He aha ʻo Ixazomib: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻo Ixazomib e hana ana ma ka pale ʻana i nā protein e kōkua ana i nā sela maʻi e ulu a ola. No kēia lāʻau lapaʻau waha i kahi papa o nā lāʻau i kapa ʻia he proteasome inhibitors, e hana maoli ana i ka mīkini kelepona e hiki ai i nā sela myeloma he nui ke hoʻonui.

Hiki paha iā ʻoe ke noʻonoʻo e pili ana i kēia lāʻau lapaʻau inā ua ʻōlelo kāu kauka iā ia ma ke ʻano he ʻāpana o kāu hoʻolālā lapaʻau maʻi. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o ixazomib a me ka mea e manaʻo ai hiki ke kōkua iā ʻoe e manaʻoʻiʻo i kāu huakaʻi lapaʻau.

He aha ʻo Ixazomib?

He lāʻau chemotherapy waha ʻo Ixazomib i hoʻolālā ʻia e mālama i ka myeloma he nui, kahi ʻano maʻi koko e pili ana i nā sela plasma i loko o kou iwi iwi. Hele mai ka lāʻau lapaʻau i ke ʻano capsule, e maʻalahi ai ma mua o nā lāʻau lapaʻau maʻi ʻē aʻe e koi ai i nā kipa i ka haukapila.

ʻO kēia lāʻau lapaʻau ka mea a nā kauka e kāhea ai he

ʻO ka myeloma nui he maʻi maʻi e hoʻomaka ana i nā pūnaewele plasma, he ʻano keʻokeʻo keʻokeʻo i loaʻa i loko o kou iwi iwi. Kōkua maʻamau kēia mau pūnaewele i kāu ʻōnaehana pale e hakakā i nā maʻi ma ka hana ʻana i nā antibodies. Ke lilo lākou i maʻi maʻi, hoʻonui lākou me ka ʻole o ka mana a hoʻopilikia i nā pūnaewele koko olakino.

Ua ʻae ʻia kēia lāʻau lapaʻau no nā maʻi i hoʻi mai kā lākou maʻi maʻi ma hope o nā lāʻau lapaʻau mua a i ʻole ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe. He koho nui ia no ka poʻe e pono ai ka lāʻau lapaʻau e mālama i ko lākou maʻi.

Pehea e hana ai ʻo Ixazomib?

Hana ʻo Ixazomib ma ka ʻimi ʻana i kahi nāwaliwali kikoʻī i nā pūnaewele maʻi maʻi. Palaka ia i nā proteasomes, e like me nā mea hoʻolei ʻōpala kelepona e wāwahi i nā protein kahiko. Hana nā pūnaewele maʻi maʻi i nā protein ʻoi aku ka wikiwiki ma mua o nā pūnaewele maʻamau, no laila e hilinaʻi nui lākou i kēia mau proteasomes e hoʻomaʻemaʻe i ka nui.

Ke ālai ʻo ixazomib i kēia mau proteasomes, ua lanakila nā pūnaewele maʻi maʻi me ka hana ʻana o ka protein a make maoli mai kā lākou huahana ʻōpala ponoʻī. Kapa ʻia kēia kaʻina hana ʻo apoptosis, a i ʻole ka make ʻana o ke kelepona i hoʻolālā ʻia, a hana maoli ia ke lilo nā pūnaewele i mea i hōʻino ʻia e hana pono.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika iki i hoʻohālikelike ʻia me nā lāʻau lapaʻau maʻi maʻi ʻē aʻe. Hiki iā ia ke hana i nā hopena ʻaoʻao nui, akā ʻike ka nui o nā kānaka he mea hiki ke mālama ʻia ma mua o ka chemotherapy intravenous kuʻuna no ka mea hiki iā ʻoe ke lawe ma ka home ma ke ʻano he pila.

Pehea wau e lawe ai iā Ixazomib?

E lawe iā ixazomib e like me ke kauoha a kāu kauka, maʻamau i hoʻokahi manawa i ka pule ma ka lā like i kēlā me kēia pule. ʻO ka maʻamau ka maʻamau he 4 mg, akā hiki i kāu kauka ke hoʻoponopono i kēia ma muli o ka maikaʻi o kou ʻae ʻana i ka lāʻau lapaʻau a me ka pane ʻana o kāu maʻi maʻi.

