He aha ka Linaclotide: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ka Linaclotide e kōkua i ka mālama ʻana i ka paʻa mau a me ka maʻi ʻōpū huhū me ka paʻa (IBS-C). He ʻano lāʻau lapaʻau kū hoʻokahi e hana pololei ana i loko o kou ʻōpū e kōkua i ka hoʻihoʻi ʻana i nā neʻe ʻana o ka ʻōpū maʻamau a hoʻemi i ka ʻeha o ka ʻōpū. Inā ua pilikia ʻoe me nā pilikia digestive e hoʻomau nei, ua ʻōlelo paha kāu kauka i kēia lāʻau lapaʻau ma ke ʻano he ʻāpana o kāu hoʻolālā lapaʻau.

He aha ka Linaclotide?

ʻO ka Linaclotide he guanylate cyclase-C agonist, ʻo ia hoʻi e hoʻāla ia i nā mea loaʻa kikoʻī i loko o kou ʻōpū. E noʻonoʻo iā ia he kī e wehe i nā hana maoli i loko o kou ʻōpū e kōkua i nā mea e neʻe mālie. ʻAʻole like me nā lāʻau lapaʻau paʻa ʻē aʻe, hana ka linaclotide ma ka hoʻohālike ʻana i kahi mea maoli i hana mua ʻia e kou kino.

Hele mai kēia lāʻau lapaʻau ma ke ʻano he capsule āu e lawe ai ma ka waha i hoʻokahi manawa i ka lā. Ua hoʻolālā ʻia e hana ma kahi o kāu ʻōnaehana digestive, no laila ua komo iki loa i loko o kou kahe koko. Kōkua kēia ala i ka hoʻemi ʻana i nā hopena ʻaoʻao i ka wā e hoʻonui ai i nā pōmaikaʻi kahi āu e pono ai.

No ke aha e hoʻohana ʻia ai ka Linaclotide?

Hoʻomaʻamaʻa ʻo Linaclotide i nā kūlana nui ʻelua e pili ana i kāu ʻōnaehana digestive. E kauoha kāu kauka iā ia ma muli o kāu mau hōʻailona a me ka mōʻaukala olakino.

ʻO ke kūlana mua he constipation idiopathic mau, ʻo ia hoʻi ka paʻa lōʻihi me ka ʻole o ke kumu i ʻike ʻia. Inā ʻaʻole ʻoe i loaʻa i ʻekolu neʻe ʻana o ka ʻōpū i kēlā me kēia pule no kekahi mau mahina, me nā stools paʻakikī a i ʻole ke kaumaha, ʻo kēia paha kāu hōʻailona.

ʻO ke kūlana ʻelua he maʻi ʻōpū huhū me ka paʻa (IBS-C). ʻAʻole kēia e pili wale i ka paʻa, akā ʻo ka ʻeha o ka ʻōpū, ka pehu ʻana, a me nā loli i kāu mau hana ʻōpū. ʻO ka poʻe me IBS-C e ʻike pinepine i ka ʻeha a me ka hōʻoluʻolu ʻole e hiki ke hoʻopilikia nui i ko lākou ola i kēlā me kēia lā.

I kekahi mau hihia, kuhikuhi nā kauka i ka linaclotide no ka constipation hana i nā keiki mai 6 a 17 mau makahiki. Hana ʻia kēia ke loaʻa i nā keiki ka constipation e hoʻomau nei ʻaʻole e pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe.

Pehea e Hana ai ʻo Linaclotide?

Hana ʻo Linaclotide ma ka hoʻopaʻa ʻana i nā mea loaʻa ma ka ʻili o nā cell i loko o kou ʻōpū. Ke hoʻopili ʻia i kēia mau mea loaʻa, hoʻomaka ia i kahi kaʻina o nā hana kūlohelohe e kōkua i kāu ʻōnaehana digestive e hana maikaʻi.

