He aha ka Infigratinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i hoʻopaʻa ʻia ʻo Infigratinib e ālai ana i nā protein kikoʻī e kōkua ana i ka ulu ʻana o kekahi mau ʻōpū. Ua hoʻolālā ʻia e mālama i kahi ʻano maʻi maʻi bile duct i kapa ʻia ʻo cholangiocarcinoma ke loaʻa iā ia kahi loli genetic kikoʻī. Hana kēia lāʻau lapaʻau waha ma ka hoʻopilikia ʻana i nā hōʻailona cell maʻi maʻi, e kau ana i nā kaʻa ma ka ulu ʻana o ka ʻōpū i nā maʻi i koho pono ʻia.

He aha ka Infigratinib?

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo kinase inhibitors ʻo Infigratinib. E noʻonoʻo iā ia he kī kikoʻī loa e kūpono i nā laka kikoʻī ma nā cell maʻi maʻi. Hoʻopaʻa ʻo ia i nā protein i kapa ʻia ʻo fibroblast growth factor receptors (FGFR), hiki ke lilo i mea hana nui i kekahi mau maʻi maʻi a me ka wahie i ka ulu ʻana o ka ʻōpū.

ʻO kēia lāʻau lapaʻau ka mea a nā kauka e kapa ai he lāʻau lapaʻau pololei. Hana wale ia no nā maʻi nona nā ʻōpū i nā loli genetic kikoʻī e pili ana i nā genes FGFR. Ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, e hoʻāʻo kāu kauka i kāu ʻiʻo ʻōpū e hōʻoia ua loaʻa iā ʻoe ke ʻano genetic kūpono no kēia lāʻau lapaʻau e pono ai.

No ke aha e hoʻohana ʻia ai ʻo Infigratinib?

Hoʻomaʻamaʻa ʻo Infigratinib i nā mākua me ka maʻi maʻi bile duct holomua (cholangiocarcinoma) i loaʻa nā loli genetic FGFR kikoʻī. E kauoha wale kāu kauka i kēia lāʻau lapaʻau inā ua mālama ʻia kāu maʻi maʻi me nā lāʻau lapaʻau ʻē aʻe a ua hoʻi mai a ua laha paha i nā ʻāpana ʻē aʻe o kou kino.

He mea maʻamau ka maʻi maʻi bile duct, e pili ana i nā paipu e lawe ai i ka bile mai kou ate i kou ʻōpū liʻiliʻi. Ke loaʻa i kēia maʻi maʻi nā loli FGFR, hiki i ka infigratinib ke kōkua i ka hoʻolohi ʻana i kona ulu ʻana a hiki ke hōʻemi i nā ʻōpū i kekahi mau maʻi. Eia naʻe, he mea nui e hoʻomaopopo i kēia lāʻau lapaʻau e mālama i ka maʻi ma mua o ka hoʻōla ʻana.

Ua hōʻoia kāu kauka oncologist ma o ka hoʻāʻo genetic i loaʻa i kāu maʻi ʻaʻai ka hui ʻana a i ʻole ka hoʻoponopono hou ʻana o FGFR2 e hiki ai i ka infigratinib ke kōkua. Inā ʻaʻole i loaʻa kēia mau loli genetic, ʻaʻole e hana ka lāʻau lapaʻau no kāu maʻi ʻaʻai.

Pehea e Hana ai ʻo Infigratinib?

Hana ʻo Infigratinib ma ka pale ʻana i nā hōʻailona hewa e haʻi ana i nā pūnaewele maʻi ʻaʻai e ulu a hoʻonui. I loko o nā pūnaewele olakino, kōkua nā protein FGFR i ka mālama ʻana i ka ulu ʻana o nā pūnaewele maʻamau. Akā i kekahi mau maʻi ʻaʻai, lilo kēia mau protein i mea hana nui, e hoʻouna ana i nā hōʻailona

E manaʻo paha kāu kauka e hahai i ka ʻai haʻahaʻa phosphate i ka wā e lawe ana i ka infigratinib. ʻO ia hoʻi ka palena ʻana i nā meaʻai kiʻekiʻe i ka phosphorus e like me nā huahana waiū, nā nati, a me kekahi mau ʻiʻo. E hāʻawi kāu hui mālama ola kino i nā alakaʻi meaʻai kikoʻī e hahai ai.

