He aha ʻo Inclisiran: Nā Hoʻohana, Nā Ana, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He ʻano lāʻau lapaʻau hou ʻo Inclisiran e hoʻohaʻahaʻa i ka cholesterol e hana ʻokoʻa mai nā statins kuʻuna. Hāʻawi ʻia ma ke ʻano he injection ma lalo o kou ʻili i ʻelua manawa i ka makahiki e kāu mea mālama ola, e lilo ia i koho kūpono no ka poʻe e pono ai ke kōkua hou i ka mālama ʻana i ko lākou pae cholesterol.

No kahi papa i kapa ʻia ʻo PCSK9 inhibitors kēia lāʻau lapaʻau, e ālai ana i kahi protein e pale ai i kou ate mai ka wehe ʻana i ka cholesterol maikaʻi ʻole mai kou koko. E noʻonoʻo e like me ka hāʻawi ʻana i kou ate i ke kōkua e hana pono i kāna hana hoʻomaʻemaʻe cholesterol.

He aha ʻo Inclisiran?

He lāʻau lapaʻau ʻo Inclisiran i kauoha ʻia e hoʻohaʻahaʻa i ka LDL cholesterol, i kapa pinepine ʻia ʻo

He mea waiwai nui ka lāʻau lapaʻau no ka poʻe me ka hypercholesterolemia ʻohana, he maʻi genetic e hoʻoulu ai i nā pae cholesterol kiʻekiʻe loa mai ka wā hānau. Pono pinepine kēia poʻe i nā lāʻau lapaʻau he nui e mālama pono i kā lākou cholesterol.

Hoʻohana mau ʻia ʻo Inclisiran me ka ʻai olakino a me nā loli o ke ola. ʻAʻole ia he pani no ka ʻai maikaʻi a me ka noho ʻana i ka hana, akā he mea hana hou e kōkua iā ʻoe e hiki i kāu mau pahuhopu cholesterol.

Pehea e hana ai ʻo Inclisiran?

Hana ʻo Inclisiran ma ka hoʻopaʻa ʻana i kahi protein kikoʻī i kapa ʻia ʻo PCSK9 i loko o kou ate. Kāohi maʻamau kēia protein i kou ate mai ka wehe pono ʻana i ka cholesterol LDL mai kou kahe koko.

Hoʻohana ka lāʻau lapaʻau i ka ʻenehana RNA liʻiliʻi e

ʻAʻole pono ʻoe e hana i kekahi mea kūikawā ma mua o kāu manawa hoʻopaʻa ʻana. Hiki iā ʻoe ke ʻai maʻamau a lawe i kāu mau lāʻau ʻē aʻe e like me ka maʻamau. He mau minuke wale nō ka hoʻopaʻa ʻana a ua like ia me ka loaʻa ʻana o ka lāʻau lapaʻau.

Ma hope o kāu hoʻopaʻa ʻana, hiki iā ʻoe ke hoʻomau i nā hana maʻamau i kēia manawa. Loaʻa i kekahi poʻe ka ʻeha maʻalahi ma kahi i hoʻopaʻa ʻia ai, e like me ka mea āu e manaʻo ai ma hope o kekahi hoʻopaʻa ʻana, akā e hala ana kēia i loko o hoʻokahi a ʻelua paha lā.

Pehea ka lōʻihi e lawe ai au i ka Inclisiran?

ʻO ka Inclisiran ka mea maʻamau he lapaʻau lōʻihi no ka mālama ʻana i ka cholesterol kiʻekiʻe mau. Hoʻomau ka hapa nui o nā kānaka i ka loaʻa ʻana o nā injections no nā makahiki, e like me ke ʻano o kā lākou lawe ʻana i nā lāʻau cholesterol i kēlā me kēia lā.

E nānā kāu kauka i kāu pae cholesterol a me ke olakino holoʻokoʻa i kēlā me kēia manawa e hoʻoholo ai inā kūpono ka inclisiran iā ʻoe. E nānā lākou i kāu mau pae ma kahi o 3-6 mau mahina ma hope o ka hoʻomaka ʻana i ka lapaʻau a laila i kēlā me kēia manawa ma hope.

ʻO ka hoʻoholo e hoʻomau a hoʻōki paha i ka inclisiran e pili ana i ka maikaʻi o kāna hana ʻana, inā e ʻike ana ʻoe i nā hopena ʻaoʻao, a me kou pilikia cardiovascular holoʻokoʻa. Hiki i kekahi poʻe ke hoʻololi i nā lapaʻau ʻē aʻe inā loli ko lākou kūlana.

