He aha ka Lomitapide: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Lomitapide e kōkua ana i ka hoʻohaʻahaʻa ʻana i nā pae cholesterol kiʻekiʻe loa i ka poʻe me kahi maʻi genetic laha ʻole i kapa ʻia ʻo homozygous familial hypercholesterolemia (HoFH). Hana ʻokoʻa kēia lāʻau lapaʻau ikaika mai nā lāʻau cholesterol maʻamau, e kuhikuhi ana i kahi protein kikoʻī i kou ate e hōʻemi nui i ka hana ʻana o ka cholesterol a me nā ʻāpana momona i kou koko.

Inā ua kau ʻia ʻo lomitapide iā ʻoe a i ʻole kekahi āu e ʻike nei, ke hana nei ʻoe me kahi maʻi koʻikoʻi akā hiki ke mālama ʻia e pono ai ka mālama kūikawā. Hōʻike kēia lāʻau lapaʻau i ka manaʻolana no ka poʻe nona nā pae cholesterol e noho weliweli kiʻekiʻe me ka hoʻāʻo ʻana i nā lāʻau lapaʻau ʻē aʻe.

He aha ka Lomitapide?

He lāʻau lapaʻau hoʻohaʻahaʻa cholesterol kūikawā ʻo Lomitapide i pili i kahi papa i kapa ʻia ʻo microsomal triglyceride transfer protein (MTP) inhibitors. Hana ia ma ka pale ʻana i kahi protein kikoʻī i kou ate e kōkua ana i ka hana ʻana i nā ʻāpana momona, e kau ana i nā kaʻa ma ka ʻōnaehana hana cholesterol o kou kino.

Hoʻolālā ʻia kēia lāʻau lapaʻau no ka poʻe me ka homozygous familial hypercholesterolemia, kahi maʻi genetic laha ʻole kahi i hala nā mākua ʻelua i nā genes e hoʻoulu ai i nā pae cholesterol kiʻekiʻe loa. ʻAʻole like me nā lāʻau cholesterol maʻamau e lawe ai ka poʻe he nui, mālama ʻia ʻo lomitapide no nā hihia kahi i lawa ʻole ai nā lāʻau lapaʻau ʻē aʻe e lawe mai i ka cholesterol i nā pae palekana.

Hele mai ka lāʻau lapaʻau ma ke ʻano o nā capsules waha āu e lawe ai i hoʻokahi manawa i ka lā, a hoʻohana mau ʻia me ka meaʻai momona haʻahaʻa loa a me nā lāʻau lapaʻau hoʻohaʻahaʻa cholesterol ʻē aʻe. E noʻonoʻo iā ia ma ke ʻano he ʻāpana o kahi ala ākea ma mua o kahi hopena kū hoʻokahi.

No ke aha e hoʻohana ʻia ai ʻo Lomitapide?

Ua kauoha ʻia ʻo Lomitapide no ka mālama ʻana i ka homozygous familial hypercholesterolemia (HoFH), he maʻi genetic laha ʻole e pili ana i kahi 1 i 300,000 a i 1 i 1,000,000 poʻe ma ka honua holoʻokoʻa. Hoʻoulu kēia maʻi i nā pae cholesterol e kiʻekiʻe loa mai ka wā hānau, e alakaʻi pinepine ana i ka maʻi puʻuwai i ka wā ʻōpio loa inā ʻaʻole i mālama ʻia.

ʻO ka poʻe me HoFH ka mea maʻamau i nā pae cholesterol he 6 a 10 mau manawa kiʻekiʻe ma mua o ka maʻamau, ʻoiai me nā mea nui loa o nā lāʻau cholesterol maʻamau. Ua hoʻolālā ʻia ko lākou kino e hana i nā mea nui o ka cholesterol no ka mea ua hoʻoilina lākou i nā genes hewa mai nā mākua ʻelua.

