He aha ka Inotuzumab Ozogamicin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO ka inotuzumab ozogamicin he lāʻau lapaʻau maʻi maʻi kūikawā e hui pū ana i kahi antibody i manaʻo ʻia me kahi lāʻau chemotherapy ikaika. Hoʻolālā ʻia kēia lapaʻau hou no nā pākeke me kahi ʻano maʻi koko i kapa ʻia ʻo acute lymphoblastic leukemia (ALL) i hoʻi mai a ʻaʻole i pane i nā lāʻau lapaʻau ʻē aʻe.

E noʻonoʻo i kēia lāʻau lapaʻau he pōkā naʻauao e hiki ke ʻimi a hoʻouka i nā sela maʻi maʻi me ka waiho ʻana i ka hapa nui o nā sela olakino. Hāʻawi ʻia ma o ka IV i loko o kahi haukapila, a ʻoiai he mea maikaʻi loa ia, pono ia e nānā pono ʻia e kāu hui mālama maʻi maʻi.

He aha ka Inotuzumab Ozogamicin?

ʻO ka inotuzumab ozogamicin ka mea a nā kauka e kapa ai he antibody-drug conjugate. ʻO ia hoʻi, ua hana ʻia me nā ʻāpana ʻelua e hana pū ana: kahi antibody e hana ana e like me ka missile alakaʻi e ʻimi i nā sela maʻi maʻi kikoʻī, a me kahi lāʻau chemotherapy e luku ai i kēlā mau sela ke loaʻa.

Hoʻomaopopo ka ʻāpana antibody i kahi protein i kapa ʻia ʻo CD22 e noho ana ma ka ʻili o kekahi mau sela leukemia. Ke loaʻa iā ia kēia mau sela, hāʻawi ia i ka chemotherapy i loko o lākou. Kōkua kēia hana i manaʻo ʻia e pale i kāu mau sela olakino mai ka pōʻino pono ʻole.

No kēia lāʻau lapaʻau i kahi papa hou o nā lāʻau lapaʻau maʻi maʻi e hōʻike ana i kahi holomua nui i ke ʻano o kā mākou hakakā ʻana i nā maʻi koko. He mea waiwai nui ia no ka mea hiki ke hana ʻoiai inā ʻaʻole i hana nā lāʻau lapaʻau ʻē aʻe.

No ke aha e hoʻohana ʻia ai ka Inotuzumab Ozogamicin?

Ua ʻae ʻia kēia lāʻau lapaʻau no ka mālama ʻana i nā pākeke me ka relapsed a i ʻole refractory B-cell acute lymphoblastic leukemia. ʻO ke ʻano o ka

Ua hana maikaʻi ka lāʻau lapaʻau i nā maʻi nona nā pūnaewele leukemia i ka protein CD22 ma ko lākou ʻili. E hoʻāʻo kāu hui lapaʻau i kāu mau pūnaewele maʻi maʻi e hōʻoia i ka pono o kēia lapaʻau iā ʻoe ma mua o ka hoʻomaka ʻana.

Pehea e hana ai ʻo Inotuzumab Ozogamicin?

Hana kēia lāʻau lapaʻau e like me kahi ʻōnaehana hoʻouna i alakaʻi ʻia e ka pololei. Hele ka ʻāpana antibody ma kou kahe koko a hiki i ka loaʻa ʻana o nā pūnaewele leukemia me ka protein CD22. Ke pili ia i kēia mau pūnaewele, hoʻokuʻu ia i ka lāʻau chemotherapy pololei i loko o lākou.

A laila, hōʻino ka mea chemotherapy i ka DNA i loko o nā pūnaewele maʻi maʻi, e pale ana iā lākou mai ka mahele ʻana a me ka hopena e make ai lākou. No ka mea, ua hāʻawi pololei ʻia ka lāʻau i nā pūnaewele maʻi maʻi, hiki ke ʻoi aku ka maikaʻi me ka hana ʻana i nā hopena ʻaoʻao liʻiliʻi ma mua o ka chemotherapy kuʻuna.

Ua manaʻo ʻia he lapaʻau maʻi maʻi ikaika. ʻOiai ua lawa ka ikaika e hakakā i ka leukemia kūʻē, ua hoʻolālā ʻia nō hoʻi e ʻoi aku ka pahuhopu ma mua o nā lāʻau chemotherapy kahiko, ka mea e pili pinepine i nā pūnaewele olakino.

Pehea wau e lawe ai iā Inotuzumab Ozogamicin?

