He aha ka Lanadelumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Lanadelumab i hoʻolālā ʻia e pale i nā hōʻeha o ka hereditary angioedema (HAE), kahi maʻi genetic kakaʻikahi e hoʻoulu ai i ka pehu koke ʻana i nā ʻāpana like ʻole o kou kino. Hana kēia lāʻau lapaʻau injectable ma ka pale ʻana i kahi protein i kapa ʻia ʻo kallikrein, e hoʻomaka ai i nā hanana pehu e hiki ke ʻeha a weliweli paha.

Inā ua ʻike ʻia ʻoe a i ʻole kekahi āu e aloha ai me HAE, e manaʻo paha ʻoe e lanakila ʻia e ka paʻakikī o ka mālama ʻana i kēia maʻi. ʻO ka lono maikaʻi ʻo ka lanadelumab e hōʻike ana i kahi holomua nui i ka mālama ʻana iā HAE, e hāʻawi ana i nā poʻe he nui i ka manawa e ola me ka liʻiliʻi o nā hōʻeha a me ka maluhia o ka noʻonoʻo.

He aha ka Lanadelumab?

ʻO Lanadelumab kahi lāʻau lapaʻau monoclonal antibody e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo kallikrein inhibitors. E noʻonoʻo iā ia he lāʻau lapaʻau i manaʻo ʻia e hana e like me kahi kiaʻi palekana kūikawā i loko o kou kino, e nānā pono ana a me ka pale ʻana i ka protein e hoʻoulu ai i nā hōʻeha HAE.

He wai maopopo kēia lāʻau lapaʻau e hoʻokomo ai ʻoe ma lalo o kou ʻili (subcutaneously) me ka hoʻohana ʻana i kahi syringe i hoʻopiha mua ʻia. Ua ʻike ʻia ka lāʻau lapaʻau e kona inoa inoa ʻo Takhzyro, a ua hana ʻia me ka hoʻohana ʻana i ka biotechnology kiʻekiʻe e hana i kahi lāʻau lapaʻau kūikawā no HAE.

ʻO ka mea e kū hoʻokahi ai ka lanadelumab ʻo kona pololei. Ma kahi o ka hoʻopaʻa ʻana i kāu ʻōnaehana pale e like me kekahi mau lāʻau lapaʻau ʻē aʻe, ua manaʻo ʻia wale nō ke ala kikoʻī e hoʻoulu ai i nā hōʻeha HAE, e waiho ana i ke koena o kāu hana pale i kahi kūlana maikaʻi.

No ke aha i hoʻohana ʻia ai ka Lanadelumab?

Ua ʻae ʻia ʻo Lanadelumab e ka FDA no ka pale ʻana i nā hōʻeha o ka hereditary angioedema i nā pākeke a me nā ʻōpio 12 mau makahiki a ʻoi aku paha. He maʻi genetic ʻo HAE kahi e hoʻoponopono pono ʻole ai kou kino i kahi protein i kapa ʻia ʻo C1 esterase inhibitor, e alakaʻi ana i nā hanana o ka pehu nui.

I ka wā o ka hoʻouka ʻana o ka HAE, hiki iā ʻoe ke ʻike i ka pehu koke ʻana i kou maka, nā lehelehe, ke alelo, ka ʻāʻī, nā lima, nā wāwae, a i ʻole nā ʻōpū. Hiki ke ʻike ʻole ʻia kēia mau hanana a ʻokoʻa ka paʻakikī. Hiki i kekahi mau hoʻouka ʻana ke hoʻoulu i ka ʻoluʻolu, ʻoiai hiki i nā mea ʻē aʻe ke hoʻoweliweli i ke ola inā pili lākou i kou ala ea.

Hoʻolālā ʻia ka lāʻau lapaʻau no ka pale lōʻihi, ʻaʻole no ka mālama ʻana i kahi hoʻouka ʻana e hana nei. Inā loaʻa iā ʻoe kahi hoʻouka HAE nui, pono ʻoe i nā lāʻau lapaʻau pilikia like ʻole e hana wikiwiki e hoʻōki i ka pehu.

Hiki i kāu kauka ke ʻōlelo aku i ka lanadelumab inā ʻoe e ʻike nei i nā hoʻouka HAE pinepine e pili nui ana i kou maikaʻi o ke ola, ka hana, a i ʻole nā hana i kēlā me kēia lā. ʻO ka pahuhopu ka hōʻemi ʻana i ke alapine a me ka paʻakikī o kēia mau hanana.

