He aha ʻo Midostaurin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻo Midostaurin e kōkua ana i ka mālama ʻana i kekahi mau ʻano maʻi koko, ʻo ia hoʻi ka acute myeloid leukemia (AML) a me ka mastocytosis systemic holomua. Hana kēia lāʻau lapaʻau waha ma ka pale ʻana i nā protein kikoʻī e kōkua ana i nā cell maʻi e ulu a laha i loko o kou kino.

Inā ua kauoha kāu kauka iā midostaurin, ke hana nei ʻoe me kahi maʻi koʻikoʻi e pono ai ka mālama kūikawā. ʻOiai he mea kaumaha paha kēia, ʻo ka hoʻomaopopo ʻana i ka hana ʻana o kēia lāʻau lapaʻau hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu huakaʻi lapaʻau.

He aha ʻo Midostaurin?

He ʻano lapaʻau maʻi ʻo Midostaurin i kapa ʻia he kinase inhibitor. Ua hoʻolālā ʻia e kuhikuhi a pale i kekahi mau enzymes e pono ai nā cell maʻi e ola a hoʻonui.

E noʻonoʻo iā ia he kī kikoʻī loa e kūpono i nā laka kikoʻī ma nā cell maʻi. Ke hoʻopaʻa ʻo midostaurin i kēia mau

No ka systemic mastocytosis, kōkua ʻo midostaurin ke holomua ka maʻi i kahi pae kiʻekiʻe. Hoʻokumu kēia maʻi laha i ka nui o nā cell mast (he ʻano cell immune) e kūkulu i loko o kou mau ʻōkana, e alakaʻi ana i nā hōʻailona like ʻole ma kou kino.

E hana kāu kauka i nā hoʻokolohua genetic kikoʻī e hōʻoia inā ʻo midostaurin ka lāʻau lapaʻau kūpono no kāu ʻano maʻi maʻi.

Pehea e Hana ai ʻo Midostaurin?

Hana ʻo Midostaurin ma ka pale ʻana i nā enzyme kinase he nui e hilinaʻi ai nā cell maʻi maʻi no ke ola. Hana kēia mau enzyme e like me nā kuapo e haʻi ana i nā cell i ka wā e ulu ai, mahele, a i ʻole e noho ola.

Hoʻopā pololei ka lāʻau lapaʻau i nā kinase FLT3, KIT, a me PDGFR. Ke hana nui kēia mau enzyme ma muli o nā loli genetic, hoʻouna lākou i nā hōʻailona

E ale i nā capsules holoʻokoʻa me ke aniani wai piha. Mai wehe, ʻoki, a nau paha iā lākou, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o kou kino. Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe.

E hoʻāʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā, e hoʻokaʻawale iā lākou ma kahi o 12 mau hola. Kōkua kēia i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kāu ʻōnaehana. Nui ka poʻe i ʻike he mea kōkua ke lawe i nā lāʻau me ka ʻaina kakahiaka a me ka ʻaina ahiahi.

Pehea ka lōʻihi e lawe ai au i ka Midostaurin?

ʻO ka lōʻihi o ka mālama ʻana i ka midostaurin e ʻokoʻa loa ma muli o kou kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. E hoʻoholo kāu kauka i ka lōʻihi kūpono o ka mālama ʻana no kou kūlana.

No AML, inā e loaʻa ana iā ʻoe ka midostaurin me ka chemotherapy, e lawe maʻamau ʻoe i ka wā o nā pōʻai chemotherapy a hiki ke hoʻomau no ka 12 mau pōʻai inā ʻae maikaʻi kou kino. Ma hope o ka mālama mua ʻana, hiki i kekahi poʻe ke lawe i ka midostaurin wale nō ma ke ʻano he mālama.

No ka systemic mastocytosis, hoʻomau pinepine ka mālama ʻana i ka wā e kōkua ana ka lāʻau lapaʻau i ka mālama ʻana i kou kūlana a ʻaʻole ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi. Hiki i kēia ke lawe iā ia no nā mahina a i ʻole nā ​​makahiki.

E loiloi mau kāu kauka i kāu holomua ma o nā hoʻokolohua koko, nā scans, a me nā hoʻokolohua kino. E hoʻoponopono lākou i kāu hoʻolālā lapaʻau ma muli o ke ʻano o ka pane ʻana o kāu maʻi maʻi a me ke ʻano o kou kino e mālama ai i ka lāʻau lapaʻau. Mai hooki i ka lawe ʻana i ka midostaurin me ka ʻole e kūkākūkā mua me kāu hui mālama ola.

He aha nā hopena ʻaoʻao o Midostaurin?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka midostaurin ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. He nui nā hopena ʻaoʻao e hiki ke mālama ʻia me ka nānā pono a me ka mālama kākoʻo mai kāu hui lapaʻau.

