He aha ʻo Mercaptopurine: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Mercaptopurine e kōkua ana i ka mālama ʻana i kekahi mau ʻano maʻi maʻi a me nā maʻi autoimmune ma ka hoʻolohi ʻana i ka ulu ʻana o nā cell abnormal. No kēia lāʻau lapaʻau i kuhikuhi ʻia i kahi hui i kapa ʻia ʻo antimetabolites, e hana ana ma ka hoʻopilikia ʻana i ke ʻano o ka hana ʻana o nā cell i ka DNA a me RNA. Hiki i kāu kauka ke kuhikuhi i kēia lāʻau lapaʻau ma ke ʻano he ʻāpana o kāu hoʻolālā lapaʻau no ka leukemia a i ʻole ka maʻi ʻāʻī.

He aha ʻo Mercaptopurine?

He lāʻau lapaʻau chemotherapy waha ʻo Mercaptopurine i hele mai i ke ʻano papa. Ua hoʻolālā ʻia e kuhikuhi i nā cell e mahele wikiwiki ana, e komo pū ana me nā cell maʻi a me kekahi mau cell olakino i kou kino. Hana ka lāʻau lapaʻau ma ka hoʻohālike ʻana i kahi mea maoli e pono ai kāu mau cell e ulu a mahele.

Ua hoʻohana palekana ʻia kēia lāʻau lapaʻau no nā makahiki he nui e mālama i nā maʻi like ʻole. ʻOiai ua manaʻo ʻia he lāʻau chemotherapy, ʻoi aku ka haʻahaʻa o nā mea i hoʻohana ʻia ma mua o ka mea āu e manaʻo ai mai nā lāʻau lapaʻau maʻi maʻamau. E nānā pono kāu kauka i kāu pane a hoʻoponopono i ka nui e like me ka mea e pono ai.

No ke aha e hoʻohana ʻia ai ʻo Mercaptopurine?

Hoʻomaʻamaʻa ʻo Mercaptopurine i ka leukemia lymphoblastic acute (ALL), kahi ʻano maʻi koko e pili ana i nā keʻokeʻo keʻokeʻo. Ua kuhikuhi ʻia nō hoʻi no nā maʻi ʻāʻī e like me ka maʻi Crohn a me ka ulcerative colitis i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe.

No nā maʻi leukemia, ʻo kēia lāʻau lapaʻau he ʻāpana maʻamau o kahi hoʻolālā lapaʻau lōʻihi e komo pū ana me nā lāʻau lapaʻau ʻē aʻe. ʻO ka pahuhopu e kōkua i kou kino e hoʻopau i nā cell maʻi a pale iā lākou mai ka hoʻi ʻana mai. I ka maʻi ʻāʻī, kōkua ʻo mercaptopurine i ka hoʻomaha ʻana i ka pane nui o kāu ʻōnaehana pale e hoʻoulu ai i ka mumū i loko o kāu ʻōnaehana digestive.

I kekahi manawa, kuhikuhi nā kauka i ka mercaptopurine no nā maʻi autoimmune ʻē aʻe ke hāʻawi ʻole nā lāʻau lapaʻau maʻamau i ka hōʻoluʻolu lawa. E wehewehe pono kāu mea mālama ola i ke kumu kūpono o kēia lāʻau lapaʻau no kou kūlana kikoʻī.

Pehea e hana ai ka Mercaptopurine?

Hana ʻo Mercaptopurine ma ka hoʻohui ʻia ʻana i ke kaʻina hana DNA a me RNA o kāu mau keena. Ke hoʻāʻo nā keena ʻino e ulu a māhele, keakea ka lāʻau lapaʻau i ko lākou hiki ke kope pololei i kā lākou mea genetic. ʻO kēia ke kumu e make ai kēia mau keena pilikia.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika iki, akā ua ʻae maikaʻi ʻia ke hoʻohana ʻia i nā lāʻau kūpono. Hoʻoponopono kou kino i ka mercaptopurine ma o kou ate, kahi e hoʻololi ʻia ai i nā ʻano hana e hana maoli ai. Lawe kēia kaʻina hana i ka manawa, ʻo ia ke kumu ʻaʻole ʻoe e ʻike i nā hopena koke.

