Macitentan (ma ka waha)
Nā mea hōʻailona e loaʻa ana
ʻOpiuma
E pili ana i kēia lāʻau
Ho'ōla ka Macitentan i nā hōʻailona o ka hypertension arterial pulmonary, ʻo ia hoʻi ka piʻi kiʻekiʻe o ke koko i loko o ke kīʻaha nui e lawe ana i ke koko mai ka ʻaoʻao ʻākau o ka naʻau (ka ventricle) i nā māmā. I ka wā e kū'ē ai nā kīʻaha koko liʻiliʻi i loko o nā māmā i ke kahe koko, pono e hana nui ka ventricle ʻākau e hoʻopuka i ke koko lawa i nā māmā. Hana ka Macitentan ma ka hoʻomaha ʻana i kēia mau kīʻaha koko a hoʻonui i ka lako o ke koko i nā māmā, kahi e ho'ēmi ai i ka hana o ka naʻau. Loaʻa wale kēia lāʻau lapaʻau me ke kauoha a kāu kauka. Loaʻa kēia huahana ma nā ʻano helu helu e like me kēia:
Ma mua o ka hoʻohana ʻana i kēia lāʻau
I ka hoʻoholo ʻana e hoʻohana i kahi lāʻau lapaʻau, pono e kaulike ke kaumaha o ka lawe ʻana i ka lāʻau lapaʻau me ka pono e hana ai. He hoʻoholo kēia āu a me kāu kauka e hana ai. No kēia lāʻau lapaʻau, pono e noʻonoʻo i nā mea aʻe: E haʻi aku i kāu kauka inā ua loaʻa iā ʻoe kekahi hopena maʻamau ʻole a i ʻole nā hopena ʻē aʻe i kēia lāʻau lapaʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe. E haʻi aku pū i kāu limahana mālama ola inā loaʻa iā ʻoe nā ʻano ʻē aʻe o nā maʻi ʻiliʻili, e like me nā meaʻai, nā kala, nā mea mālama, a i ʻole nā holoholona. No nā huahana kūʻai ʻole ʻia, e heluhelu pono i ka lepili a i ʻole nā mea hoʻohui pūʻolo. ʻAʻole i hana ʻia nā haʻawina kūpono ma ka pilina o ka makahiki i nā hopena o ka macitentan i ka heluna keiki. ʻAʻole i hoʻokumu ʻia ka palekana a me ka pono. ʻAʻole i hōʻike nā haʻawina kūpono i hana ʻia a hiki i kēia manawa i nā pilikia kūikawā geriatric e kaupalena ai i ka pono o ka macitentan i nā ʻelemakule. ʻAʻohe haʻawina lawa i nā wahine no ka hoʻoholo ʻana i ka pilikia o ka pēpē i ka wā e hoʻohana ana i kēia lāʻau lapaʻau i ka wā hānai. E kaulike i nā pono hiki ke loaʻa me nā pilikia hiki ke loaʻa ma mua o ka lawe ʻana i kēia lāʻau lapaʻau i ka wā hānai. ʻOiai ʻaʻole pono e hoʻohana pū ʻia kekahi mau lāʻau lapaʻau, i nā hihia ʻē aʻe, hiki ke hoʻohana pū ʻia ʻelua mau lāʻau lapaʻau ʻokoʻa ʻoiai inā hiki ke loaʻa kahi pilina. I kēia mau hihia, makemake paha kāu kauka e hoʻololi i ka nui, a i ʻole nā ʻano palekana ʻē aʻe paha e pono ai. I ka wā e lawe ana ʻoe i kēia lāʻau lapaʻau, he mea nui loa ia i kāu limahana mālama ola e ʻike inā ke lawe nei ʻoe i kekahi o nā lāʻau lapaʻau i helu ʻia ma lalo nei. Ua koho ʻia nā pilina aʻe ma muli o ko lākou koʻikoʻi hiki ke loaʻa a ʻaʻole pono nā mea āpau. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe. Hiki i kāu kauka ke hoʻoholo ʻaʻole e mālama iā ʻoe me kēia lāʻau lapaʻau a hoʻololi paha i kekahi o nā lāʻau lapaʻau ʻē aʻe āu e lawe nei. