He aha ʻo Maraviroc: Nā Hoʻohana, Nā Ana, Nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Maraviroc i hoʻolālā ʻia e mālama i ka maʻi HIV i nā pākeke. No kahi papa kūʻokoʻa o nā lāʻau HIV i kapa ʻia ʻo CCR5 antagonists, e hana ana i nā ʻano like ʻole mai nā lāʻau HIV ʻē aʻe ma ka pale ʻana i kahi puka kikoʻī e hoʻohana ai ka HIV e komo i loko o kāu mau pūnaewele immune.

ʻAʻole kēia lāʻau lapaʻau he lāʻau lapaʻau no ka HIV, akā hiki ke lilo i mea hana ikaika i kāu pahu hana lapaʻau. Ke hoʻohana ʻia ma ke ʻano he ʻāpana o ka lāʻau hui pū me nā lāʻau HIV ʻē aʻe, kōkua ʻo maraviroc i ka mālama ʻana i ka maʻi a kākoʻo i ka hiki o kāu ʻōnaehana immune e noho ikaika.

He aha ʻo Maraviroc?

ʻO Maraviroc kahi lāʻau antiretroviral e kālele ana i ka pehea e komo ai ka HIV i kāu mau pūnaewele CD4. E noʻonoʻo iā ia he laka kūikawā e pale ai i ka HIV mai ka hoʻohana ʻana i kekahi o kāna mau wahi komo nui i loko o kāu mau pūnaewele immune.

ʻAʻole like me nā lāʻau HIV ʻē aʻe e hana ma hope o ka maʻi ʻana o ka maʻi i kāu mau pūnaewele, hana ʻo maraviroc i ka hoʻomaka ʻana o ke kaʻina maʻi. Palaka ia i ka mea loaʻa CCR5, e like me ka puka e hoʻohana ai kekahi mau ʻano HIV e komo i loko o kāu mau pūnaewele immune olakino.

Hoʻohana mau ʻia kēia lāʻau lapaʻau me nā lāʻau HIV ʻē aʻe, ʻaʻole wale nō. E kauoha maʻamau kāu kauka iā ia ma ke ʻano he ʻāpana o ka mea i kapa ʻia ʻo ka lāʻau antiretroviral hui pū, a i ʻole cART, e hoʻohana ana i nā lāʻau he nui e hoʻouka i ka HIV mai nā kihi like ʻole.

No ke aha e hoʻohana ʻia ai ʻo Maraviroc?

Hoʻohana nui ʻia ʻo Maraviroc e mālama i ka maʻi HIV-1 i nā pākeke i loaʻa i kahi ʻano kikoʻī o ka HIV i kapa ʻia ʻo CCR5-tropic virus. Ma mua o ke kau ʻana i kēia lāʻau lapaʻau, pono i kāu kauka e hoʻāʻo i kāu HIV e hōʻoia i ke ʻano kūpono e hiki ai i ka maraviroc ke hana pono.

He mea nui kēia lāʻau lapaʻau no ka poʻe i kūʻē i nā lāʻau lapaʻau HIV ʻē aʻe. Inā ʻaʻole e hana pono ana kāu lapaʻau HIV i kēia manawa, a i ʻole inā ua hoʻāʻo ʻoe i nā ʻano lapaʻau like ʻole me ka holomua ʻole, hiki i ka maraviroc ke hāʻawi i kahi ala hou e kāohi ai i ka maʻi.

Hiki nō hoʻi i kāu kauka ke noʻonoʻo i ka maraviroc inā e hoʻomaka ana ʻoe i ka lapaʻau HIV no ka manawa mua, ʻoi aku hoʻi inā hōʻike nā hoʻokolohua he CCR5-tropic HIV kāu. Eia naʻe, hoʻohana pinepine ʻia ia i nā maʻi i loaʻa ka ʻike lapaʻau e pono ai i nā koho hou.

Pehea e hana ai ʻo Maraviroc?

