He aha ka Muromonab-CD3: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau immunosuppressive ikaika ka Muromonab-CD3 i hoʻohana ʻia e pale i ka hōʻole ʻana i nā ʻōpū ma hope o ke ʻoki ʻana i ka transplant. Hana kēia lāʻau lapaʻau ma ka hoʻopau ʻana i kāu ʻōnaehana pale e kōkua i kou kino e ʻae i kahi ʻōpū i hoʻololi ʻia, ʻo ia hoʻi nā puʻupaʻa, ka puʻuwai, a i ʻole ke akepaʻa.

I ka wā i hoʻomohala mua ʻia ma ke ʻano he hoʻokahi o nā lāʻau lapaʻau monoclonal antibody mua, ua hoʻohana nui ʻia ka muromonab-CD3 i ka lāʻau lapaʻau transplant no nā makahiki he nui. Eia naʻe, he mea nui e ʻike ʻaʻole i loaʻa hou kēia lāʻau lapaʻau ma nā ʻāina he nui, no ka mea, ua pani ʻia e nā mea ʻē aʻe hou a palekana i ka mālama transplant hou.

He aha ka Muromonab-CD3?

ʻO Muromonab-CD3 kahi monoclonal antibody e kuhikuhi ana i nā cell immune kikoʻī i kapa ʻia ʻo T-cells. E noʻonoʻo iā ia he lāʻau lapaʻau i kuhikuhi ʻia e ālai ana i kekahi mau ʻāpana o kāu ʻōnaehana pale mai ka hoʻouka ʻana i kahi ʻōpū i hoʻololi ʻia.

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo immunosuppressants kēia lāʻau lapaʻau, ʻo ia hoʻi, hoʻonāwaliwali ʻo ia i ka ʻōnaehana pale kūlohelohe o kou kino. ʻOiai he mea hopohopo paha kēia, ʻo kēia nāwaliwali i mālama ʻia ka mea e hiki ai ke hoʻololi ʻana i nā ʻōpū ma ka pale ʻana i kāu ʻōnaehana pale mai ka ʻike ʻana i ka ʻōpū hou he malihini.

ʻO ka

Ua kauoha pinepine ʻia ka lāʻau lapaʻau no nā maʻi i loaʻa i ka transplant ʻana i ka puʻupaʻa e ʻike nei i nā hanana hōʻole. Eia naʻe, ua hoʻohana ʻia nō hoʻi no ka poʻe i loaʻa i ka transplant ʻana i ka naʻau a me ke akepaʻa i ka wā i hāʻule ai nā lāʻau lapaʻau ʻē aʻe i ka mālama ʻana i ka hōʻole.

He mea pono e hoʻomaopopo ʻia ua mālama ʻia kēia lāʻau lapaʻau no nā hanana hōʻole koʻikoʻi ma mua o ka pale maʻamau. E hoʻāʻo mua nā kauka i nā lāʻau immunosuppressive ʻē aʻe, ʻaʻole ikaika, ma mua o ka noʻonoʻo ʻana i ka muromonab-CD3.

Pehea e hana ai ʻo Muromonab-CD3?

Ua manaʻo ʻia ʻo Muromonab-CD3 he lāʻau immunosuppressive ikaika loa e hana ana ma ka hoʻopaʻa pololei ʻana i nā T-cell. Ke loaʻa iā ʻoe kēia lāʻau lapaʻau, pili ia i nā mea loaʻa CD3 ma nā T-cell, e hōʻailona ana iā lākou no ka wehe ʻana mai kou kahe koko.

I loko o nā hola o ka loaʻa ʻana o ka lāʻau lapaʻau, e emi nui ana kāu helu T-cell. ʻO kēia kaohi wikiwiki ʻana o nā T-cell e kōkua i ka hoʻōki ʻana i ke kaʻina hana hōʻole wikiwiki, ʻo ia ke kumu i hoʻohana pinepine ʻia ai i nā kūlana pilikia i ka wā i koʻikoʻi ai ka hōʻole ʻana o ka ʻōpū.

