He aha ʻo Margetuximab-cmkb: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i manaʻo ʻia ʻo Margetuximab-cmkb e hana ana ma ke kōkua ʻana i kāu ʻōnaehana pale e hakakā i nā ʻano maʻi maʻi umauma. No kēia lāʻau lapaʻau i kuhikuhi ʻia i kahi papa i kapa ʻia he monoclonal antibodies, i hoʻolālā ʻia e hoʻopili i nā pūnaewele maʻi a hōʻailona iā lākou no ka luku ʻia e nā pale kūlohelohe o kou kino.

Hiki paha iā ʻoe ke heluhelu e pili ana i kēia lāʻau lapaʻau no ka mea ua ʻike ʻia ʻoe a i ʻole kekahi āu e mālama nei me ka maʻi maʻi umauma HER2-positive. ʻOiai ʻo ke aʻo ʻana e pili ana i nā lāʻau lapaʻau maʻi e hiki ke manaʻo nui, hiki i ka hoʻomaopopo ʻana i kāu mau koho ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu huakaʻi mālama.

He aha ʻo Margetuximab-cmkb?

He antibody i hana ʻia ma ka hale hana ʻo Margetuximab-cmkb e manaʻo ana i kahi protein kikoʻī i kapa ʻia ʻo HER2 i loaʻa ma nā pūnaewele maʻi umauma. E noʻonoʻo iā ia he missile alakaʻi e ʻimi a hoʻopili i nā pūnaewele maʻi, a laila hōʻailona i kāu ʻōnaehana pale e hoʻouka iā lākou.

Ua hoʻolālā ʻia kēia lāʻau lapaʻau no ka poʻe me ka maʻi maʻi umauma metastatic HER2-positive. ʻO ka ʻāpana

E ʻōlelo maʻamau kāu kauka i kēia lāʻau lapaʻau ke hoʻāʻo mua ʻoe i nā lāʻau lapaʻau ʻē aʻe i manaʻo ʻia e HER2 e like me trastuzumab (Herceptin) a me pertuzumab (Perjeta). Hoʻohana pinepine ʻia ia me nā lāʻau chemotherapy e hana i kahi ala lapaʻau piha.

Ua ʻae ʻia ka lāʻau lapaʻau no nā hihia i holomua ai ka maʻi maʻi me ka nānā ʻole i nā lāʻau lapaʻau mua. E hoʻāʻo kāu hui mālama ola i kāu mau sela maʻi maʻi e hōʻoia i ka loaʻa ʻana o ka protein HER2 ma mua o ka hoʻomaka ʻana i kēia lapaʻau, no ka mea, ʻaʻole ia e hana no nā maʻi maʻi HER2-negative.

Pehea e Hana ai ʻo Margetuximab-cmkb?

Hana ʻo Margetuximab-cmkb ma ka hoʻopaʻa ʻana i ka protein HER2 ma nā sela maʻi maʻi a me ka hoʻohui ʻana i kāu ʻōnaehana pale e kōkua i ka luku ʻana iā lākou. He lāʻau lapaʻau ikaika kēia i hoʻolālā ʻia e ʻoi aku ka maikaʻi ma mua o kekahi mau lāʻau lapaʻau HER2-targeted kahiko.

Ke hoʻopili ka lāʻau lapaʻau i ka protein HER2, ālai ia i nā hōʻailona e kōkua i nā sela maʻi maʻi e ulu a hoʻonui. I ka manawa like, hana ia e like me ka beacon, e kāhea ana i nā sela pale i ka wahi e hoʻouka i nā sela maʻi maʻi i kaha ʻia.

ʻO ka mea e ʻokoʻa ai kēia lāʻau lapaʻau mai nā lāʻau HER2-targeted kahiko, ua hana ʻia ia e hana maikaʻi me kahi ʻano kikoʻī o ka mea hoʻokipa sela pale. Hiki i kēia pilina i hoʻonui ʻia ke kōkua i kāu ʻōnaehana pale e hoʻokomo i kahi pane ikaika i nā sela maʻi maʻi.

Pehea wau e Lawe ai iā Margetuximab-cmkb?

Hāʻawi ʻia ʻo Margetuximab-cmkb ma ke ʻano he intravenous (IV) infusion pololei i loko o kou kahe koko ma kahi kikowaena lapaʻau maʻi maʻi a i ʻole ka haukapila. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home, no ka mea, pono ia i ka nānā pono ʻana a me nā lako kūikawā.

ʻO ka mea maʻamau, e lawe ana kāu infusion mua ma kahi o 120 mau minuke, ʻoiai e lawe maʻamau nā lapaʻau ma hope ma kahi o 30 mau minuke. E nānā pono kāu hui mālama ola iā ʻoe i ka wā o kēlā me kēia infusion a no kekahi manawa ma hope e nānā i nā hopena koke.