Hana ʻo Maraviroc ma ke ʻano he lāʻau lapaʻau HIV ikaika e ālai ana i kahi ala kikoʻī e hoʻohana ai ka HIV e hoʻopōʻino i kāu mau cell. Manaʻo ʻia he lāʻau lapaʻau i manaʻo ʻia no ka mea e kālele ana i hoʻokahi hana kikoʻī o ka maʻi HIV.

Ke hoʻāʻo ka HIV e komo i kāu mau cell CD4, pono ia e hoʻopili i kekahi mau mea hoʻokipa ma ka ʻili o ka cell. Hoʻopaʻa kikoʻī ʻo Maraviroc i ka mea hoʻokipa CCR5, e pale ana i ka CCR5-tropic HIV mai ke komo pono ʻana a me ka hoʻopōʻino ʻana i kāu mau cell immune olakino.

Hana ʻia kēia hana ālai ma waho o kāu mau cell, kahi e hana ai ʻo maraviroc i mea kū hoʻokahi i waena o nā lāʻau lapaʻau HIV. ʻO ka hapa nui o nā lāʻau HIV ʻē aʻe e hana i loko o nā cell ma hope o ka maʻi ʻana, akā hoʻōki ʻo maraviroc i ke kaʻina hana ma mua o ka hoʻomaka ʻana.

Aia ka pono o ka lāʻau lapaʻau i kāu HIV e CCR5-tropic. Loaʻa i kekahi poʻe ka CXCR4-tropic HIV a i ʻole dual-tropic HIV, e hoʻohana ana i nā wahi komo like ʻole ʻaʻole hiki i ka maraviroc ke ālai.

Pehea e lawe ai au i ka Maraviroc?

Lawe pinepine ʻia ʻo Maraviroc ma ke ʻano he papa ʻelua manawa i ka lā, me ka ʻai a i ʻole me ka ʻole. Hiki iā ʻoe ke lawe me ka wai, ka waiū, a i ʻole ka wai - ʻo nā mea a pau e ʻoluʻolu ai kou ʻōpū.

ʻO ka lawe ʻana i ka maraviroc me ka meaʻai e kōkua paha i ka hōʻemi ʻana i nā pilikia o ka ʻōpū, ʻoiai ʻaʻole pono. ʻIke kekahi poʻe i ka lawe ʻana me kahi meaʻai māmā a i ʻole ka ʻai ʻana e maʻalahi ai ka hoʻomanaʻo a me ka mālie i kā lākou ʻōnaehana digestive.

He mea nui ka manawa o kāu mau lāʻau ma mua o kāu mea e ʻai ai me lākou. E hoʻāʻo e lawe i kāu mau lāʻau ma kahi o 12 hola kaʻawale a i nā manawa like i kēlā me kēia lā. Kōkua kēia i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kou ʻōnaehana.

Inā ʻoe e lawe i nā lāʻau HIV ʻē aʻe, pono ʻoe e hoʻopili i ka manawa me ka maraviroc. Pono e lawe pū ʻia kekahi mau hui lāʻau, aʻo nā mea ʻē aʻe e hana maikaʻi ke kaʻawale. Hiki i kāu kauka lapaʻau ke kōkua iā ʻoe e hana i kahi papa manawa e hana pū me kāu mau lāʻau ʻē aʻe.

Pehea ka lōʻihi e lawe ai au i ka Maraviroc?

ʻO Maraviroc ka mea maʻamau he lāʻau lapaʻau lōʻihi e lawe ʻoe no ka lōʻihi e hoʻomau ana i ka hana ʻana i ka mālama ʻana i kāu HIV. ʻO ka hapa nui o ka poʻe e pane maikaʻi ana i nā regimens i loaʻa ka maraviroc e lawe mau ana ia mea ma ke ʻano he ʻāpana o kā lākou mālama ʻana i ka HIV.

E nānā mau kāu kauka i kāu ukana viral e hōʻoia i ka hana pono ʻana o ka maraviroc. Inā noho ʻole kāu ukana viral a paʻa a hoʻomaikaʻi paha kāu helu CD4, e hoʻomau paha ʻoe i ka lawe ʻana.

