Created at:1/13/2025
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ʻO Nadofaragene firadenovec he lāʻau lapaʻau gene i hoʻolālā ʻia e mālama i kekahi mau ʻano maʻi maʻi ʻōpū. Hana kēia lapaʻau hana hou ma ka hāʻawi ʻana i nā mea genetic pololei i loko o nā cell maʻi maʻi ʻōpū e kōkua i kāu ʻōnaehana pale e ʻike a hakakā i ka maʻi maʻi maikaʻi.
Inā ua ʻike ʻia ʻoe a i ʻole kekahi āu e mālama nei me ka maʻi maʻi ʻōpū, hiki ke manaʻo nui ka aʻo ʻana e pili ana i kēia koho lapaʻau. E hele kākou i nā mea a pau e pono ai ʻoe e ʻike e pili ana i kēia lāʻau lapaʻau ma ke ʻano e maopopo ai a kōkua iā ʻoe e ʻike hou aku e pili ana i kāu mau hoʻoholo mālama ola.
ʻO Nadofaragene firadenovec he lāʻau lapaʻau gene e hoʻohana ana i kahi maʻi i hoʻololi ʻia e hāʻawi i nā genes e hakakā ana i ka maʻi maʻi pololei i nā cell maʻi maʻi ʻōpū. Hāʻawi ʻia ka lapaʻau ma o ka catheter i hoʻokomo ʻia i loko o kou ʻōpū, e ʻae ana i ka lāʻau lapaʻau e hana pololei i kahi e pono ai.
Hōʻike kēia lāʻau lapaʻau i kahi ala hou i ka mālama ʻana i ka maʻi maʻi i kapa ʻia ʻo immunotherapy. Ma kahi o ka hoʻohana ʻana i nā lāʻau chemotherapy kuʻuna e hiki ke hoʻopilikia i kou kino holoʻokoʻa, kōkua kēia lapaʻau i ka hoʻomaʻamaʻa ʻana i kāu ʻōnaehana pale e ʻike a hoʻouka i nā cell maʻi maʻi i loko o kou ʻōpū.
Ua ʻike ʻia ka lāʻau lapaʻau ma kona inoa inoa ʻo Adstiladrin. Hoʻolālā ʻia ia no ka poʻe me kekahi mau ʻano maʻi maʻi ʻōpū i pane ʻole i nā lāʻau lapaʻau ʻē aʻe.
Hoʻohana ʻia kēia lāʻau lapaʻau gene e mālama i ka maʻi maʻi ʻōpū non-muscle invasive kiʻekiʻe e loaʻa ana kahi hōʻailona genetic kikoʻī i kapa ʻia ʻo BCG-unresponsive carcinoma in situ. He paʻakikī paha kēia, akā e hoʻāʻo kāu kauka i kāu mau cell maʻi maʻi e hoʻoholo inā kūpono kēia lapaʻau iā ʻoe.
Hoʻomaopopo ʻia ka lāʻau lapaʻau i ka wā i kūleʻa ʻole ai nā lāʻau lapaʻau ʻē aʻe, ʻo ia hoʻi ka BCG immunotherapy, i ka mālama ʻana i kāu maʻi kanesa. ʻO ka BCG ka lāʻau lapaʻau mua no kēia ʻano maʻi kanesa o ka ʻōpū, a i ka wā e pau ai ka hana pono, lilo ka nadofaragene firadenovec i koho nui.
Hiki i kāu oncologist ke ʻōlelo aku i kēia lāʻau lapaʻau inā ʻaʻole ʻoe he moho no ka wehe ʻana i kāu ʻōpū ma ke ʻoki a i ʻole inā makemake ʻoe e hoʻāʻo i nā koho ʻē aʻe ma mua o ka noʻonoʻo ʻana i ke ʻoki. ʻO ka pahuhopu ke kōkua i ka mālama ʻana i ka maʻi kanesa me ka mālama ʻana i kou ʻōpū a me ka mālama ʻana i kou maikaʻi o ke ola.
