He aha ka Irinotecan: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Irinotecan kahi lāʻau chemotherapy e kōkua ana i ka hakakā ʻana i kekahi mau ʻano maʻi maʻi ma ka hoʻōki ʻana i nā cell maʻi mai ka ulu ʻana a me ka hoʻonui ʻana. Hāʻawi ʻia kēia lāʻau ikaika ma o ka IV (intravenous) laina pololei i loko o kou kahe koko, e ʻae ana iā ia e hiki i nā cell maʻi ma ke kino holoʻokoʻa.

Inā ua ʻōlelo kāu kauka i ka irinotecan ma ke ʻano he ʻāpana o kāu mālama ʻana i ka maʻi maʻi, aia paha kāu mau nīnau e pili ana i ke ʻano o ka hana a me ka mea e manaʻo ai. ʻO ka hoʻomaopopo ʻana i kāu lāʻau lapaʻau hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kou neʻe ʻana i mua me kāu hoʻolālā lapaʻau.

He aha ka Irinotecan?

No ka hui o nā lāʻau lapaʻau e hakakā ana i ka maʻi maʻi i kapa ʻia ʻo topoisomerase inhibitors ʻo Irinotecan. Hana ia ma ka hoʻopilikia ʻana i kahi enzyme e pono ai nā cell maʻi e kope i kā lākou DNA a mahele i nā cell hou.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau chemotherapy ikaika, ʻo ia hoʻi he mea maikaʻi loa ia i ka ʻimi ʻana i nā cell maʻi akā hiki nō hoʻi ke hoʻopilikia i kekahi mau cell olakino i kou kino. E nānā pono kāu hui mālama ola iā ʻoe i ka wā o ka mālama ʻana e kōkua i ka mālama ʻana i nā hopena ʻaoʻao e hiki ke hana.

Ua hoʻohana maikaʻi ʻia ʻo Irinotecan no nā makahiki he nui e mālama i nā maʻi maʻi like ʻole. Hāʻawi pinepine ʻia ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau hui pū me nā lāʻau lapaʻau maʻi maʻi ʻē aʻe e hoʻonui i ka pono.

No ke aha i hoʻohana ʻia ai ʻo Irinotecan?

Hoʻohana nui ʻia ʻo Irinotecan e mālama i ka maʻi maʻi colorectal, e pili ana i nā maʻi maʻi colon a me ka rectal. Hiki i kāu kauka ke ʻōlelo iā ia inā ua laha kou maʻi maʻi i nā ʻāpana ʻē aʻe o kou kino a i ʻole inā ʻaʻole i maikaʻi nā lāʻau lapaʻau ʻē aʻe.

Hoʻohana ʻia kēia lāʻau lapaʻau i kekahi manawa e mālama i nā ʻano maʻi maʻi ʻē aʻe, me kekahi mau maʻi maʻi maʻi, ka maʻi maʻi ovarian, a me nā maʻi lolo. E hoʻoholo kāu oncologist inā kūpono ʻo irinotecan no kāu ʻano a me ke kahua o ka maʻi maʻi.

I nā hihia he nui, hui pū ʻia ka irinotecan me nā lāʻau chemotherapy ʻē aʻe e like me 5-fluorouracil a me leucovorin i nā hana lapaʻau i ʻike ʻia ʻo FOLFIRI. ʻOi aku ka maikaʻi o kēia hui pū ʻana ma mua o ka hoʻohana ʻana i kekahi lāʻau hoʻokahi wale nō.

Pehea ka hana ʻana o Irinotecan?

Hoʻopaʻa ʻo Irinotecan i nā pūnaewele maʻi maʻi ma ka pale ʻana i kahi enzyme i kapa ʻia ʻo topoisomerase I, pono nā pūnaewele maʻi maʻi e wehe i kā lākou DNA i ka wā o ka mahele cell. Ke ālai ʻia kēia enzyme, ʻaʻole hiki i nā pūnaewele maʻi maʻi ke kope pono i kā lākou mea genetic.

E noʻonoʻo e like me ka hoʻopaʻa ʻana i ka mīkini e hoʻohana ai nā pūnaewele maʻi maʻi e hana i nā kope o lākou iho. Me ka ʻole o ka topoisomerase I e hana ana, ua pōʻino nā pūnaewele maʻi maʻi a make hope loa, e kōkua ana e hoʻolohi a hoʻōki paha i ka ulu ʻana o ka ʻōpū.