Pehea e hana ai ʻo Lanadelumab?

Hana ʻo Lanadelumab ma ka pale ʻana i ka plasma kallikrein, kahi protein e pāʻani nui i ke kaʻina o nā hanana e alakaʻi ana i nā hoʻouka HAE. Ke hana kēia protein, hoʻomaka ia i ka hana ʻana o ka bradykinin, kahi mea e hoʻoulu ai i nā kīʻaha koko e lilo i leaky a alakaʻi i ka pehu ʻana o ka HAE.

Ma ka pale ʻana i ka kallikrein, hoʻōki maoli ʻo lanadelumab i kēia kaulahao ma mua o ka hiki ke hoʻoulu i nā hōʻailona. Hoʻopaʻa ka lāʻau lapaʻau i ka kallikrein a pale iā ia mai ka hana ʻana i kāna hana, kahi e hōʻemi nui ai i ka hiki ʻana o kahi hoʻouka.

Manaʻo ʻia he lāʻau lapaʻau ikaika a paʻa loa. ʻAʻole like me kekahi mau lāʻau lapaʻau e pili ākea i kāu ʻōnaehana pale, ua hoʻolālā ʻia ʻo lanadelumab e kikoʻī loa i kāna hana, ʻo ia hoʻi ka liʻiliʻi o nā hopena ʻaoʻao a me nā pilina me nā ʻōnaehana kino ʻē aʻe.

Hoʻokumu ʻia nā hopena o ka lanadelumab i ka manawa, ʻo ia ke kumu he mea nui e lawe mau ia e like me ke kauoha. Hoʻomaka ka hapa nui o nā kānaka e ʻike i ka hōʻemi ʻana i ke alapine o ka hoʻouka ʻana i loko o nā mahina mua o ka mālama ʻana.

Pehea wau e lawe ai iā Lanadelumab?

Hāʻawi ʻia ʻo Lanadelumab ma ke ʻano he injection subcutaneous, ʻo ia hoʻi, hoʻokomo ʻoe iā ia i loko o ka ʻiʻo momona ma lalo pono o kou ʻili. ʻO ka maʻamau maʻamau he 300 mg i kēlā me kēia ʻelua pule, akā hiki i kāu kauka ke hoʻoponopono i kēia ma muli o ka maikaʻi o kāu pane ʻana i ka lāʻau.

Hiki iā ʻoe ke hoʻokomo i ka lanadelumab i loko o kou ʻūhā, lima luna, a i ʻole ka ʻōpū. He mea nui e hoʻololi i nā wahi injection e pale ai i ka huhū o ka ʻili a i ʻole ka ulu ʻana o nā puʻupuʻu paʻakikī ma lalo o ka ʻili. E aʻo kāu mea mālama ola iā ʻoe a i ʻole kekahi lālā o ka ʻohana pehea e hāʻawi palekana ai i kēia mau injections ma ka home.

Ma mua o ka hoʻokomo ʻana, e lawe i ka lāʻau mai loko mai o ka pahu hau a e ʻae iā ia e hiki i ka mahana o ka lumi no kahi o 15-20 mau minuke. Hiki i ka lāʻau lapaʻau ke anuanu ke ʻoluʻolu ʻole ke hoʻokomo. E nānā mau i ka maopopo a me ka ʻole o ka wai ma mua o ka hoʻohana ʻana.

Hiki iā ʻoe ke lawe i ka lanadelumab me ka ʻole o ka meaʻai, no ka mea, ua hoʻokomo ʻia ma mua o ka lawe ʻia ʻana ma ka waha. Eia naʻe, he mea kōkua ke hoʻokumu i kahi hana maʻamau, e like me ka hoʻokomo ʻana iā ia i nā lā like o ka pule, e kōkua iā ʻoe e hoʻomanaʻo i kāu mau lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Lanadelumab?

Hoʻolālā ʻia ʻo Lanadelumab no ka hoʻohana lōʻihi, no ka mea, he maʻi genetic mau ʻo HAE e koi ana i ka mālama mau. Hoʻomau ka hapa nui o nā kānaka i ka lawe ʻana i kēia lāʻau no ka pale ʻana i nā hoʻouka ʻana.