Hana kēia gene therapy ma ka hoʻohana ʻana i kahi adenovirus i hoʻololi ʻia ma ke ʻano he ʻōnaehana hāʻawi e lawe pololei i nā genes therapeutic i loko o kāu mau cell maʻi kanesa o ka ʻōpū. Ua hana ʻia ka maʻi e palekana a ʻaʻole hiki ke hoʻoulu i ka maʻi, akā maikaʻi loa ia i ke komo ʻana i loko o nā cell.
I ka manawa i loko o nā cell maʻi kanesa, hāʻawi ka lāʻau lapaʻau i kahi gene e hana ana i kahi protein i kapa ʻia ʻo interferon alfa-2b. Hana kēia protein e like me ka hōʻailona e makaʻala i kou ʻōnaehana pale i ke alo o nā cell maʻi kanesa a kōkua i ka hoʻonohonoho ʻana i kahi pane pale ikaika e kūʻē iā lākou.
E noʻonoʻo e like me ka hāʻawi ʻana i kāu ʻōnaehana pale i nā ʻōlelo aʻo maikaʻi aʻe e pili ana i ka pehea e ʻike ai a hakakā i ka maʻi kanesa. Hana ka lāʻau lapaʻau ma kou ʻōpū, ʻo ia hoʻi e kālele ana i kāna mau hopena ma kahi o ka maʻi kanesa ma mua o ka hoʻopilikia ʻana i kou kino holoʻokoʻa.
Ua manaʻo ʻia kēia ʻano he lāʻau lapaʻau i manaʻo ʻia no ka mea ua hoʻolālā ʻia e hana kūikawā i nā cell maʻi kanesa me ka waiho ʻana i nā cell olakino i ka nui ʻole. Aia ka ikaika o kēia lāʻau lapaʻau i kona pololei a me kona hiki ke hoʻohana i nā pale pale kūlohelohe o kou kino.
Hāʻawi ʻia ka nadofaragene firadenovec ma ke ʻano he lapaʻau pololei i loko o kou ʻōpū ma o ka catheter, ʻaʻole ma ke ʻano he pila a i ʻole ka pahu. E mālama kāu hui mālama ola i ke kaʻina hana holoʻokoʻa, no laila ʻaʻole pono ʻoe e hopohopo e pili ana i ka lawe ʻana i kēia lāʻau ma ka home.
Ma mua o kāu lapaʻau, pono ʻoe e kaupalena i kāu inu wai no kahi o 4 mau hola e hōʻoia ʻaʻole i piha loa kou ʻōpū. E hoʻokomo kāu kauka i kahi paipu liʻiliʻi a maʻalahi i kapa ʻia he catheter ma kou urethra i loko o kou ʻōpū, a laila e hāʻawi i ka lāʻau ma o kēia paipu.
Ma hope o ka lāʻau i loko o kou ʻōpū, pono ʻoe e paʻa ma laila no kahi o 1-2 mau hola ma mua o ka mimi ʻana. I kēia manawa, e noi ʻia ʻoe e hoʻololi i nā kūlana i kēlā me kēia manawa e kōkua i ka lāʻau e uhi i ka ʻili holoʻokoʻa o loko o kou ʻōpū.
Hāʻawi ʻia ka lapaʻau i hoʻokahi manawa i kēlā me kēia ʻekolu mahina. E nānā kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau a e hoʻoholo i ka papa manawa maikaʻi loa no kou kūlana pilikino.
He ʻokoʻa ka lōʻihi o ka lapaʻau ʻana me ka nadofaragene firadenovec mai kēlā kanaka i kēia kanaka a pili i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi i ka lāʻau lapaʻau. E nānā mau kāu kauka i kou holomua me ka cystoscopy a me nā hoʻokolohua ʻē aʻe e ʻike i ka maikaʻi o ka lapaʻau.
