopili pono ia i ka enzyme telomerase a pale iā ia mai ka hana pono ʻana, kahi e hoʻoulu mālie ai i nā keʻena maʻi maʻi e hiki i ko lākou palena mahele maoli a make.

ʻAʻole koke ke kaʻina hana - pono maʻamau i kekahi mau pōʻai lapaʻau no ka imetelstat e kūkulu i loko o kāu ʻōnaehana a hoʻomaka e hōʻike i nā hopena kūpono. E nānā kāu kauka i kāu helu koko a me ke olakino holoʻokoʻa i nā manawa maʻamau e nānā i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau a hoʻoponopono i kāu hoʻolālā mālama e like me ka mea e pono ai.

Pehea e lawe ai au i ka Imetelstat?

Hāʻawi ʻia ka Imetelstat ma ke ʻano he infusion intravenous, ʻo ia hoʻi, hāʻawi pololei ʻia i loko o kou kahe koko ma o ka vein no kekahi mau hola. Lawe maʻamau ka infusion ma kahi o 2-4 mau hola a hāʻawi ʻia i loko o kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi maʻi kūikawā kahi e hiki ai i nā poʻe lapaʻau i aʻo ʻia ke nānā iā ʻoe i ke kaʻina hana.

ʻAʻole pono ʻoe e hoʻokē ʻai ma mua o ka mālama ʻana, akā ua ʻōlelo ʻia e ʻai i ka meaʻai māmā ma mua e kōkua ai i ka pale ʻana i ka nausea. ʻO ka noho ʻana i ka wai maikaʻi ma ka inu ʻana i ka wai nui i nā lā e alakaʻi ana i kāu mālama ʻana hiki ke kōkua i kou kino e hana i ka lāʻau lapaʻau me ka ʻoi aku ka maikaʻi.

ʻO ka papa hana lapaʻau maʻamau i hoʻokahi manawa i kēlā me kēia 4 pule, ʻoiai e hoʻoponopono paha kāu kauka i kēia ma muli o ke ʻano o kou pane ʻana a me nā hopena ʻaoʻao āu e ʻike ai. Ma mua o kēlā me kēia infusion, e nānā kāu hui mālama ola i kāu helu koko a me ke olakino holoʻokoʻa e hōʻoia i ka palekana e hoʻomau me ka mahele aʻe.

I ka wā o ka infusion, e noho ʻoe i loko o kahi noho ʻoluʻolu a i ʻole kahi moe, a e hāʻawi ʻia ka lāʻau lapaʻau ma o ka laina IV. Hiki i ka hapa nui o nā kānaka ke heluhelu, nānā i ke TV, a i ʻole e hoʻomaha i kēia manawa, a paipai ka nui o nā kikowaena lapaʻau iā ʻoe e lawe mai i kahi lālā ʻohana a i ʻole hoaaloha no ke kākoʻo.

Pehea ka lōʻihi e lawe ai au i ka Imetelstat?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana i ka imetelstat mai kēlā kanaka i kēia kanaka a pili i ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau a me ke ʻano o kou ʻae ʻana i nā hopena ʻaoʻao. Hiki i kekahi poʻe ke loaʻa ka mālama ʻana no kekahi mau mahina, a ʻo nā mea ʻē aʻe e hoʻomau paha no hoʻokahi makahiki a ʻoi aku paha inā e kōkua ana ka lāʻau lapaʻau i ka mālama ʻana i ko lākou maʻi.

E loiloi mau kāu kauka i kāu holomua ma o nā hoʻokolohua koko, nā biopsies iwi iwi, a me nā hoʻokolohua kino e hoʻoholo ai inā e hana pono ana ka mālama ʻana. Inā hoʻomaikaʻi kāu helu koko a maikaʻi aʻe kāu mau hōʻailona, ​​hiki iā ʻoe ke hoʻomau i ka mālama ʻana no ka manawa lōʻihi e mālama ai i kēia mau pōmaikaʻi.