ʻOiai he maikaʻi loa ka irinotecan i nā pūnaewele maʻi maʻi, hiki nō hoʻi ke hoʻopilikia i kekahi mau pūnaewele olakino e mahele wikiwiki ana, e like me nā mea i loko o kāu ʻōnaehana digestive, nā follicles lauoho, a me ka iwi iwi. ʻO ia ke kumu e hiki ai ke hana ʻia nā hopena ʻaoʻao, akā e kōkua kāu hui lapaʻau iā ʻoe e mālama iā lākou.

Pehea wau e lawe ai iā Irinotecan?

Hāʻawi mau ʻia ʻo Irinotecan ma o ka laina IV ma kahi kikowaena lapaʻau maʻi maʻi a i ʻole ka haukapila. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka waha ma ka home. E hoʻokomo mālie kahi kahu hānai i hoʻomaʻamaʻa ʻia a i ʻole ka mea mālama ola i ka lāʻau lapaʻau i loko o kou kahe koko ma luna o 90 mau minuke.

Ma mua o kāu lapaʻau, e loaʻa paha iā ʻoe nā lāʻau lapaʻau ʻē aʻe e kōkua ai i ka pale ʻana i ka nausea a me nā hopena maʻi. Hiki i kāu hui mālama ola ke hāʻawi iā ʻoe i nā wai ma o kāu IV e kōkua i ka pale ʻana i kou mau puʻupaʻa a mālama iā ʻoe i ka wai.

ʻAʻole pono ʻoe e pale i ka meaʻai ma mua o ka lapaʻau, akā ʻo ka ʻai ʻana i ka meaʻai māmā i kekahi mau hola ma mua e hiki ke kōkua i ka pale ʻana i ka ʻōpū. E wehewehe pono kāu kahu hānai i ka mea e manaʻo ai i ka wā o kāu hoʻokomo ʻana a pane i nā nīnau āu.

Pehea ka lōʻihi e lawe ai au iā Irinotecan?

Aia ke ana o kāu lapaʻau irinotecan ma ke ʻano o kāu maʻi maʻi, pehea ka maikaʻi o kou pane ʻana i ka lāʻau, a me ka maikaʻi o kou ʻae ʻana i nā hopena ʻaoʻao. Loaʻa ka hapa nui o nā kānaka i nā lapaʻau ma nā pōʻaiapuni, me kēlā me kēia pōʻaiapuni e mau ana i 2-3 pule.

Hiki iā ʻoe ke loaʻa irinotecan i kēlā me kēia pule no kekahi mau pule, a ma hope e hoʻomaha ai i kou kino e ola. E nānā mau kāu oncologist i ke ʻano o ka pane ʻana o kāu maʻi maʻi ma o nā hoʻokolohua koko a me nā kiʻi imaging.

Hoʻomau ka lapaʻau no kekahi mau mahina, akā e hoʻoponopono kāu kauka i ka hoʻolālā ma muli o kou kūlana. Pono paha kekahi poʻe i ka lapaʻau no 6 mahina a ʻoi aku paha, a ʻo nā mea ʻē aʻe he mau manawa lapaʻau pōkole.

He aha nā hopena ʻaoʻao o Irinotecan?

E like me nā lāʻau chemotherapy a pau, hiki i ka irinotecan ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā ​​mea a pau e ʻike like iā lākou. E nānā pono kāu hui mālama ola iā ʻoe a hāʻawi i nā lāʻau lapaʻau a me nā hoʻolālā e kōkua i ka mālama ʻana i nā hōʻailona e kū mai.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike, me ka noʻonoʻo ʻana e ʻae maikaʻi ka nui o nā kānaka i kēia lāʻau me ke kākoʻo kūpono:

• Pāpaʻa (i kekahi manawa koʻikoʻi) - ʻo kēia ka hopena ʻaoʻao maʻamau
• Nausea a me ka luaʻi
• Luhi a me ka nāwaliwali
• Ka nalowale o ka lauoho a i ʻole ka lahilahi
• Hoʻemi ʻia ka ʻai
• Nā ʻeha waha
• Haʻahaʻa keʻokeʻo koko (hoʻonui i ka pilikia o ka maʻi)
• Haʻahaʻa ʻulaʻula koko (anemia)
• ʻO ka ʻōpū o ka ʻōpū

E hāʻawi kāu hui lapaʻau iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka mālama ʻana i ka maʻi pāpaʻa, me nā lāʻau lapaʻau e loaʻa. E nānā pū lākou i kāu helu koko i nā manawa a pau e nānā ai i nā loli e pili ana.