No ka mea e pili ana ka mercaptopurine i ka mahele ʻana o ke keena, hiki iā ia ke hoʻopilikia i nā keena ʻino a me kekahi mau keena olakino e māhele wikiwiki ana. Aia kēia i nā keena i loko o kou iwi iwi, ka ʻōpū digestive, a me ka ʻōnaehana pale. E nānā pono kāu kauka i kēia mau wahi i ka wā o ka mālama ʻana.

Pehea wau e lawe ai i ka Mercaptopurine?

E lawe i ka mercaptopurine e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā ma ka ʻōpū ʻole. ʻO ka manawa maikaʻi loa ma kahi o hoʻokahi hola ma mua o ka ʻai ʻana a i ʻole ʻelua hola ma hope o ka ʻai ʻana, no ka mea hiki i ka meaʻai ke keakea i ka maikaʻi o kou kino e komo ai i ka lāʻau lapaʻau.

E ale i nā papa holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a ʻokiʻoki paha iā lākou, no ka mea hiki i kēia ke hoʻopilikia i ka hana ʻana o ka lāʻau lapaʻau. Inā pilikia ʻoe i ka ale ʻana i nā papa, e kamaʻilio me kāu kauka lapaʻau e pili ana i nā koho e kōkua ai.

E ho'āʻo e lawe i kāu lāʻau lapaʻau i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i loko o kou kahe koko. Nui ka poʻe i ʻike he mea kōkua ke hoʻonohonoho i kahi hoʻomanaʻo i kēlā me kēia lā ma kā lākou kelepona. Inā ʻoe e lawe ana i nā lāʻau lapaʻau ʻē aʻe, e nānā me kāu kauka e pili ana i ka manawa maikaʻi loa e pale ai i nā pilina.

E hōʻalo i ka inu ʻana i ka waiʻona i ka wā e lawe ana i ka mercaptopurine, no ka mea, hiki ke hoʻonui i ka pilikia o nā pilikia o ke ake. Eia kekahi, e hōʻalo i ka huaʻala a me ka wai huaʻala, hiki ke hoʻopilikia i ke ʻano o ka hana ʻana o kou kino i ka lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Mercaptopurine?

ʻO ka lōʻihi o ka mālama ʻana i ka mercaptopurine e loli nui ana ma muli o kou maʻi a me ka maikaʻi o kou pane ʻana i ka lāʻau. No ka leukemia, hoʻomau pinepine ka mālama ʻana no ʻelua a ʻekolu mau makahiki ma ke ʻano he ʻāpana o ka mālama ʻana ma hope o ka mālama ʻana mua.

Inā ʻoe e lawe ana i ka mercaptopurine no ka maʻi ʻōpū mumū, pono paha ʻoe ia no kekahi mau mahina a i ʻole mau makahiki. Pono kekahi poʻe i ka mālama lōʻihi e mālama i ko lākou maʻi ma lalo o ka mana. E loiloi mau kāu kauka inā pono a pono ka lāʻau lapaʻau iā ʻoe.

Mai hooki i ka lawe ʻana i ka mercaptopurine me ka ʻole e kamaʻilio mua me kāu kauka. ʻO ka hooki koke ʻana hiki ke hoʻoulu i kou maʻi a i ʻole e ʻino. Inā pono ʻoe e hooki i ka lāʻau lapaʻau, e hana kāu kauka i kahi hoʻolālā e hana pēlā me ka palekana.

He aha nā hopena ʻaoʻao o Mercaptopurine?

E like me nā lāʻau lapaʻau a pau, hiki i ka mercaptopurine ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao a maikaʻi ke hoʻololi kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Nausea a me ka nalowale o ka ʻai
• Luhi a me ka nāwaliwali
• Hoʻonui ʻia ka pilikia o nā maʻi ma muli o ka emi ʻana o ka helu o nā keʻena koko keʻokeʻo
• Maʻalahi ka ʻeha a i ʻole ke kahe ʻana mai nā helu platelet haʻahaʻa
• Nā ʻeha waha a i ʻole nā ʻōpū
• Pāpaʻa a i ʻole ka ʻoluʻolu o ka ʻōpū
• Hoʻopōkole lauoho (maʻamau maʻalahi)

ʻO kēia mau hopena maʻamau e lilo pinepine i mea liʻiliʻi ke hoʻomau ʻia kāu mālama ʻana. Hiki i kāu hui mālama ola ke hōʻike i nā ala e mālama pono ai iā lākou.

