He aha ʻo Lorlatinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi ʻo Lorlatinib e ālai ana i nā protein kikoʻī e kōkua ana i kekahi mau maʻi maʻi maʻi maʻi e ulu a laha. No ka papa o nā mea i kapa ʻia ʻo ALK inhibitors kēia lāʻau lapaʻau, e hana ana ma ka hoʻopilikia ʻana i nā hōʻailona e haʻi ana i nā cell maʻi e hoʻonui.

Inā ua kau ʻia ʻo lorlatinib iā ʻoe a i ʻole kekahi āu e mālama ai, he mea maʻamau ke loaʻa nā nīnau e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai. He hōʻailona kēia lāʻau lapaʻau i kahi holomua nui i ka mālama ʻana i nā ʻano maʻi maʻi maʻi maʻi, e hāʻawi ana i ka manaʻolana a me nā hopena maikaʻi no nā maʻi he nui.

He aha ʻo Lorlatinib?

He lāʻau lapaʻau i manaʻo ʻia ʻo Lorlatinib i hoʻolālā ʻia e mālama i ka maʻi maʻi maʻi maʻi ʻole (NSCLC) i loaʻa nā loli genetic kikoʻī. ʻO ia ka mea a nā kauka e kāhea ai he

Ua kauoha pinepine ʻia kēia lāʻau lapaʻau ke pau ka hana ʻana o nā mea pale ALK ʻē aʻe. He mea waiwai nui ia no ka mea hiki iā ia ke hele i ka pale koko-lolo, e hana pono ai i ka maʻi ʻaʻai i laha i ka lolo. Nui nā maʻi i ʻike i kēia mea e hōʻoluʻolu ai no ka mea hiki i nā metastases lolo ke hopohopo nui.

Hiki i kāu kauka oncologist ke ʻōlelo aku i ka lorlatinib ma ke ʻano he lapaʻau laina mua inā ua ʻike ʻia ʻoe i ka maʻi maʻi maʻi maʻi maʻi ALK-positive. Aia ka hoʻoholo i nā kumu like ʻole me kou olakino holoʻokoʻa, ka nui o kāu maʻi maʻi, a me kou mau kūlana pilikino.

Pehea e hana ai ʻo Lorlatinib?

Hana ʻo Lorlatinib ma ka pale ʻana i nā protein kikoʻī e pono ai nā sela maʻi maʻi e ulu a ola. E noʻonoʻo i kēia mau protein e like me nā kuapo e haʻi ana i nā sela maʻi maʻi e hoʻonui a laha i kou kino.

Ke lawe ʻoe i ka lorlatinib, pili ia i kēia mau kuapo protein a hoʻopau iā lākou. Hoʻopau kēia hana i nā sela maʻi maʻi mai ka loaʻa ʻana o nā hōʻailona e pono ai lākou e ulu a māhele. ʻO ka hopena, make pinepine nā sela maʻi maʻi a i ʻole e hooki i ka laha ʻana i nā wahi hou o kou kino.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia he ikaika a maikaʻi. He mea ikaika loa ia no ka mea hiki iā ia ke hiki i nā sela maʻi maʻi i ka lolo, ʻaʻole hiki i nā lāʻau maʻi maʻi ʻē aʻe ke hana pono. ʻO kēia ka mea e waiwai nui ai no ka mālama ʻana i ka maʻi maʻi maʻi e laha ana i ka lolo.

Pehea e lawe ai au i ka Lorlatinib?

E lawe i ka lorlatinib e like me ke kauoha a kāu kauka, maʻamau i hoʻokahi manawa i ka lā me ka ʻole o ka meaʻai. Hiki iā ʻoe ke lawe me ke aniani wai i kēlā me kēia manawa o ka lā, akā e hoʻāʻo e lawe i ka manawa like i kēlā me kēia lā e kōkua iā ʻoe e hoʻomanaʻo.

E ale i nā papa holoʻokoʻa me ka ʻole o ka ʻoki ʻana, ka nau ʻana, a i ʻole ka wāwahi ʻana iā lākou. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai. Loaʻa paha iā lākou nā manaʻo e maʻalahi ai ka lawe ʻana i kāu lāʻau lapaʻau.