ʻAʻole pono ʻoe e pale i ka meaʻai a i ʻole nā mea inu ma mua o kāu lapaʻau ʻana, akā he mea kōkua pinepine ka ʻai ʻana i ka meaʻai māmā ma mua e pale ai i ka nausea. Manaʻo kekahi poʻe he mea hōʻoluʻolu ke lawe mai i kahi puke, papa, a i ʻole mele e kōkua i ka hala ʻana o ka manawa i ka wā o ka hoʻokomo ʻana.

E hāʻawi kāu hui lapaʻau iā ʻoe i nā lāʻau lapaʻau ma mua o kēlā me kēia hoʻokomo ʻana e kōkua i ka pale ʻana i nā hopena maʻi. Hiki i kēia mau lāʻau lapaʻau mua ke komo i nā antihistamines, steroids, a i ʻole nā mea hoʻemi kuni, a he ʻāpana maʻamau lākou o ke kaʻina hana lapaʻau.

Pehea ka lōʻihi e lawe ai au i ka Margetuximab-cmkb?

ʻO ka lōʻihi o ka lapaʻau ʻana me ka margetuximab-cmkb e ʻokoʻa mai kēlā me kēia kanaka a pili i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi i ka lāʻau lapaʻau. Loaʻa ka hapa nui o nā kānaka i nā lapaʻau i kēlā me kēia ʻekolu pule, a e hoʻomau ʻoe i ka wā e kōkua ana ka lāʻau lapaʻau i ka mālama ʻana i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe iā ia.

E nānā mau kāu kauka i kāu holomua ma o nā kiʻi kiʻi, nā hoʻokolohua koko, a me nā hoʻokolohua kino. Inā pau ka pane ʻana o kāu maʻi maʻi i ka lapaʻau a i ʻole ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi, e kūkākūkā kāu hui mālama ola i nā koho ʻē aʻe me ʻoe.

Hiki i kekahi poʻe ke loaʻa kēia lapaʻau no nā mahina he nui a i ʻole nā makahiki, aʻo nā mea ʻē aʻe e hoʻololi i nā lāʻau lapaʻau ʻē aʻe i ka wā mua. ʻO ke kī ka loaʻa ʻana o ke kaulike kūpono ma waena o ka mālama ʻana i kāu maʻi maʻi a me ka mālama ʻana i kou ola maikaʻi.

He aha nā hopena ʻaoʻao o Margetuximab-cmkb?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka margetuximab-cmkb ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama kūpono a me ka nānā ʻana mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike i ka wā o ka lapaʻau ʻana:

• Ka luhi a me ka manaʻo e piʻi nui ana ka luhi ma mua o ka maʻamau
• Ka luaʻi a me kekahi manawa ka luaʻi
• Ka maʻi palahī a i ʻole nā loli i nā hana o ka ʻōpū
• Ka emi ʻana o ka ʻai
• Ke poʻo
• Ka ʻeha o nā ʻiʻo a i ʻole nā hui
• Nā hopena o ka hoʻokomo ʻana e like me ke kuni, ke anu, a i ʻole ka ʻōpala i ka wā o ka mālama ʻana
• Ka helu haʻahaʻa o nā keʻena koko keʻokeʻo, hiki ke hoʻonui i ka pilikia o ka maʻi

He maʻalahi a he kūpono paha kēia mau hopena ʻaoʻao maʻamau a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Nui nā hoʻolālā a kāu hui mālama e kōkua ai i ka mālama ʻana i kēia mau hōʻailona a e hōʻoluʻolu iā ʻoe.

ʻOiai ʻaʻole maʻamau, aia kekahi mau hopena ʻaoʻao koʻikoʻi e pono ai ka lāʻau lapaʻau koke:

• Nā pilikia o ka naʻau, me ka nāwaliwali o ka ʻiʻo o ka naʻau a i ʻole ka puʻuwai ʻole
• Nā hopena maʻi maʻi koʻikoʻi me ka pilikia o ka hanu ʻana a i ʻole ka pehu
• Nā maʻi koʻikoʻi ma muli o ka emi ʻana o ka ʻōnaehana pale
• Nā pilikia o ka māmā a i ʻole ka pilikia o ka hanu ʻana
• Ka maʻi palahī koʻikoʻi ʻaʻole e pane i ka lāʻau
• Nā hōʻailona o ka maʻi lysis tumor, kahi e wāwahi koke ai nā keʻena maʻi kanesa

E nānā pono kāu hui mālama ola iā ʻoe no kēia mau hopena koʻikoʻi ma o nā hoʻokolohua hana naʻau maʻamau, ka hana koko, a me nā hoʻokolohua kino. Hiki i ka hapa nui o nā kānaka ke hoʻomau i ka mālama ʻana me ka palekana me ka nānā pono a me ka mālama kākoʻo.