Aia nō hoʻi ka lōʻihi o ka mālama ʻana i ka maikaʻi o kou ʻae ʻana i ka lāʻau lapaʻau a inā paha e mau ana kāu HIV CCR5-tropic. Hiki ke loli ka HIV o kekahi poʻe i ka manawa, e lilo ana i mea kūʻē i ka maraviroc a i ʻole ka hoʻololi ʻana i ka hoʻohana ʻana i nā ala komo like ʻole.

Mai hooki i ka lawe ʻana i ka maraviroc me ka ʻole e kūkākūkā mua me kāu kauka. ʻO ka hoʻōki ʻana i nā lāʻau HIV i ka wā koke hiki ke alakaʻi i ka viral rebound a me ka hoʻomohala ʻana i ke kūʻē lāʻau.

He aha nā hopena ʻaoʻao o Maraviroc?

E like me nā lāʻau lapaʻau a pau, hiki i ka maraviroc ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO ka hapa nui o nā hopena ʻaoʻao he maʻalahi a maʻalahi a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike, a he mea kōkua ke ʻike i ka mea e manaʻo ai i hiki iā ʻoe ke kūkākūkā i nā hopohopo me kāu hui mālama ola:

• Ka luaʻi ʻana a me ka ʻōpū ʻeha
• Ka maʻi palahē a i ʻole nā noho palupalu
• Ke poʻo
• Ka luhi a i ʻole ka manaʻo e luhi
• Ka wili, ʻoi loa ke kū i luna
• Ka pilikia o ka hiamoe
• Ka ʻeha ʻana o nā ʻiʻo a i ʻole nā hui
• Nā loli i ka ʻai

ʻO kēia mau hopena ʻaoʻao maʻamau e emi pinepine ana i loko o nā pule mua o ka lapaʻau. Inā mau lākou a i ʻole e hoʻopilikia i kou ola i kēlā me kēia lā, hiki i kāu kauka ke hōʻike i nā hoʻolālā e kōkua i ka mālama ʻana iā lākou.

ʻAʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, akā pono lākou i ka lāʻau lapaʻau koke. Aia i loko o kēia mau hōʻailona o nā pilikia o ke ake e like me ka melemele ʻana o kou ʻili a i ʻole nā maka, ka ʻeha nui o ka ʻōpū, a i ʻole ka luhi maʻamau ʻole ʻaʻole e hoʻomaikaʻi me ka hoʻomaha.

Hiki i kekahi poʻe ke ʻike i nā hopena maʻi, e komo pū ana me ka ʻōpala, ka ʻūlū, ka pehu, a i ʻole ka pilikia o ka hanu ʻana. Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​e hoʻokaʻaʻike koke i kāu mea mālama ola.

Aia kekahi mau hopena ʻaoʻao laha akā koʻikoʻi e nānā ai kāu kauka ma o nā hoʻokolohua koko maʻamau a me nā nānā ʻana. Hiki i kēia ke komo i nā loli i kāu hana ake, nā pilikia o ka naʻau, a i ʻole nā maʻi maʻamau ʻole.

ʻO wai ka mea pono ʻole e lawe iā Maraviroc?

ʻAʻole kūpono ʻo Maraviroc no nā mea a pau, a e loiloi pono kāu kauka inā ʻo ia ke koho kūpono no kāu kūlana kikoʻī. ʻO ka mea nui loa, ʻo ka loaʻa ʻana o ka CCR5-tropic HIV, no ka mea, ʻaʻole e hana ka lāʻau lapaʻau i nā ʻano HIV ʻē aʻe.

Pono ka poʻe me nā pilikia ake koʻikoʻi e hoʻohana iā maraviroc me ka akahele a i ʻole e pale loa iā ia. Mai ka wā i hana ʻia ai ka lāʻau lapaʻau ma o kou ake, hiki i ka maʻi ake e kū nei ke paʻakikī i kou kino ke mālama pono i ka lāʻau lapaʻau.

Inā loaʻa iā ʻoe kekahi mau maʻi o ka naʻau, ʻoiai nā mea e pili ana i kāu puʻuwai, pono kāu kauka e kaupaona pono i nā pōmaikaʻi a me nā pilikia. Hiki i ka Maraviroc ke hoʻopilikia i ka hana o ka naʻau, ʻoi loa i ka poʻe me nā pilikia cardiac i mua.