E loaʻa iā ʻoe kēia lāʻau lapaʻau ma o ka IV infusion i loko o kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi maʻi. Hāʻawi ʻia ka lapaʻau i nā pōʻai, me kēlā me kēia pōʻai e mau ana ma kahi o 3 a 4 mau pule. E hāʻawi ʻia kāu mahele mua i ka lohi e nānā i nā hopena koke.

Ma mua o kēlā me kēia infusion, e hāʻawi kāu hui lapaʻau iā ʻoe i nā lāʻau lapaʻau e kōkua i ka pale ʻana i nā hopena maʻi. Hiki i kēia mau mea ke komo i nā antihistamines, steroids, a me nā mea hoʻemi wela. ʻAʻole pono ʻoe e pale i ka meaʻai ma mua o ka lapaʻau, akā he mea nui ka noho ʻana i ka wai.

ʻO ka maʻamau, lawe ʻia kēlā me kēia infusion 1 a 2 mau hola, ʻoiai paha e lōʻihi ana kāu lapaʻau mua. E hoʻolālā e hoʻolilo i ka hapa nui o ka lā ma ke kikowaena lapaʻau, no ka mea, pono ʻoe i ka manawa nānā ma mua a ma hope o ka infusion.

E nānā mau kāu hui mālama ola i kāu helu koko a me ka hana ate i ka wā e mālama ʻia ai. Hiki iā lākou ke hoʻoponopono i kāu mahele lāʻau a i ʻole e hoʻopaneʻe i ka mālama ʻana inā pono ke kino i ka manawa hou e ola ai ma waena o nā pōʻaiapuni.

Pehea ka lōʻihi e lawe ai au i ka Inotuzumab Ozogamicin?

Loaʻa i ka hapa nui o nā maʻi kēia lapaʻau no ka 3 pōʻaiapuni, akā pono paha kekahi poʻe i ka liʻiliʻi inā loaʻa koke iā lākou ka remission. Hoʻokaʻawale ʻia kēlā me kēia pōʻaiapuni e pili ana i 3 a 4 mau pule e hiki ai i kou kino ke ola.

E nānā kāu kauka i ka maikaʻi o ka hana ʻana o ka lapaʻau ma o nā hoʻokolohua koko maʻamau a me nā biopsy iwi iwi. Inā pane maikaʻi kāu leukemia, hiki iā ʻoe ke hoʻololi i kahi transplant iwi iwi a i ʻole nā ​​lapaʻau mālama ʻē aʻe.

Aia ka lōʻihi pololei i ka pane ʻana o kāu maʻi maʻi a me ka maikaʻi o kou hoʻomanawanui ʻana i ka lapaʻau. Pono paha kekahi poʻe maʻi e hooki koke ma muli o nā hopena ʻaoʻao, ʻoiai e hiki i nā mea ʻē aʻe ke hoʻopau i nā pōʻaiapuni i hoʻolālā ʻia.

He aha nā hopena ʻaoʻao o Inotuzumab Ozogamicin?

E like me nā lapaʻau maʻi maʻi, hiki i kēia lāʻau lapaʻau ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka mea hiki ke mālama ʻia me ka mālama kūpono. E nānā pono kāu hui lapaʻau iā ʻoe a hāʻawi i ka mālama kākoʻo e kōkua iā ʻoe e ʻoluʻolu e like me ka hiki.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike, me ka noʻonoʻo ʻana ʻaʻole nā ​​mea a pau e loaʻa i kēia mau mea:

• Luhi a me ka nāwaliwali
• Nausea a me ka luaʻi
• Fiva a me ke anu
• Poʻo
• Haʻahaʻa nā helu koko
• Hoʻonui i ka pilikia o ka maʻi
• Ke kahe koko a i ʻole ka ʻeha maʻalahi
• ʻEha ʻōpū

ʻO ka hapa nui o kēia mau hopena ʻaoʻao he manawa pōkole a e hoʻomaikaʻi i ka wā e ola ai kou kino ma waena o nā lapaʻau. Nui nā ala o kāu hui mālama e kōkua ai i ka mālama ʻana i kēia mau hōʻailona.

Aia kekahi mau hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e koi i ka lāʻau lapaʻau koke. Aia kēia mau mea i kahi maʻi ate kakaʻikahi akā koʻikoʻi i kapa ʻia ʻo ka maʻi veno-occlusive, nā maʻi koʻikoʻi, a me ka maʻi lysis tumor kahi e wāwahi koke ai nā cell maʻi maʻi.