He mea nui e mālama i kāu mau injections i hoʻonohonoho ʻia inā maikaʻi ʻoe. ʻAʻole maʻamau ka cholesterol kiʻekiʻe i nā hōʻailona, ​​no laila ʻaʻole paha ʻoe e ʻike i ka ʻokoʻa ʻoiai e hana ana ka lāʻau lapaʻau e pale i kou puʻuwai a me nā kīʻaha koko.

He aha nā hopena ʻaoʻao o Inclisiran?

ʻO ka hapa nui o nā kānaka e ʻae maikaʻi i ka inclisiran, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO ka lono maikaʻi, ʻaʻole maʻamau nā hopena ʻaoʻao koʻikoʻi.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Nā hopena ma ke kahua o ka pahu, e like me ka ʻulaʻula, ka pehu, a i ʻole ka ʻeha
• ʻEha hui a i ʻole nā ʻeha ʻiʻo
• Luhi a i ʻole ka manaʻo e luhi pinepine
• Bronchitis a i ʻole nā maʻi hanu luna
• Pōniuniu a i ʻole ka māmā

He maʻalahi kēia mau hopena ʻaoʻao a maʻa mau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hoʻoponopono maʻa mau nā hopena ma ke kahua o ka pahu i loko o kekahi mau lā.

ʻAʻole maʻamau akā ʻoi aku ka koʻikoʻi o nā hopena ʻaoʻao hiki ke komo i nā hopena maʻi koʻikoʻi, akā he mea maʻamau kēia. ʻO nā hōʻailona o ka hopena maʻi koʻikoʻi e komo i ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole ka ʻōpala ākea.

Hopohopo kekahi poʻe e pili ana i nā pilikia o ke ake, akā ʻike ʻia ʻo inclisiran he ʻoluʻolu i ke ake ma mua o kekahi mau lāʻau cholesterol ʻē aʻe. Eia naʻe, e nānā mau kāu kauka i kāu hana ake me nā hoʻokolohua koko manawa.

Inā loaʻa iā ʻoe kekahi mau hōʻailona maʻamau ma hope o kāu pahu, mai kānalua e hoʻokaʻaʻike i kāu mea mālama ola. Hiki iā lākou ke kōkua i ka hoʻoholo ʻana inā pili kāu mea e ʻike nei i ka lāʻau a pehea e mālama ai.

ʻO wai ka mea pono ʻole e lawe iā Inclisiran?

ʻAʻole kūpono ʻo Inclisiran no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻAʻole ʻōlelo ʻia ka lāʻau lapaʻau no nā poʻe ma lalo o 18 mau makahiki, no ka mea, ʻaʻole i hoʻokumu ʻia kona palekana a me ka pono i nā keiki.

Pono ʻoe e pale i ka inclisiran inā loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi iā ia a i ʻole kekahi o kāna mea i hala. E nānā kāu kauka i ka papa inoa piha o nā meaʻai me ʻoe inā he mau maʻi āu i ʻike ʻia.

Pono nā wahine e hāpai ana a i ʻole e hānai ana i ka waiū e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou kauka. ʻOiai aia nā ʻikepili palena ʻia e pili ana i ka hoʻohana ʻana i ka inclisiran i ka wā hāpai, ua ʻōlelo ʻia e pale iā ia ke ʻole ka maikaʻi e ʻoi aku ka nui o nā pilikia.

ʻO ka poʻe me kekahi mau maʻi ate, pono paha i ka nānā ʻana kūikawā a i ʻole ʻaʻole paha he mau moho maikaʻi no ka inclisiran. E loiloi kāu kauka i kāu hana ate ma mua o ka hoʻomaka ʻana i ka lapaʻau a nānā mau ia.

Inā he moʻolelo kou o ka maʻi kīkī koʻikoʻi, e noʻonoʻo pono kāu kauka inā kūpono ka inclisiran iā ʻoe. ʻAʻole i aʻo nui ʻia ka lāʻau lapaʻau i ka poʻe me nā pilikia kīkī koʻikoʻi.

Nā inoa inoa inoa inclisiran

Hoʻolaha ʻia ʻo Inclisiran ma lalo o ka inoa inoa Leqvio ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia wale nō ka inoa inoa i loaʻa no ka inclisiran.