E hoʻomaka kākou me nā hopena ʻaoʻao maʻamau e hiki ke loaʻa iā ʻoe. Loaʻa kēia mau mea i nā kānaka he nui e lawe ana i ka midostaurin, akā maʻamau lākou i ka maʻalahi a i ka waena a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau:

• Nausea a me ka luaʻi
• Pāpaʻa a i ʻole ka paʻa ʻana
• Nā poʻo
• ʻĀwili
• Luhi a me ka nāwaliwali
• Hoʻemi ʻia ka ʻai
• ʻEha ʻiʻo a me ka iwi
• Pāpaʻa ʻili a i ʻole ka ʻū
• Fiva
• Pehu i nā lima, nā wāwae, a i ʻole nā wāwae

He manawa pōkole kēia mau hopena ʻaoʻao maʻamau a hiki ke mālama ʻia me nā lāʻau a i ʻole nā hoʻololi ola. E hāʻawi kāu hui mālama ola i ke alakaʻi kikoʻī i ka mālama ʻana i kēlā me kēia.

ʻOi aku ka koʻikoʻi o kekahi mau hopena ʻaoʻao a pono e mālama koke ʻia. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike i ka mea e nānā ai:

• Pōkole hanu nui a i ʻole ka pilikia o ka hanu
• ʻEha umauma a i ʻole ka puʻuwai ʻole
• Nā hōʻailona o ka maʻi e like me ke kuni mau, nā anu, a i ʻole ka nāwaliwali ʻole
• Ke kahe ʻana o ke koko a i ʻole ka ʻeha ʻole
• ʻEha ʻōpū nui a i ʻole nā noho koko
• Melemele o ka ʻili a i ʻole nā maka (jaundice)
• Nā hopena ʻili nui a i ʻole ka pāpaʻa ākea
• Luaʻi mau e pale iā ʻoe mai ka mālama ʻana i ka meaʻai a i ʻole nā wai

E hoʻokaʻaʻike koke i kāu kauka inā loaʻa iā ʻoe kekahi o kēia mau hopena ʻaoʻao koʻikoʻi. Pono paha lākou e hoʻoponopono i kāu mahele a i ʻole e hāʻawi i ka lāʻau lapaʻau hou e kōkua i ka mālama ʻana i kēia mau hōʻailona.

Aia kekahi mau hopena ʻaoʻao laha akā hiki ke koʻikoʻi e loaʻa ana i kahi pākēneka liʻiliʻi o nā kānaka e lawe ana i ka midostaurin. Aia kēia mau mea i nā pilikia o ka māmā (e like me ka maʻi māmā interstitial), nā pilikia ate nui, a me nā maʻi puʻuwai. E nānā mau kāu kauka iā ʻoe me nā hoʻokolohua koko a me nā hoʻokolohua ʻē aʻe e hopu iā lākou i ka wā mua inā loaʻa lākou.

ʻO wai ka mea ʻaʻole pono e lawe i ka Midostaurin?

ʻAʻole kūpono ʻo Midostaurin no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia nāu. Hiki i kekahi mau maʻi olakino a me nā lāʻau lapaʻau ke hoʻoweliweli a i ʻole ka liʻiliʻi o ka midostaurin.

ʻAʻole pono ʻoe e lawe i ka midostaurin inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mau mea. ʻO nā hōʻailona o nā hopena maʻi e komo pū ana me ka ʻeha nui, ka pilikia o ka hanu ʻana, a i ʻole ka pehu ʻana o kou maka, nā lehelehe, ke alelo, a i ʻole ka ʻāʻī.

He nui nā maʻi olakino e koi ai i ka akahele hou aʻe a i ʻole e pale iā ʻoe mai ka lawe ʻana i ka midostaurin me ka palekana. Pono kāu kauka e ʻike e pili ana i kēia mau mea ma mua o ke kau ʻana i ka lāʻau:

• ʻO ka maʻi ate nui a i ʻole nā pilikia o ka hana ate
• Nā maʻi puʻuwai a i ʻole nā maʻi puʻuwai
• Nā pilikia o ka māmā a i ʻole nā pilikia o ka hanu
• Nā maʻi hana a i ʻole ka nāwaliwali o ka ʻōnaehana pale
• Nā maʻi koko a i ʻole ke ʻoki hou ʻana
• Maʻi kīkī
• Hāpai a i ʻole nā hoʻolālā e hāpai
• Ka hānai ʻana a i ʻole nā hoʻolālā e hānai

Nui nā lāʻau lapaʻau e hiki ke launa pū me ka midostaurin, e hiki ai ke hoʻemi i ka pono a i ʻole ka hoʻonui ʻana i nā hopena ʻaoʻao. E hōʻoia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau a pau āu e lawe nei, me nā lāʻau lapaʻau i kau ʻia, nā lāʻau lapaʻau ma luna o ka pāʻani, nā huaora, a me nā mea hoʻohui lāʻau.