Hana ʻokoʻa ka lāʻau lapaʻau mai nā immunosuppressants ʻē aʻe no ka mea e wehe maoli ia i nā T-cell mai ke kahe ʻana ma mua o ka ālai ʻana i kā lākou hana. ʻO kēia ka mea e ʻoi aku ka ikaika ma mua o nā lāʻau anti-rejection ʻē aʻe, akā hiki nō hoʻi ke ʻoi aku ka maikaʻi i nā kūlana pilikia.

Pehea e lawe ai au i ka Muromonab-CD3?

Hāʻawi ʻia ʻo Muromonab-CD3 ma o ka laina IV (intravenous) wale nō i loko o kahi haukapila. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home, a pono ia i ka mālama olakino akahele i ka wā e lawelawe ai.

Ma mua o ka loaʻa ʻana o ka lāʻau lapaʻau, e hāʻawi paha kāu hui mālama ola iā ʻoe i nā lāʻau ʻē aʻe e kōkua i ka pale ʻana i nā hopena ʻaoʻao koʻikoʻi. Hiki i kēia mau mea ke komo i nā antihistamines, corticosteroids, a i ʻole nā lāʻau e hōʻemi ana i ke kuni ma kahi o 30 mau minuke ma mua o kāu mahele muromonab-CD3.

Hāʻawi ʻia ka lāʻau lapaʻau ma ke ʻano he hoʻokahi lā i kēlā me kēia lā, maʻamau i ke kakahiaka. He mau minuke wale nō ka lōʻihi o kēlā me kēia mahele e hāʻawi ai, akā pono ʻoe e noho i ka haukapila no kekahi mau hola ma hope i hiki i nā limahana lapaʻau ke nānā iā ʻoe no nā hopena.

ʻAʻole pono ʻoe e hopohopo e pili ana i nā kapu meaʻai me kēia lāʻau lapaʻau no ka mea e hāʻawi pololei ʻia i loko o kou kahe koko. Eia naʻe, he mea nui ka noho ʻana i ka wai maikaʻi, no laila e paipai paha kāu hui lapaʻau iā ʻoe e inu i ka wai nui ke ʻole ʻoe he mau kapu kūikawā.

Pehea ka lōʻihi e lawe ai au i ka Muromonab-CD3?

ʻO ka papa lapaʻau maʻamau me ka muromonab-CD3 e mau ana ma waena o 10 a 14 mau lā. Ua manaʻo ʻia kēia manawa pōkole, no ka mea, ua hoʻolālā ʻia ka lāʻau lapaʻau e hoʻohuli koke i nā hanana hōʻole ʻoi aku ka wikiwiki ma mua o ka hāʻawi ʻana i ka immunosuppression lōʻihi.

Na kāu kauka e hoʻoholo i ka lōʻihi pololei o ka lapaʻau e pili ana i ka maikaʻi o ka pane ʻana o kou kino i ka lāʻau lapaʻau. Pono paha kekahi poʻe maʻi i ka papa 14-lā piha, a ʻike paha kekahi poʻe i ka hoʻoponopono ʻana o kā lākou hōʻole ʻana.

Ma hope o ka pau ʻana o ka lapaʻau muromonab-CD3, e hoʻi ʻoe i kāu mau lāʻau anti-rejection maʻamau. E nānā pono kāu hui mālama ola i ka hana o kou kino e hōʻoia i ka mālama pono ʻia ʻana o ka hōʻole ʻana a hoʻoponopono i kāu regimen immunosuppressive lōʻihi e like me ka mea e pono ai.

He aha nā hopena ʻaoʻao o Muromonab-CD3?