Hana ʻia ʻo Leqvio e Novartis a loaʻa ma ke ʻano he syringe i hoʻopiha mua ʻia no ka injection. Hele mai ka lāʻau lapaʻau i kahi maʻamau maʻamau o 284 mg, ʻo ia ka nui i hāʻawi ʻia i kēlā me kēia injection.

ʻAʻole like me kekahi mau lāʻau lapaʻau i loaʻa nā inoa inoa he nui a i ʻole nā ​​mana generic, he mea hou ka inclisiran a pale ʻia e ka patent. ʻO ia hoʻi, ʻo Leqvio wale nō ka mana i loaʻa.

Ke kūkākūkā ʻana i kēia lāʻau lapaʻau me kāu kauka a i ʻole ka mea kūʻai lāʻau, hiki iā ʻoe ke kuhikuhi iā ia ma ke ʻano he inclisiran a i ʻole Leqvio. E maopopo iā lākou e kamaʻilio ana ʻoe e pili ana i ka lāʻau lapaʻau like.

Nā koho ʻē aʻe inclisiran

Inā ʻaʻole kūpono ka inclisiran iā ʻoe, aia kekahi mau koho hoʻohaʻahaʻa cholesterol ʻē aʻe. Noho mau nā statins i ka lapaʻau laina mua a komo pū i nā lāʻau lapaʻau e like me atorvastatin, rosuvastatin, a me simvastatin.

ʻO nā mea pale PCSK9 ʻē aʻe e pili ana i ka evolocumab (Repatha) a me alirocumab (Praluent). Hana like kēia mau mea me ka inclisiran akā hāʻawi ʻia ma ke ʻano he injections i kēlā me kēia pule ʻelua a i ʻole i kēlā me kēia mahina, ma mua o ʻelua manawa i ka makahiki.

No ka poʻe hiki ʻole ke ʻae i nā statins, nā koho ʻē aʻe e pili ana i ka ezetimibe (Zetia), e ālai ana i ka absorption cholesterol i loko o kou ʻōpū, a me nā mea hoʻokaʻawale waikawa bile e like me cholestyramine.

Aia nā koho hou i ka waikawa bempedoic (Nexletol), e hana ʻokoʻa ana mai nā statins akā e hoʻēmi ana i ka hana cholesterol i loko o ke ake. Manaʻo kekahi poʻe he maʻalahi kēia e ʻae ma mua o nā statins kuʻuna.

E kōkua kāu kauka iā ʻoe e koho i ke koho maikaʻi loa e pili ana i kāu kūlana kikoʻī, me kāu pae cholesterol, nā maʻi olakino ʻē aʻe, a me ka maikaʻi o kou ʻae ʻana i nā lāʻau like ʻole.

Ua ʻoi aku ka maikaʻi o Inclisiran ma mua o Evolocumab?

ʻO Inclisiran a me evolocumab (Repatha) nā mea pale PCSK9 e hoʻohaʻahaʻa pono i ka LDL cholesterol, akā he mau mea maikaʻi ʻokoʻa ko lākou e pili ana i kāu makemake a me ke ʻano o ke ola.

ʻO ka pōmaikaʻi nui o inclisiran he maʻalahi. Pono ʻoe i nā injections ʻelua wale nō i ka makahiki ma hope o ka pae hoʻouka mua, i hoʻohālikelike ʻia me nā injections i kēlā me kēia pule ʻelua a i ʻole i kēlā me kēia mahina o evolocumab. Hiki i kēia ke maʻalahi no ka poʻe i makemake ʻole i nā injections pinepine a i ʻole nā papa hana paʻahana.

Ua loaʻa ʻo Evolocumab no ka lōʻihi a loaʻa nā ʻikepili hoʻokolohua lapaʻau nui aʻe, me nā haʻawina e hōʻike ana hiki iā ia ke hōʻemi i nā puʻuwai a me nā hahau. He mea hou ʻo Inclisiran, no laila ʻoiai e hoʻohaʻahaʻa pono ana i ka cholesterol, ʻaʻohe o mākou ʻikepili lōʻihi e pili ana i nā hopena cardiovascular.

He like ka maikaʻi o nā lāʻau ʻelua i ka hoʻohaʻahaʻa ʻana i ka LDL cholesterol, e hoʻēmi ana i nā pae e 50-60% ke hoʻohui ʻia i ka lāʻau statin. ʻO ke koho ma waena o lākou e pili pinepine ana i nā makemake o ka pinepine o ka injection a me ka pane pilikino.