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe, akā hiki ke koi ʻia i kekahi mau hihia. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua. ʻAʻole pono e hoʻohana ʻia kekahi mau lāʻau lapaʻau i ka wā a i ʻole kokoke i ka wā e ʻai ai i ka meaʻai a i ʻole ka ʻai ʻana i kekahi mau ʻano meaʻai ʻoiai hiki ke loaʻa nā pilina. Hiki i ka hoʻohana ʻana i ka waiʻona a i ʻole ka paka me kekahi mau lāʻau lapaʻau ke hoʻokumu pū i nā pilina. E kūkākūkā me kāu limahana mālama ola i ka hoʻohana ʻana i kāu lāʻau lapaʻau me ka meaʻai, ka waiʻona, a i ʻole ka paka. Hiki i ka loaʻa ʻana o nā pilikia olakino ʻē aʻe ke hoʻopilikia i ka hoʻohana ʻana i kēia lāʻau lapaʻau. E hōʻoia e haʻi aku i kāu kauka inā loaʻa iā ʻoe nā pilikia olakino ʻē aʻe, ʻoiai:
Pehea e hoʻohana ai i kēia lāʻau
E lawe pono i kēia lāʻau e like me ke kauoha a kāu kauka. Mai lawe hou aku, mai lawe pinepine aku, a mai lawe lōʻihi aku ma mua o ka kauoha a kāu kauka. Eia kekahi, mai ho'ōki i ka lawe ʻana i kēia lāʻau me ka nīnau ʻole mua i kāu kauka. He mea nui loa ia e hoʻomaopopo pono ʻoe i nā rula o ka papahana Opsumit® REMS. E heluhelu i ke alakaʻi lāʻau no nā mea maʻi. E nīnau i kāu kauka a i ʻole ke kauka lāʻau inā he nīnau kāu. Malia paha e noi ʻia ʻoe e kau inoa i kahi palapala e hōʻike ai ua hoʻomaopopo ʻoe i ka ʻike. E ʻai pono i ka papa holoʻokoʻa. Mai haki, ʻoki, a i ʻole ʻai. E ʻokoʻa ka nui o kēia lāʻau no nā mea maʻi like ʻole. E hahai i nā kauoha a kāu kauka a i ʻole nā kuhikuhi ma ka lepili. ʻO ka ʻike ma lalo nei ke komo wale nei i nā nui awelika o kēia lāʻau. Inā ʻokoʻa kāu nui, mai hoʻololi inā ʻaʻole i kauoha mai kāu kauka. ʻO ka nui o ka lāʻau āu e lawe ai e hilinaʻi ana i ka ikaika o ka lāʻau. Eia kekahi, ʻo ka nui o nā nui āu e lawe ai i kēlā me kēia lā, ka manawa i ʻae ʻia ma waena o nā nui, a me ka lōʻihi o ka manawa āu e lawe ai i ka lāʻau e hilinaʻi ana i ka pilikia olakino āu e hoʻohana ai i ka lāʻau. Inā poina ʻoe i kahi nui o kēia lāʻau, e lawe koke iā ia. Eia naʻe, inā kokoke ka manawa no kāu nui aʻe, e haʻalele i ka nui i poina a hoʻi i kāu papa hana maʻamau. Mai pālua i nā nui. E mālama i ka lāʻau i loko o kahi pahu pani ʻia ma ka mahana o ka lumi, mamao aku i ka wela, ka pulu, a me ka mālamalama pololei. E mālama mai ka hau. E mālama mamao aku i nā keiki. Mai mālama i ka lāʻau i hala ka lā a i ʻole ka lāʻau ʻaʻole pono hou. E nīnau i kāu limahana mālama ola pehea ʻoe e hoʻolei ai i kekahi lāʻau āu ʻaʻole e hoʻohana.
Hōʻole: He kahua ʻike olakino ʻo ʻAukake a ʻaʻole hōʻike kāna mau pane i ka ʻōlelo aʻoaʻo lapaʻau. E kūkākūkā mau me kahi ʻoihana lapaʻau laikini kokoke iā ʻoe ma mua o ka hana ʻana i nā hoʻololi.
Hana ʻia i India, no ka honua