Hiki ke loaʻa nā hopena ʻaoʻao koʻikoʻi, ʻoiai ʻaʻole maʻamau. Pono kēia mau mea i ka mālama olakino koke a komo pū:

• Nā hōʻailona o nā pilikia o ke ake e like me ka melemele o ka ʻili a i ʻole nā maka, ka mimi ʻeleʻele, a i ʻole ka nausea mau
• Nā maʻi koʻikoʻi me ke kuni, nā anu, a i ʻole ka ʻū mau
• Ke kahe ʻana o ke koko a i ʻole ka ʻeha ʻana i ka maʻamau ʻole
• ʻEha ʻōpū nui a i ʻole ka luaʻi mau
• Nā hopena maʻi maʻi me ka ʻōpala, ka pilikia o ka hanu ʻana, a i ʻole ka pehu

E nānā pono kāu kauka iā ʻoe me nā hoʻokolohua koko maʻamau e hopu i nā pilikia i ka wā mua. Mai kānalua e hoʻokaʻaʻike i kāu hui mālama ola inā ʻike ʻoe i nā hōʻailona e pili ana.

ʻO kekahi mau hopena ʻaoʻao maʻamau akā koʻikoʻi e komo pū ana me ka hoʻopaʻa ʻana i ka iwi iwi, ka ʻona o ke ake, a me ka piʻi ʻana o ka pilikia o kekahi mau maʻi maʻi me ka hoʻohana lōʻihi. E ana kāu kauka i kēia mau pilikia i nā pōmaikaʻi o ka mālama ʻana no kou kūlana kikoʻī.

ʻO wai ka mea pono ʻole e lawe iā Mercaptopurine?

ʻAʻole kūpono ʻo Mercaptopurine no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Pono paha nā kānaka me kekahi mau ʻano genetic e pili ana i ke ʻano o ka hana ʻana i ka lāʻau lapaʻau i nā ʻano lāʻau like ʻole a i ʻole nā lāʻau lapaʻau ʻē aʻe.

ʻAʻole pono ʻoe e lawe iā mercaptopurine inā he maʻi ʻoe iā ia a i ʻole nā lāʻau lapaʻau like. E haʻi i kāu kauka e pili ana i nā hopena maʻi maʻi i nā lāʻau chemotherapy a i ʻole nā lāʻau lapaʻau ʻē aʻe. ʻO ka hāpai ʻana kekahi mea nui e noʻonoʻo ai, no ka mea, hiki i ka mercaptopurine ke hōʻino i kahi pēpē e ulu ana.

Pono kekahi mau maʻi olakino i ka mālama hou aʻe a i ʻole e pale iā ʻoe mai ka lawe ʻana iā mercaptopurine me ka palekana:

• Maʻi ate koʻikoʻi a i ʻole hepatitis hana
• Nā maʻi iwi iwi e kū nei
• Nā maʻi hana ʻole i ka mana
• Maʻi kīkī e koi ana i nā hoʻoponopono ʻana i ka mahele
• Nā hopena koʻikoʻi i nā lāʻau lapaʻau like

Inā ʻoe e hoʻolālā ana e hāpai a i ʻole e hānai ana i ka waiū, e kūkākūkā me kāu kauka. Pono nā kāne a me nā wahine e hoʻohana i ka mana hānau pono i ka wā o ka mālama ʻana a no kekahi manawa ma hope.

E noʻonoʻo nō hoʻi kāu kauka i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, no ka mea, hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka mercaptopurine. Aia kēia i kekahi mau lāʻau antibiotic, nā mea hoʻokahe koko, a me nā lāʻau lapaʻau e hoʻopau ana i ka ʻōnaehana pale.

Nā inoa inoa o Mercaptopurine

Loaʻa ka Mercaptopurine ma lalo o nā inoa inoa like ʻole, ʻo Purinethol ka mea i ʻike nui ʻia. Hiki nō hoʻi iā ʻoe ke ʻike ʻia e like me 6-mercaptopurine a i ʻole 6-MP i nā palapala lapaʻau a me nā kūkākūkā me kāu hui mālama ola.

Loaʻa nui nā mana generic o mercaptopurine a hana like ka maikaʻi me nā mana inoa inoa. Hiki i kāu hale kūʻai lāʻau lapaʻau ke pani i ka ʻano generic ke ʻole kāu kauka e noi pono i ka inoa inoa. Loaʻa i nā ʻano ʻelua ka mea hana like a hoʻokō i nā kūlana palekana a me ka pono.