Hiki i ke kumukūʻai a me ka uhi ʻinikua ke hoʻopili i ka hoʻoholo. Hiki i kāu kauka ke kōkua iā ʻoe e kaupaona i kēia mau mea a hoʻoholo i ke koho e kūpono loa no kāu kūlana kikoʻī.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Inclisiran

He palekana ʻo Inclisiran no ka poʻe me ka maʻi diabetes?

ʻAe, me he mea lā he palekana ʻo inclisiran no ka poʻe me ka maʻi diabetes a hiki ke pōmaikaʻi nui no kēia heluna kanaka. He kiʻekiʻe nā pilikia o ka maʻi puʻuwai i ka poʻe me ka maʻi diabetes, e hana ana i ka mālama cholesterol pono.

ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kōpaʻa koko, no laila ʻaʻole pono e keakea i kāu mālama ʻana i ka maʻi diabetes. Eia naʻe, e nānā pono kāu kauka iā ʻoe no ka mea he nui nā lāʻau lapaʻau e lawe pinepine ai ka poʻe me ka maʻi diabetes.

Hōʻike kekahi mau haʻawina e loaʻa paha i ka inclisiran nā pōmaikaʻi hou aʻe ma mua o ka hoʻohaʻahaʻa ʻana i ka cholesterol e hiki ke kōkua i ka pale ʻana i nā pilikia diabetes, ʻoiai pono ka noiʻi hou e hōʻoia i kēia mau hopena.

He aha kaʻu e hana ai inā ua hala au i kaʻu Injection Inclisiran?

Inā ua hala ʻoe i kāu injection inclisiran i hoʻonohonoho ʻia, e kelepona i ke keʻena o kāu kauka i ka hiki wawe e hoʻonohonoho hou. E pau mālie nā hopena o ka lāʻau lapaʻau i ka manawa, no laila he mea nui ka hoʻi ʻana i ka papa hana no ka mālama ʻana i kāu mana cholesterol.

Mai ho'āʻo e

Hiki iaʻu ke lawe iā Inclisiran me nā lāʻau lapaʻau cholesterol ʻē aʻe?

ʻAe, hoʻohana pinepine ʻia ʻo inclisiran me nā lāʻau lapaʻau cholesterol ʻē aʻe, ʻo ia hoʻi nā statins. ʻO ka ʻoiaʻiʻo, hoʻohui pinepine ʻia ia i ka mālama ʻana i ka cholesterol e kū nei ma mua o ka hoʻololi ʻana iā ia.

Hiki i ka hui pū ʻana o inclisiran me nā statins ke maikaʻi loa, e hoʻokō pinepine ana i ka hōʻemi ʻana o ka cholesterol ʻaʻole hiki i kekahi lāʻau lapaʻau ke hana wale. He mea kōkua nui kēia ala no ka poʻe me ka cholesterol kiʻekiʻe loa a i ʻole ka poʻe i pilikia nui i ka maʻi puʻuwai.

E hoʻopili pono kāu kauka i kāu mau lāʻau lapaʻau a pau e hōʻoia i ka hana maikaʻi ʻana a ʻaʻole e hana i nā pilina pōʻino. E hōʻike mau i kāu mau mea mālama ola kino a pau e pili ana i kēlā me kēia lāʻau lapaʻau āu e lawe nei, me inclisiran.

Pehea ka wikiwiki o ka Inclisiran e hoʻomaka ai e hana?

Hoʻomaka ʻo Inclisiran e hana i loko o nā lā o kāu injection, akā e ʻike ʻoe i nā hopena hoʻohaʻahaʻa cholesterol kiʻekiʻe ma hope o 3 mau mahina. ʻO kēia ke kumu e hoʻonohonoho ai kāu kauka i kāu injection ʻelua i ʻekolu mahina ma hope o ka mea mua.

E nānā maʻamau kāu kauka i kāu pae cholesterol ma kahi o 3-6 mau mahina ma hope o ka hoʻomaka ʻana i ka lāʻau lapaʻau e ʻike i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. Nui ka poʻe e ʻike i nā hoʻomaikaʻi nui i kā lākou helu cholesterol i kēia nānā mua.

Kūkulu nā hopena o ka lāʻau lapaʻau i ka manawa, no laila e ʻike paha ʻoe i nā hopena maikaʻi aʻe ma hope o kekahi mau injections. He mea maʻamau kēia a manaʻo ʻia me ka inclisiran treatment.