Hoʻohana ʻia ka lāʻau lapaʻau ma ke ʻano he lāʻau lapaʻau, ʻo ia hoʻi ua kauoha ʻia me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol e like me statins, ezetimibe, a i kekahi manawa nā lāʻau lapaʻau hou e like me PCSK9 inhibitors. Pono nō hoʻi kāu kauka e hahai i ka meaʻai momona haʻahaʻa loa i ka wā e lawe ana i ka lomitapide.

Pehea e hana ai ʻo Lomitapide?

Hana ʻo Lomitapide ma ka pale ʻana i kahi protein i kapa ʻia ʻo microsomal triglyceride transfer protein (MTP) i loko o kāu mau cell ate. Kōkua maʻamau kēia protein i ka hoʻopili ʻana i ka cholesterol a me nā momona ʻē aʻe i loko o nā ʻāpana i hoʻokuʻu ʻia i loko o kou kahe koko.

Ke pale ʻo lomitapide i kēia protein, ʻaʻole hiki i kou ate ke hoʻopili pono a hoʻokuʻu i kēia mau ʻāpana momona, e hōʻemi nui ana i ka nui o ka cholesterol a me nā triglycerides e holo ana i loko o kou koko. He mea like ia me ka waiho ʻana i kahi alahaka ma ke alanui e lawe ana i ka cholesterol mai kou ate i ke koena o kou kino.

Ua manaʻo ʻia kēia lāʻau lapaʻau he mea ikaika loa i kāna mau hopena hoʻohaʻahaʻa cholesterol. I nā haʻawina lapaʻau, ua ʻike ka poʻe e lawe ana i ka lomitapide i kā lākou LDL cholesterol (ka cholesterol

Pono e lawe ʻia ka lomitapide e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā i ke ahiahi me ke aniani wai piha. He mea nui ka manawa no ka mea, ʻo ka lawe ʻana i ka pō hiki ke kōkua i ka hōʻemi ʻana i kekahi o nā hopena ʻaoʻao digestive āu e ʻike ai.

Pono ʻoe e hahai i ka meaʻai momona haʻahaʻa loa i ka wā e lawe ana i kēia lāʻau, e kaupalena ana i kāu ʻai momona i lalo o 20% o kāu mau calorie i kēlā me kēia lā. ʻO ka maʻamau, ʻaʻole iʻoi aku ma mua o 20 grams o ka momona i kēlā me kēia lā no ka hapa nui o nā kānaka. E hāʻawi kāu hui mālama ola kino i nā alakaʻi meaʻai kikoʻī a hiki ke kuhikuhi iā ʻoe i kahi meaʻai.

Pono e moni ʻia ka lāʻau lapaʻau holoʻokoʻa me ka ʻole o ka ʻoki ʻana, ka nau ʻana, a i ʻole ka wehe ʻana i nā capsules. E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa haʻahaʻa a hoʻonui mālie i loko o kekahi mau pule e kōkua i kou kino e hoʻoponopono a hōʻemi i nā hopena ʻaoʻao.

He mea nui e pale loa i ka waiʻona i ka wā e lawe ana i ka lomitapide, no ka mea, hiki i kēia hui ʻana ke hana i nā pilikia ate koʻikoʻi. Pono nō hoʻi ʻoe i nā hoʻokolohua koko maʻamau e nānā i kāu hana ate a hoʻoponopono i ka mahele e like me ka mea e pono ai.

Pehea ka lōʻihi e lawe ai au i ka Lomitapide?

ʻO ka Lomitapide ka mea maʻamau he lapaʻau lōʻihi e pono ai ʻoe e hoʻomau mau e mālama i kāna mau pono hoʻohaʻahaʻa cholesterol. No ka mea he maʻi genetic ola mau ka homozygous familial hypercholesterolemia, ʻo ka hoʻōki ʻana i ka lāʻau lapaʻau e hoʻonui hou i kāu mau pae cholesterol i nā pae weliweli.

