He aha ka Natalizumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Natalizumab i hāʻawi ʻia ma o ka IV infusion e mālama i ka sclerosis lehulehu a me ka maʻi o Crohn. Hana ia ma ka pale ʻana i kekahi mau pūnaewele ʻōnaehana pale mai ka hiki ʻana i kou lolo a me nā ʻōpū, kahi e kōkua ai i ka hōʻemi ʻana i ka mumū a me ka lohi ʻana i ka holomua o ka maʻi.

No kēia lāʻau lapaʻau i kahi papa i kapa ʻia he monoclonal antibodies, ʻo ia nā protein i hoʻolālā kūikawā ʻia e kuhikuhi i nā ʻāpana kikoʻī o kāu ʻōnaehana pale. E noʻonoʻo iā ia he ala i kuhikuhi ʻia ma mua o kahi lapaʻau ākea e pili ana i kou kino holoʻokoʻa.

No ke aha e hoʻohana ʻia ai ka Natalizumab?

Hoʻomaʻamaʻa ʻo Natalizumab i nā kūlana nui ʻelua kahi e hoʻouka hewa ai kāu ʻōnaehana pale i ka ʻiʻo olakino. Kauoha kāu kauka iā ia i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe a i ʻole ke pono ʻoe i ka hana ikaika.

No ka sclerosis lehulehu, kōkua ʻo natalizumab i ka pale ʻana i nā relapses a hōʻemi i ka hana ʻana o nā lesions lolo hou. He mea maikaʻi loa ia no nā ʻano relapsing o MS, kahi e hele mai ai nā hōʻailona a hele i nā hanana.

I ka maʻi o Crohn, kōkua kēia lāʻau lapaʻau i ka mālama ʻana i ka mumū nui i loko o kou ʻōpū. Hiki i kāu gastroenterologist ke ʻōlelo iā ia i ka wā i hāʻawi ʻole ai nā lāʻau lapaʻau maʻamau e like me nā steroids a i ʻole nā ​​immunosuppressants i ka hōʻoluʻolu kūpono.

Hoʻopaʻa ʻia ka lāʻau lapaʻau no nā hihia mai ka maʻamau a i ke koʻikoʻi no ka mea he ikaika loa ia. E loiloi pono kāu kauka inā ʻoi aku ka maikaʻi ma mua o nā pilikia no kāu kūlana.

Pehea e hana ai ka Natalizumab?

Pale ʻo Natalizumab i kahi protein i kapa ʻia ʻo alpha-4 integrin ma nā pūnaewele immune, e pale ana iā lākou mai ke komo ʻana i kou lolo a i ʻole ka ʻiʻo intestinal. Hana kēia i kahi pale pale e hōʻemi i ka mumū kahi āu e pono ai.

Hoʻohana maʻamau kāu ʻōnaehana pale i kēia mau protein e like me nā kī e wehe ai i ke komo ʻana i nā ʻāpana like ʻole o kou kino. Ma ka pale ʻana i kēia mau

He mana ikaika kēia i manaʻo ʻia no ka mea e hoʻopilikia nui ana i ka hiki o kou ʻōnaehana pale e hana maʻamau. ʻOiai e kōkua ana kēia i ka mālama ʻana i kou maʻi, pono nō hoʻi ka nānā pono ʻana no nā pilikia hiki ke loaʻa.

Hiki mai nā hopena i ka wā, no laila ʻaʻole paha ʻoe e ʻike i ka hoʻomaikaʻi koke ʻana. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā pōmaikaʻi i loko o nā mahina mua o ka mālama ʻana.

Pehea e lawe ai au i ka Natalizumab?

Hāʻawi ʻia ka Natalizumab ma ke ʻano he infusion intravenous i loko o kahi keʻena lapaʻau, maʻamau i hoʻokahi manawa i kēlā me kēia ʻehā pule. E loaʻa iā ʻoe ka lāʻau lapaʻau ma o kahi paipu liʻiliʻi i waiho ʻia i loko o kou aa lima ma kahi o hoʻokahi hola.

