He aha ka Lomustine: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau chemotherapy ikaika ka Lomustine i hoʻohana ʻia e mālama i kekahi mau ʻano maʻi lolo a me nā lymphomas. No kēia lāʻau lapaʻau waha i kahi papa o nā lāʻau i kapa ʻia he mau mea hana alkylating, e hana ana ma ka hoʻopilikia ʻana i ka DNA cell maʻi e hoʻōki i ka ulu ʻana o ka maʻi.

Inā ua kauoha kāu kauka iā lomustine, he mau nīnau paha kāu e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai. Pono kēia lāʻau lapaʻau i ka nānā pono ʻana a hele mai me nā mea nui e pono ai e hele pū mākou.

He aha ka Lomustine?

He lāʻau chemotherapy ka Lomustine i hele mai i ke ʻano capsule no ka hoʻohana waha. Ua hoʻolālā ʻia e hele i ka pale koko-lolo, e hana ana i mea kūpono loa no ka mālama ʻana i nā maʻi lolo kahi e hiki ʻole ai i nā lāʻau lapaʻau ʻē aʻe ke hiki.

He ʻāpana kēia lāʻau lapaʻau o ka ʻohana nitrosourea o nā lāʻau chemotherapy. ʻAʻole like me kekahi mau lāʻau lapaʻau maʻi e koi ai i ka hoʻokomo intravenous, hāʻawi ʻo lomustine i ka maʻalahi o ka lawe ʻana ma ka waha ma ka home.

Hana ka lāʻau lapaʻau ma ka hana ʻana i nā paʻa kemika me ka DNA i nā cell e mahele wikiwiki ana. ʻO kēia kaʻina hana e pale ai i nā cell maʻi mai ka hana hou ʻana a me ka laha ʻana i kou kino.

No ke aha i hoʻohana ʻia ai ka Lomustine?

Hoʻonohonoho mua ʻia ka Lomustine no ka mālama ʻana i nā maʻi lolo a me kekahi mau maʻi koko. Hiki i kāu oncologist ke ʻōlelo i kēia lāʻau lapaʻau ke ʻole nā lāʻau lapaʻau ʻē aʻe i kūpono a i ʻole ke waiho ʻia ka maʻi ma nā wahi paʻakikī.

ʻO nā kūlana maʻamau i mālama ʻia me ka lomustine me:

• Glioblastoma a me nā maʻi lolo ʻino ʻē aʻe
• Ua hoʻi mai ka lymphoma o Hodgkin ma hope o nā lāʻau lapaʻau ʻē aʻe
• ʻAʻole ʻo Hodgkin's lymphoma i nā hihia kikoʻī
• Nā ʻano maʻi lolo metastatic

Na kou kauka e hoʻoholo inā he kūpono ka lomustine no kou kūlana kikoʻī e pili ana i ke ʻano o kāu maʻi ʻaʻai, ke kahua, a me ke olakino holoʻokoʻa. Hoʻohana pinepine ʻia ka lāʻau lapaʻau ke kūʻē nā ʻōpū i nā lāʻau chemotherapy ʻē aʻe.

Pehea e Hana ai ka Lomustine?

Hana ʻo Lomustine ma ka hōʻino ʻana i ka DNA i loko o nā pūnaewele maʻi ʻaʻai, e pale ana iā lākou mai ka mahele a me ka ulu ʻana. Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau chemotherapy ikaika e hiki ke komo pono i ka pale koko-lolo.

Ke lawe ʻoe i ka capsule, e wāwahi ʻo lomustine i loko o kou kino a hoʻokuʻu i nā mea hana. Hoʻopili kēia mau mea i nā kaula DNA i nā pūnaewele e mahele wikiwiki ana, e hana ana i nā cross-link e pale ai i ka mahele pūnaewele maʻamau.