Hiki i ka Muromonab-CD3 ke hana i nā hopena ʻaoʻao nui, ʻoi aku hoʻi me nā mahele mua. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻaʻole hopohopo e pili ana i ke kaʻina hana.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai:

• Hiva a me ke anu, i kekahi manawa he koʻikoʻi
• Nausea a me ka luaʻi
• Poʻo a me nā ʻeha o ke kino
• Pōkole o ka hanu a i ʻole ka paʻa o ka umauma
• Pāpaʻa
• ʻEha ʻiʻo a me nā hui
• Luhi a me ka nāwaliwali

Hiki ke ʻike ʻia kēia mau hōʻailona i loko o nā hola mua ma hope o ka loaʻa ʻana o ka lāʻau lapaʻau a pinepine e hoʻomaikaʻi me nā mea i ukali ʻia. E nānā pono kāu hui lapaʻau iā ʻoe a hāʻawi i nā lāʻau lapaʻau e kōkua i ka mālama ʻana i kēia mau hopena ʻaoʻao.

Hiki ke loaʻa nā hopena ʻaoʻao koʻikoʻi, ʻoiai ʻaʻole maʻamau. Pākuʻi ʻia kēia mau mea i nā hopena maʻi maʻi koʻikoʻi, nā hāʻule nui i ke koko, a me nā pilikia hanu. Ma muli o kēia mau pilikia, e loaʻa iā ʻoe ka lāʻau lapaʻau ma ka haukapila wale nō kahi e loaʻa koke ai ka lāʻau lapaʻau.

Hoʻonui nui ka lāʻau lapaʻau i kou pilikia o nā maʻi no ka mea e kāohi ana i kou ʻōnaehana pale. ʻOiai e loaʻa ana ka lāʻau lapaʻau, pono ʻoe e mālama nui i ka hōʻike ʻana i nā maʻi a me ka hoʻomaʻamaʻa ʻana i ka maʻemaʻe maikaʻi e hōʻemi i ka pilikia o ka maʻi.

ʻO wai ka mea pono ʻole e lawe iā Muromonab-CD3?

ʻAʻole pono kekahi poʻe e loaʻa iā muromonab-CD3 ma muli o nā pilikia palekana. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ka ʻōlelo ʻana i kēia lāʻau lapaʻau.

ʻAʻole pono ʻoe e loaʻa i kēia lāʻau lapaʻau inā loaʻa iā ʻoe:

• He maʻi maʻi i ʻike ʻia iā muromonab-CD3 a i ʻole nā ​​protein ʻiole
• He maʻi ikaika, ʻaʻole i mālama ʻia
• He maʻi puʻuwai koʻikoʻi a i ʻole ka puʻuwai i hala koke
• Ka mālama ʻana i ka wai nui a i ʻole ka hāʻule ʻole o ka puʻuwai
• He moʻolelo o nā hopu
• Nā pilikia kīkī a i ʻole ke akepaʻa koʻikoʻi ma mua o kou kūlana transplant

ʻAʻole pono nā wahine hāpai e loaʻa i kēia lāʻau lapaʻau, no ka mea, hiki iā ia ke hōʻeha i ka pēpē e ulu ana. Inā ʻoe i ka makahiki hānau keiki, e koi paha kāu kauka i kahi hoʻāʻo hāpai ma mua o ka hoʻomaka ʻana o ka lāʻau lapaʻau.

ʻO ka poʻe me kekahi mau maʻi autoimmune a i ʻole ka poʻe i loaʻa i nā lāʻau lapaʻau ola i kēia manawa, pono paha e pale i kēia lāʻau lapaʻau. E loiloi pono kāu hui transplant i kēia mau mea a pau ma mua o ka hoʻoholo ʻana inā kūpono ʻo muromonab-CD3 no kou kūlana.

ʻO ka inoa inoa ʻo Muromonab-CD3

Ua kūʻai mua ʻia ʻo Muromonab-CD3 ma lalo o ka inoa inoa ʻo Orthoclone OKT3. ʻO kēia ka inoa inoa mua i hoʻohana ʻia i ka wā i loaʻa nui ai ka lāʻau lapaʻau no nā maʻi transplant.