ʻO ka hoʻoholo e hooki i ka lapaʻau e hilinaʻi pinepine ʻia ma nā mea he nui: inā e pane ana ka maʻi ʻaʻai, pehea ka nui o nā hopena ʻaoʻao, a me kou maikaʻi o ke ola. E hana pū ana kāu hui mālama ola me ʻoe e loaʻa ke kaulike kūpono ma waena o ka mālama ʻana i kou maʻi a me ka mālama ʻana i kou hōʻoluʻolu a me kou olakino.

He aha nā hopena ʻaoʻao o Imetelstat?

E like me nā lāʻau lapaʻau maʻi ʻaʻai a pau, hiki i ka imetelstat ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā mea a pau e ʻike iā lākou ma ke ala like. ʻO nā hopena ʻaoʻao maʻamau e pili ana i nā loli i kāu helu koko a me ke ʻano o kou kino e hana ai i ka lāʻau.

ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e launa pū ai me kāu hui mālama ola no ke kākoʻo.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai:

• Luhi a me ka nāwaliwali ma muli o ka helu haʻahaʻa o nā keʻena koko ʻulaʻula
• Hoʻonui ʻia ka pilikia o nā maʻi mai ka helu haʻahaʻa o nā keʻena koko keʻokeʻo
• Maʻalahi ka ʻeha a i ʻole ke kahe ʻana mai ka helu haʻahaʻa o nā platelet
• Nausea a me ka emi ʻana o ka ʻai
• ʻEha poʻo a me ka noʻonoʻo
• ʻEha ʻiʻo a me nā hui
• Nā loli i nā hoʻokolohua hana ate

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao me ke kākoʻo olakino kūpono a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lapaʻau.

ʻO nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e komo pū ana:

• Nā hāʻule nui i nā helu keʻena koko e koi ana i nā lohi lapaʻau
• Nā maʻi koʻikoʻi e pono ai ka lāʻau lapaʻau koke
• Nā pilikia ate nui e pili ana i ke ʻano o kou kino e hana ai i nā lāʻau
• Nā hopena maʻi maʻi koʻikoʻi i ka wā a i ʻole ma hope o ka hoʻokomo ʻana
• Nā koko koko i loko o nā veins a i ʻole nā māmā
• Nā loli o ka puʻuwai a i ʻole nā pilikia cardiovascular

E nānā pono kāu hui mālama ola iā ʻoe no kēia mau hopena koʻikoʻi a hoʻoponopono i kāu hoʻolālā lapaʻau e like me ka mea e pono ai e mālama iā ʻoe.

ʻO wai ka mea pono ʻole e lawe iā Imetelstat?

ʻAʻole kūpono ʻo Imetelstat no nā mea a pau, a e loiloi pono kāu kauka inā ʻo ia ka koho lapaʻau kūpono no kou kūlana kikoʻī. Hiki i kekahi mau maʻi olakino a i ʻole nā kūlana ke hoʻolilo i kēia lāʻau lapaʻau i mea palekana ʻole a i ʻole ka liʻiliʻi o ka hopena iā ʻoe.

E nānā kāu hui mālama ola i kāu mōʻaukala olakino piha a me ke kūlana olakino o kēia manawa ma mua o ka ʻōlelo ʻana i ka lāʻau lapaʻau imetelstat.

ʻAʻole paha ʻoe he moho no ka imetelstat inā loaʻa iā ʻoe:

• ʻO ka maʻi kīkī a i ʻole ke ake nui e pili ana i ke ʻano o ka hana ʻana o kou kino i nā lāʻau lapaʻau
• Nā maʻi ikaika, ʻaʻole i hoʻomalu ʻia e hiki ke lilo i mea hoʻoweliweli i ke ola
• Nā pilikia o ka naʻau nui a i ʻole ka puʻuwai i hala koke
• Mōʻaukala o nā hopena maʻi maʻi koʻikoʻi i nā lāʻau lapaʻau like
• Nā helu koko haʻahaʻa loa e hiki ke lilo i mea weliweli
• Hāpai a i ʻole nā hoʻolālā e hāpai i ka wā o ka lāʻau lapaʻau
• Ka hānai ʻana a i ʻole ka hiki ʻole ke hooki i ka hānai ʻana i ka wā o ka lāʻau lapaʻau

Eia kekahi, inā ʻoe e lawe ana i kekahi mau lāʻau lapaʻau e launa pū me imetelstat, pono paha i kāu kauka e hoʻoponopono i kāu hoʻolālā lapaʻau a i ʻole e noʻonoʻo i nā koho ʻē aʻe.