Ma mua o kēlā me kēia infusion, pono ʻoe i nā hoʻokolohua koko e nānā i kāu ʻōnaehana pale a me ke olakino holoʻokoʻa. E nānā pū kāu hui mālama ola iā ʻoe no hoʻokahi hola ma hope o ka infusion e nānā i nā hopena koke.

ʻAʻole pono ʻoe e hoʻokē ʻai ma mua o ka mālama ʻana, akā ʻo ka ʻai ʻana i ka meaʻai māmā ma mua e hiki ke kōkua i ka pale ʻana i ka nausea. E lawe mai i kekahi mea e mālama iā ʻoe iho i ka wā o ka infusion, e like me ka puke a i ʻole ka papa.

E hāʻawi kāu hui lapaʻau iā ʻoe i nā antihistamines a i ʻole nā steroids inā loaʻa iā ʻoe nā hopena ma mua. Kōkua kēia i ka pale ʻana i nā hopena ʻaoʻao e pili ana i ka infusion e like me ke poʻo a i ʻole nā hopena ʻili.

Pehea ka lōʻihi e lawe ai au i ka Natalizumab?

Lawe ka hapa nui o nā kānaka i ka natalizumab no hoʻokahi a ʻelua mau makahiki e ʻike i nā pōmaikaʻi nui, ʻoiai e hoʻomau kekahi poʻe i ka lōʻihi e pili ana i kā lākou pane. E loiloi mau kāu kauka inā e kōkua ana ka lāʻau lapaʻau a inā ʻo ia nō ke koho kūpono iā ʻoe.

Aia ka hoʻoholo e hoʻomau i ka maikaʻi o kāu pane ʻana a me nā mea pilikia no nā pilikia. E nānā kāu kauka i kou kūlana antibody virus JC i kēlā me kēia ʻeono mahina, no ka mea, pili kēia i kāu ʻikepili pilikia.

Lawe kekahi poʻe i nā wā hoʻomaha mai ka mālama ʻana, i kapa ʻia nā lā hoʻomaha lāʻau, e hōʻemi i kekahi mau pilikia. Hiki i kāu kauka ke ʻōlelo aku i kēia ala inā ua lawe ʻoe i ka lāʻau lapaʻau no kekahi mau makahiki.

Mai hooki koke i ka natalizumab me ka ʻole o ke alakaʻi lapaʻau. E kōkua kāu kauka iā ʻoe e hoʻololi palekana i kahi lapaʻau ʻē aʻe inā pono e pale i ka hoʻi ʻana mai o ka maʻi.

He aha nā hopena ʻaoʻao o Natalizumab?

Hoʻomanawanui ka hapa nui o nā kānaka i ka natalizumab, akā e like me nā lāʻau ikaika a pau, hiki iā ia ke hana i nā hopena ʻaoʻao mai ka maʻalahi a i ka koʻikoʻi. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai e kōkua iā ʻoe e mākaukau a ʻike i ka manawa e ʻimi ai i ke kōkua.

ʻO nā hopena ʻaoʻao maʻamau e ʻike ai ka poʻe he nui, ʻo ia nā poʻo, ka luhi, a me ka ʻeha hui. Hana pinepine kēia i loko o nā lapaʻau mua a hoʻomaikaʻi pinepine i ka wā e hoʻoponopono ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia:

• Nā poʻo e like me ke kaomi ʻana a i ʻole ke kaomi sinus
• Ka luhi a i ʻole ka luhi ma mua o ka maʻamau
• Nā ʻeha hui a i ʻole ka ʻoʻoleʻo ʻiʻo
• Nausea a i ʻole ka ʻōpū ʻoluʻolu
• ʻO ka dizziness a i ʻole ka manaʻo māmā
• Nā hopena ʻili ma ke kahua hoʻokomo

Hiki ke mālama ʻia kēia mau hopena maʻamau a ʻaʻole pono e hoʻōki i ka lapaʻau. Hiki i kāu hui mālama ola ke hōʻike i nā ala e hōʻemi ai i ka hōʻoluʻolu.

Pono nā hopena ʻaoʻao koʻikoʻi i ka nānā ʻana i ka lāʻau lapaʻau koke, ʻoiai ʻaʻole lākou i maʻamau. ʻO ka mea e hopohopo nui nei, ʻo ia ka progressive multifocal leukoencephalopathy (PML), kahi maʻi lolo laha akā koʻikoʻi.