Pehea ka lōʻihi e lawe ai au i ka Infigratinib?

E lawe maʻamau ʻoe i ka infigratinib no ka lōʻihi e hoʻomau ana ia i ka mālama ʻana i kāu maʻi kanesa a hiki iā ʻoe ke ʻae i nā hopena ʻaoʻao. Nui ka poʻe maʻi e hahai i kahi papa manawa kikoʻī: 21 mau lā o ka lawe ʻana i ka lāʻau a ukali ʻia e 7 mau lā hoʻomaha, e like me hoʻokahi pōʻai lapaʻau.

E nānā kāu kauka i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau ma o nā scans maʻamau a me nā hoʻokolohua koko. Inā pau ka pane ʻana o kāu maʻi kanesa i ka infigratinib a i ʻole e paʻakikī loa nā hopena ʻaoʻao e mālama ai, hiki i kāu kauka ke ʻōlelo e hoʻōki i ka lāʻau a i ʻole e hoʻololi i kahi lapaʻau ʻē aʻe.

Lawe kekahi poʻe maʻi i ka infigratinib no nā mahina he nui a i ʻole nā makahiki, a ʻo nā mea ʻē aʻe e pono e hoʻōki koke. Aia ka lōʻihi i kāu pane pilikino, nā hopena ʻaoʻao, a me ke olakino holoʻokoʻa. E hana pū kāu oncologist me ʻoe e ʻimi i ke kaulike kūpono ma waena o ka mālama ʻana i kāu maʻi kanesa a me ka mālama ʻana i kou maikaʻi o ke ola.

He aha nā hopena ʻaoʻao o Infigratinib?

E like me nā lāʻau lapaʻau maʻi kanesa a pau, hiki i ka infigratinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka nānā pono a me ka mālama kākoʻo mai kāu hui mālama ola kino.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Luhi a me ka nāwaliwali
• Nā loli kui, me ka nalowale ʻana o ke kui a i ʻole nā kui palupalu
• Nā ʻeha waha a i ʻole ka waha maloʻo
• Pāpaʻa a i ʻole ka paʻa
• Hoʻemi ʻia ka ʻai
• Hoʻopōkole a i ʻole nā loli i ke ʻano o ka lauoho
• Maloʻo ʻili a i ʻole ka ʻōpala
• ʻEha hui a i ʻole ka ʻiʻo

E nānā pono kāu kauka iā ʻoe no nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau. Pono kēia mau mea i ka nānā koke ʻana a hiki ke komo i nā pilikia maka koʻikoʻi, nā pilikia kīkī, a i ʻole nā loli weliweli i kou kemika koko.

ʻO kekahi mea e hopohopo nui ʻia me ka infigratinib ʻo ia ka wehe ʻana o ka retina, kahi e kaʻawale ai ka ʻiʻo ʻike māmā ma ke kua o kou maka mai nā papa ma lalo. Pono ʻoe i nā hoʻokolohua maka maʻamau i ka wā o ka mālama ʻana, a pono ʻoe e hōʻike koke i nā loli ʻike koke.

Hiki nō hoʻi ke loaʻa nā pae phosphate kiʻekiʻe i kou koko, ʻo ia ke kumu he mea nui ka hahai ʻana i ka meaʻai haʻahaʻa phosphate. E nānā mau kāu hui mālama ola i nā pae phosphate koko a hiki ke kauoha i nā lāʻau lapaʻau e kōkua i ka mālama ʻana iā lākou i kahi pae palekana.

ʻO wai ka mea ʻaʻole pono e lawe i ka Infigratinib?

ʻAʻole kūpono ka Infigratinib no nā mea a pau, a hiki i kekahi mau maʻi ke palekana ʻole iā ʻoe ke lawe i kēia lāʻau lapaʻau. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana.

ʻAʻole pono ʻoe e lawe i ka infigratinib inā he maʻi ʻoe i ka lāʻau lapaʻau a i ʻole kekahi o kāna mea ʻai. Eia kekahi, ʻaʻole ʻōlelo ʻia kēia lāʻau lapaʻau i ka wā hāpai a i ka wā e hānai ai, no ka mea, hiki iā ia ke hōʻeha i kāu pēpē.