Eia nā kūlana kahi e kūpono ʻole ai ka maraviroc, a e kūkākūkā kāu kauka i kēia mau mea me ʻoe i ka wā o kāu kūkākūkā:

• Maʻi HIV CXCR4-tropic a i ʻole dual-tropic
• Maʻi ate nui a i ʻole ka hāʻule ʻana o ke ake
• Nā maʻi puʻuwai puʻuwai
• Maʻi kīkī nui
• Hāpai (ʻikepili palekana palena ʻia)
• Hānai umauma
• Ma lalo o 18 makahiki (ʻaʻole i ʻae ʻia no ka hoʻohana ʻana i nā keiki)

E noʻonoʻo pū kāu kauka i kāu mau lāʻau lapaʻau ʻē aʻe, no ka mea, hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka maraviroc ma nā ʻano e hoʻemi ai i ka pono a i ʻole e hoʻonui i nā hopena ʻaoʻao.

Inā he moʻolelo kou o ke kaumaha a i ʻole nā ​​maʻi olakino noʻonoʻo ʻē aʻe, e nānā pono kāu kauka iā ʻoe, no ka mea, ʻike kekahi poʻe i nā loli o ke ʻano i ka hoʻomaka ʻana i nā lāʻau HIV hou.

Nā inoa inoa Maraviroc

Loaʻa ka Maraviroc ma lalo o ka inoa inoa ʻo Selzentry ma ʻAmelika Hui Pū ʻIa a me Celsentri ma nā ʻāina ʻē aʻe. Loaʻa i nā mea ʻelua ka mea hana like a hana like.

Hele mai ka lāʻau lapaʻau i nā papa 150mg a me 300mg, a e hoʻoholo kāu kauka i ka ikaika kūpono e pili ana i kāu mau lāʻau lapaʻau ʻē aʻe a me nā pono pilikino. Hiki ke ʻokoʻa ka dosage ma muli o nā lāʻau HIV ʻē aʻe āu e lawe nei.

Hiki ke loaʻa nā mana generic o maraviroc ma kekahi mau wahi, akā ʻo nā mana inoa inoa ka mea i kauoha pinepine ʻia. Hiki i kāu kauka lāʻau ke kōkua iā ʻoe e hoʻomaopopo i ka mea i loaʻa ma kou wahi.

Nā koho ʻē aʻe o Maraviroc

Inā ʻaʻole kūpono ka maraviroc iā ʻoe, aia kekahi mau koho lāʻau HIV ʻē aʻe i loaʻa. ʻO ke koho maikaʻi loa e pili ana i kāu ʻano HIV, kāu mōʻaukala lapaʻau, a me ka maikaʻi o kāu pane ʻana i nā lāʻau lapaʻau ʻē aʻe.

ʻO nā lāʻau lapaʻau pale komo ʻē aʻe e pili ana i ka enfuvirtide, ʻoiai ua hāʻawi ʻia e ka injection a ʻaʻole hoʻohana pinepine ʻia i kēia lā. ʻOi aku ka maʻamau, hiki i kāu kauka ke noʻonoʻo i nā mea pale hoʻoili kaula integrase e like me ka dolutegravir a i ʻole raltegravir.

ʻO nā mea pale protease e like me darunavir a i ʻole atazanavir he ʻano lāʻau lapaʻau HIV ʻē aʻe e hana ana ma o kahi ʻano hana ʻokoʻa. He mau koho maikaʻi paha kēia inā loaʻa iā ʻoe ka HIV CXCR4-tropic ʻaʻole e pane i ka maraviroc.

ʻO nā mea pale transcriptase reverse non-nucleoside (NNRTIs) e like me efavirenz a i ʻole rilpivirine e hāʻawi i kahi ala ʻē aʻe i ka mālama ʻana i ka HIV. E noʻonoʻo kāu kauka i nā mea e like me kāu ʻano kūʻē viral a me nā hopena ʻaoʻao e hiki ai ke koho i nā koho ʻē aʻe.