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, hiki i ka midostaurin ke hōʻino i kāu pēpē i hānau ʻole ʻia. Pono nā kāne a me nā wahine e hoʻohana i ka mana hānau kūpono i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope o ka hoʻōki ʻana i ka lāʻau.

Nā inoa inoa Midostaurin

Loaʻa ka Midostaurin ma lalo o ka inoa inoa Rydapt ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia ka inoa maʻamau āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau.

I kekahi mau ʻāina, hiki ke kūʻai ʻia ka midostaurin ma lalo o nā inoa inoa like ʻole, akā like ka mea hana. E nānā mau me kāu kauka lapaʻau inā he nīnau kāu e pili ana i kāu lāʻau lapaʻau a i ʻole inā e hele ana ʻoe a pono e hoʻopiha hou i kāu kauoha ma waho.

Ua hana ʻia ka lāʻau lapaʻau e Novartis, a loaʻa wale nō me ka palapala kauoha mai kahi oncologist a i ʻole hematologist i loea i ka mālama ʻana i nā maʻi koko.

Nā Koho ʻē aʻe no Midostaurin

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i nā maʻi like me midostaurin, akā naʻe, pili ka koho maikaʻi loa i kāu ʻano maʻi maʻi a me ke ʻano genetic. E koho kāu kauka i ka lāʻau lapaʻau kūpono loa e pili ana i kou kūlana pilikino.

No AML me nā loli FLT3, hiki i nā koho ʻē aʻe ke komo i ka gilteritinib (Xospata), he mea pale FLT3 ʻē aʻe e hana like me midostaurin. ʻO Quizartinib kekahi koho ʻē aʻe i loaʻa i kekahi mau kūlana.

No ka mastocytosis systemic, nā koho ʻē aʻe e komo i ka imatinib (Gleevec) no kekahi mau ʻano o ke kūlana, a i ʻole avapritinib (Ayvakit) no nā hihia holomua. Hiki nō hoʻi ke noʻonoʻo ʻia nā ʻano chemotherapy kuʻuna i kekahi mau kūlana.

Pili ka koho ma waena o kēia mau lāʻau lapaʻau i nā mea e like me nā loli genetic kikoʻī i loko o kāu mau sela maʻi maʻi, kou olakino holoʻokoʻa, nā lāʻau lapaʻau āu i loaʻa ai ma mua, a me ka maikaʻi o kou hiki ke ʻae i nā hopena ʻaoʻao like ʻole. E kūkākūkā kāu kauka i kēia mau koho me ʻoe inā ʻaʻole kūpono ʻo midostaurin a i ʻole e pau ka hana pono.

Ua ʻoi aku ka maikaʻi o Midostaurin ma mua o nā mea pale FLT3 ʻē aʻe?

Loaʻa i ka Midostaurin a me nā mea pale FLT3 ʻē aʻe ko lākou mau ikaika ponoʻī a hoʻohana ʻia i nā kūlana like ʻole. ʻAʻole pono he koho

Hoʻohana maʻamau ʻia ʻo Gilteritinib (Xospata) no ka poʻe i hoʻi mai kā lākou AML ma hope o ka mālama mua ʻana. Hōʻike nā haʻawina he ʻoi aku ka ikaika o ia mea i nā loli FLT3 ma mua o midostaurin, akā hoʻohana mua ʻia ia i nā kūlana like ʻole.

Aia ke koho ma waena o kēia mau lāʻau i ka loaʻa ʻana o ka mālama mua ʻana a i ʻole ka mālama ʻana no ka maʻi i hoʻi hou ʻia, kāu mau loli genetic kikoʻī, a pehea ka pane ʻana o kou kino i ka mālama ʻana. E noʻonoʻo kāu kauka i kēia mau mea a pau i ka wā e ʻōlelo ai i ke koho maikaʻi loa no kou kūlana.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Midostaurin

He Palekana ʻo Midostaurin no ka poʻe me ka maʻi puʻuwai?

Pono ʻo Midostaurin i ka mālama kūikawā inā he pilikia kou puʻuwai. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai a me ka hana, no laila pono kāu kauka e loiloi pono i ke olakino o kou puʻuwai ma mua o ke kau ʻana.

Inā he moʻolelo kou o ka maʻi puʻuwai, e kauoha paha kāu kauka i kahi electrocardiogram (EKG) a me nā hoʻokolohua puʻuwai ʻē aʻe ma mua o ka hoʻomaka ʻana i ka mālama ʻana. E nānā pū lākou i kou puʻuwai i nā manawa maʻamau i ka wā o ka mālama ʻana e nānā i nā loli.