Pono kekahi mau maʻi olakino i ka mālama kūikawā a i ʻole e pale iā ʻoe mai ka lawe ʻana i ka infigratinib me ka palekana:

• Maʻi kīkī koʻikoʻi
• Nā pilikia maka e kū nei, ʻoi aku ka nui o nā pilikia retinal
• Nā maʻi puʻuwai
• Maʻi ate
• Moʻolelo o nā pōhaku kīkī
• ʻO kekahi mau maʻi hoʻoilina e pili ana i ka metabolism phosphate

E noʻonoʻo pū kāu kauka i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, no ka mea, hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka infigratinib. E hōʻoia e haʻi i kāu hui mālama ola e pili ana i nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ka pā, a me nā mea hoʻohui āu e hoʻohana ai.

Infigratinib Brand Name

Kūʻai ʻia ka Infigratinib ma lalo o ka inoa inoa ʻo Truseltiq. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau lapaʻau ma ʻAmelika Hui Pū ʻIa.

I ka wā e loaʻa ai kāu palapala kauoha, e ʻike ʻoe i ka huaʻōlelo "Truseltiq" ma ka lepili o ka hue me ka inoa maʻamau "infigratinib." He mau inoa like nō nā mea ʻelua, no laila, mai hopohopo inā ʻoe e ʻike i kekahi o lākou i hoʻohana ʻia i kāu moʻolelo olakino a i ʻole e kāu hui mālama olakino.

Nā Koho ʻē aʻe no Infigratinib

I kēia manawa, he palena nā koho ʻē aʻe no ka infigratinib no ka mālama ʻana i ka maʻi ʻaʻai o ka ʻōpū bile me nā loli FGFR. ʻO nā mea pale FGFR ʻē aʻe e like me ka pemigatinib he mau koho paha i kekahi mau hihia, akā pili ka koho i kāu kūlana kikoʻī a me nā genetics maʻi ʻaʻai.

Inā pau ka hana ʻana o ka infigratinib a i ʻole e hana i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, hiki i kāu oncologist ke noʻonoʻo i nā lāʻau lapaʻau i manaʻo ʻia, nā lāʻau immunotherapy, a i ʻole ka chemotherapy kuʻuna. ʻO ke koho maikaʻi loa e pili ana i ka ʻikepili genetic o kāu maʻi ʻaʻai, nā lāʻau lapaʻau i hala, a me ke olakino holoʻokoʻa.

Hiki nō hoʻi ke lilo i nā hoʻokolohua lapaʻau e noiʻi ana i nā lāʻau lapaʻau hou no ka maʻi ʻaʻai o ka ʻōpū bile. Hiki i kāu oncologist ke kōkua iā ʻoe e ʻimi inā he kūpono kekahi mau haʻawina noiʻi no kāu kūlana.

Ua ʻoi aku ka maikaʻi o Infigratinib ma mua o nā mea pale FGFR ʻē aʻe?

ʻAʻole maʻalahi ka hoʻohālikelike ʻana i ka infigratinib me nā mea pale FGFR ʻē aʻe no ka mea ua aʻo ʻia kēlā me kēia lāʻau lapaʻau i nā heluna kanaka like ʻole a me nā hoʻonohonoho lapaʻau. ʻO ka mea nui ka loaʻa ʻana o ka lāʻau lapaʻau kūpono no kāu maʻi ʻaʻai a me ke kūlana.

Ua aʻo ʻia a ʻae ʻia ka infigratinib no ka maʻi ʻaʻai o ka ʻōpū bile me nā loli FGFR2. Ua aʻo ʻia nā mea pale FGFR ʻē aʻe e like me ka pemigatinib i nā ʻano maʻi ʻaʻai ākea akā he ʻokoʻa paha nā ʻano hopena ʻaoʻao a i ʻole nā helu pono.

E noʻonoʻo kāu oncologist i nā mea e like me nā loli genetic kikoʻī o kāu maʻi ʻaʻai, kou olakino holoʻokoʻa, nā lāʻau lapaʻau i hala, a me nā hopena ʻaoʻao e hiki ke hana i ke koho ʻana i ka mea pale FGFR maikaʻi loa nāu. ʻO ke koho "maikaʻi" ka mea e hana maikaʻi loa no kāu mau kūlana pilikino.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Infigratinib

He Palekana anei ʻo Infigratinib no nā kānaka me ka maʻi kīkī?