E nānā kāu kauka i kāu pane ʻana i ka lāʻau i nā mahina mua a hiki ke hoʻoponopono i ka papa hana dosing ma muli o ka maikaʻi o kāu hana. Hiki i kekahi poʻe i loaʻa ka mana maikaʻi loa o kā lākou mau hōʻailona ke hiki ke hoʻokaʻawale i kā lākou mau injections i kēlā me kēia ʻehā pule ma kahi o kēlā me kēia ʻelua pule.

He mea nui ʻaʻole e hooki i ka lawe ʻana i ka lanadelumab me ka ʻole e kamaʻilio mua me kāu kauka. No ka mea, hana ka lāʻau lapaʻau ma ka mālama ʻana i nā pae paʻa i loko o kāu ʻōnaehana, hiki i ka hoʻōki ʻana ke alakaʻi i ka hoʻi ʻana mai o nā hoʻouka HAE.

E nānā mau ana kāu mea mālama ola i kāu hoʻolālā lapaʻau a loiloi inā he koho maikaʻi loa ʻo lanadelumab iā ʻoe. E noʻonoʻo lākou i nā mea e like me ke alapine o ka hoʻouka ʻana, nā hopena ʻaoʻao, a me kou maikaʻi o ke ola.

He aha nā hopena ʻaoʻao o Lanadelumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka lanadelumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hana maʻamau ma kahi e hoʻokomo ʻia ai ka lāʻau.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e hiki iā ʻoe ke ʻike:

• Nā hopena ma kahi e hoʻokomo ʻia ai ka lāʻau, me ka ʻulaʻula, ka pehu ʻana, ka ʻeha, a i ʻole ka ʻeha
• Nā maʻi o ka ʻōnaehana hanu luna e like me ke anu
• Nā poʻo
• ʻAmi
• ʻO ka ʻili a i ʻole ka huhū o ka ʻili

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao maʻamau iā lākou iho a ʻaʻole pono e hoʻōki i ka lāʻau. Hiki i ka ʻenehana hoʻokomo kūpono a me ka hoʻololi ʻana i ka pūnaewele ke kōkua i ka hōʻemi ʻana i nā hopena ma kahi e hoʻokomo ʻia ai ka lāʻau.

Aia kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e pono ai ka lāʻau lapaʻau koke. ʻOiai he kakaikahi kēia, he mea nui e ʻike iā lākou:

• Nā hopena maʻi maʻi koʻikoʻi me ka pilikia o ka hanu ʻana, ka pehu ʻana o ka maka a i ʻole ka ʻāʻī, a i ʻole ka ʻili ākea
• Nā hōʻailona o ka maʻi koʻikoʻi e like me ke kuni, nā anu, a i ʻole nā ​​hōʻailona e like me ka maʻi flu
• Ke kahe koko ʻokoʻa a i ʻole ka ʻeha
• Nā poʻo koʻikoʻi a mau loa

ʻIke ka hapa nui o ka poʻe i nā hopena ʻaoʻao a lākou e ʻike ai he hiki ke mālama ʻia a ʻaʻole hoʻi e hoʻopilikia nui ʻia ma mua o nā hoʻouka HAE a lākou i loaʻa ai ma mua o ka lapaʻau.

ʻO wai ka mea pono ʻole e lawe iā Lanadelumab?

ʻAʻole kūpono ʻo Lanadelumab no nā mea a pau, a aia kekahi mau kūlana kahi e ʻōlelo ai kāu kauka i kahi ala lapaʻau ʻē aʻe. ʻO ka contraindication nui loa inā ua loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi iā lanadelumab a i ʻole kekahi o kāna mea i hala.

E loiloi pono kāu kauka inā kūpono ʻo lanadelumab iā ʻoe inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• Nā maʻi koʻikoʻi ikaika
• Maʻi ate a i ʻole nā puʻupaʻa koʻikoʻi
• He moʻolelo o nā hopena maʻi maʻi koʻikoʻi i nā lāʻau lapaʻau antibody monoclonal ʻē aʻe
• Hāpai a i ʻole nā hoʻolālā e hāpai
• Hānai ʻana i ka waiū

Pono nō hoʻi ka noʻonoʻo kūikawā no ka poʻe me nā maʻi autoimmune, no ka mea, pili ʻo lanadelumab i ka hana ʻōnaehana immune. E kaupaona kāu kauka i nā pōmaikaʻi i nā pilikia hiki ke loaʻa i kēia mau kūlana.