Hoʻomau ka hapa nui o nā kānaka i ka lapaʻau inā e kōkua ana ia i ka mālama ʻana i kā lākou maʻi maʻi a ke ʻae maikaʻi nei lākou. Hiki i kekahi poʻe maʻi ke loaʻa nā lapaʻau no kekahi mau mahina a i ʻole nā makahiki, aʻo nā mea ʻē aʻe e pono paha i kahi papa lapaʻau pōkole.
E hana pū kāu oncologist me ʻoe e hana i kahi hoʻolālā lapaʻau e kaulike ana i nā pōmaikaʻi o ka lapaʻau mau me kou maikaʻi o ke ola a me ke olakino holoʻokoʻa. E kōkua nā koho ukali maʻamau e hoʻoholo inā e hoʻomau, hoʻoponopono, a i ʻole e hoʻōki i ka lapaʻau.
He mea nui e mālama i nā koho i hoʻonohonoho ʻia a me nā hoʻokolohua ukali, ʻoiai inā maikaʻi ʻoe. Kōkua kēia mau kipa i kāu hui lapaʻau e hana i nā hoʻoholo maikaʻi loa e pili ana i kāu mālama mau.
E like me nā lāʻau lapaʻau maʻi kanesa a pau, hiki i ka nadofaragene firadenovec ke hana i nā hopena ʻaoʻao, akā nui ka poʻe e ʻae maikaʻi ana. ʻO nā hopena ʻaoʻao maʻamau e pili ana i ka ʻōpū a me ka ʻōnaehana mimi no ka mea ma laila e hāʻawi ʻia ai ka lāʻau lapaʻau.
Hiki i ka hoʻomaopopo ʻana i ka mea e manaʻo ai ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻopili ai i kāu hui mālama ola. E nānā kākou i nā hopena ʻaoʻao āu e ʻike ai, e hoʻomaka ana me nā mea maʻamau:
Hiki kēia mau hopena ʻaoʻao i ka nui o ka poʻe e loaʻa ana i kēia lāʻau lapaʻau, akā hiki ke mālama ʻia a maʻa mau e hoʻomaikaʻi i ka manawa:
Hiki ke ʻike ʻia kēia mau hōʻailona i loko o nā lā mua ma hope o ka lāʻau lapaʻau a hoʻoponopono pinepine iā lākou iho. Hiki i kāu kauka ke ʻōlelo i nā ala e mālama ai i kēia mau hopena ʻaoʻao a e hōʻoluʻolu iā ʻoe.
ʻOiai ʻaʻole pinepine, pono kekahi mau hopena ʻaoʻao i ka lāʻau lapaʻau koke. E hoʻokaʻaʻike koke i kāu hui mālama ola inā ʻike ʻoe:
Hāʻawi kāu hui lapaʻau iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka manawa e kāhea ai iā lākou a me nā hōʻailona e nānā ai. ʻO ka loaʻa ʻana o kēia ʻike e kōkua i ka hōʻoia ʻana e loaʻa iā ʻoe ka mālama wikiwiki inā pono.
Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao kakaʻikahi e pili ana i nā ʻāpana ʻē aʻe o ke kino. Hiki i kēia mau mea ke komo:
ʻOiai he mea hopohopo kēia mau hopena ʻaoʻao, ua aʻo ʻia kāu hui mālama ola e ʻike a mālama koke iā lākou. ʻO nā pōmaikaʻi o ka mālama ʻana e ʻoi aku ka nui o kēia mau pilikia, ʻoiai no ka poʻe me nā koho lapaʻau palena.
ʻAʻole kūpono ʻo Nadofaragene firadenovec no nā mea a pau me ka maʻi maʻi ʻōpū. E loiloi pono kāu kauka inā palekana a kūpono kēia lapaʻau no kāu kūlana kikoʻī.