Pono ʻoe e lawe i kēia lāʻau lapaʻau i ka ʻōpū ʻole, ma ka liʻiliʻi hoʻokahi hola ma mua o ka ʻai ʻana a i ʻole ma ka liʻiliʻi ʻelua hola ma hope o ka ʻai ʻana. E ale i ka capsule holoʻokoʻa me ke aniani wai piha - mai wehe, ʻoki, a nau paha. Inā luaʻi ʻoe i loko o hoʻokahi hola o ka lawe ʻana i kāu mahele, mai lawe i kekahi capsule i kēlā lā.

E hoʻāʻo e lawe i kāu mahele i ka manawa like i kēlā me kēia pule e mālama i nā pae kūlike i loko o kou kino. Nui ka poʻe i ʻike he mea kōkua ke hoʻonohonoho i kahi hoʻomanaʻo i kēlā me kēia pule ma kā lākou kelepona a i ʻole kalena. E mālama i nā capsules i loko o kā lākou pahu kumu ma ka lumi wela, mai ka wai a me ka wela.

Pehea ka lōʻihi e lawe ai au i ka Ixazomib?

Lawe ka hapa nui o nā kānaka i ka ixazomib no ka lōʻihi e hoʻomau ana e hana pono ana i kā lākou maʻi ʻaʻai a hiki ke mālama ʻia nā hopena ʻaoʻao. ʻO ka maʻamau, 28 mau lā ka lōʻihi o nā pōʻai lapaʻau, me ʻoe e lawe ana i ka lāʻau lapaʻau i nā lā 1, 8, a me 15 o kēlā me kēia pōʻai, a laila loaʻa kahi pule hoʻomaha.

E nānā kāu kauka i kāu pane ma o nā hoʻokolohua koko maʻamau a me nā haʻawina kiʻi. Hiki i kekahi poʻe ke lawe i kēia lāʻau lapaʻau no kekahi mau mahina, ʻoiai e hoʻomau ana kekahi no hoʻokahi makahiki a ʻoi aku paha. Aia ka lōʻihi i ka maikaʻi o ka pane ʻana o kāu maʻi ʻaʻai a me ke ʻano o kou kino e ʻae ai i ka lapaʻau.

E loiloi mau kāu hui mālama ola inā ʻoi aku ka maikaʻi o ka hoʻomau ʻana i ka lapaʻau ma mua o nā hopena ʻaoʻao āu e ʻike nei. Hiki iā lākou ke hoʻoponopono i kāu mahele a i ʻole e ʻōlelo i nā wā hoʻomaha lapaʻau inā pono e kōkua i ka mālama ʻana i nā pilikia.

He aha nā hopena ʻaoʻao o Ixazomib?

E like me nā lāʻau lapaʻau maʻi ʻaʻai a pau, hiki i ka ixazomib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka nānā pono ʻana a me ka mālama kākoʻo mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Nā pilikia ʻōpū: He mea maʻamau ka maʻi palahē, ka luaʻi, ka ninini ʻana, a me ka paʻa ʻana o ka ʻōpū. E hoʻomaikaʻi pinepine kēia mau mea i ka wā e hoʻoponopono ai kou kino i ka lāʻau.
• Nā pilikia ʻili: Hoʻopilikia ka ʻōpū, ka ʻū, a me ka ʻili maloʻo i nā kānaka he nui. Hiki i kāu kauka ke ʻōlelo i nā mea hoʻomaʻemaʻe a me nā lāʻau e kōkua i ka mālama ʻana i kēia mau hōʻailona.
• Luhi: He mea maʻamau ka manaʻo luhi a nāwaliwali paha. Hiki ke pili kēia i ka lāʻau a me ka maʻi ʻaʻai ponoʻī.
• Nā pilikia o nā aʻalolo: Hiki ke ʻike ʻia ka ʻeha, ka ʻūlū, a i ʻole ka ʻeha ma kou mau lima a me kou mau wāwae (peripheral neuropathy) akā ʻaʻole pinepine i ʻoi aku ka nui ma mua o nā lāʻau like ʻē aʻe.
• ʻEha kua: He hopena ʻaoʻao i hōʻike pinepine ʻia e hiki ke mālama ʻia me nā lāʻau ʻeha.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau. Pono kēia mau mea i ka mālama olakino koke a me nā maʻi koʻikoʻi, ke kahe ʻana o ke koko a i ʻole ka ʻeha, ka pilikia o ka hanu ʻana, a i ʻole nā ​​hōʻailona o nā pilikia o ke ake e like me ka melemele ʻana o ka ʻili a i ʻole nā ​​maka.