ʻIke kekahi poʻe i nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e koi ai i ka lāʻau lapaʻau koke. ʻO kēia mau hōʻailona kakaʻikahi akā koʻikoʻi e pili ana i ka dehydration koʻikoʻi, nā hōʻailona o ka maʻi e like me ke kuni, ke kahe ʻana a i ʻole ka ʻeha ʻana, a me ka ʻeha o ka ʻōpū.

ʻO ka hapa nui o nā hopena ʻaoʻao he mea manawa wale nō a hoʻomaikaʻi ma waena o nā lāʻau lapaʻau a i ʻole ma hope o ka pau ʻana o kāu papa irinotecan. E hana pū kāu hui mālama ola me ʻoe e hōʻemi i ka hōʻoluʻolu ʻole a e mālama iā ʻoe i ka ʻoluʻolu e like me ka hiki i ka wā o ka mālama ʻana.

ʻO wai ka mea pono ʻole e lawe iā Irinotecan?

ʻAʻole kūpono ʻo Irinotecan no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ka ʻōlelo ʻana i kēia lapaʻau. Hiki i kekahi mau maʻi olakino ke hoʻolilo i ka irinotecan i mea palekana ʻole a i ʻole ka liʻiliʻi.

ʻAʻole pono ʻoe e loaʻa iā irinotecan inā he maʻi koʻikoʻi ʻoe i kēia lāʻau lapaʻau a i ʻole kekahi o kāna mau mea. E akahele nō hoʻi kāu kauka inā loaʻa iā ʻoe kekahi mau ʻano genetic e pili ana i ke ʻano o ka hana ʻana o kou kino i kēia lāʻau.

ʻO ka poʻe me nā pilikia ate koʻikoʻi, nā maʻi maʻi, a i ʻole nā helu koko haʻahaʻa loa e pono e kali a hoʻohana paha i nā lāʻau lapaʻau ʻē aʻe. E hana kāu oncologist i nā hoʻokolohua koko a loiloi i kou olakino holoʻokoʻa ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, ʻaʻole ʻōlelo ʻia ka irinotecan no ka mea hiki iā ia ke hōʻeha i kāu pēpē. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka mana hānau kūpono i ka wā o ka lapaʻau a no kekahi mau mahina ma hope.

Irinotecan Brand Names

Loaʻa ʻo Irinotecan ma lalo o kekahi mau inoa inoa, ʻo Camptosar ka mea i ʻike nui ʻia. Hiki iā ʻoe ke ʻike iā ia i kapa ʻia ʻo CPT-11 i kekahi mau palapala lapaʻau a i ʻole nā hoʻolālā lapaʻau.

Loaʻa nō hoʻi nā mana generic o irinotecan a hana like me nā mana inoa inoa. E haʻi aku kāu hale kūʻai lāʻau lapaʻau a i ʻole ke kikowaena lapaʻau iā ʻoe i ka mana āu e loaʻa nei.

Ma waho aʻe o ka inoa inoa, aia nā mana a pau o irinotecan i ka mea hana like a hana like i kou kino. Loaʻa paha i kāu ʻinikua nā makemake no kekahi mau hōʻailona, ​​akā e hōʻoia kāu hui lapaʻau e loaʻa iā ʻoe ka lāʻau lapaʻau āu e pono ai.

Irinotecan Alternatives

Inā ʻaʻole kūpono ʻo irinotecan iā ʻoe a i ʻole e pau ka hana pono ʻana, he nui nā koho chemotherapy ʻē aʻe i loaʻa i kāu oncologist. ʻO ke koho maikaʻi loa e hilinaʻi ana i kāu ʻano maʻi maʻi kikoʻī a me kāu mau lapaʻau mua.

No ka maʻi maʻi colorectal, hiki i nā koho ʻē aʻe ke komo i nā ʻōnaehana oxaliplatin, bevacizumab, a i ʻole nā ​​lāʻau lapaʻau i manaʻo ʻia. Hiki i kāu kauka ke noʻonoʻo i nā lāʻau immunotherapy a i ʻole nā ​​hoʻokolohua lapaʻau o nā lapaʻau hoʻokolohua.