Hoʻopilikia ka lāʻau lapaʻau i nā pūnaewele maʻi ʻaʻai a me kekahi mau pūnaewele olakino e mahele wikiwiki ana, e like me nā pūnaewele koko a me nā pūnaewele e laina ana i kāu ʻōpū. ʻO kēia ke kumu e hiki ai i ka lomustine ke hana i nā hopena ʻaoʻao, akā ʻoi aku ka maikaʻi o ka mālama ʻana i ka maʻi ʻaʻai ma mua o kēia mau pilikia.

ʻO ka mea e waiwai ai ka lomustine ʻo ia kona hiki ke hiki i ka ʻiʻo lolo kahi e hiki ʻole ai i nā lāʻau chemotherapy ʻē aʻe ke komo pono.

Pehea e Lawe ai au i ka Lomustine?

Pono e lawe ʻia ka Lomustine e like me ke kauoha a kāu oncologist, ma ke ʻano he hoʻokahi mahele i kēlā me kēia 6 pule. E lawe i nā capsules ma ka ʻōpū ʻole, ma ka liʻiliʻi he 1 hola ma mua a i ʻole 2 hola ma hope o ka ʻai ʻana.

E ale i nā capsules holoʻokoʻa me ke aniani wai piha - mai ʻoki, nau, a wehe paha iā lākou. Inā ʻoe e lawe ana i nā capsules he nui, e lawe iā lākou a pau i ka manawa like ma ke ʻano he hoʻokahi mahele piha.

Eia nā ʻanuʻu nui e hahai ai i ka wā e lawe ai i ka lomustine:

1. E wikiwiki no ka liʻiliʻi he 2 hola ma mua o ka lawe ʻana i kāu mahele
2. E lawe i nā capsules a pau i ka manawa hoʻokahi me ka nui o ka wai
3. E pale i ka ʻai ʻana no 1-2 hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau
4. E mālama pono i nā capsules a holoi pono i nā lima ma hope

E hāʻawi kāu hui mālama ola i nā ʻōlelo kikoʻī e pili ana i ka manawa a me ka hoʻomākaukau. Mai hoʻololi i kāu mahele lāʻau a i ʻole ka papa manawa me ka ʻole e kūkākūkā mua me kāu oncologist.

Pehea ka lōʻihi e lawe ai au i ka Lomustine?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana me ka lomustine ma muli o kāu ʻano maʻi maʻi kikoʻī a me ka maikaʻi o kāu pane ʻana i ka lāʻau. Lawe ka hapa nui o nā kānaka i ka lomustine i nā pōʻaiapuni, a ʻo kēlā me kēia pōʻaiapuni e mau ana no 6 pule.

E nānā kāu oncologist i kāu holomua ma o nā hoʻokolohua koko maʻamau a me nā haʻawina kiʻi. Hiki ke hoʻomau ʻia ka mālama ʻana no kekahi mau pōʻaiapuni inā e hana pono ana ka lāʻau a ke ʻae maikaʻi nei ʻoe iā ia.

Hiki i kekahi poʻe maʻi ke lawe i ka lomustine no 3-4 pōʻaiapuni, a ʻo nā mea ʻē aʻe e pono paha i nā manawa lōʻihi o ka mālama ʻana. E loiloi mau kāu kauka inā e hoʻomau, hoʻololi, a i ʻole e hoʻōki i ka mālama ʻana ma muli o kāu pane a me nā hopena ʻaoʻao.

Mai hoʻōki koke i ka lawe ʻana i ka lomustine me ka ʻole e kūkākūkā me kāu hui mālama ola, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike i nā hopena ʻaoʻao.

He aha nā hopena ʻaoʻao o Lomustine?