Hiki ke pili nā manaʻo kūikawā inā ʻoe:

• Ma luna o 75 mau makahiki a loaʻa nā maʻi olakino he nui
• Ua loaʻa i nā lāʻau lapaʻau maʻi ma mua i pili i kou puʻuwai a i ʻole ke ake
• Ke lawe nei i nā mea lahilahi koko a i ʻole nā lāʻau lapaʻau e pili ana i ka hoʻopaʻa ʻana o ke koko
• He mōʻaukala o nā koko koko a i ʻole ka hahau
• Ke hoʻolālā nei i ke ʻoki a i ʻole nā kaʻina hana niho i ka wā o ka lāʻau lapaʻau

E hana pū kāu hui mālama ola me ʻoe e hoʻoholo inā kūpono ʻo imetelstat no kou kūlana a kūkākūkā i nā koho lapaʻau ʻē aʻe inā pono.

Nā inoa inoa o Imetelstat

Loaʻa ʻo Imetelstat ma lalo o ka inoa inoa Rytelo ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka hoʻohui ʻana i ʻae ʻia e ka FDA i hoʻolālā ʻia no ka mālama ʻana i nā maʻi myelodysplastic a me nā maʻi koko pili.

Hiki ke loaʻa ka lāʻau lapaʻau ma lalo o nā inoa inoa like ʻole ma nā ʻāina ʻē aʻe, akā ʻo ka mea hana a me ka hana ʻana e like nō ia. E hōʻoia kāu hale kūʻai lāʻau lapaʻau a me kāu hui mālama ola e loaʻa iā ʻoe ka lāʻau lapaʻau kūpono me ka nānā ʻole i ka inoa inoa i hoʻohana ʻia ma kou wahi.

E hōʻoia mau me kāu mea mālama ola e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono, ʻoiai inā ʻoe e hele ana a i ʻole e loaʻa ana ka lāʻau lapaʻau ma nā wahi like ʻole. Hiki ke ʻokoʻa iki ka ʻeke a me ke ʻano ma waena o nā mea hana, akā pono e mau ka mea hana a me ka dosage.

Nā Koho ʻē aʻe no Imetelstat

Inā ʻaʻole kūpono ʻo imetelstat no kou kūlana a i ʻole ʻaʻole e hana pono ana, hiki ke loaʻa nā lāʻau lapaʻau ʻē aʻe no nā maʻi myelodysplastic a me nā maʻi koko pili. E hana pū kāu hui mālama ola me ʻoe e ʻimi i ke koho kūpono loa e pili ana i kou kūlana a me ke olakino holoʻokoʻa.

ʻO nā koho lapaʻau kuʻuna e pili ana i nā mea hypomethylating e like me azacitidine (Vidaza) a i ʻole decitabine (Dacogen), e hana ʻokoʻa ana ma mua o imetelstat akā hiki nō ke kōkua i ka hoʻomaikaʻi ʻana i ka hana ʻana o ke koko. Hoʻāʻo pinepine ʻia kēia mau lāʻau lapaʻau ma mua o imetelstat a hiki ke noʻonoʻo hou ʻia inā pono.

ʻO nā koho ʻē aʻe e pili ana i nā ana mālama kākoʻo e like me nā transfusions koko maʻamau, nā injections factor ulu e hoʻoulu ai i ka hana ʻana o ke koko, a i ʻole nā lāʻau immunosuppressive e pili ana i kāu ʻano maʻi koko.

No kekahi poʻe maʻi, hiki ke noʻonoʻo ʻia ka transplantation iwi iwi, ʻoiai inā ʻoe ʻōpio a loaʻa kahi mea hāʻawi kūpono. Hiki i kēia koho lapaʻau ikaika ke hoʻōla i ke kūlana akā pono e loiloi pono i nā pilikia a me nā pōmaikaʻi.