ʻO ka mea mua, hoʻonui ia i ka hana ʻana o kahi mea i kapa ʻia ʻo cyclic GMP, e hana ana e like me ka ʻelele i loko o kāu mau cell ʻōpū. Hōʻike kēia ʻelele i kou ʻōpū e hoʻokuʻu i ka wai hou i loko o kou ʻōpū, e kōkua ana i ka palupalu ʻana i ka stool a maʻalahi hoʻi ke hala.

I ka manawa like, kōkua ʻo linaclotide i ka hōʻemi ʻana i nā hōʻailona ʻeha mai kou ʻōpū i kou lolo. He mea nui kēia no ka poʻe me IBS-C, ka poʻe e ʻike pinepine i ka ʻeha a me ka ʻeha o ka ʻōpū me kā lākou constipation.

Kōkua pū ka lāʻau lapaʻau i ka wikiwiki ʻana i ka neʻe ʻana o ka meaʻai a me ka ʻōpala ma o kāu ʻōnaehana digestive. ʻO kēia kaʻina hana, i kapa ʻia ʻo ka hele ʻana o ka ʻōpū, e lilo maoli i mea maikaʻi aʻe ke hana pono ʻo linaclotide i kāu ʻōnaehana.

Pehea e Lawe ai au i ka Linaclotide?

E lawe i ka linaclotide e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā i ke kakahiaka. He mea nui ka manawa no ka mea ʻo ka lawe mau ʻana i ka manawa like i kēlā me kēia lā e kōkua i ka mālama ʻana i nā pae paʻa i kāu ʻōnaehana.

Pono ʻoe e lawe i ka linaclotide ma ka ʻōpū ʻole, ma ka liʻiliʻi he 30 mau minuke ma mua o kāu ʻai mua o ka lā. Hiki i ka meaʻai ke keakea i ka maikaʻi o kou kino e komo i ka lāʻau lapaʻau, no laila he mea nui kēia manawa no ka loaʻa ʻana o ka pōmaikaʻi piha.

E ale i ka capsule holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a wehe paha i ka capsule, no ka mea, hiki i kēia ke hoʻopilikia i ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o kāu ʻōnaehana digestive. Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe.

Inā pono ʻoe e lawe i ka lāʻau lapaʻau ma o ka paipu hānai, hiki i kāu mea mālama ola ke hōʻike iā ʻoe pehea e wehe ai i ka capsule a hui pū i nā mea me ka wai. Pono e hana ʻia kēia ma lalo o ka mālama olakino a me nā ʻōlelo aʻo kūpono.

Pehea ka lōʻihi e lawe ai au i ka Linaclotide?

Pono ka hapa nui o nā kānaka e lawe i ka linaclotide no ka manawa lōʻihi e mālama ai i kāna mau pōmaikaʻi. ʻAʻole like me kekahi mau lāʻau lapaʻau e hiki ai iā ʻoe ke lawe no kekahi mau lā a i ʻole mau pule, ua kauoha ʻia ka linaclotide ma ke ʻano he lapaʻau lōʻihi.

Hiki iā ʻoe ke hoʻomaka e ʻike i nā hoʻomaikaʻi ʻana i kāu neʻe ʻana o ka ʻōpū i loko o ka pule mua o ka lapaʻau. Eia naʻe, hiki ke lawe i kekahi mau pule e ʻike i nā pōmaikaʻi piha, ʻoiai no ka hōʻoluʻolu ʻana i ka ʻeha o ka ʻōpū i nā maʻi IBS-C.

E nānā kāu kauka i kāu holomua a hiki ke hoʻololi i kāu hoʻolālā lapaʻau ma muli o ke ʻano o kāu pane ʻana. ʻIke kekahi poʻe pono lākou e hoʻomau i ka lawe ʻana i ka linaclotide no ka manawa pau ʻole e mālama i nā neʻe ʻana o ka ʻōpū a me ka mālama ʻana i nā hōʻailona.