I kekahi manawa, ʻoi aku ka maikaʻi o ka hoʻololi ʻana i kahi hui chemotherapy ʻokoʻa ma mua o ka hoʻomau ʻana me ka regimen like. E kūkākūkā kāu oncologist i nā koho i loaʻa a kōkua iā ʻoe e hoʻomaopopo i nā pōmaikaʻi a me nā pilikia o kēlā me kēia ala.

Ua ʻoi aku ka maikaʻi o Irinotecan ma mua o Oxaliplatin?

He mau lāʻau chemotherapy maikaʻi ʻo Irinotecan a me oxaliplatin no ka maʻi maʻi colorectal, akā hana lākou i nā mea like ʻole a loaʻa nā ʻano hopena ʻokoʻa. ʻAʻole ʻoi aku ka maikaʻi o kekahi ma mua o kekahi - e hilinaʻi ka koho i kou kūlana pilikino.

ʻOi aku ka nui o nā hopena ʻaoʻao digestive e like me ka maʻi maʻi ʻo Irinotecan, ʻoiai ʻo oxaliplatin ke kumu pinepine i ka pōʻino o ke aʻalolo a me ka ʻike anu. E noʻonoʻo kāu kauka i kāu mōʻaukala olakino, nā maʻi olakino ʻē aʻe, a me nā makemake pilikino i ke koho ʻana ma waena o lākou.

Nui nā hoʻolālā lapaʻau e hoʻohana maoli i nā lāʻau ʻelua i nā manawa like ʻole a i ʻole i hui pū ʻia me nā lāʻau ʻē aʻe. E hana kāu oncologist i kahi hoʻolālā lapaʻau pilikino e hāʻawi iā ʻoe i ka manawa maikaʻi loa o ka holomua me ka hōʻemi ʻana i nā hopena ʻaoʻao.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Irinotecan

He palekana ʻo Irinotecan no ka poʻe me nā pilikia ate?

Hiki ke hoʻohana ʻia ʻo Irinotecan i ka poʻe me nā pilikia ate māmā, akā pono kāu kauka e hoʻoponopono i kāu mahele a nānā pono iā ʻoe. Hoʻoponopono ʻia ka lāʻau lapaʻau e kou ate, no laila hiki i ka hana ate i hōʻemi ʻia ke hoʻopilikia i ke ʻano o kou kino e mālama ai i ka lāʻau.

Inā he maʻi ate koʻikoʻi kou, ʻaʻole paha he palekana ka irinotecan iā ʻoe. E hana kāu oncologist i nā hoʻokolohua hana ate ma mua a i ka wā o ka mālama ʻana e hōʻoia i ka hana maikaʻi ʻana o kou ate i ka lāʻau lapaʻau.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Irinotecan?

No ka mea, hāʻawi ʻia ka irinotecan e nā poʻe loea mālama ola i aʻo ʻia i nā wahi lapaʻau, he mea maʻamau loa ka overdose ulia pōpilikia. Ana ʻia ka lāʻau lapaʻau a mālama pono ʻia e kāu hui lapaʻau.

Inā hopohopo ʻoe no kāu mahele a i ʻole e ʻike i nā hōʻailona maʻamau ma hope o ka mālama ʻana, e hoʻokaʻaʻike koke i kāu oncologist a i ʻole ke kikowaena lapaʻau. Hiki iā lākou ke loiloi i kāu mau hōʻailona a hāʻawi i ka mālama kūpono inā pono.

He aha kaʻu e hana ai inā hala wau i kahi mahele o Irinotecan?

Inā hala ʻoe i kahi mālama irinotecan i hoʻonohonoho ʻia, e hoʻokaʻaʻike koke i ke keʻena o kāu oncologist e hoʻonohonoho hou. Mai ho'āʻo e

Inā e inu ʻoe i ka waiʻona i kekahi manawa, e kūkākūkā me kāu hui mālama ola. Hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kou olakino holoʻokoʻa a me ka hoʻolālā lapaʻau. Manaʻo ka hapa nui o nā kauka e pale loa i ka waiʻona i ka wā e mālama ʻia ana ka chemotherapy.