E nānā kāu kauka i kāu holomua ma o nā hoʻokolohua koko maʻamau, maʻamau i kēlā me kēia mau mahina i ka wā mua a laila ʻaʻole pinepine i ka wā e paʻa ai kāu mau pae. ʻAʻole wale kēia mau hoʻokolohua e nānā i kāu mau pae cholesterol akā i kāu hana ate, no ka mea hiki i ka lāʻau lapaʻau ke hoʻopilikia i kou ate.

Pono paha kekahi poʻe e hoʻōki a hoʻemi paha i kā lākou mahele inā loaʻa iā lākou nā hopena ʻaoʻao a i ʻole inā hōʻike kā lākou hoʻokolohua hana ate i nā loli e pili ana. E hana pū kāu kauka me ʻoe e ʻimi i ke kaulike kūpono ma waena o ka hoʻohaʻahaʻa pono ʻana i kāu cholesterol a me ka mālama ʻana i nā hopena ʻaoʻao.

He aha nā hopena ʻaoʻao o Lomitapide?

ʻO nā hopena ʻaoʻao maʻamau o ka lomitapide e pili ana i kāu ʻōnaehana digestive, no ka mea, pili ka lāʻau i ke ʻano o ka hana ʻana o kou kino i nā momona. Hiki ke mālama pinepine ʻia kēia mau hopena me nā hoʻololi ʻai a maʻa mau e hoʻomaikaʻi i ka wā e maʻa ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao digestive āu e ʻike ai, ʻoiai ke hoʻomaka ʻoe i ka lāʻau a i ʻole e hoʻonui i ka mahele:

• Pāpaʻa (e pili ana i 80% o nā kānaka e lawe ana i ka lāʻau)
• Nausea a me ka luaʻi
• ʻEha ʻōpū a me ka pehu
• ʻO ke kinoea nui
• Pono koke e loaʻa nā neʻe ʻana o ka ʻōpū
• Nā noho ʻaila a momona paha

Hoʻomaikaʻi pinepine kēia mau hōʻailona digestive i ka wā e pili ana ʻoe i ka meaʻai momona haʻahaʻa i kauoha ʻia e kāu kauka. Nui ka poʻe i ʻike i ka maʻalahi o kā lākou mau hōʻailona ma hope o nā pule mua o ka mālama ʻana.

ʻO nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e pili ana i nā pilikia o ke ake, ʻo ia ke kumu e pono ai ʻoe i nā hoʻokolohua koko maʻamau. ʻO nā hōʻailona o nā pilikia o ke ake e pili ana i ka melemele o kou ʻili a i ʻole nā maka, ka mimi ʻeleʻele, ka luhi nui, a i ʻole ka nausea mau. Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​e kelepona koke i kāu kauka.

Hiki i kekahi poʻe ke ʻike i ka pohō kaumaha, hiki ke koʻikoʻi i kekahi mau hihia. E nānā kāu kauka i kou kaumaha a me ke kūlana meaʻai i ka wā o ka mālama ʻana.

ʻO wai ka mea ʻaʻole pono e lawe iā Lomitapide?

ʻAʻole kūpono ʻo Lomitapide no nā mea a pau, a aia kekahi mau kūlana koʻikoʻi e palekana ʻole ai kēia lāʻau. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana.

ʻAʻole pono ʻoe e lawe iā lomitapide inā loaʻa iā ʻoe ka maʻi ate hana a i ʻole inā kiʻekiʻe loa kāu mau hoʻokolohua hana ate. No ka mea hiki i ka lāʻau ke hoʻopilikia i kou ate, ʻo ka hoʻomaka ʻana me kahi ate i hoʻopilikia mua ʻia hiki ke alakaʻi i nā pilikia koʻikoʻi.

Pono nō hoʻi ka poʻe me kekahi mau maʻi ʻōpū e pale aku i ka lomitapide. Inā loaʻa iā ʻoe ka maʻi ʻōpū mumū, ka maʻi maʻi mau, a i ʻole nā pilikia malabsorption koʻikoʻi, hiki i kēia lāʻau lapaʻau ke hoʻonui nui i kāu mau hōʻailona.