ʻO wai ka mea pono ʻole e lawe iā Margetuximab-cmkb?

ʻAʻole kūpono ʻo Margetuximab-cmkb no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. Hoʻolālā kūikawā ʻia kēia lāʻau no nā maʻi kanesa HER2-positive, no laila ʻaʻole ia e hana inā ʻaʻole loaʻa i kāu maʻi kanesa kēia protein.

ʻAʻole pono ʻoe e loaʻa i kēia lāʻau inā ua loaʻa iā ʻoe nā hopena maʻi maʻi koʻikoʻi iā margetuximab-cmkb a i ʻole kekahi o kāna mea i loko i ka wā i hala. E noʻonoʻo pono kāu kauka i kou olakino holoʻokoʻa a me nā maʻi olakino ʻē aʻe āu e loaʻa ai.

ʻO nā kānaka me kekahi mau maʻi puʻuwai e pono paha i ka nānā hou ʻana a i ʻole ʻaʻole paha he moho no kēia lapaʻau. E nānā kāu hui mālama ola i kāu hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lapaʻau a e nānā mau ia i kāu mālama ʻana.

Inā hāpai ʻoe a hānai paha i ka waiū, ʻaʻole i ʻōlelo ʻia kēia lāʻau lapaʻau no ka mea hiki ke hōʻeha i kāu pēpē. E kūkākūkā kāu kauka i nā ʻano hana hoʻomalu hānau kūpono inā he makahiki hānau keiki kāu, no ka mea, pono ʻoe e pale i ka hāpai ʻana i ka wā o ka lapaʻau a no kekahi mau mahina ma hope.

Inoa Brand Margetuximab-cmkb

Kūʻai ʻia ʻo Margetuximab-cmkb ma lalo o ka inoa brand Margenza. ʻO kēia inoa brand ka mea āu e ʻike ai ma kāu papa hana lapaʻau a me nā palapala ʻinikua.

Hana ʻia ka lāʻau lapaʻau e MacroGenics a ua ʻae ʻia e ka FDA i ka makahiki 2020. Ke kūkākūkā ʻana i kāu lapaʻau me kāu hui mālama ola, hiki iā lākou ke kuhikuhi iā ia ma ka inoa generic margetuximab-cmkb a i ʻole ka inoa brand Margenza.

Nā Koho ʻē aʻe o Margetuximab-cmkb

Inā ʻaʻole kūpono ʻo margetuximab-cmkb iā ʻoe a i ʻole e pau ka hana ʻana, aia nā koho lapaʻau ʻē aʻe no ka maʻi maʻi umauma HER2-positive. E hana pū kāu oncologist me ʻoe e ʻimi i ke koho maikaʻi loa e pili ana i kāu kūlana.

ʻO nā lāʻau lapaʻau ʻē aʻe i hoʻopaʻa ʻia i ka HER2, ʻo ia hoʻi ka trastuzumab (Herceptin), pertuzumab (Perjeta), a me ka trastuzumab emtansine (Kadcyla). Hana iki kēlā me kēia o kēia mau mea a kūpono paha ma muli o kāu mau lapaʻau mua a me ke kūlana olakino o kēia manawa.

ʻO nā koho hou aku, ʻo ia hoʻi ka tucatinib (Tukysa) a me ka neratinib (Nerlynx), he mau lāʻau lapaʻau waha e hiki ke lawe ʻia ma ka home. Hiki i kāu kauka ke noʻonoʻo i nā hui pū ʻana o kēia mau lāʻau lapaʻau a i ʻole e hoʻokomo iā lākou me nā lāʻau chemotherapy like ʻole.

ʻO ke koho ʻana i ka lapaʻau ʻē aʻe e pili ana i nā mea he nui, me nā lāʻau lapaʻau āu i hoʻāʻo ai ma mua, pehea ka pane ʻana o kāu maʻi maʻi, a me kou olakino holoʻokoʻa. E alakaʻi kāu hui mālama ola iā ʻoe ma kēia mau koho inā pono.

Ua ʻoi aku ka maikaʻi o Margetuximab-cmkb ma mua o Trastuzumab?

Ua hana ʻia ʻo Margetuximab-cmkb i mea e ʻoi aku ka maikaʻi ma mua o trastuzumab (Herceptin) no kekahi poʻe me ka maʻi ʻaʻai umauma HER2-positive. Ua hōʻike nā haʻawina lapaʻau hiki iā ia ke hāʻawi i nā hopena maikaʻi aʻe no kekahi poʻe maʻi, ʻo ia hoʻi ka poʻe me nā ʻano genetic kikoʻī.