Nā koho ʻē aʻe o Mercaptopurine

Hiki ke noʻonoʻo ʻia kekahi mau lāʻau lapaʻau ʻē aʻe inā ʻaʻole kūpono ka mercaptopurine iā ʻoe a i ʻole ʻaʻole hana maikaʻi. Aia ke koho i kāu kūlana kikoʻī, ka mōʻaukala olakino, a me ke ʻano o kāu pane ʻana i nā lāʻau lapaʻau ma mua.

No ka maʻi ʻāʻī ʻāʻī, nā koho ʻē aʻe e komo pū me azathioprine (ua pili pili i ka mercaptopurine), methotrexate, a i ʻole nā lāʻau lapaʻau biologic hou e like me infliximab a i ʻole adalimumab. Loaʻa i kēlā me kēia mea kona mau pono a me ka hopena ʻaoʻao e kūkākūkā ai kāu kauka me ʻoe.

I ka mālama ʻana i ka maʻi maʻi, hiki i nā koho ʻē aʻe ke komo i nā lāʻau chemotherapy ʻē aʻe, nā lāʻau lapaʻau i manaʻo ʻia, a i ʻole nā koho immunotherapy. E noʻonoʻo kāu oncologist i nā mea e like me kāu ʻano maʻi maʻi, ke kahua o ka maʻi, a me ke olakino holoʻokoʻa i ka wā e ʻōlelo ai i nā koho ʻē aʻe.

Pono e hana ʻia ka hoʻoholo e hoʻololi i nā lāʻau lapaʻau ma ke kūkākūkā ʻana me kāu hui mālama ola. Hiki iā lākou ke kōkua iā ʻoe e loiloi i nā pono a me nā pōʻino o nā koho like ʻole e pili ana i kāu kūlana pilikino.

Ua ʻoi aku ka maikaʻi o Mercaptopurine ma mua o Azathioprine?

He mau lāʻau lapaʻau pili pili ʻo Mercaptopurine a me azathioprine e hana ana ma nā ʻano like, akā ʻaʻole like lākou. Hoʻololi ʻia ʻo Azathioprine i mercaptopurine i loko o kou kino, no laila ʻo mercaptopurine ke ʻano hana e hana maoli ai.

ʻAʻole maikaʻi loa kekahi lāʻau lapaʻau ma mua o kekahi - pili ka koho i kāu mau kūlana pilikino. ʻAe kekahi poʻe i kekahi ma mua o kekahi, aʻo kekahi mau kauka e makemake i kekahi e pili ana i kā lākou ʻike a i ʻole nā ​​ʻano kikoʻī o kou maʻi.

Hoʻāʻo pinepine ʻia ʻo Azathioprine no ka maʻi ʻōpū mumū no ka mea ua aʻo nui ʻia no kēia hoʻohana. Eia naʻe, makemake ʻia ʻo mercaptopurine inā loaʻa iā ʻoe kekahi mau ʻano genetic e pili ana i ke ʻano o kāu hana ʻana i ka azathioprine. Hiki i kāu kauka ke kauoha i ka hoʻāʻo genetic e kōkua i ke alakaʻi ʻana i kēia hoʻoholo.

Pono nā lāʻau lapaʻau ʻelua i ka nānā ʻana a loaʻa nā ʻano hopena ʻaoʻao like. ʻO ka hoʻoholo ma waena o lākou e pili pinepine ana i ka makemake o kāu kauka, kāu pane ʻana i ka lāʻau lapaʻau, a me nā mea kikoʻī i kāu mōʻaukala olakino.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Mercaptopurine

Q1. He palekana anei ʻo Mercaptopurine no ka hoʻohana lōʻihi?

Hiki ke hoʻohana palekana ʻia ʻo Mercaptopurine no nā wā lōʻihi ke nānā pono ʻia e kāu hui mālama ola. Nui ka poʻe e lawe iā ia no nā mahina a i ʻole nā ​​makahiki me ka ʻole o nā pilikia koʻikoʻi. E nānā mau kāu kauka i kāu helu koko, hana ate, a me ke olakino holoʻokoʻa e hōʻoia i ka palekana a me ka maikaʻi o ka lāʻau lapaʻau iā ʻoe.