Hiki i ka Lomustine ke hana i kekahi mau hopena ʻaoʻao no ka mea e pili ana i nā cell maʻi a me nā cell olakino e mahele wikiwiki ana i kou kino. ʻIke ka hapa nui o nā kānaka i kekahi mau hopena ʻaoʻao, akā hiki ke mālama ʻia me ke kākoʻo olakino kūpono.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia:

• Ka luaʻi a me ka luaʻi ʻana, e hoʻomaka ana ma 2-4 mau hola ma hope o ka lawe ʻana i ka mahele lāʻau
• Ka nalowale o ka ʻai e mau ana no kekahi mau lā
• Luhi a me ka nāwaliwali
• Nā helu cell koko haʻahaʻa (ʻike ʻia ma o nā hoʻokolohua koko)
• Ka nalowale o ka lauoho a i ʻole ka lahilahi
• Nā ʻeha waha a i ʻole ka hōʻoluʻolu waha

Hiki ke hana i nā hopena ʻaoʻao koʻikoʻi, akā ʻaʻole maʻamau. Pono kēia mau mea i ka lāʻau lapaʻau koke a me:

• Nā pilikia nui o ka māmā (ʻawahia pulmonary)
• Poino a i ʻole hana ʻole o ke ake
• Nā pilikia o ka puʻupaʻa
• Kaomi nui ʻana o ka iwi iwi
• Nā maʻi ʻaʻai lua (ʻaʻole maʻamau, pilikia lōʻihi)

E nānā pono kāu hui mālama ola iā ʻoe ma o nā hoʻokolohua koko maʻamau a me nā nānā ʻana e ʻike koke i nā hopena ʻaoʻao koʻikoʻi. ʻO ka hapa nui o nā hopena ʻaoʻao he mea manawa wale nō a hoʻomaikaʻi ma waena o nā pōʻai lapaʻau.

ʻO wai ka mea pono ʻole e lawe iā Lomustine?

ʻAʻole kūpono ʻo Lomustine no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia no ʻoe. ʻO kekahi mau kūlana olakino a me nā kūlana e hoʻoweliweli loa ai kēia lāʻau lapaʻau.

ʻAʻole pono ʻoe e lawe iā lomustine inā loaʻa iā ʻoe:

• Kaomi nui ʻana o ka iwi iwi a i ʻole nā helu koko haʻahaʻa loa
• Nā maʻi maʻi e hana nei, ʻaʻole i mālama ʻia
• ʻO ke ake nui a i ʻole ka maʻi puʻupaʻa
• ʻIke ʻia ka hypersensitivity iā lomustine a i ʻole nā lāʻau pili
• Nā lāʻau lapaʻau virus ola hou

Pono ka mālama kūikawā inā hāpai ʻoe a i ʻole e hānai ana i ka umauma, no ka mea, hiki i ka lomustine ke hōʻino i nā pēpē e ulu nei. E noʻonoʻo pū kāu kauka i kou makahiki, ke olakino holoʻokoʻa, a me nā lāʻau chemotherapy ma mua.

Pono ka poʻe me nā pilikia o ka māmā i ka nānā ʻana, no ka mea, hiki i ka lomustine ke kumu i nā pilikia nui o ka māmā. E kaupaona kāu oncologist i kēia mau pilikia e kūʻē i nā pōmaikaʻi e hiki mai ana no kāu kūlana.

Nā inoa inoa Lomustine

Loaʻa ʻo Lomustine ma lalo o ka inoa inoa CeeNU ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka mea i kauoha pinepine ʻia o ka lāʻau lapaʻau.

Hiki ke loaʻa ka mana generic o lomustine, ʻoiai hiki ke ʻokoʻa ka loaʻa ʻana ma kahi a me ka hale kūʻai lāʻau lapaʻau. Loaʻa nā inoa inoa a me nā mana generic i ka mea hana like a hana like.

Hiki i kāu kauka lāʻau ke kōkua iā ʻoe e hoʻomaopopo i ka mana āu e loaʻa nei a e hōʻoia ana e loaʻa ana iā ʻoe ka lāʻau kūpono. E nānā mau e loaʻa ana iā ʻoe ka ikaika a me ka nui kūpono e like me ke kauoha.