ʻAʻole pono ʻoe e lawe i ka lorlatinib me nā meaʻai kūikawā, akā he mea nui ka mālama ʻana i ka meaʻai maikaʻi i ka wā e mālama ʻia ai ka maʻi kanesa. Manaʻo kekahi poʻe he mea kōkua ka lawe ʻana me kahi mea ʻai māmā e pale ai i ka ʻōpū, ʻoiai ʻaʻole koi ʻia kēia.

E pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana i ka lorlatinib, no ka mea, hiki i kēia mau mea ke hoʻonui i ka nui o ka lāʻau lapaʻau i loko o kou kahe koko. E hāʻawi kāu kauka iā ʻoe i kahi papa inoa piha o nā meaʻai a me nā lāʻau lapaʻau e pale ai.

Pehea ka lōʻihi e lawe ai au i ka Lorlatinib?

E hoʻomau ʻoe i ka lawe ʻana i ka lorlatinib no ka lōʻihi e hana pono ana a ke ʻae nei ʻoe iā ia. Hiki i kēia ke mau mahina a i ʻole mau makahiki, ma muli o ke ʻano o ka pane ʻana o kāu maʻi kanesa i ka lāʻau lapaʻau.

E nānā kāu kauka i kou holomua ma o nā scans maʻamau a me nā hoʻokolohua koko. Kōkua kēia mau loiloi e hoʻoholo inā e kāohi ana ka lāʻau lapaʻau i kāu maʻi kanesa a inā e ʻike nei ʻoe i nā hopena ʻaoʻao e pili ana. Ma muli o kēia mau hopena, hiki ke hoʻololi ʻia kāu hoʻolālā lapaʻau.

Mai hooki i ka lawe ʻana i ka lorlatinib me ka kūkākūkā ʻole ʻana me kāu oncologist mua. ʻOiai inā maikaʻi kou manaʻo, hiki nō i ka lāʻau lapaʻau ke hana e kāohi i nā sela maʻi kanesa ʻaʻole hiki iā ʻoe ke ʻike a ʻike paha. E alakaʻi kāu hui mālama ola iā ʻoe i ka wā a pehea e hoʻopau palekana ai i ka lāʻau lapaʻau inā hiki mai kēlā manawa.

He aha nā hopena ʻaoʻao o Lorlatinib?

E like me nā lāʻau lapaʻau a pau, hiki i ka lorlatinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. He nui ka poʻe e ʻae maikaʻi i kēia lāʻau lapaʻau, a hiki ke mālama ʻia nā hopena ʻaoʻao me ke kākoʻo kūpono a me ka nānā ʻana.

Hiki i ka hoʻomaopopo ʻana i ka mea e manaʻo ai ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu lapaʻau. E nānā kākou i nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Nā pae cholesterol kiʻekiʻe (i ʻike ʻia ma nā hoʻokolohua koko)
• Ka pehu ʻana ma kou mau lima, nā wāwae, a i ʻole a puni kou mau maka
• Ka loaʻa ʻana o ke kaumaha mai ka paʻa wai
• ʻO ka luhi a i ʻole ka manaʻo e piʻi aʻe ka luhi ma mua o ka maʻamau
• Nā loli i ke ʻano a i ʻole ka noʻonoʻo ʻana, me ka huikau
• Nā pilikia o ke aʻalolo e hana ana i ka ʻeha a i ʻole ka ʻehaʻeha
• Ka maʻi palahī a i ʻole nā loli i nā hana o ka ʻōpū
• Ka luaʻi ʻana a i ʻole ka emi ʻana o ka ʻai

ʻO ka hapa nui o kēia mau hopena ʻaoʻao he maʻalahi a i ʻole he kūpono a hiki ke mālama pono ʻia. E nānā pono kāu hui mālama ola iā ʻoe a hāʻawi i nā hoʻolālā e kōkua iā ʻoe e ʻoluʻolu e like me ka hiki i ka wā o ka mālama ʻana.

ʻOiai ʻaʻole maʻamau, hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke. ʻO kēia mau hopena ʻaoʻao laha akā koʻikoʻi, e komo pū ana:

• Nā loli nui o ke ʻano, nā hallucinations, a i ʻole psychosis
• Ka mumū nui o ka māmā (pneumonitis)
• Nā pilikia o ka puʻuwai
• Nā pilikia nui o ke ake
• Nā pilikia o ka maka e pili ana i ka ʻike
• Nā hopena ʻili koʻikoʻi

E hoʻokaʻaʻike koke i kāu hui mālama ola inā ʻike ʻoe i nā hōʻailona koʻikoʻi a i ʻole nā hōʻailona e pili ana. Aia lākou ma laila e kākoʻo iā ʻoe a hiki ke hāʻawi pinepine i nā hoʻonā e kōkua iā ʻoe e hoʻomau i ka mālama ʻana me ka palekana.