He nui nā pilikia i ka hoʻohana ʻana i ka wā lōʻihi, me ka piʻi iki ʻana o ka hiki ke loaʻa i kekahi mau maʻi a i ʻole, i kekahi manawa, nā maʻi ʻē aʻe. Akā naʻe, no ka hapa nui o nā kānaka, ʻoi aku ka maikaʻi o ka mālama ʻana i ko lākou maʻi ma mua o kēia mau pilikia. E kūkākūkā kāu kauka i kēia mau mea me ʻoe a hoʻoponopono i kāu hoʻolālā lapaʻau e like me ka mea e pono ai.

Q2. He aha kaʻu e hana ai inā ua lawe au i ka nui o ka Mercaptopurine?

Inā ua lawe ʻoe i ka nui o ka mercaptopurine ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make, ʻoiai inā maikaʻi ʻoe. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i ka pilikia o nā hopena ʻaoʻao koʻikoʻi, e pili ana i kāu helu koko a me ka hana ate.

Mai kali a hiki i ka hōʻike ʻana o nā hōʻailona ma mua o ka ʻimi ʻana i ke kōkua. E kākau i lalo i ka nui āu i lawe ai a me ka manawa, no ka mea, e kōkua kēia ʻike i nā mea mālama ola e hoʻoholo i ke ala maikaʻi loa o ka hana. I kekahi mau hihia, pono paha ʻoe i nā hoʻokolohua koko hou a i ʻole ka nānā ʻana e hōʻoia i kou palekana.

Q3. He aha kaʻu e hana ai inā ua hala au i ka mahele o Mercaptopurine?

Inā ua hala ʻoe i kahi mahele a aia i loko o kekahi mau hola o kou manawa maʻamau, e lawe koke iā ia ke hoʻomanaʻo ʻoe. Akā naʻe, inā kokoke ka manawa no kāu mahele aʻe, e lele i ka mahele i hala a hoʻomau me kāu papa manawa maʻamau. Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻopiha ai i kahi mahele i hala.

Inā poina pinepine ʻoe i nā mahele, e kamaʻilio me kāu kauka e pili ana i nā hoʻolālā e kōkua iā ʻoe e hoʻomanaʻo. He mea nui ka hoʻopaʻa ʻana i ka mahele no ka hana pono ʻana o ka lāʻau. E noʻonoʻo e hoʻonohonoho i nā ʻōhua kelepona, e hoʻohana i kahi mea hoʻonohonoho pila, a i ʻole e hoʻopili i kāu lāʻau i kahi hana maʻamau i kēlā me kēia lā.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Mercaptopurine?

ʻO ka hoʻoholo e hooki i ka mercaptopurine e hana mau ʻia me ke alakaʻi a kāu kauka. No ka mālama ʻana i ka maʻi kanesa, aia maʻamau kahi hoʻolālā lapaʻau i hoʻonohonoho mua ʻia e kuhikuhi ana i ka lōʻihi o kou pono i ka lāʻau. No ka maʻi ʻōpū inflammatory, pili ka manawa i ka maikaʻi o ka mālama ʻana i kou maʻi a inā paha e kūpono nā lāʻau lapaʻau ʻē aʻe.

E noʻonoʻo kāu kauka i nā mea e like me kāu pane ʻana i ka lāʻau lapaʻau, nā hopena ʻaoʻao āu e ʻike nei, a me ka pilikia o ka hoʻi ʻana mai o kou maʻi. Hiki iā lākou ke hoʻemi mālie i kāu mahele lāʻau ma mua o ka hoʻōki koke ʻana e hōʻemi i ka pilikia o ka flare-ups.

Q5. Hiki iaʻu ke loaʻa nā lāʻau lapaʻau ʻoiai e lawe ana i ka Mercaptopurine?

He palekana ka hapa nui o nā lāʻau lapaʻau maʻamau ʻoiai e lawe ana i ka mercaptopurine, akā pono ʻoe e pale i nā lāʻau lapaʻau ola e like me ka lāʻau flu nasal, ka lāʻau chickenpox, a i ʻole ka lāʻau MMR. Hiki ke hoʻopaʻa ʻia kāu ʻōnaehana pale, no laila hiki i nā lāʻau lapaʻau ola ke hana i nā pilikia.

Manaʻo ʻia a palekana nā lāʻau lapaʻau i hoʻopau ʻia e like me ka pana flu, ka lāʻau pneumonia, a me nā lāʻau lapaʻau COVID-19. Eia naʻe, ʻaʻole paha lākou e hana maikaʻi e like me ka maʻamau no ka mea ua hoʻemi ʻia kāu pane immune. E nānā mau me kāu hui mālama ola ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau e hōʻoia i ka kūpono no kou kūlana.