Nā Koho ʻē aʻe o Lomustine

Hiki ke hoʻohana ʻia kekahi mau lāʻau chemotherapy ʻē aʻe ma ke ʻano he koho ʻē aʻe i ka lomustine, ma muli o ke ʻano o kāu maʻi maʻi a me ka mōʻaukala lapaʻau. E koho kāu oncologist i ke koho maikaʻi loa e pili ana i kāu kūlana pilikino.

ʻO nā koho maʻamau no nā maʻi lolo e komo pū ana:

• Temozolomide (Temodar) - he lāʻau chemotherapy waha ʻē aʻe
• Carmustine (BCNU) - he hui nitrosourea pili
• Bevacizumab (Avastin) - e kālele ana i ka ulu ʻana o nā kīʻaha koko
• Nā papa hana chemotherapy hui pū

No nā lymphomas, hiki i nā koho ʻē aʻe ke komo i nā hui lāʻau like ʻole a i ʻole nā ​​lāʻau i manaʻo ʻia. Aia ke koho i nā mea e like me nā lāʻau lapaʻau mua, nā ʻano maʻi maʻi, a me kou olakino holoʻokoʻa.

E kūkākūkā kāu hui mālama ola i kēia mau koho me ʻoe inā ʻaʻole kūpono ka lomustine a i ʻole e pau ka hana pono.

ʻOi aku ka maikaʻi o Lomustine ma mua o Temozolomide?

He mau lāʻau chemotherapy waha maikaʻi ʻo Lomustine a me temozolomide no nā maʻi lolo, akā hana lākou i nā ʻano like ʻole a loaʻa nā pōmaikaʻi like ʻole. ʻAʻole maikaʻi loa kekahi - pili ke koho i kāu kūlana.

Makemake pinepine ʻia ʻo Lomustine i ka wā i pau ai ka hana ʻana o temozolomide a i ʻole no kekahi mau ʻano maʻi lolo hou. He mea pono loa ia no nā ʻōpū i lilo i mea kūʻē i nā lāʻau lapaʻau ʻē aʻe.

Hoʻohana pinepine ʻia ʻo Temozolomide ma ke ʻano he lāʻau lapaʻau mua a ua ʻoi aku ka maikaʻi me nā hopena ʻaoʻao liʻiliʻi. Hoʻohui pinepine ʻia me ka radiation therapy no nā maʻi lolo i hōʻike ʻia.

E noʻonoʻo ana kāu kauka oncologist i nā mea e like me ke ʻano o kāu maʻi kanesa, nā lāʻau lapaʻau i hala, nā hōʻailona genetic, a me ke olakino holoʻokoʻa i ke koho ʻana ma waena o kēia mau lāʻau. Hiki i kekahi poʻe maʻi ke loaʻa nā lāʻau ʻelua i nā manawa like ʻole i kā lākou huakaʻi lapaʻau.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Lomustine

Q1. He palekana anei ʻo Lomustine no nā maʻi ʻelemakule?

Hiki ke hoʻohana ʻia ʻo Lomustine i nā maʻi ʻelemakule, akā pono e nānā pono ʻia a me nā mea liʻiliʻi. Hiki i nā mākua kahiko ke ʻoi aku ka naʻau i nā hopena o ka lāʻau, ʻo ka hoʻopaʻa ʻana i ka iwi iwi.

E noʻonoʻo ana kāu kauka oncologist i kou olakino holoʻokoʻa, ka hana ʻana o ka puʻupaʻa, a me ka hiki ke ʻae i nā hopena ʻaoʻao i ka wā e hoʻoholo ai inā kūpono ʻo lomustine. ʻAʻole hoʻokaʻawale wale ka makahiki iā ʻoe mai ka lapaʻau ʻana, akā he mea ia i ke kaʻina hana hoʻoholo.