E nānā ana kāu hui lapaʻau i nā hōʻailona mua o kēia mau pilikia nui ma o nā hoʻokolohua koko maʻamau a me nā hoʻokolohua kino. Inā ʻike ʻoe i ka ʻeha nui o ka ʻōpū, ka melemele ʻana o kou ʻili a i ʻole nā maka, a i ʻole nā hōʻailona o ka maʻi nui, e hoʻokaʻaʻike koke i kāu mea mālama ola.

ʻO wai ka mea pono ʻole e lawe iā Inotuzumab Ozogamicin?

ʻAʻole kūpono kēia lāʻau lapaʻau no nā mea a pau. E nānā pono kāu kauka i kāu moʻolelo olakino e hōʻoia i ka palekana iā ʻoe.

ʻAʻole pono ʻoe e loaʻa i kēia lapaʻau inā he maʻi ʻoe i ka inotuzumab ozogamicin a i ʻole kekahi o kāna mau mea. E makaʻala nō hoʻi kāu kauka inā he maʻi nui kou e pono ai ka lapaʻau mua.

ʻAʻole paha he moho maikaʻi nā poʻe me nā pilikia ate nui no kēia lapaʻau, no ka mea, hiki iā ia ke hoʻopilikia i ka hana ate. Inā loaʻa iā ʻoe ka maʻi ate ma mua a i ʻole i loaʻa nā lapaʻau i hōʻino i kou ate, pono kāu kauka e loiloi pono i nā pilikia.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, ʻaʻole ʻōlelo ʻia kēia lāʻau lapaʻau no ka mea hiki iā ia ke hōʻeha i kāu pēpē. Pono nā wahine o ka makahiki hānau e hoʻohana i ka mana hānau kūpono i ka wā o ka lapaʻau a no kekahi mau mahina ma hope.

Inotuzumab Ozogamicin Brand Name

ʻO ka inoa inoa no ka inotuzumab ozogamicin ʻo Besponsa. ʻO kēia ka inoa āu e ʻike ai ma kāu mau moʻolelo lapaʻau a me ka ʻike lāʻau lapaʻau.

Hana ʻia ʻo Besponsa e Pfizer a ua ʻae ʻia e ka FDA i ka makahiki 2017. ʻO ia wale nō ka mana o kēia lāʻau lapaʻau i loaʻa i kēia manawa, no ka mea, ʻaʻohe mea ʻē aʻe.

Ke kūkākūkā ʻana i kāu lapaʻau me kāu hui mālama ola a i ʻole ka hui ʻinikua, hiki iā lākou ke hoʻohana i ka inoa maʻamau (inotuzumab ozogamicin) a i ʻole ka inoa inoa (Besponsa) me ka hoʻololi.

Inotuzumab Ozogamicin Alternatives

ʻOiai he mea kū hoʻokahi ka inotuzumab ozogamicin i kāna mīkini, aia nā koho lapaʻau ʻē aʻe no ka ALL i hoʻihoʻi ʻia a i ʻole refractory. E noʻonoʻo kāu kauka i kekahi mau mea i ke koho ʻana i ke ala maikaʻi loa no ʻoe.

ʻO nā ʻano lapaʻau i manaʻo ʻia, ʻo ia hoʻi ka blinatumomab, e kōkua ana i kou ʻōnaehana pale e hakakā i ka maʻi kanesa, a me ka CAR-T cell therapy, kahi e hoʻololi ʻia ai kāu mau pūnaewele pale e kūʻē i ka leukemia. He ʻokoʻa ka hana ʻana o kēia mau lapaʻau akā hiki ke maikaʻi no nā kūlana like.

He koho nō hoʻi nā hui chemotherapy kuʻuna, ʻoiai paha ʻaʻole lākou e maikaʻi inā ua hoʻāʻo mua ʻoe iā lākou. Hiki nō hoʻi i nā hoʻokolohua lapaʻau ke hāʻawi i ke komo ʻana i nā lapaʻau hou i hoʻokolohua ʻia ʻaʻole i loaʻa ākea.

Ke hilinaʻi nei ke koho ma waena o kēia mau koho ʻē aʻe i kāu ʻano leukemia, kāu mau lapaʻau i hala, kou olakino holoʻokoʻa, a me kāu mau makemake pilikino. E kōkua kāu oncologist iā ʻoe e loiloi i nā pōmaikaʻi a me nā pilikia o kēlā me kēia koho.

Ua ʻoi aku ka maikaʻi o Inotuzumab Ozogamicin ma mua o nā lapaʻau ALL ʻē aʻe?