Mai hooki i ka lawe ʻana i ka linaclotide me ka ʻole e kamaʻilio mua me kāu kauka. Hiki ke hoʻi mai kāu mau hōʻailona inā e hoʻōki koke ʻoe i ka lāʻau lapaʻau, a hiki i kāu kauka ke kōkua iā ʻoe e hoʻoholo i ke ala maikaʻi loa no kou kūlana.

He aha nā hopena ʻaoʻao o Linaclotide?

E like me nā lāʻau lapaʻau a pau, hiki i ka linaclotide ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. ʻO ka hopena ʻaoʻao maʻamau ka maʻi maʻi, e pili ana i ka nui o nā kānaka i ka wā e hoʻomaka ai lākou e lawe i ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e hiki iā ʻoe ke ʻike:

• Maʻi maʻi, he maʻamau ka maʻalahi a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino
• ʻEha o ka ʻōpū a i ʻole ka ʻeha, maʻamau ka manawa
• Flatulence a i ʻole ke kinoea nui
• ʻO ka ʻōpū a i ʻole ka distension
• ʻO ka ʻoluʻolu o ka ʻōpū a i ʻole nā leo gurgling

E hōʻemi pinepine ʻia kēia mau hopena ʻaoʻao maʻamau i ka wā e maʻa ai kou kino i ka lāʻau. ʻO ka hapa nui o nā kānaka e ʻike hiki iā lākou ke hoʻomau i ka lawe ʻana i ka linaclotide inā loaʻa iā lākou kekahi pilikia digestive mua.

He mea maʻamau nā hopena ʻaoʻao koʻikoʻi, akā pono lākou i ka lāʻau lapaʻau koke. Pono ʻoe e hoʻokaʻaʻike i kāu kauka i kēia manawa inā loaʻa iā ʻoe ka maʻi maʻi koʻikoʻi ʻaʻole e hoʻomaikaʻi, nā hōʻailona o ka dehydration e like me ka dizziness a i ʻole ka waha maloʻo, a i ʻole ka ʻeha o ka ʻōpū koʻikoʻi e ʻokoʻa ana mai kāu mau hōʻailona maʻamau.

Hiki i kekahi poʻe ke loaʻa nā hopena maʻi, ʻoiai he mea maʻamau ʻole kēia. ʻO nā hōʻailona o ka hopena maʻi e komo pū ana me ka ʻulaʻula, ka ʻūlū, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole ka pilikia o ka hanu.

ʻO wai ka mea ʻaʻole pono e lawe i ka Linaclotide?

ʻAʻole kūpono ka Linaclotide no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻO ka mea nui loa, ʻaʻole pono nā keiki ma lalo o 6 mau makahiki e lawe i kēia lāʻau.

ʻAʻole pono ʻoe e lawe i ka linaclotide inā loaʻa iā ʻoe kahi pilikia o ka ʻōpū a i ʻole ka maʻi ʻāʻī koʻikoʻi. Hiki i kēia mau kūlana ke palekana ʻole a i ʻole ka maikaʻi ʻole o ka lāʻau no kou kūlana.

Pono ka poʻe me kekahi mau maʻi digestive i ka noʻonoʻo kūikawā ma mua o ka hoʻomaka ʻana i ka linaclotide:

• ʻO ka maʻi ʻāʻī hana e like me ka maʻi o Crohn a i ʻole ka ulcerative colitis
• Moʻolelo o ka pilikia o ka ʻōpū a i ʻole nā adhesions abdominal koʻikoʻi
• Dehydration koʻikoʻi a i ʻole nā ​​hana ʻole o ka electrolyte
• ʻIke ʻia ka hypersensitivity i ka linaclotide a i ʻole kekahi o kāna mau meaʻai

E noʻonoʻo pū kāu kauka i kou kūlana olakino holoʻokoʻa a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei. E hōʻoia e haʻi i kāu mau lāʻau lapaʻau a me nā mea hoʻohui i kēia manawa i kāu kūkākūkā.