E nānā pono kāu hui mālama ola iā ʻoe no kēia mau hopena ma o nā hoʻokolohua koko maʻamau a me nā nānā ʻana. Mai kānalua e hoʻokaʻaʻike iā lākou inā ʻike ʻoe i nā hōʻailona e pili ana, ʻoiai inā he mea liʻiliʻi lākou.

ʻO wai ka mea pono ʻole e lawe iā Ixazomib?

ʻAʻole kūpono ʻo Ixazomib no nā mea a pau. E loiloi pono kāu kauka inā palekana kēia lāʻau lapaʻau iā ʻoe e pili ana i kou olakino holoʻokoʻa, nā lāʻau ʻē aʻe āu e lawe nei, a me kāu mōʻaukala olakino.

ʻAʻole pono ʻoe e lawe iā ixazomib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna meaʻai. ʻAʻole pono nā wahine hāpai a i ʻole e hānai ana i ka waiū e hoʻohana i kēia lāʻau lapaʻau, no ka mea, hiki iā ia ke hōʻino i kahi pēpē e ulu ana. Inā ʻoe i ka makahiki hānau keiki, pono ʻoe e hoʻohana i ka contraception maikaʻi i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope.

ʻAʻole paha e hiki i nā kānaka me nā pilikia ate koʻikoʻi ke lawe palekana i kēia lāʻau. E nānā kāu kauka i kāu hana ate ma mua o ka hoʻomaka ʻana i ka lāʻau a e nānā mau ia i kāu lāʻau lapaʻau.

Inā he moʻolelo kou o nā pilikia o ka puʻuwai, nā koko koko, a i ʻole nā maʻi koʻikoʻi, pono i kāu kauka e ana pono i nā pōmaikaʻi a me nā pilikia. Hiki iā lākou ke ʻōlelo i ka nānā hou ʻana a i ʻole ke koho ʻana i kahi ala lapaʻau ʻē aʻe.

Nā inoa inoa o Ixazomib

Kūʻai ʻia ʻo Ixazomib ma lalo o ka inoa inoa ʻo Ninlaro ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa. ʻO kēia wale nō ka inoa inoa i loaʻa no kēia lāʻau, no ka mea, aia nō ia ma lalo o ka pale palapala.

Hiki nō hoʻi iā ʻoe ke lohe i nā mea mālama ola e kuhikuhi ana iā ia ma kona inoa kemika, ixazomib citrate, ʻoi aku hoʻi i nā palapala lapaʻau a i ʻole nā haʻawina noiʻi. Eia naʻe, ke kiʻi ʻoe i kāu kauoha, e ʻike ʻoe ua lepili ʻia ʻo Ninlaro.

Hana ʻia ka lāʻau e Takeda Pharmaceuticals a loaʻa wale nō ma o nā hale kūʻai lāʻau lapaʻau kūikawā i loaʻa ka ʻike i ka mālama ʻana i nā lāʻau lapaʻau maʻi maʻi. E kōkua kāu hui mālama ola iā ʻoe e loaʻa i kāu lāʻau lapaʻau ma o kekahi o kēia mau wahi kūikawā.

Nā koho ʻē aʻe o Ixazomib

Inā ʻaʻole kūpono ʻo ixazomib iā ʻoe a i ʻole e pau ka hana pono ʻana, aia kekahi mau koho lapaʻau ʻē aʻe no ka myeloma nui. Hiki i kāu kauka ke noʻonoʻo i nā mea pale proteasome ʻē aʻe e like me bortezomib (Velcade) a i ʻole carfilzomib (Kyprolis), ʻoiai ua hāʻawi ʻia kēia mau mea ma ke ʻano he injections ma mua o nā pills.

Hana nā lāʻau immunomodulatory e like me lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst) i nā mea like ʻole ma ka hoʻonui ʻana i ka hiki o kāu ʻōnaehana pale e hakakā i nā sela maʻi. ʻO nā lāʻau lapaʻau hou e komo pū ana i nā antibodies monoclonal e like me daratumumab (Darzalex) a i ʻole elotuzumab (Empliciti).