He mea nui nō hoʻi ka makahiki. Ua ʻae ʻia ʻo Lanadelumab no ka poʻe 12 makahiki a ʻoi aku, no ka mea, ʻaʻole lawa ka ʻikepili palekana a me ka pono no nā keiki ʻōpio.

Inoa Brand Lanadelumab

Hoʻolaha ʻia ʻo Lanadelumab ma lalo o ka inoa brand Takhzyro. ʻO kēia ka inoa āu e ʻike ai ma ka lepili kauoha a me ka ʻeke ke kiʻi ʻoe i kāu lāʻau lapaʻau mai ka hale kūʻai lāʻau.

Hana ʻia ʻo Takhzyro e Takeda Pharmaceuticals a ua ʻae mua ʻia e ka FDA i ka makahiki 2018. Hele mai ka lāʻau lapaʻau i nā syringes i hoʻopiha mua ʻia me 150 mg o lanadelumab i 1 mL o ka hopena.

I kēia manawa, ʻaʻohe mana generic o lanadelumab i loaʻa, no ka mea, aia nō ka lāʻau lapaʻau ma lalo o ka pale patent. ʻO ia hoʻi, ʻo Takhzyro wale nō ka mana inoa brand hiki iā ʻoe ke kiʻi.

Nā koho ʻē aʻe o Lanadelumab

ʻOiai he mea maikaʻi loa ʻo lanadelumab no ka nui o ka poʻe me HAE, ʻaʻole ʻo ia wale nō ke koho lapaʻau i loaʻa. Hiki i kāu kauka ke noʻonoʻo i nā koho ʻē aʻe inā ʻaʻole hana maikaʻi ʻo lanadelumab iā ʻoe a i ʻole inā loaʻa iā ʻoe nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia.

ʻO nā lāʻau lapaʻau pale ʻē aʻe no HAE:

• Berotralstat (Orladeyo) - he lāʻau lapaʻau waha i lawe ʻia i kēlā me kēia lā
• C1 esterase inhibitor concentrates i hāʻawi ʻia e IV infusion
• Danazol - he lāʻau lapaʻau waha i hoʻohana ʻia no nā makahiki he nui
• Tranexamic acid - he lāʻau lapaʻau waha e hiki ke kōkua i kekahi poʻe

He ʻokoʻa nā pōmaikaʻi a me nā hemahema o kēlā me kēia koho. No ka laʻana, hāʻawi ʻo berotralstat i ka maʻalahi o ka lāʻau lapaʻau waha i kēlā me kēia lā, ʻoiai ʻo C1 esterase inhibitor concentrates e pani i ka protein i nele i ka HAE.

E kōkua kāu kauka iā ʻoe e noʻonoʻo i nā mea e like me ka pono, nā hopena ʻaoʻao, ka maʻalahi, a me ke kumukūʻai i ke koho ʻana i ka lāʻau lapaʻau maikaʻi loa no kāu kūlana kikoʻī.

Ua ʻoi aku ka maikaʻi o Lanadelumab ma mua o Berotralstat?

He mau lāʻau lapaʻau maikaʻi ʻo Lanadelumab a me berotralstat no ka pale ʻana i ka HAE, akā hana lākou ma nā ʻano like ʻole a he mau mea maikaʻi ʻokoʻa. Aia ke koho

ʻAʻole maʻamau ka lāʻau lapaʻau i nā loli i ke koko a i ʻole ka puʻuwai. No ka mea, ua hoʻokomo ʻia ma lalo o ka ʻili ma mua o ka lawe ʻia ʻana e ka waha, ʻaʻole ia e launa pū me nā lāʻau lapaʻau puʻuwai he nui e like me ka hana ʻana o nā lāʻau lapaʻau waha.

Inā he maʻi puʻuwai kou, e hōʻoia e haʻi i kāu kauka e pili ana i kāu mau lāʻau lapaʻau cardiac a pau ma mua o ka hoʻomaka ʻana i ka lanadelumab. Hiki iā lākou ke hana i kekahi mau hoʻokolohua kumu a nānā pono iā ʻoe i ka wā mua.

Q2. He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Lanadelumab?