Pono nā wāhine hāpai a me nā wāhine e hānai ana i nā pēpē e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola. ʻOiai he liʻiliʻi ka linaclotide i komo i loko o ke kahe koko, e kōkua kāu kauka iā ʻoe e kaupaona i nā pōmaikaʻi kūpono e kūʻē i nā pilikia hiki.

Nā inoa inoa o Linaclotide

Loaʻa ka Linaclotide ma lalo o ka inoa inoa Linzess ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka mana i kauoha pinepine ʻia o ka lāʻau lapaʻau āu e ʻike ai ma ka hapa nui o nā hale kūʻai lāʻau lapaʻau.

Ma nā ʻāina ʻē aʻe, loaʻa paha ka linaclotide ma lalo o nā inoa inoa like ʻole, akā like ka mea hana. E nānā mau me kāu lāʻau lapaʻau e hōʻoia e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono, ʻoiai inā ʻoe e hele a hoʻopiha i nā kauoha ma nā wahi like ʻole.

Hiki ke loaʻa nā mana generic o linaclotide i ka wā e hiki mai ana, akā i kēia manawa, ʻo Linzess ka inoa inoa mua i loaʻa. Hiki i kāu ʻinikua ke hoʻopilikia i ka mana āu e hiki ai ke komo i ke kumukūʻai.

Nā koho ʻē aʻe o Linaclotide

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i ka constipation mau a me IBS-C inā ʻaʻole kūpono ka linaclotide iā ʻoe. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe e pili ana i kāu mau hōʻailona kikoʻī a me ka mōʻaukala olakino.

ʻO nā lāʻau lapaʻau ʻē aʻe e hana like ana me plecanatide (Trulance), he mea hoʻohui guanylate cyclase-C. Hana ʻokoʻa ka Lubiprostone (Amitiza) ma ka hoʻonui ʻana i ka huna wai o ka ʻōpū a kūpono paha no kekahi poʻe.

No IBS-C wale nō, hiki i kāu kauka ke noʻonoʻo:

• Alosetron (Lotronex) no nā hihia koʻikoʻi i nā wahine
• Eluxadoline (Viberzi) no nā hōʻailona IBS hui pū ʻia
• Rifaximin (Xifaxan) no kekahi mau ʻano IBS
• Nā lāʻau antispasmodic no ka ʻeha a me ka ʻeha

Hiki i nā koho ma luna o ka pāʻani e like me nā mea hoʻohui fiber, nā mea palupalu, a me nā laxatives osmotic ke kūpono no kekahi poʻe. Eia naʻe, hana ʻokoʻa kēia mau mea ma mua o ka linaclotide a ʻaʻole paha e hāʻawi i ka pae like o ka hōʻoluʻolu hōʻailona.

Na kāu kauka e kōkua iā ʻoe e hoʻoholo i ke ʻano lapaʻau kūpono loa no kou kūlana pilikino, me ka noʻonoʻo ʻana i nā mea e like me ke koʻikoʻi o nā hōʻailona, nā maʻi olakino ʻē aʻe, a me ke ʻano o kou pane ʻana i nā lapaʻau mua.

Ua ʻoi aku ka maikaʻi o Linaclotide ma mua o Lubiprostone?

He mau lapaʻau maikaʻi ʻo Linaclotide a me Lubiprostone no ka paʻa ʻana o ka ʻōpū a me ka IBS-C, akā hana lākou ma o nā ʻano hana like ʻole i loko o kāu ʻōnaehana digestive. ʻO ke koho

No ka mea, he mea liʻiliʻi loa o ka lāʻau lapaʻau e komo i loko o kou kahe koko, hana nui ia ma kou ʻōnaehana digestive. Hoʻemi kēia hana i ka pilikia o nā hopena ʻaoʻao systemic e hiki ke hana me nā lāʻau lapaʻau e holo ana i loko o kou kino.