Q2. He aha kaʻu e hana ai inā lawe hewa au i ka nui o Lomustine?

Inā lawe hewa ʻoe i ka nui o ka lomustine ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka oncologist a i ʻole ke kikowaena mana. Mai kali e ʻike inā e ulu nā hōʻailona, ​​no ka mea, ʻaʻole paha e ʻike koke ʻia nā hopena o ka overdose.

E hele i ka lumi pilikia inā ʻaʻole hiki iā ʻoe ke kiʻi i kāu hui mālama ola. E lawe mai i ka hue lāʻau me ʻoe i hiki i nā limahana lapaʻau ke ʻike pololei i ka mea a me ka nui āu i lawe ai.

Hiki i ka overdose Lomustine ke hoʻoulu i ka hoʻopaʻa ʻana i ka iwi iwi a me nā pilikia koʻikoʻi ʻē aʻe e koi ai i ka lāʻau lapaʻau koke a me ka mālama kākoʻo.

Q3. He aha kaʻu e hana ai inā hala wau i kahi mahele o Lomustine?

Inā hala ʻoe i kāu mahele lomustine i hoʻonohonoho ʻia, e kelepona koke i ke keʻena o kāu kauka oncologist no ke alakaʻi. Mai lawe i ka mahele i hala me ka ʻole o nā ʻōlelo kikoʻī mai kāu hui mālama ola.

Hiki i kāu kauka ke hoʻonohonoho hou i kāu mahele a i ʻole e hoʻoponopono i kāu hoʻolālā lapaʻau. Mai pāpālua i nā mahele a i ʻole e lawe i ka lomustine ma waho o kāu papa i kauoha ʻia, no ka mea, he mea weliweli kēia.

Hoʻolālā ʻia ka manawa o nā pōʻai chemotherapy me ka mālama nui, no laila he mea nui e loaʻa ke alakaʻi ʻoihana e pili ana i nā lāʻau i hala.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Lomustine?

Pono ʻoe e hooki i ka lawe ʻana iā lomustine ma lalo o ka nānā pono ʻana o kāu oncologist. ʻO ka hoʻoholo e hooki i ka lāʻau lapaʻau e hilinaʻi ana i nā mea e like me ka pane ʻana i ka lāʻau lapaʻau, nā hopena ʻaoʻao, a me ke kūlana olakino holoʻokoʻa.

E hoʻohana kāu kauka i nā scans maʻamau a me nā hoʻokolohua koko e nānā i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. Inā maikaʻi ka pane ʻana o ka maʻi kanesa, hiki iā ʻoe ke hoʻomau i ka lāʻau lapaʻau no kekahi mau pōʻai hou.

Inā kū mai nā hopena ʻaoʻao koʻikoʻi a i ʻole e hooki ka maʻi kanesa i ka pane ʻana, hiki i kāu oncologist ke ʻōlelo aku e hooki i ka lomustine a hoʻololi i nā lāʻau lapaʻau ʻē aʻe.

Q5. Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Lomustine?

Pono ʻoe e pale i ka waiʻona i ka wā e lawe ana iā lomustine, no ka mea, hiki iā ia ke hoʻonui i ka pilikia o ka pōʻino o ke ake a hoʻonui i nā hopena ʻaoʻao e like me ka nausea. Hiki nō hoʻi i ka waiʻona ke keakea i ka hiki o kou kino ke hakakā i nā maʻi.

Inā inu ʻoe i ka waiʻona i kekahi manawa, e kūkākūkā i kēia me kāu oncologist. Hiki iā lākou ke hāʻawi i ke alakaʻi kikoʻī e pili ana i kou olakino holoʻokoʻa a me ka hoʻolālā lapaʻau.

E kālele ana i ka noho ʻana i ka wai me ka wai a me ka mālama ʻana i ka meaʻai maikaʻi e kākoʻo i kou kino i ka wā o ka lāʻau chemotherapy.