Ua ʻoi aku ka maikaʻi o Maraviroc ma mua o nā lāʻau lapaʻau HIV ʻē aʻe?

ʻAʻole pono ʻo Maraviroc i ʻoi aku ka maikaʻi a i ʻole ka ʻino ma mua o nā lāʻau lapaʻau HIV ʻē aʻe - ʻokoʻa wale nō ia a he mea waiwai loa ia no nā kūlana kikoʻī. ʻO ka lāʻau lapaʻau HIV

E kauoha paha kāu kauka i nā hoʻokolohua hana ate maʻamau e nānā i ke ʻano o ka hana ʻana o kou ate i ka lāʻau. Inā he maʻi hepatitis B a i ʻole C kāu me ka maʻi HIV, ʻoi aku ka nui o ka nānā ʻana i ka hana o kou ate.

ʻO nā hōʻailona o nā pilikia o ke ake e komo pū ana me ka melemele o kou ʻili a i ʻole nā maka, ka mimi ʻeleʻele, nā noho māmā, a i ʻole ka ʻeha mau o ka ʻōpū. Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​e kelepona koke i kāu kauka.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o Maraviroc?

Inā ua lawe hewa ʻoe i ka nui o ka maraviroc ma mua o ka mea i kauoha ʻia, mai hopohopo, akā e kelepona i kāu kauka a i ʻole ke kikowaena mana ʻawaʻawa no ke alakaʻi. ʻO ka lawe ʻana i nā lāʻau hou aʻe hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao e like me ka ʻūlū, ka nausea, a i ʻole nā ​​hoʻololi ʻana o ka puʻuwai.

Mai ho'āʻo e

ʻAʻole pono ʻoe e hooki i ka lawe ʻana i ka maraviroc me ka ʻole e kūkākūkā mua me kāu kauka. ʻOi aku ka maikaʻi o nā lāʻau lapaʻau HIV ke lawe mau ʻia, a ʻo ka hooki ʻana i ka lāʻau koke hiki ke alakaʻi i ka hoʻi hou ʻana o ka maʻi a me ka hoʻomohala ʻana i ke kūpaʻa.

Hiki i kāu kauka ke noʻonoʻo e hoʻololi i kāu lāʻau lapaʻau inā ʻoe e ʻike nei i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, inā e kūpaʻa ana kāu HIV i ka maraviroc, a i ʻole inā loaʻa nā koho lapaʻau maikaʻi aʻe no kou kūlana.

Hiki i kekahi poʻe ke hoʻololi i nā ʻano lāʻau HIV like ʻole i ka wā, akā pono e hana mau ʻia kēia hoʻoholo me kāu hui mālama ola ma muli o kāu ukana viral, helu CD4, a me ke kūlana olakino holoʻokoʻa.

Hiki i ka Maraviroc ke launa pū me nā lāʻau lapaʻau ʻē aʻe?

ʻAe, hiki i ka maraviroc ke launa pū me kekahi mau lāʻau lapaʻau ʻē aʻe, ʻo ia ke kumu e pono ai kāu kauka e ʻike e pili ana i nā mea a pau āu e lawe nei, me nā lāʻau lapaʻau ma luna o ka pāʻani, nā mea hoʻohui, a me nā huahana lāʻau.

Hiki i kekahi mau lāʻau lapaʻau ke hoʻonui i nā pae maraviroc i loko o kou koko, e alakaʻi ana i nā hopena ʻaoʻao hou aku. Hiki i nā mea ʻē aʻe ke hoʻemi i nā pae maraviroc, e hoʻemi ana i ka maikaʻi e kūʻē i ka HIV.

Pono paha kāu kauka e hoʻoponopono i kāu mahele maraviroc inā ʻoe e lawe ana i kekahi mau lāʻau lapaʻau e like me kekahi mau antibiotics, nā lāʻau antifungal, a i ʻole nā lāʻau lapaʻau. E nānā mau me kāu kauka lāʻau ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou i ka wā e lawe ana i ka maraviroc.