E nānā i kēia mau hōʻailona ʻōlelo aʻo e pono ai ka loiloi wikiwiki:

• Huikau nui a i ʻole nā ​​hoʻololi i ka noʻonoʻo
• Nā pilikia o ka ʻike a i ʻole ka nalowale o ka hoʻonohonoho
• Nāwaliwali ma kekahi ʻaoʻao o kou kino
• Nā loli pilikino a i ʻole nā ​​hana maʻamau
• Paʻakikī i ka ʻōlelo a i ʻole ka hoʻomaopopo ʻana i ka ʻōlelo
• Nā hopena maʻi maʻi koʻikoʻi i ka wā o ka hoʻokomo

Nānā pono kāu hui lapaʻau iā ʻoe no kēia mau pilikia laha akā koʻikoʻi. Kōkua nā MRI lolo maʻamau i ka ʻike ʻana i nā loli e pili ana i ka wā mua.

Hiki nō ke loaʻa nā pilikia o ke akepaʻa, ʻoiai ʻaʻole maʻamau kēia. E nānā mau kāu kauka i ka hana o kou akepaʻa ma o nā hoʻokolohua koko e ʻike koke i nā pilikia.

ʻO wai ka mea pono ʻole e lawe iā Natalizumab?

ʻAʻole kūpono ʻo Natalizumab no nā mea a pau, ʻoiai no ka poʻe me kekahi mau maʻi a i ʻole nā maʻi o ka ʻōnaehana pale. E nānā pono kāu kauka iā ʻoe ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau e hōʻoia i ka palekana.

ʻAʻole pono ʻoe e lawe iā natalizumab inā he maʻi ikaika kou, ʻoiai nā mea e pili ana i kou lolo a i ʻole ka ʻōnaehana nerve. Aia kēia i nā maʻi e like me ka meningitis a i ʻole ka encephalitis.

Pono ka poʻe me nā ʻōnaehana pale i hoʻopilikia ʻia mai nā kumu ʻē aʻe e pale i kēia lāʻau lapaʻau. Aia kēia i ka poʻe me ka HIV, nā mea hoʻololi kino, a i ʻole e lawe ana i nā lāʻau immunosuppressive ikaika ʻē aʻe.

Hana kekahi mau maʻi lapaʻau iā natalizumab i mea pilikia loa e hoʻohana palekana:

• Nā maʻi ikaika ma nā wahi a pau o kou kino
• Mōʻaukala o ka leukoencephalopathy multifocal holomua
• Maʻi akepaʻa koʻikoʻi a i ʻole ka hāʻule ʻana o ke akepaʻa
• ʻIke ʻia ka hypersensitivity i natalizumab
• Hāpai a i ʻole ka hānai ʻana
• Nā lāʻau lapaʻau ola hou i ka mahina i hala

E noʻonoʻo pū kāu kauka i ke kūlana antibody o kāu maʻi JC, no ka mea, hoʻonui nā hopena maikaʻi i kou pilikia o nā pilikia. ʻAʻole kēia e hoʻokaʻawale iā ʻoe, akā pili ia i ka helu ʻana i ka pōmaikaʻi.

ʻAʻole pono ka makahiki i mea pale, akā pono paha nā mākua kahiko i ka nānā ʻana. E kaupaona kāu kauka i nā mea a pau e hoʻoholo ai inā kūpono ʻo natalizumab no kou kūlana.

Nā inoa inoa o Natalizumab

Loaʻa ʻo Natalizumab ma lalo o ka inoa inoa Tysabri, ʻo ia ka mana i kauoha pinepine ʻia. ʻO kēia ka formulation kumu i hoʻohana ʻia no nā makahiki he nui me ka noiʻi nui e kākoʻo ana i kona pono.

Ua loaʻa kekahi mana hou i kapa ʻia ʻo Tyruko (natalizumab-sztn), he mea i ʻike ʻia he biosimilar. Ua like loa nā biosimilars me ka lāʻau lapaʻau kumu akā hiki ke hana ʻia e nā mea hana like ʻole.