ʻAʻole hoʻi i ʻōlelo ʻia ka lāʻau lapaʻau i ka wā e hāpai ana a i ʻole ka hānai ʻana i ka waiū, no ka mea, hiki iā ia ke hoʻopilikia i ka meaʻai o ka pēpē e ulu ana. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka contraception pono i ka wā e lawe ana i ka lomitapide.

Eia kekahi, inā ʻoe e inu mau i ka waiʻona a i ʻole he moʻolelo o ka hoʻomāinoino ʻana i ka waiʻona, ʻaʻole kūpono paha ka lomitapide iā ʻoe ma muli o ka piʻi ʻana o ka pilikia o nā pilikia o ke ake.

Nā inoa inoa o Lomitapide

Loaʻa ka Lomitapide ma lalo o ka inoa inoa ʻo Juxtapid ma ʻAmelika Hui Pū ʻIa a me Lojuxta ma ʻEulopa a me nā ʻāina ʻē aʻe. Loaʻa i nā mea ʻelua ka mea hana like a hana like.

Hana ʻia kēia lāʻau lapaʻau e Aegerion Pharmaceuticals (i kēia manawa he ʻāpana o Amryt Pharma) a loaʻa wale nō ma o nā hale kūʻai lāʻau lapaʻau kūikawā ma muli o kona ʻano kūikawā a me ka pono e nānā pono.

No ka mea, hoʻohana ʻia ka lomitapide no kahi maʻi laha loa, ʻaʻole loaʻa ia ma ke ʻano he lāʻau lapaʻau generic. ʻO ka mana inoa inoa wale nō ka koho i loaʻa i kēia manawa.

Nā koho ʻē aʻe o Lomitapide

ʻOiai he mea kū hoʻokahi ka lomitapide i ke ʻano o kāna hana, aia nā koho lapaʻau ʻē aʻe no ka poʻe me ka homozygous familial hypercholesterolemia. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ka lomitapide iā ʻoe a i ʻole inā pono ʻoe i ka mana hoʻohaʻahaʻa cholesterol hou.

ʻO nā mea pale PCSK9 e like me ka evolocumab (Repatha) a me alirocumab (Praluent) he mau lāʻau lapaʻau hou e hiki ke hoʻohaʻahaʻa nui i nā pae cholesterol. Hāʻawi ʻia kēia mau mea ma ke ʻano he injections i kēlā me kēia pule ʻelua a i ʻole i kēlā me kēia mahina a hana ma ka kōkua ʻana i kou ake e wehe i ka cholesterol hou mai kou koko.

ʻO kekahi koho ʻē aʻe ʻo evinacumab (Evkeeza), i ʻāpono ʻia no ka homozygous familial hypercholesterolemia a hāʻawi ʻia ma ke ʻano he infusion intravenous i kēlā me kēia mahina. Hana kēia lāʻau lapaʻau ma ka pale ʻana i kahi protein i kapa ʻia ʻo ANGPTL3.

No kekahi poʻe, hiki ke ʻōlelo ʻia kahi kaʻina hana i kapa ʻia ʻo LDL apheresis. He like kēia me ka dialysis akā e wehe pono i ka cholesterol mai kou koko. Hana ʻia ia i kēlā me kēia pule hoʻokahi a ʻelua paha a hiki ke maikaʻi loa i ka hoʻohaʻahaʻa ʻana i nā pae cholesterol.