ʻOi aku ka maikaʻi o Imetelstat ma mua o Azacitidine?

ʻAʻole maʻalahi ka hoʻohālikelike ʻana i ka imetelstat me ka azacitidine no ka mea e hana ana lākou ma nā ʻano hana like ʻole a hoʻohana pinepine ʻia i nā pae lapaʻau like ʻole. Ua hōʻike ʻia nā lāʻau lapaʻau ʻelua i ka pono i ka mālama ʻana i nā maʻi myelodysplastic, akā kūpono paha lākou no nā maʻi like ʻole a i ʻole nā kūlana.

Manaʻo pinepine ʻia ka Azacitidine he lapaʻau laina mua no ka nui o nā maʻi me MDS no ka mea ua loaʻa ia no ka manawa lōʻihi a he nui nā ʻikepili lapaʻau e kākoʻo ana i kāna hoʻohana. Hana ia ma ka hoʻopilikia ʻana i ke ʻano o ka hōʻike ʻana o nā genes i nā cella maʻi, ʻoiai ʻo ka imetelstat e kuhikuhi pololei i ka enzyme telomerase.

Hiki ke noʻonoʻo ʻia ka Imetelstat ke hana ʻole ka azacitidine a me nā lāʻau lapaʻau like a i ʻole ua pau ka hana ʻana i ka manawa. Hiki i kekahi poʻe maʻi ke pane maikaʻi i kekahi lāʻau lapaʻau ma mua o kekahi ma muli o kā lākou ʻano genetic a me nā ʻano maʻi.

E noʻonoʻo kāu hui mālama ola i nā mea e like me kou olakino holoʻokoʻa, nā lapaʻau mua, nā hopena hoʻāʻo genetic, a me nā makemake pilikino i ka wā e hoʻoholo ai i ka lāʻau lapaʻau e hana maikaʻi loa iā ʻoe. ʻO ke koho

Mai ka wā e hāʻawi ʻia ai ka imetelstat ma ke ʻano he infusion IV i mālama ʻia ma kahi hoʻoponopono olakino, he mea maʻamau loa ka nui o ka lāʻau. Eia naʻe, inā manaʻo ʻoe ua loaʻa iā ʻoe ka lāʻau nui a i ʻole e ʻike i nā hōʻailona koʻikoʻi i ka wā a i ʻole ma hope o ka mālama ʻana, e haʻi koke i kāu hui mālama olakino.

ʻO nā hōʻailona e hōʻike ana ua loaʻa iā ʻoe ka lāʻau nui e komo pū ana me ka nausea koʻikoʻi, ka luhi nui, ka ʻūlū, a i ʻole nā hōʻailona e ʻoi aku ka maikaʻi ma mua o ka mea i manaʻo ʻia. E nānā pono kāu hui lapaʻau iā ʻoe a hāʻawi i ka mālama kākoʻo e kōkua i kou kino e hana i ka lāʻau me ka palekana.

He aha kaʻu e hana ai inā e hala wau i kahi mahele o Imetelstat?

Inā e hala ʻoe i kahi infusion imetelstat i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui mālama olakino i ka hiki wawe e hoʻonohonoho hou. Mai ho'āʻo e

Hiki ke hele i ka wā e loaʻa ana ka lapaʻau imetelstat, akā pono ka hoʻolālā pono a me ka hui pū ʻana me kāu hui mālama ola. Ma muli o ka pono o nā infusions maʻamau a me ka nānā ʻana, pono ʻoe e hōʻoia e hiki iā ʻoe ke komo i ka mālama olakino kūpono ma nā wahi āu e hele nei.

Hiki i kāu kauka ke kōkua iā ʻoe e hoʻolālā i ka huakaʻi a puni kāu papa hana lapaʻau a hāʻawi iā ʻoe i ka ʻike olakino e pono ai nā mea mālama ola ʻē aʻe. Manaʻo ʻia e pale i ka hele ʻana i nā wahi me nā hale lapaʻau liʻiliʻi a i ʻole nā pilikia maʻi kiʻekiʻe, no ka mea, hiki i ka imetelstat ke hoʻopilikia i kāu ʻōnaehana pale.