Ua like nā mana ʻelua i ka hana a loaʻa nā hopena like. Hiki i kāu kauka a i ʻole ka hoʻolālā ʻinikua ke makemake i kekahi ma mua o kekahi ma muli o ka loaʻa a i ʻole nā kumukūʻai.

ʻO ka hope -sztn ma natalizumab-sztn he ala wale nō e hoʻokaʻawale ai i kēia mana biosimilar mai ke kumu. ʻAʻole ia e hōʻike i kekahi ʻokoʻa i ke ʻano o ka hana ʻana o ka lāʻau lapaʻau.

Nā koho ʻē aʻe o Natalizumab

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i ka sclerosis lehulehu a me ka maʻi o Crohn inā ʻaʻole kūpono ʻo natalizumab iā ʻoe. E noʻonoʻo kāu kauka i kou kūlana kikoʻī, ka mōʻaukala olakino, a me nā pahuhopu lapaʻau i ka wā e ʻimi ai i nā koho ʻē aʻe.

No ka sclerosis lehulehu, nā lāʻau lapaʻau hoʻololi maʻi ʻē aʻe e pili ana i nā lāʻau interferon, glatiramer acetate, a me nā koho waha hou e like me fingolimod a i ʻole dimethyl fumarate. Loaʻa i kēlā me kēia mea nā pōmaikaʻi a me nā hopena ʻaoʻao like ʻole.

ʻO nā koho ʻē aʻe o ka maʻi o Crohn e pili ana i nā lāʻau biologic ʻē aʻe e like me infliximab, adalimumab, a i ʻole vedolizumab. Hana kēia mau mea ma o nā ʻano hana like ʻole akā hiki ke like ka hopena no nā kānaka he nui.

Ua maikaʻi kekahi poʻe me nā immunosuppressants kuʻuna e like me methotrexate a i ʻole azathioprine. Pono kēia mau mea i ka nānā ʻokoʻa akā kūpono paha ma muli o kou kūlana.

Aia ke koho i nā mea e like me ke koʻikoʻi o kou maʻi, ka pane ʻana i ka lāʻau lapaʻau ma mua, a me nā makemake pilikino e pili ana i ke ala o ka lawelawe ʻana. E kōkua kāu kauka iā ʻoe e noʻonoʻo pono i kēia mau koho.

ʻOi aku ka maikaʻi o Natalizumab ma mua o Ocrelizumab?

He mau lāʻau lapaʻau maikaʻi ʻo Natalizumab a me ocrelizumab no ka sclerosis lehulehu, akā hana lākou i nā ʻano like ʻole a ʻoi aku ka maikaʻi no nā kānaka like ʻole. Aia ke koho

Hāʻawi ʻia ʻo Natalizumab i kēlā me kēia mahina a kuhikuhi i kahi ala kikoʻī e pale ai i nā pūnaewele immune mai ke komo ʻana i ka lolo. Hāʻawi ʻia ʻo Ocrelizumab i kēlā me kēia ʻeono mahina a hana ma ka hoʻopau ʻana i kekahi mau pūnaewele immune i kapa ʻia ʻo B cells.

Ma ke ʻano o ka pono, hoʻemi nui nā lāʻau lapaʻau ʻelua i nā helu relapse a hoʻolohi i ka holomua o ke kino kīnā. Hōʻike kekahi mau haʻawina e ʻoi aku ka maikaʻi o ka natalizumab i ka pale ʻana i nā relapses, ʻoiai ʻoi aku ka maikaʻi o ka ocrelizumab i ka hoʻolohi ʻana i ka holomua o ke kino kīnā.

He ʻokoʻa nui nā ʻano hopena ʻaoʻao ma waena o kēia mau lāʻau lapaʻau. Loaʻa i ka Natalizumab ka pilikia o PML, ʻoiai ʻo ocrelizumab e hoʻonui i ka pilikia o ka maʻi a he mau hopohopo e pili ana i kekahi mau maʻi maʻi.