ʻO wai ka mea pono ʻole e lawe iā Lorlatinib?

ʻAʻole kūpono ʻo Lorlatinib no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻO kēia loiloi akahele e kōkua i ka hōʻoia ʻana i ka palekana a me ke kūpono o ka lāʻau lapaʻau no kāu kūlana.

ʻAʻole pono ʻoe e lawe iā lorlatinib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna meaʻai. E kūkākūkā kāu kauka i nā maʻi āpau i ʻike ʻia me ʻoe ma mua o ka hoʻomaka ʻana i ka mālama ʻana. Pono paha ka poʻe me kekahi mau maʻi i loaʻa mua i ka nānā ʻana a i ʻole nā lāʻau lapaʻau ʻē aʻe.

Nui nā mea e pili ana inā kūpono ʻo lorlatinib iā ʻoe:

• He maʻi ate nui a i ʻole nā pilikia o ka hana ate
• Nā pilikia o ka puʻuwai i kēia manawa a i ʻole i hala koke
• He maʻi kīkī nui
• He moʻolelo o nā maʻi noʻonoʻo nui
• Hāpai a i ʻole nā hoʻolālā e hāpai
• Hānai waiū a i ʻole nā hoʻolālā e hānai waiū

Inā hāpai ʻoe a i ʻole hiki ke hāpai, he mea nui e kūkākūkā i kēia me kāu kauka i kēia manawa. Hiki i ka Lorlatinib ke hōʻeha i ka pēpē i loko o ka ʻōpū, no laila he mea nui ka hoʻohana ʻana i nā mea pale hāpai i ka wā e mālama ʻia ai a no kekahi manawa ma hope o ka pau ʻana o ka lāʻau.

E hana pū kāu hui mālama ola me ʻoe e hoʻoholo inā ʻo lorlatinib ke koho lapaʻau maikaʻi loa e pili ana i kou kūlana pilikino a me ka mōʻaukala olakino.

Inoa Brand Lorlatinib

Kūʻai ʻia ʻo Lorlatinib ma lalo o ka inoa brand Lorbrena. ʻO kēia ka inoa āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau.

Hana ʻia ʻo Lorbrena e Pfizer a loaʻa wale nō me ke kauoha mai kāu oncologist. Hiki i kāu lāʻau lapaʻau ke hoʻohana i kekahi inoa ke kūkākūkā ʻana i kāu lāʻau, no laila he mea kōkua ke ʻike i ka inoa maʻamau (lorlatinib) a me ka inoa brand (Lorbrena).

Ke kiʻi ʻana i kāu kauoha a i ʻole ke kūkākūkā ʻana i kāu lāʻau me nā mea mālama ola, hiki iā ʻoe ke kuhikuhi iā ia ma kekahi inoa. E pili ana nā inoa ʻelua i ka lāʻau like me ka mea hana like.

Nā Koho ʻē aʻe o Lorlatinib

Loaʻa kekahi mau mea pale ALK ʻē aʻe inā ʻaʻole ʻo lorlatinib ke koho kūpono iā ʻoe. E noʻonoʻo kāu oncologist i nā mea like ʻole i ke koho ʻana i ka lāʻau kūpono loa no kou kūlana.

ʻO nā mea pale ALK ʻē aʻe e komo pū ana me alectinib (Alecensa), ceritinib (Zykadia), crizotinib (Xalkori), a me brigatinib (Alunbrig). Hana like kēlā me kēia lāʻau i ka pale ʻana i nā protein ALK, akā he ʻokoʻa nā hopena ʻaoʻao a me ka pono e kūʻē i nā ʻano like ʻole o nā loli ALK.

Ke koho ʻana i ka mea kāohi ALK e hilinaʻi ana i nā mea he nui, me ka mea i loaʻa iā ʻoe ka lāʻau lapaʻau ALK ma mua, ke ʻano kikoʻī o ka mutation ALK āu i loaʻa, a inā paha ua laha kāu maʻi maʻi i kou lolo. E kūkākūkā kāu kauka i kēia mau koho me ʻoe inā ʻaʻole kūpono ʻo lorlatinib a i ʻole e pau ka hana pono.