Ua hōʻike ʻo Inotuzumab ozogamicin i nā pono nui ma luna o ka chemotherapy kuʻuna i nā hoʻokolohua lapaʻau, ʻoi aku hoʻi no nā maʻi i hoʻi mai ai ka leukemia a i ʻole ʻaʻole i pane i ka lapaʻau mua. Ua hōʻike nā haʻawina hiki iā ia ke hoʻokō i nā helu remission kiʻekiʻe a kōkua i nā maʻi hou aku e lilo i mea kūpono no nā transplants iwi iwi.

I ka hoʻohālikelike ʻana me ka chemotherapy maʻamau, ʻo kēia ʻano hana i manaʻo ʻia e hana pinepine i nā hopena ʻaoʻao koʻikoʻi liʻiliʻi ʻoiai e ʻoi aku ka maikaʻi i ka hoʻopau ʻana i nā pūnaewele leukemia. Eia naʻe, lawe pū ia i kekahi mau pilikia kū hoʻokahi, ʻoi aku hoʻi i ke ake, e koi ana i ka nānā pono.

ʻO ka lapaʻau

Pono e noʻonoʻo pono i kēia lāʻau lapaʻau inā he pilikia kou ate. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana o ka ate a hiki ke hana i kahi maʻi koʻikoʻi i kapa ʻia ʻo ka maʻi veno-occlusive, ʻoi aku ka maʻamau i ka poʻe me nā pilikia ate.

E loiloi pono kāu kauka i ka hana o kou ate ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a e nānā pono iā ia i nā manawa a pau. Hiki iā lākou ke ʻōlelo aku i nā lāʻau lapaʻau ʻē aʻe inā he koʻikoʻi kou maʻi ate a i ʻole inā ʻoi aku ka nui o nā pilikia ma mua o nā pōmaikaʻi.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Inotuzumab Ozogamicin?

No ka mea, hāʻawi ʻia kēia lāʻau lapaʻau i loko o kahi haukapila i mālama ʻia e nā poʻe loea i hoʻomaʻamaʻa ʻia, he mea maʻamau loa nā overdoses. Hoʻoholo ʻia ka dosage me ka akahele e pili ana i ka ʻili o kou kino a hāʻawi ʻia ma o nā mea IV pololei.

Inā hopohopo ʻoe e pili ana i kāu mahele a i ʻole e ʻike i nā hōʻailona koʻikoʻi i manaʻo ʻole ʻia ma hope o ka lāʻau lapaʻau, e hoʻokaʻaʻike koke i kāu hui mālama ola. Hiki iā lākou ke loiloi i kou kūlana a hāʻawi i ka mālama kākoʻo kūpono inā pono.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Inotuzumab Ozogamicin?

No ka mea, hāʻawi ʻia kēia lāʻau lapaʻau ma kahi papa manawa ma kahi keʻena lapaʻau, mālama ʻia nā mahele i hala e kāu hui mālama ola. Inā ʻaʻole hiki iā ʻoe ke hele i kāu manawa i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui oncology i ka hiki wawe e hoʻonohonoho hou.

Pono paha kāu kauka e hoʻoponopono i kāu papa manawa lapaʻau a i ʻole e loiloi inā e pili ana nā lohi i kāu hoʻolālā lapaʻau. Mai ho'āʻo e

Hoʻoholo ʻia ka hoʻōki ʻana i ka lāʻau lapaʻau ma waena o ʻoe a me kāu oncologist. E noʻonoʻo lākou i nā mea e like me kāu pane ʻana i ka lāʻau lapaʻau, nā hopena ʻaoʻao, a me nā pahuhopu lapaʻau holoʻokoʻa. Mai hoʻōki i kēia lāʻau lapaʻau ma kāu iho me ka ʻole e kūkākūkā mua me kāu hui mālama ola.

Hiki iaʻu ke hāpai i ka wā e lawe ana i ka Inotuzumab Ozogamicin?

Hiki i kēia lāʻau lapaʻau ke hōʻeha i kahi pēpē i hānau ʻole ʻia, no laila pono e pale ʻia ka hāpai ʻana i ka wā o ka lāʻau lapaʻau. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka mana hānau kūpono i ka wā o ka lāʻau lapaʻau a no ka liʻiliʻi o 8 mau mahina ma hope o ka lāʻau hope loa.

Inā ʻoe e hoʻāʻo nei e hāpai, e kūkākūkā me kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau. Hiki iā lākou ke ʻōlelo e hoʻopaneʻe i ka lāʻau lapaʻau inā hiki a i ʻole ke kūkākūkā ʻana i nā koho mālama momona. Inā hāpai ʻoe i ka wā o ka lāʻau lapaʻau, e hoʻokaʻaʻike koke i kāu hui mālama ola.