E noʻonoʻo kāu kauka i nā mea e like me kāu kūlana maʻi JC, ka mōʻaukala maʻi, a me nā makemake lapaʻau i ke koho ʻana ma waena o kēia mau koho. He mau lāʻau lapaʻau maikaʻi ʻelua i ka wā e hoʻohana ʻia ai i ke kanaka kūpono.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Natalizumab

He palekana anei ʻo Natalizumab no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana palekana ʻia ʻo Natalizumab i ka poʻe me ka maʻi diabetes, akā pono e mālama maikaʻi ʻia kāu mana kōpaʻa koko ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau. He mea nui ka mālama maikaʻi ʻana i ka maʻi diabetes no ka mea e pili ana ka natalizumab i kāu ʻōnaehana immune.

Makemake kāu kauka e hōʻoia i ka paʻa ʻana o kāu maʻi diabetes a ʻaʻole ʻoe i nā pilikia e like me nā maʻi ʻeha wāwae diabetic a i ʻole nā maʻi pinepine. Hiki ke ʻoi aku ka maikaʻi o kēia mau kūlana inā hoʻopaʻa ʻia kāu ʻōnaehana immune.

He mea nui ka nānā mau ʻana ke loaʻa iā ʻoe nā kūlana ʻelua. E hoʻopili kāu hui mālama ola ma waena o kāu neurologist a i ʻole gastroenterologist a me kāu loea maʻi diabetes.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o Natalizumab?

ʻAʻole paha e loaʻa ka overdose me ka natalizumab no ka mea ua hāʻawi ʻia e nā poʻe loea mālama ola i nā hoʻonohonoho lapaʻau i mālama ʻia. Eia naʻe, inā loaʻa iā ʻoe kahi mahele kiʻekiʻe ma mua o ka mea i kuhikuhi ʻia, e haʻi koke i kāu hui lapaʻau.

ʻAʻohe lāʻau kūpono kikoʻī no ka lāʻau natalizumab, no laila e kālele ana ka mālama ʻana i ka nānā ʻana a me ka mālama ʻana i nā hōʻailona e ulu ana. E nānā pono kāu hui mālama ola iā ʻoe no nā hopena ʻaoʻao i hoʻonui ʻia.

ʻO ka hapa nui o nā kūlana overdose e pili ana i ka loaʻa ʻana o ka lāʻau i nā manawa pinepine ma mua o ka nui i ka manawa hoʻokahi. E hoʻoponopono kāu kauka i kāu papa manawa a me ka nānā ʻana inā e hana kēia.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Natalizumab?

Inā e poina iā ʻoe kāu infusion natalizumab i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu mea mālama ola i ka hiki wawe e hoʻonohonoho hou. Aia ka manawa o kāu mahele aʻe i ka lōʻihi o ka manawa mai kāu mālama hope loa.

ʻAʻole pilikia ka poina ʻana i hoʻokahi mahele i kekahi manawa, akā he mea nui ka kūlike no ka mālama ʻana i ka pono o ka lāʻau. Hiki i kāu kauka ke ʻōlelo e hoʻi i kāu papa manawa maʻamau a i ʻole e hoʻoponopono i ka manawa.

Mai hoʻāʻo e

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana i ka natalizumab, akā pono e pale ʻia nā lāʻau lapaʻau ola no ka mea hiki iā lākou ke hoʻoulu i nā maʻi i ka poʻe me nā ʻōnaehana pale i hoʻopaʻa ʻia. E nānā kāu kauka i kāu mau pono e loaʻa ai nā lāʻau lapaʻau.

ʻO nā lāʻau lapaʻau i hoʻopau ʻia e like me ka pana flu, ka lāʻau lapaʻau pneumonia, a me nā lāʻau lapaʻau COVID-19 he palekana a paipai ʻia. Eia naʻe, ʻaʻole paha lākou e hana maikaʻi i ka wā e lawe ana ʻoe i ka natalizumab.

E hoʻolālā e hōʻano hou i kāu mau lāʻau lapaʻau ma mua o ka hoʻomaka ʻana i ka natalizumab inā hiki. E hāʻawi kāu kauka i ke alakaʻi kikoʻī e pili ana i kāu kūlana pilikino a me ke kūlana o kēia manawa.