ʻAʻole pono e hoʻohana ʻia kēia lāʻau lapaʻau inā he maʻi maʻi urinary tract ʻoe a i ʻole e lawe ana ʻoe i nā lāʻau immunosuppressive e hiki ke hoʻopilikia i ka hana ʻana o ka lāʻau lapaʻau. Pono kāu ʻōnaehana pale e hana maikaʻi no kēia gene therapy e pono ai.
ʻO ka poʻe me kekahi mau maʻi autoimmune a i ʻole ka poʻe i loaʻa i nā hopena koʻikoʻi i nā lāʻau lapaʻau like i ka wā i hala, ʻaʻole paha he moho maikaʻi no kēia lāʻau lapaʻau. E nānā kāu kauka i kāu mōʻaukala olakino piha e hana i kēia hoʻoholo.
ʻAʻole pono nā wahine hāpai a hānai paha i kēia lāʻau lapaʻau, no ka mea, ʻaʻole ʻike ʻia nā hopena i nā pēpē e ulu ana. Inā he makahiki hānau keiki ʻoe, e kūkākūkā kāu kauka i nā ʻano hana contraception kūpono i ka wā o ka mālama ʻana.
ʻO ka inoa inoa no nadofaragene firadenovec ʻo Adstiladrin. ʻO kēia ka inoa āu e ʻike ai ma kāu papa hana lapaʻau a me nā moʻolelo olakino.
Hana ʻia ʻo Adstiladrin e Ferring Pharmaceuticals a ua ʻae ʻia e ka FDA no ka mālama ʻana i ka maʻi maʻi ʻōpū ʻaʻole i pane i ka BCG. Ke kūkākūkā ʻana i kāu lapaʻau me nā hui ʻinikua a i ʻole nā mea mālama ola ʻē aʻe, pono paha ʻoe e hoʻohana i ka inoa maʻamau a me ka inoa inoa.
E ʻōlelo maʻamau kāu hui lapaʻau iā ia ma ka inoa i ʻike nui ʻia e lākou, akā pili nā inoa ʻelua i ka lāʻau lapaʻau a me ka mālama like.
Inā ʻaʻole kūpono ʻo nadofaragene firadenovec iā ʻoe a i ʻole ʻaʻole hana pono, aia kekahi mau koho lapaʻau ʻē aʻe no ka maʻi maʻi ʻōpū. ʻO ke koho maikaʻi loa e pili ana i kāu ʻano maʻi maʻi a me ke olakino holoʻokoʻa.
ʻO nā lāʻau lapaʻau intravesical ʻē aʻe (pololei i loko o ka ʻōpū) e komo pū ana i nā ʻano lāʻau immunotherapy like ʻole e like me BCG, inā ʻaʻole ʻoe i hoʻāʻo, a i ʻole nā mea lapaʻau chemotherapy e like me mitomycin C a i ʻole gemcitabine. Hana kēia mau lāʻau lapaʻau ma nā ʻano hana like ʻole akā hāʻawi pololei ʻia i kou ʻōpū.
No kekahi poʻe, hiki ke noʻonoʻo ʻia nā koho ʻokiʻoki, e komo pū ana me ka wehe ʻana i ka ʻōpū (cystectomy) a i ʻole nā hana ʻē aʻe e wehe i ka ʻiʻo maʻi maʻi. Hiki i kāu urologist ke wehewehe i kēia mau koho a kōkua iā ʻoe e hoʻomaopopo i nā pōmaikaʻi a me nā pilikia o kēlā me kēia ala.
Loaʻa pinepine nā hoʻokolohua lapaʻau e noiʻi ana i nā lāʻau lapaʻau hou no ka maʻi maʻi ʻōpū. Hāʻawi kēia mau hoʻokolohua iā ʻoe i ke komo ʻana i nā lāʻau lapaʻau kiʻekiʻe ʻaʻole i loaʻa ākea akā hōʻike i ka hoʻohiki i ka mālama ʻana i kāu ʻano maʻi maʻi.