ʻO ka pōmaikaʻi nui o margetuximab-cmkb ʻo ia ka mea i hana ʻia e hana maikaʻi me nā hiki ke hakakā maʻi ʻaʻai maoli o kou ʻōnaehana pale. Hiki i kēia pane immune i hoʻonui ʻia ke kōkua iā ia e ʻoi aku ka maikaʻi ma mua o trastuzumab i kekahi mau hihia.

Eia naʻe, pili ka

Mai ka margetuximab-cmkb e hāʻawi ʻia ana ma ke ʻano he infusion ma kahi keʻena lapaʻau, ʻaʻole ʻoe e poina i kahi mahele ma ka home. Eia naʻe, inā pono ʻoe e hoʻololi i kahi manawa, e hoʻokaʻaʻike i kāu hui mālama ola i ka wā hiki loa e hoʻonohonoho i kahi manawa lapaʻau hou.

He mea nui e hoʻāʻo e noho ma ka papa me kāu mau lapaʻau, no ka mea, ʻo ka hoʻohana mau ʻana e kōkua i ka mālama ʻana i ka pono o ka lāʻau. Hiki i kāu hui ke hana pū me ʻoe e ʻimi i nā manawa manawa e kūpono i kāu papa hana a kōkua iā ʻoe e mālama i nā manawa lapaʻau maʻamau.

Q3. He aha kaʻu e hana ai inā loaʻa iaʻu kahi hopena i ka wā o kaʻu infusion?

Inā ʻike ʻoe i nā hōʻailona maʻamau i ka wā o kāu infusion, e like me ka pilikia o ka hanu ʻana, ka paʻa o ka umauma, ka ʻōpala, a i ʻole nā ​​anu anuanu nui, e makaʻala koke i kāu hui mālama ola. Ua aʻo ʻia lākou e mālama i nā hopena infusion a loaʻa nā lāʻau lapaʻau e mālama koke iā lākou.

ʻO ka hapa nui o nā hopena infusion he maʻalahi a hiki ke mālama ʻia ma ka hoʻolohi ʻana i ka wikiwiki o ka infusion a i ʻole ka hāʻawi ʻana i nā lāʻau lapaʻau hou. E nānā pono kāu hui iā ʻoe i ka wā o kēlā me kēia lapaʻau a hiki ke hoʻoponopono i ka wikiwiki o ka infusion a i ʻole e hoʻōki i ka lapaʻau inā pono.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Margetuximab-cmkb?

E hoʻomau ʻoe i ka lawe ʻana iā margetuximab-cmkb inā e kōkua ana ia i ka mālama ʻana i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe iā ia. E loiloi mau kāu kauka i kāu pane ʻana i ka lapaʻau ma o nā scans a me nā hoʻokolohua koko, a e kūkākūkā i nā hoʻololi i kāu hoʻolālā lapaʻau me ʻoe.

Mai hooki i kēia lāʻau lapaʻau iā ʻoe iho, ʻoiai inā ʻoe e manaʻo maikaʻi ana a i ʻole e ʻike ana i nā hopena ʻaoʻao. Hiki i kāu hui mālama ola ke kōkua i ka mālama ʻana i nā hopena ʻaoʻao a e hana i nā hoʻoponopono e pono ai i kāu hoʻolālā lapaʻau e pili ana i kāu pane a me nā pono.

Q5. Hiki iaʻu ke lawe i nā lāʻau lapaʻau ʻē aʻe i ka wā e loaʻa ana iā Margetuximab-cmkb?

Hiki iā ʻoe ke hoʻomau i ka lawe ʻana i ka hapa nui o kāu mau lāʻau lapaʻau maʻamau i ka wā e loaʻa ana iā margetuximab-cmkb, akā he mea nui e kūkākūkā i kāu mau lāʻau lapaʻau a pau me kāu hui mālama ola. Aia kēia me nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau i kūʻai ʻia ma luna o ka pāʻālua, nā huaora, a me nā mea hoʻohui lāʻau.

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me kāu mālama maʻi ʻaʻai a i ʻole e pili i ke ʻano o ka hana ʻana o kou kino i ka lāʻau lapaʻau. Hiki i kāu kauka a i ʻole ka mea kūʻai lāʻau lapaʻau ke nānā i kāu papa inoa lāʻau lapaʻau piha a hana i nā hoʻoponopono e pono ai e hōʻoia i ka hana pū ʻana o nā mea a pau me ka palekana.