Pono ʻo Infigratinib i ka nānā pono ʻana i nā kānaka me nā pilikia kīkī, a ʻaʻole paha he palekana no ka poʻe me ka maʻi kīkī koʻikoʻi. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana kīkī a hiki ke hana i nā pōhaku kīkī i kekahi poʻe maʻi.

Inā he maʻi kīkī maʻalahi a kūpono paha kou, hiki i kāu kauka ke kuhikuhi iā infigratinib akā e nānā pono i kāu hana kīkī ma o nā hoʻokolohua koko maʻamau. Hiki iā lākou ke hoʻoponopono i kāu mahele a i ʻole e ʻōlelo aku i nā hana hou e pale ai i kou mau kīkī.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Infigratinib?

Inā lawe hewa ʻoe i ka nui o infigratinib, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā loaʻa iā ʻoe nā hōʻailona, no ka mea, hiki i ka overdose ke hana i nā pilikia koʻikoʻi.

Iā ʻoe e kali nei i ka ʻōlelo aʻo olakino, mai hoʻāʻo e hoʻokuke iā ʻoe iho e luaʻi ke ʻole i kuhikuhi ʻia e hana pēlā. E mālama i ka hue lāʻau me ʻoe i hiki iā ʻoe ke haʻi pololei i nā mea mālama ola i ke aha a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Infigratinib?

Inā haʻalele ʻoe i kahi mahele o infigratinib, e lawe koke iā ia ke hoʻomanaʻo ʻoe, inā aia i loko o 12 mau hola o kāu manawa i hoʻonohonoho ʻia. Inā ua hala ma mua o 12 mau hola, e lele i ka mahele i haʻalele ʻia a lawe i kāu mahele i hoʻonohonoho ʻia e hiki mai ana.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i haʻalele ʻia, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i nā ʻōhua kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Infigratinib?

Pono ʻoe e hooki i ka lawe ʻana iā infigratinib ke haʻi kāu kauka iā ʻoe e hana pēlā. ʻOiai inā maikaʻi kou manaʻo a i ʻole e ʻike nei i nā hopena ʻaoʻao, ʻo ka hooki ʻana i ka lāʻau lapaʻau me ka ʻole o ke alakaʻi olakino hiki ke ʻae i kāu maʻi maʻi e ulu.

E loiloi mau ana kāu kauka inā e kōkua ana ka infigratinib i ka mālama ʻana i kāu maʻi kanesa a inā e ʻoi aku ana nā pōmaikaʻi ma mua o nā hopena ʻaoʻao. E ʻōlelo lākou e hooki i ka lāʻau lapaʻau inā e holomua ana kāu maʻi kanesa me ka mālama ʻana a i ʻole inā e lilo nā hopena ʻaoʻao i mea koʻikoʻi loa e mālama palekana.

Hiki iaʻu ke lawe i ka Infigratinib me nā lāʻau lapaʻau ʻē aʻe?

Hiki i ka Infigratinib ke launa pū me kekahi mau lāʻau lapaʻau ʻē aʻe, no laila he mea nui e haʻi aku i kāu kauka i nā mea a pau āu e lawe nei. Hiki i kekahi mau lāʻau lapaʻau ke hoʻonui a hoʻemi paha i nā pae infigratinib i loko o kou kino, e pili ana i kona pono a i ʻole e hoʻonui i nā hopena ʻaoʻao.

ʻO nā pilina nui e pili ana i kekahi mau mea hoʻemi waikawa ʻōpū, kekahi mau lāʻau antibiotic, a me nā lāʻau lapaʻau e pili ana i nā enzyme ate. E nānā kāu kauka i nā lāʻau lapaʻau a pau a hiki ke hoʻoponopono i nā meaʻai a i ʻole e ʻōlelo i nā mea ʻē aʻe inā pono. E nānā mau me kāu hui mālama ola ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou, me nā lāʻau lapaʻau ma luna o ka pā a me nā mea hoʻohui.