Hana ʻo Nadofaragene firadenovec a me BCG ma nā ʻano hana like ʻole, no laila ʻaʻole maʻalahi ka hoʻohālikelike ʻana iā lākou. ʻO BCG ka mea maʻamau i ka lāʻau lapaʻau mua i hoʻāʻo ʻia no ka maʻi maʻi ʻōpū non-muscle invasive kiʻekiʻe, ʻoiai ʻo nadofaragene firadenovec i manaʻo ʻia ke pau ka hana ʻana o BCG.
Ua hoʻohana ʻia ʻo BCG no nā makahiki he nui a he moʻolelo maikaʻi loa o ka pono no ka nui o ka poʻe me ka maʻi maʻi ʻōpū. Eia naʻe, ke hāʻule ʻo BCG i ka mālama ʻana i ka maʻi maʻi a i ʻole ke kumu o nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, hāʻawi ʻo nadofaragene firadenovec i kahi koho waiwai.
He ʻokoʻa nā ʻano hopena ʻaoʻao o kēia mau lapaʻau. Hiki i ka BCG ke hoʻoulu i nā hōʻailona e like me ka maʻi flu, ʻoiai ʻo nadofaragene firadenovec e hoʻoulu pinepine i nā hopena ʻaoʻao e pili ana i ka ʻōpū. Ua ʻoi aku ka maikaʻi o kekahi poʻe i kekahi ma mua o kekahi.
E kōkua kāu kauka iā ʻoe e hoʻomaopopo i ka lapaʻau kūpono loa no kou kūlana e pili ana i nā ʻano o kāu maʻi kanesa, kāu mōʻaukala lapaʻau mua, a me kāu mau makemake pilikino a me ke olakino.
Manaʻo ʻia ʻo Nadofaragene firadenovec he palekana no ka poʻe me ka maʻi puʻuwai no ka mea e hana kūloko ana ia i loko o ka ʻōpū ma mua o ka hoʻopilikia ʻana i kou kino holoʻokoʻa. Eia naʻe, pono e hana pū kāu cardiologist a me ka oncologist e nānā i kou olakino holoʻokoʻa i ka wā o ka lapaʻau.
ʻAʻole maʻamau ka lapaʻau i nā hopena ʻaoʻao e pili ana i ka puʻuwai, akā hiki i kekahi lapaʻau maʻi kanesa ke hoʻoluhi i kou kino. E loiloi kāu hui lapaʻau i kou kūlana puʻuwai a me ke olakino holoʻokoʻa e hōʻoia i ka kūpono o kēia lapaʻau iā ʻoe.
Inā loaʻa iā ʻoe ka maʻi puʻuwai, e hōʻoia e haʻi i kāu oncologist e pili ana i kāu mau lāʻau lapaʻau puʻuwai a pau, no ka mea, hiki i kekahi mau lāʻau lapaʻau ke hoʻopilikia i kāu ʻōnaehana pale a i ʻole e launa pū me nā lapaʻau maʻi kanesa.
No ka mea, hāʻawi ʻia ʻo nadofaragene firadenovec e kāu hui mālama ola i kahi hoʻonohonoho lapaʻau, ʻo ka hala ʻana i kahi mahele, ʻo ia hoʻi ka hala ʻana i kahi manawa i hoʻonohonoho ʻia. Inā hiki kēia, e hoʻokaʻaʻike i ke keʻena o kāu oncologist i ka wā hiki wawe e hoʻonohonoho hou.
Ua hoʻolālā ʻia kāu papa hana lapaʻau e hāʻawi i kou ʻōnaehana pale i ka manawa e pane ai i ka wā e mālama ana i ke kaomi mau i nā cell maʻi kanesa. ʻAʻole maʻamau ka lohi ʻana i ka lapaʻau no ka manawa pōkole, akā he mea nui e hoʻi koke i ke ala.