E nānā kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau a hiki ke ʻōlelo aku i nā nānā manawa e hōʻoia i ka hana maikaʻi ʻana iā ʻoe. Inā ʻike ʻoe i nā hōʻailona hou a i ʻole e ʻinoʻino ana, he mea nui e kūkākūkā me kāu mea mālama ola.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o Linaclotide?

Inā ua lawe hewa ʻoe i ka nui o ka linaclotide ma mua o kāu kauoha, e kelepona koke i kāu kauka a i ʻole ka mea kūʻai lāʻau lapaʻau no ke alakaʻi. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o ka maʻi maʻi nui a me ka dehydration.

E nānā iā ʻoe iho no nā hōʻailona o ka maʻi maʻi nui, ka ʻeha o ka ʻōpū, a i ʻole ka dehydration e like me ka dizziness, ka waha maloʻo, a i ʻole ka mimi liʻiliʻi. Inā ʻike ʻoe i nā hōʻailona koʻikoʻi, e ʻimi koke i ka lāʻau lapaʻau.

Mai hoʻāʻo e

ʻAʻole e hana ʻino ke haʻalele ʻana i kahi lāʻau i kekahi manawa, akā e hoʻāʻo e mālama i ke kūlike me kāu papa hana lāʻau no nā hopena maikaʻi loa. E noʻonoʻo e hoʻonohonoho i kahi hoʻomanaʻo i kēlā me kēia lā ma kāu kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Linaclotide?

Pono ʻoe e hooki i ka lawe ʻana iā linaclotide ma hope o ke kūkākūkā ʻana me kāu kauka, ʻoiai inā maikaʻi ʻoe. Nui ka poʻe e pono e hoʻomau i ka lawe ʻana i ka lāʻau lapaʻau no ka manawa lōʻihi e mālama i ka hoʻomaikaʻi ʻana i kā lākou mau hōʻailona.

E kōkua kāu kauka iā ʻoe e hoʻoholo inā a i ka manawa hea e kūpono ai ke hoʻāʻo e hoʻōki i ka lāʻau lapaʻau. Aia kēia hoʻoholo i nā mea e like me ka lōʻihi o kou lawe ʻana iā ia, pehea ka maikaʻi o ka mālama ʻia ʻana o kāu mau hōʻailona, ​​a inā paha ua hana ʻoe i nā loli ʻē aʻe o ke ola e kākoʻo i ke olakino digestive.

Inā ʻoe e hooki i ka lawe ʻana iā linaclotide, e hoʻi mālie paha kāu mau hōʻailona mua. Hiki i kāu kauka ke ʻōlelo aku i ka hoʻemi ʻana i ka lāʻau a i ʻole e hōʻike i nā lāʻau lapaʻau ʻē aʻe e kōkua i ka mālama ʻana i kou olakino digestive.

Hiki iaʻu ke lawe iā Linaclotide me nā lāʻau ʻē aʻe?

He liʻiliʻi ka absorption o Linaclotide i loko o kou kahe koko, no laila he liʻiliʻi nā pilina lāʻau ma mua o nā lāʻau lapaʻau ʻē aʻe. Eia naʻe, pono ʻoe e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana ma luna o ka counter āu e lawe nei.

Hiki i kekahi mau lāʻau lapaʻau e pili ana i ka waika ʻōpū a i ʻole ka hana ʻōpū ke hoʻopilikia i ka maikaʻi o ka hana ʻana o linaclotide. Hiki i kāu kauka ke aʻo iā ʻoe i ka manawa kūpono inā pono ʻoe e lawe i nā lāʻau lapaʻau he nui e pili ana i kāu ʻōnaehana digestive.

E nānā mau me kāu kauka lāʻau ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou a i ʻole nā ​​mea hoʻohui i ka wā e lawe ana iā linaclotide. Hiki iā lākou ke kōkua i ka ʻike ʻana i nā pilina kūpono a hōʻike i ka manawa maikaʻi loa no ka lawe ʻana i nā lāʻau lapaʻau like ʻole.