I nā hihia koʻikoʻi, hiki ke noʻonoʻo ʻia ka transplantation ate, no ka mea, hiki i kēia ke

Eia naʻe, ʻo nā hopena ʻaoʻao o ka ʻōpū a me ka pono no ka meaʻai haʻahaʻa momona e paʻakikī ai ka lawe ʻana i ka lomitapide ma mua o ka hapa nui o nā lāʻau lapaʻau cholesterol ʻē aʻe. ʻO ia ke kumu i mālama ʻia ai no ka poʻe me nā pilikia cholesterol koʻikoʻi, kūʻē i ka lāʻau lapaʻau ma mua o ka hoʻohana ʻana ma ke ʻano he lapaʻau mua.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Lomitapide

He Palekana anei ʻo Lomitapide no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana palekana ʻia ʻo Lomitapide i ka poʻe me ka maʻi diabetes, akā pono e nānā pono. ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kōpaʻa koko, akā hiki i ka meaʻai haʻahaʻa momona a me nā hopena ʻaoʻao o ka ʻōpū ke hoʻopilikia i kāu mālama ʻana i ka maʻi diabetes.

Inā loaʻa iā ʻoe ka maʻi diabetes, e hana pū kāu kauka me ʻoe e hoʻoponopono i kāu hoʻolālā ʻai a me kāu mau lāʻau lapaʻau diabetes e hoʻokō i nā palena meaʻai e hele pū me ka lomitapide. Hiki i ka meaʻai haʻahaʻa momona ke kōkua i ka mālama ʻana i ka maʻi diabetes no kekahi poʻe, akā he mea nui e hōʻoia e loaʻa ana iā ʻoe ka meaʻai kūpono.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Lomitapide?

Inā lawe hewa ʻoe i ka nui o ka lomitapide ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu ʻona, ʻoiai inā maikaʻi ʻoe. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao o ka ʻōpū a me nā pilikia o ke ake.

Mai ho'āʻo e hoʻoponopono i ka mahele keu ma ka lele ʻana i kāu mahele aʻe. Akā, e hoʻomau me kāu papa hana maʻamau e like me ke kuhikuhi ʻia e kāu mea mālama ola. E mālama i ka mea i hana ʻia a me ka manawa, no ka mea, e kōkua kēia ʻike i kāu hui lapaʻau.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Lomitapide?

Inā haʻalele ʻoe i kahi mahele o ka lomitapide, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i haʻalele ʻia a e hoʻomau me kāu papa hana maʻamau. Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i haʻalele ʻia.

E hoʻāʻo e lawe i ka lomitapide i ka manawa like i kēlā me kēia lā e kōkua iā ʻoe e hoʻomanaʻo. Hiki i ka hoʻonohonoho ʻana i ka ʻōhua kelepona a i ʻole ka hoʻohana ʻana i ka mea hoʻonohonoho pila ke lilo i mau hoʻolālā kōkua e mālama i ka kūlike me kāu hana lāʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Lomitapide?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana i ka lomitapide me ka kūkākūkā ʻole me kāu kauka mua. No ka mea, mālama kēia lāʻau i kahi maʻi genetic ʻaʻole e hele aku, ʻo ka hooki ʻana i ka lāʻau lapaʻau e hoʻihoʻi paha i kāu pae cholesterol i nā pae kiʻekiʻe weliweli i loko o kekahi mau pule.

Hiki i kāu kauka ke hōʻemi i kāu mahele no ka manawa a i ʻole e hooki ʻoe i ka lāʻau lapaʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi a i ʻole inā hōʻike kāu mau hoʻokolohua hana ate i nā loli e pili ana. Eia naʻe, e hana pū lākou me ʻoe e ʻimi i nā lāʻau lapaʻau ʻē aʻe e mālama i kāu cholesterol.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Lomitapide?

ʻAʻole, pono ʻoe e pale loa i ka waiʻona i ka wā e lawe ana i ka lomitapide. ʻO ka hui pū ʻana o ka waiʻona a me ka lomitapide e hoʻonui nui i kou pilikia o nā pilikia ate koʻikoʻi, hiki ke hoʻoweliweli i ke ola.

Aia kēia i nā ʻano waiʻona a pau, me ka pia, ka waina, a me nā ʻuhane, a me nā lāʻau lapaʻau i loaʻa ka waiʻona. Hiki i nā mea liʻiliʻi o ka waiʻona ke pilikia i ka wā e hui pū ʻia me ka lomitapide, no laila pono ka abstinence piha no kou palekana.