ʻAʻole pono kēia manaʻo ʻaʻole hiki iā ʻoe ke lawe i ka midostaurin inā he pilikia kou puʻuwai, akā ʻo ia hoʻi e pono ʻoe i ka nānā ʻana. E kaupaona kāu kauka i nā pōmaikaʻi o ka mālama ʻana i kāu maʻi maʻi i nā pilikia hiki ke loaʻa i kou puʻuwai.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Midostaurin?

Inā lawe hewa ʻoe i ka nui o midostaurin ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena mana ʻawaʻawa. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi.

Mai ho'āʻo e hoʻoponopono i ka mahele hou ma ka lele ʻana i kāu mahele i hoʻonohonoho ʻia. Akā, e hoʻomau me kāu papa hana maʻamau ke ʻole e haʻi kāu kauka iā ʻoe.

Inā ʻike ʻoe i nā hōʻailona koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻeha o ka umauma, a i ʻole ka nausea a me ka luaʻi nui ʻana ma hope o ka lawe ʻana i ka nui loa, e ʻimi koke i ka lāʻau lapaʻau pilikia. He mea kōkua ke lawe mai i kāu ʻōmole lāʻau lapaʻau me ʻoe i hiki i nā limahana lapaʻau ke ʻike pololei i ka mea a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Midostaurin?

Inā poina iā ʻoe kahi mahele o midostaurin, e lawe koke iā ia ke hoʻomanaʻo ʻoe, inā i loko o 6 mau hola o kāu manawa i hoʻonohonoho ʻia. Inā ua hala ma mua o 6 mau hola, e lele i ka mahele i poina a lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa like e hoʻopiha ai i kahi mahele i poina. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka hāʻawi ʻole ʻana i ka pōmaikaʻi hou.

Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i nā alarms ma kāu kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pill e kōkua iā ʻoe e hoʻomanaʻo. He mea nui ka hoʻopaʻa ʻana i ka lāʻau lapaʻau e hana pono ai.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Midostaurin?

Mai hooki i ka lawe ʻana iā midostaurin me ka kūkākūkā ʻole me kāu kauka mua. ʻO ka hooki ʻana i ka hikiwawe hiki ke ʻae i kāu maʻi maʻi e ulu a laha wikiwiki.

Na kāu kauka e hoʻoholo i ka manawa kūpono e hooki ai ma muli o ka maikaʻi o ka pane ʻana o kāu maʻi maʻi i ka lāʻau lapaʻau, pehea ʻoe e ʻae ai i ka lāʻau lapaʻau, a me kou kūlana olakino holoʻokoʻa. Hana ʻia kēia hoʻoholo ma o ka nānā mau ʻana me nā hoʻokolohua koko a me nā scans.

Pono paha kekahi poʻe e hooki no ka manawa pōkole inā e hoʻomohala lākou i nā hopena ʻaoʻao koʻikoʻi, akā pono e hana mau ʻia kēia ma lalo o ka mālama ʻana i ka lāʻau lapaʻau. Hiki i kāu kauka ke hoʻomaka hou i ka lāʻau lapaʻau ke hoʻomaikaʻi nā hopena ʻaoʻao, me ka haʻahaʻa haʻahaʻa.

Hiki iaʻu ke lawe iā Midostaurin me nā lāʻau lapaʻau maʻi maʻi ʻē aʻe?

Hoʻohana pinepine ʻia ʻo Midostaurin me nā lāʻau lapaʻau maʻi maʻi ʻē aʻe, ʻoi aku hoʻi nā lāʻau chemotherapy e like me daunorubicin a me cytarabine no AML. E hoʻonohonoho kāu kauka i kāu mau lāʻau lapaʻau a pau e hōʻoia i ka hana maikaʻi ʻana.

Eia naʻe, hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka midostaurin, e hoʻemi ana i kona pono a i ʻole e hoʻonui ana i nā hopena ʻaoʻao. Aia kēia i kekahi mau lāʻau antibiotic, nā lāʻau antifungal, a me nā lāʻau lapaʻau maʻi ʻē aʻe.

E haʻi mau i kāu kauka e pili ana i nā lāʻau lapaʻau a pau āu e lawe nei, me nā lāʻau lapaʻau i kūʻai ʻia ma luna o ke counter a me nā mea hoʻohui. E nānā pono lākou iā ʻoe inā pono ʻoe e lawe i nā lāʻau lapaʻau he nui a hiki ke hoʻoponopono i nā ʻano lāʻau a i ʻole ka manawa e hōʻemi ai i nā pilina.