Ke lilo nei ka lāʻau lapaʻau CAR-T cell a me nā ʻano hana immunotherapy ʻē aʻe i mea e loaʻa ai no ka poʻe me ka myeloma nui. E noʻonoʻo kāu kauka oncologist i nā mea e like me kāu mau lāʻau lapaʻau i hala, ke olakino holoʻokoʻa, a me nā makemake pilikino i ka wā e ʻōlelo ai i ka koho maikaʻi loa no kou kūlana.

Ua ʻoi aku ka maikaʻi o Ixazomib ma mua o Bortezomib?

ʻO Ixazomib a me bortezomib nā mea pale proteasome e hana like, akā he mau ʻokoʻa nui ko lākou. ʻO ka pōmaikaʻi nui o ixazomib hiki iā ʻoe ke lawe iā ia ma ke ʻano he pila ma ka home, ʻoiai ʻo bortezomib e koi i nā injections ma kahi keʻena lapaʻau.

Hōʻike nā haʻawina e hiki i ka ixazomib ke hoʻoulu i ka pōʻino o ke aʻalolo (peripheral neuropathy) ma mua o bortezomib, he mea nui ia no nā maʻi he nui. Eia naʻe, ua hoʻohana ʻia ʻo bortezomib no ka lōʻihi a loaʻa nā noiʻi nui e kākoʻo ana i kona pono.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i nā mea like ʻole me kāu mōʻaukala lapaʻau, nā makemake o ke ola, a me ka maikaʻi o kou ʻae ʻana i nā hopena ʻaoʻao. E kōkua kāu kauka iā ʻoe e kaupaona i nā mea maikaʻi a me nā mea maikaʻi ʻole o kēlā me kēia koho e pili ana i kāu kūlana kikoʻī a me nā pahuhopu lapaʻau.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Ixazomib

He palekana anei ʻo Ixazomib no ka poʻe me ka maʻi kīkī?

Hiki ke hoʻohana ʻia ʻo Ixazomib i ka poʻe me nā pilikia kīkī maʻalahi a maʻalahi, akā e nānā pono kāu kauka i kāu hana kīkī. Hoʻoponopono mua ʻia ka lāʻau lapaʻau e kou ate ma mua o kou mau kīkī, kahi e palekana ai no ka poʻe me nā pilikia kīkī i hoʻohālikelike ʻia me kekahi mau lāʻau lapaʻau maʻi maʻi.

Inā loaʻa iā ʻoe ka maʻi kīkī koʻikoʻi a i ʻole ma ka dialysis, pono paha kāu kauka e hoʻoponopono i kāu mahele a i ʻole ke koho i kahi lāʻau lapaʻau ʻē aʻe. E hana lākou i nā hoʻokolohua koko maʻamau e nānā i ka maikaʻi o ka hana ʻana o kou mau kīkī i kāu lāʻau lapaʻau.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Ixazomib?

Inā ua lawe ʻoe i ka nui aʻe o kāu lāʻau i kuhikuhi ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make, ʻoiai inā maikaʻi kou manaʻo. Mai kali a ʻike ʻia nā hōʻailona, no ka mea, hiki i ka overdose ke hana i nā pilikia koʻikoʻi i ʻike ʻole ʻia.

E lawe pū me ʻoe i ka hue lāʻau inā pono ʻoe e hele i ke keʻena ulia pōpilikia, i hiki i nā mea mālama ola ke ʻike pololei i ka mea a me ka nui āu i lawe ai. Mai hoʻāʻo e

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ixazomib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao a i ʻole e hoʻemi i ka maikaʻi o ka mālama ʻana i ka maʻi ʻaʻai. E haʻi mau i kāu kauka e pili ana i nā lāʻau lapaʻau a pau āu e lawe nei, me nā lāʻau lapaʻau i kūʻai ʻia ma luna o ke kūʻai ʻana, nā mea hoʻohui, a me nā lāʻau lapaʻau herbal.

Hiki i nā mea hoʻokomo CYP3A ikaika e like me rifampin a i ʻole phenytoin ke hoʻemi i ka pono o ixazomib, ʻoiai hiki i nā mea pale CYP3A ikaika e like me ketoconazole ke hoʻonui i nā hopena ʻaoʻao. Pono paha kāu kauka e hoʻoponopono i nā ʻano lāʻau a i ʻole e koho i nā lāʻau lapaʻau ʻē aʻe e pale aku i kēia mau pilina.