Eia naʻe, he mea nui e ʻike ʻaʻole i hana hou ʻia ʻo Orthoclone OKT3 a ʻaʻole i loaʻa ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa. Ua hoʻōki ʻia ka lāʻau lapaʻau ma muli o ka hoʻomohala ʻana i nā mea hou aʻe, nā mea palekana no ka mālama ʻana i ka hōʻole ʻana i nā ʻōpū.

Inā haʻi kāu kauka iā muromonab-CD3 a i ʻole OKT3, e kūkākūkā ana paha lākou i loko o kahi moʻolelo mōʻaukala a i ʻole e wehewehe ana i ke kumu e makemake ʻia ai nā lāʻau lapaʻau hou no kāu mālama ʻana.

Nā Koho ʻē aʻe o Muromonab-CD3

Ua pani nui kekahi mau lāʻau lapaʻau hou i ka muromonab-CD3 i ka lāʻau lapaʻau transplant hou. Hāʻawi pinepine kēia mau koho ʻē aʻe i ka pono like me nā hopena ʻaoʻao liʻiliʻi.

ʻO nā koho maʻamau e komo pū ana:

• Antithymocyte globulin (ATG) - kahi lāʻau lapaʻau ʻē aʻe i hoʻokumu ʻia i ka antibody
• Alemtuzumab (Campath) - he monoclonal antibody me nā pahuhopu like ʻole
• Nā corticosteroids kiʻekiʻe
• Nā hoʻoponopono i nā lāʻau lapaʻau immunosuppressive maʻamau e like me tacrolimus a i ʻole mycophenolate

E koho kāu hui transplant i ke koho maikaʻi loa e pili ana i kāu kūlana kikoʻī, ke ʻano o ka ʻōpū āu i loaʻa ai, a me kou kūlana olakino holoʻokoʻa. ʻO kēia mau koho hou e ʻae pinepine i ka mālama ʻana i waho a i ʻole nā noho pōkole i ka haukapila i hoʻohālikelike ʻia me muromonab-CD3.

ʻOi aku ka maikaʻi o Muromonab-CD3 ma mua o nā lāʻau lapaʻau anti-rejection ʻē aʻe?

Ua manaʻo ʻia ʻo Muromonab-CD3 i ka manawa hoʻokahi he mea maikaʻi loa no ka mālama ʻana i ka hōʻole ʻana i nā ʻōpū koʻikoʻi, akā ʻaʻole i manaʻo ʻia ʻo ia ke koho maikaʻi loa i loaʻa. ʻOiai hiki iā ia ke hoʻohuli koke i nā hanana hōʻole, ua alakaʻi nā hopena ʻaoʻao nui a me nā hopohopo palekana i ka hoʻomohala ʻana i nā koho ʻē aʻe.

ʻO nā lāʻau lapaʻau hou e pale ai i ka hōʻole ʻana e like me ka antithymocyte globulin (ATG) e hāʻawi pinepine i ka pono like me nā hopena ʻaoʻao hiki ke mālama ʻia. ʻOi aku ka palekana o kēia mau lāʻau lapaʻau hou a hiki ke hāʻawi ʻia me ka nānā ʻana i ka liʻiliʻi.

Ua neʻe aku ke kaiāulu lapaʻau mai muromonab-CD3 ʻaʻole no ka mea ʻaʻole i hana, akā no ka mea he mau mea hana maikaʻi aʻe kā mākou e hoʻokō ai i nā pahuhopu like me ka liʻiliʻi o ka pilikia i nā maʻi. ʻO kāu hoʻolālā lapaʻau i kēia manawa e pili ana i kēia mau koho i hoʻomaikaʻi ʻia.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Muromonab-CD3

He Palekana ʻo Muromonab-CD3 no ka poʻe me ka maʻi diabetes?

Hiki i ka poʻe me ka maʻi diabetes ke loaʻa iā muromonab-CD3, akā pono lākou i ka nānā ʻana. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i nā pae kōpaʻa koko, a ʻo ke koʻikoʻi o ka mālama ʻana e paʻakikī ai ka mālama ʻana i ka maʻi diabetes.