Ua ʻOi aku ka maikaʻi o Lorlatinib ma mua o Alectinib?

He mea maikaʻi nā mea kāohi ALK ʻo Lorlatinib a me alectinib, akā he mau mea maikaʻi kū hoʻokahi ko lākou. ʻO ke koho

Inā he maʻi puʻuwai kou, ʻaʻole ia he manaʻo hiki ʻole iā ʻoe ke lawe i ka lorlatinib, akā pono ʻoe e nānā pinepine ʻia. E hana pū ana kāu cardiologist a me ka oncologist e hōʻoia i ka palekana o kāu lapaʻau. Hiki iā lākou ke hoʻoponopono i kāu mahele lāʻau a i ʻole e ʻōlelo aku i ka nānā ʻana i ka puʻuwai hou aʻe i ka wā o ka lapaʻau.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o ka Lorlatinib?

Inā ua lawe hewa ʻoe i ka nui o ka lorlatinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā ʻoe e ʻike i nā hōʻailona, no ka mea, he mea nui ka loaʻa ʻana o ke kōkua wikiwiki.

E mālama i kāu hue lāʻau me ʻoe i ka wā e kelepona ai ʻoe, no ka mea, pono nā mea mālama ola e ʻike pono i ka nui o ka lāʻau hou āu i lawe ai. ʻOiai ʻoe e kali nei i ke alakaʻi, mai lawe i nā mahele lāʻau hou aʻe a nānā iā ʻoe iho no nā hōʻailona maʻamau e like me ka nausea koʻikoʻi, ka ʻūlū, a i ʻole ka huikau.

He aha kaʻu e hana ai inā ua hala au i kahi mahele lāʻau o Lorlatinib?

Inā ua hala ʻoe i kahi mahele lāʻau a ua hala ma lalo o 20 mau hola mai kou manawa maʻamau, e lawe i ka mahele lāʻau i hala i ka wā e hoʻomanaʻo ai ʻoe. Inā ua hala ma mua o 20 mau hola, e lele i ka mahele lāʻau i hala a lawe i kāu mahele lāʻau e hiki mai ana i ka manawa maʻamau.

Mai lawe i ʻelua mahele lāʻau i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele lāʻau i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā poina pinepine ʻoe i nā mahele lāʻau, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua iā ʻoe e hoʻomanaʻo, e like me ka hoʻonohonoho ʻana i nā alarms kelepona a i ʻole ka hoʻohana ʻana i kahi mea hoʻonohonoho pila.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Lorlatinib?

Pono ʻoe e hooki i ka lawe ʻana i ka lorlatinib ke ʻōlelo aku kāu kauka iā ʻoe e hana pēlā. Hoʻokumu ʻia kēia hoʻoholo i ka maikaʻi o ka lāʻau lapaʻau e kāohi ana i kāu maʻi maʻi a inā ʻoe e ʻike nei i nā hopena ʻaoʻao hiki ke mālama ʻia.

E hoʻohana kāu kauka i nā scans maʻamau a me nā hoʻokolohua koko e nānā i kāu holomua. Inā hoʻomaka hou ka maʻi maʻi a i ʻole ʻoe e hoʻomohala i nā hopena ʻaoʻao koʻikoʻi ʻaʻole hiki ke mālama ʻia, hiki i kāu kauka ke ʻōlelo aku e hooki i ka lorlatinib a hoʻāʻo i kahi ala lapaʻau ʻē aʻe.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Lorlatinib?

ʻOi aku ka maikaʻi e kaupalena i ka inu ʻana i ka waiʻona i ka wā e lawe ana i ka lorlatinib, no ka mea, hiki i nā mea ʻelua ke hoʻopilikia i kou ate a me ka ʻōnaehana nerve. Hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka noʻonoʻo ʻole, ka huikau, a i ʻole nā loli o ka naʻau.

Inā koho ʻoe e inu i ka waiʻona i kekahi manawa, e hana me ka maʻalahi a e nānā i kou manaʻo. E kamaʻilio me kāu kauka e pili ana i ka mea kūpono no kou kūlana kikoʻī, no ka mea, ʻike lākou i kāu kiʻi olakino piha a hiki ke hāʻawi i ke alakaʻi pilikino.