Inā hoʻokomo hewa ʻoe i ka lanadelumab ma mua o ka mea i kauoha ʻia, mai hopohopo. E kelepona koke i kāu kauka a i ʻole ka mea mālama ola e haʻi iā lākou i ka mea i hana ʻia a loaʻa nā ʻōlelo kikoʻī no kou kūlana.

I ka hapanui o nā hihia, ʻaʻole paha e hoʻopilikia koke ka overdose hoʻokahi o ka lanadelumab i nā pilikia koʻikoʻi, akā pono ʻoe e ʻimi i ka ʻōlelo aʻo lapaʻau. Hiki i kāu kauka ke nānā pono iā ʻoe a i ʻole e hoʻoponopono i kāu mahele i hoʻonohonoho ʻia.

E mālama i ka ʻeke lāʻau lapaʻau a me nā syringes i koe i hiki iā ʻoe ke haʻi i kāu mea mālama ola i ka nui o ka lāʻau lapaʻau keu āu i lawe ai. E kōkua kēia ʻike iā lākou e hāʻawi iā ʻoe i ka ʻōlelo aʻo maikaʻi loa.

Q3. He aha kaʻu e hana ai inā hala au i kahi mahele o Lanadelumab?

Inā hala ʻoe i kahi mahele o ka lanadelumab, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, a laila e hoʻomau me kāu papa hana maʻamau. Mai lawe i kahi mahele pālua e hana ai no ka mea i hala.

Inā kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia, e lele i ka mahele i hala a hoʻomau me kāu papa hana maʻamau. ʻO ka lawe ʻana i nā mahele kokoke loa i kekahi i kekahi hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole o ka hāʻawi ʻana i nā pōmaikaʻi hou.

ʻO ka hala ʻana i hoʻokahi mahele i kekahi manawa ʻaʻole ia e hoʻopilikia koke, akā e hoʻāʻo e mālama i kāu papa hana maʻamau e like me ka hiki no ka pale maikaʻi loa i nā hoʻouka HAE.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Lanadelumab?

Pono ʻoe e hooki i ka lawe ʻana i ka lanadelumab ma lalo o ke alakaʻi a kāu kauka. No ka mea he maʻi genetic ola mau ka HAE, pono ka hapa nui o nā kānaka e hoʻomau i ka mālama ʻana i ka pale ʻana i nā hoʻouka ʻana.

Hiki i kāu kauka ke noʻonoʻo e hooki a i ʻole e hoʻokaʻawale i nā mahele inā ua loaʻa iā ʻoe ka mana maikaʻi loa o kāu mau hōʻailona no ka manawa lōʻihi. Eia naʻe, pono e hana ʻia kēia hoʻoholo me ka mālama nui a me ka nānā pono ʻana.

Inā makemake ʻoe e hooki i ka mālama ʻana no kekahi kumu, e kūkākūkā mua me kāu mea mālama ola. Hiki iā lākou ke kōkua iā ʻoe e kaupaona i nā pilikia a me nā pōmaikaʻi a e hōʻike paha i nā lāʻau lapaʻau ʻē aʻe inā pono.

Q5. Hiki iaʻu ke hele me Lanadelumab?

ʻAe, hiki iā ʻoe ke hele me lanadelumab, akā pono ia i kekahi hoʻolālā ʻana no ka mea pono e mālama ʻia ka lāʻau lapaʻau i loko o ka pahu hau. E lawe mau i kāu lāʻau lapaʻau i loko o kāu ʻeke lima i ka wā e lele ana, ʻaʻole loa i loko o ka ʻeke i nānā ʻia.

E kiʻi i kahi leka mai kāu kauka e wehewehe ana e pono ana ʻoe e lawe i ka lāʻau lapaʻau injectable no ke kūlana olakino. Hiki i kēia ke kōkua me ka palekana o ke kahua mokulele a me nā dute inā e hele ana ʻoe i nā ʻāina ʻē.

E hoʻohana i kahi pahu anuanu liʻiliʻi me nā pūʻolo hau e mālama i ka lāʻau lapaʻau ma ka mahana kūpono i ka wā e hele ai. Hiki i ka lāʻau lapaʻau ke waiho ʻia ma ka mahana o ka lumi no nā manawa pōkole, akā ʻaʻole pono e hōʻike ʻia i ka wela nui a i ʻole nā mahana hau.