Pono paha kāu kauka e hoʻoponopono i kāu papa hana lapaʻau a i ʻole e nānā pono iā ʻoe inā he lohi nui. E hana pū lākou me ʻoe e hoʻoholo i ke ala maikaʻi loa e hoʻomau ai i kāu lapaʻau.
Inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi e like me ka ʻeha nui o ka ʻōpū, ke kahe nui ʻana, ke kuni kiʻekiʻe, a i ʻole ka hiki ʻole ke mimi, e hoʻokaʻaʻike koke i kāu hui mālama ola a i ʻole e hele i ka lumi pilikia. Pono kēia mau hōʻailona i ka nānā ʻana i ka lāʻau lapaʻau.
No nā hōʻailona ʻaʻole koʻikoʻi akā hopohopo, e kelepona i ke keʻena o kāu oncologist i nā hola hana. Hiki iā lākou ke hāʻawi i ke alakaʻi ʻana i ka mālama ʻana i nā hopena ʻaoʻao a hoʻoholo inā pono ʻoe e ʻike ʻia ma mua o kāu manawa i hoʻonohonoho ʻia.
E mālama i kahi papa inoa o kāu mau hōʻailona a me ka manawa e hana ai. Kōkua kēia ʻike i kāu hui lapaʻau e hoʻomaopopo i ke ʻano o kāu pane ʻana i ka lapaʻau a hana i nā hoʻoponopono e pono ai i kāu hoʻolālā mālama.
Pono e hana mau ʻia ka hoʻoholo e hooki i ka lapaʻau ʻana iā nadofaragene firadenovec ma ke kūkākūkā ʻana me kāu oncologist. Hiki iā ʻoe ke hooki i ka lapaʻau inā pane piha kāu maʻi maʻi a noho i ka mana, inā loaʻa iā ʻoe nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, a i ʻole inā pau ka lapaʻau ʻana.
E hoʻohana kāu kauka i nā hoʻokolohua cystoscopy maʻamau, nā hoʻokolohua mimi, a me nā haʻawina kiʻi e nānā i kāu pane ʻana i ka lapaʻau. Ma muli o kēia mau hopena, e ʻōlelo lākou inā e hoʻomau, hoʻololi, a i ʻole e hooki i kāu lapaʻau.
ʻOiai inā e hooki ʻoe i ka lapaʻau, pono ʻoe i ka nānā ʻana e nānā i ka hoʻi hou ʻana o ka maʻi maʻi. E hoʻopilikino ʻia kāu hoʻolālā mālama e pili ana i kāu kūlana pilikino a me ka pane ʻana i ka lapaʻau.
Hiki ke hele i ka wā o ka lapaʻau ʻana iā nadofaragene firadenovec, akā he mea nui ka manawa. ʻOi aku ka maikaʻi e pale i ka hele ʻana no kekahi mau lā ma hope o kēlā me kēia kau lapaʻau, no ka mea, ʻo ia ka manawa e hiki ai ke loaʻa nā hopena ʻaoʻao.
Inā ʻoe e hoʻolālā ana e hele, e kūkākūkā i kāu mau hoʻolālā me kāu oncologist ma mua. Hiki iā lākou ke kōkua iā ʻoe e hoʻonohonoho i nā lāʻau lapaʻau a puni kāu mau lā huakaʻi a hāʻawi i ke alakaʻi ʻana i ka mālama ʻana i nā hopena ʻaoʻao e hiki ke hana i ka wā e hele ana ʻoe.
E hōʻoia e lawe mai i ka ʻike pili no kāu hui lapaʻau a loaʻa kahi hoʻolālā no ka loaʻa ʻana o ka mālama olakino inā pono i ka wā e hele ana. E noʻonoʻo i ka ʻinikua huakaʻi e uhi ana i nā pilikia olakino, ʻoiai inā e hele ana ʻoe i ka honua.