E hana pū kāu hui lapaʻau me ʻoe e nānā i kāu pae kōpaʻa koko i ka wā o ka mālama ʻana. Pono paha lākou e hoʻoponopono i kāu mau lāʻau lapaʻau diabetes no ka manawa pōkole i ka wā e loaʻa ai iā ʻoe ka muromonab-CD3.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao koʻikoʻi mai Muromonab-CD3?

No ka mea, hāʻawi ʻia ʻo muromonab-CD3 i loko o kahi haukapila, e nānā pono nā limahana lapaʻau iā ʻoe no nā hopena koʻikoʻi. Inā loaʻa iā ʻoe ka pilikia o ka hanu ʻana, ka ʻeha o ka umauma nui, a i ʻole nā ​​hōʻailona o ka hopena maʻi, e hoʻomaopopo koke i kāu mau kahu.

Ua mākaukau ka hui haukapila e mālama i kēia mau hopena me ka wikiwiki me nā lāʻau lapaʻau e like me ka epinephrine, antihistamines, a me nā corticosteroids. Mai kānalua e ʻōlelo inā ʻaʻole maikaʻi ʻoe i ka wā a i ʻole ma hope o ka mālama ʻana.

Hiki iaʻu ke loaʻa iā Muromonab-CD3 ma mua o hoʻokahi manawa?

ʻAʻole ʻōlelo ʻia nā papa hana hou o muromonab-CD3 a ʻaʻole pono. Hoʻomohala pinepine kou kino i nā antibodies e kūʻē i ka lāʻau lapaʻau ma hope o ka papa mua, e hoʻemi ana i ka pono o nā lāʻau lapaʻau a me ka pilikia.

Inā pono ʻoe i ka lāʻau no ka hōʻole ʻana i ka wā e hiki mai ana, e koho paha kāu kauka i kahi lāʻau lapaʻau ʻē aʻe i ʻike ʻole ʻia e kou kino ma mua.

Pehea ka wikiwiki o ka hana ʻana o Muromonab-CD3?

Hana wikiwiki ʻo Muromonab-CD3, pinepine i loko o nā hola o ka lāʻau mua. Hiki paha iā ʻoe ke ʻike i ka hāʻule ʻana o kāu helu T-cell i loko o ka lā mua o ka lāʻau, a hoʻomaka pinepine nā hōʻailona o ka hōʻole ʻana e hoʻomaikaʻi i loko o 2-3 mau lā.

Eia naʻe, he mea nui nō ka papa hana lapaʻau piha inā maikaʻi ʻoe i ka wikiwiki. ʻO ka hoʻopau ʻana i ka papa hana i kuhikuhi ʻia e kōkua i ka hōʻoia ʻana ua hoʻohuli ʻia ka hōʻole ʻana a hoʻemi i ka pilikia o ka hoʻi ʻana mai.

Pono anei au i ka nānā ʻana kūikawā ma hope o ka lāʻau Muromonab-CD3?

ʻAe, pono ʻoe i ka nānā ʻana kokoke no kekahi mau pule ma hope o ka hoʻopau ʻana i ka lāʻau muromonab-CD3. E nānā mau kāu hui lapaʻau i ka hana o kāu ʻōkana, nā helu koko, a e nānā i nā hōʻailona o ka maʻi no ka mea e kāohi ʻia kāu ʻōnaehana pale.

ʻO kēia nānā ʻana e pili ana i nā hoʻokolohua koko maʻamau, nā biopsies o kāu ʻōkana i hoʻololi ʻia, a me ka nānā pono ʻana i nā hōʻailona e hōʻike ana i ka maʻi a i ʻole ka hoʻi ʻana o ka hōʻole ʻana. E hoʻemi mālie kāu hui transplant i ke alapine o kēia mau loiloi i ka wā e paʻa ai kou kūlana.