He aha ʻo Neratinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i manaʻo ʻia ʻo Neratinib e hana ana ma ka pale ʻana i nā protein kikoʻī e kōkua ana i kekahi mau pūnaewele maʻi ʻaʻai umauma e ulu a laha. He ʻāpana ia o kahi pūʻulu o nā lāʻau lapaʻau i kapa ʻia ʻo tyrosine kinase inhibitors, e hana ana e like me nā kuapo molekala e hiki ke hoʻopau i nā hōʻailona ulu o nā pūnaewele maʻi ʻaʻai.

Hōʻike kēia lāʻau lapaʻau i kahi holomua nui i ka mālama ʻana i ka maʻi ʻaʻai umauma, e hāʻawi ana i ka manaʻolana no nā maʻi me ka maʻi ʻaʻai umauma HER2-positive. Hiki ke kauoha ʻia ʻo neratinib iā ʻoe inā ua pau mua ʻoe i ka mālama mua ʻana a pono ʻoe i ka lāʻau lōʻihi e kōkua i ka pale ʻana i ka maʻi ʻaʻai mai ka hoʻi ʻana mai.

No ke aha e hoʻohana ʻia ai ʻo Neratinib?

Hoʻohana nui ʻia ʻo Neratinib e mālama i nā mākua me ka maʻi ʻaʻai umauma HER2-positive i ke kahua mua. Hoʻolālā ʻia no nā maʻi i loaʻa mua i ka lāʻau trastuzumab (Herceptin) a pono i ka lāʻau hou e hōʻemi i ko lākou pilikia o ka hoʻi hou ʻana o ka maʻi ʻaʻai.

Hana ka lāʻau lapaʻau e like me ka mea a nā kauka e kapa ai he

E manaʻo e like me nā pūnaewele maʻi ʻaʻai he nui nā kuapo "on" no ka ulu ʻana. Hana ʻo Neratinib ma ka hoʻopaʻa mau ʻana i kēia mau kuapo a mālama iā lākou ma ke kūlana "off". He ʻokoʻa kēia mai kekahi mau lāʻau lapaʻau maʻi ʻaʻai ʻē aʻe e ālai wale ana i kēia mau hōʻailona no ka manawa.

Ma ke ʻano he lāʻau lapaʻau i manaʻo ʻia, ʻoi aku ka ikaika o ka neratinib ma mua o ka lāʻau hormone akā ʻoi aku ka liʻiliʻi o nā hopena ʻino ma mua o ka chemotherapy kuʻuna. Hoʻopā pololei ka lāʻau lapaʻau i nā pūnaewele maʻi ʻaʻai me ka liʻiliʻi o ka hopena i nā pūnaewele olakino, akā hiki nō iā ʻoe ke ʻike i kekahi mau hopena ʻaoʻao.

Pehea wau e lawe ai iā Neratinib?

E lawe iā neratinib e like me ke kauoha a kāu kauka, maʻamau i hoʻokahi manawa i ka lā me ka meaʻai. ʻO ka lawe ʻana me ka ʻai e kōkua i kou kino e komo maikaʻi i ka lāʻau a hiki ke hōʻemi i ka ʻōpū.

E ale i nā papa holoʻokoʻa me ka wai - mai ʻoki, nau, a haki paha iā lākou. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai, akā mai hoʻololi iā ʻoe iho i nā papa.

E ʻōlelo paha kāu kauka e ʻai i ka meaʻai māmā a i ʻole ka meaʻai māmā ma mua o ka lawe ʻana iā neratinib. E pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana i kēia lāʻau, no ka mea, hiki iā lākou ke keakea i ke ʻano o ka hana ʻana o kou kino i ka lāʻau. He mea nui nō hoʻi e lawe iā neratinib i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i kāu ʻōnaehana.

Pehea ka lōʻihi e lawe ai au iā Neratinib?

Lawe ka hapa nui o nā maʻi iā neratinib no hoʻokahi makahiki (12 mahina) ke hoʻohana ʻia e like me ka lāʻau lapaʻau adjuvant i hoʻonui ʻia. E hoʻoholo kāu oncologist i ka lōʻihi pololei e pili ana i kāu kūlana kikoʻī a me ka maikaʻi o kou ʻae ʻana i ka lāʻau.

ʻAʻole kūpono ka manawa lapaʻau - hōʻike ka noiʻi e hāʻawi ka makahiki hoʻokahi o ka lāʻau neratinib i ke kaulike maikaʻi loa ma waena o ka pono a me nā hopena ʻaoʻao hiki ke mālama ʻia. Pono paha kekahi poʻe maʻi e hoʻomaha a hoʻololi paha i kā lākou papa hana inā ʻike lākou i nā hopena ʻaoʻao nui.

Mai hooki koke i ka lawe ʻana i ka neratinib me ka ʻole e kamaʻilio mua me kāu kauka. ʻOiai inā maikaʻi kou manaʻo, he mea nui ka hoʻopau ʻana i ka papa lapaʻau piha no ka loaʻa ʻana o ka pōmaikaʻi nui loa. E nānā kāu hui mālama ola iā ʻoe i ka wā o ka lapaʻau a e hana i nā hoʻoponopono e like me ka mea e pono ai.

He aha nā hopena ʻaoʻao o Neratinib?

ʻO ka hopena ʻaoʻao maʻamau o ka neratinib ka maʻi maʻi, e pili ana i ka aneane o nā maʻi e lawe ana i kēia lāʻau. Hoʻomaka maʻamau kēia i loko o nā lā mua o ka lapaʻau a hiki ke koʻikoʻi loa i ka wā mua.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e hiki iā ʻoe ke ʻike:

• Maʻi maʻi (ʻoi loa i ka mahina mua)
• Nausea a me ka luaʻi
• ʻEha ʻōpū a me ka ʻūlū
• Luhi a me ka nāwaliwali
• Nalo o ka ʻai
• Nā ʻeha waha
• Pāpaʻa ʻili a i ʻole nā loli kui

E kuhikuhi paha kāu kauka i nā lāʻau anti-diarrheal e kōkua i ka mālama ʻana i kēia hopena ʻaoʻao. ʻIke ka hapa nui o nā maʻi e lilo ka maʻi maʻi i mea hiki ke mālama ʻia ma hope o ka mahina mua o ka lapaʻau.

ʻO nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e komo pū ana me ka maloʻo nui mai ka maʻi maʻi, nā pilikia o ke ake, a me nā pilikia o ka puʻuwai. E kelepona koke i kāu hui mālama ola inā ʻike ʻoe i ka luaʻi mau, nā hōʻailona o ka maloʻo, ka melemele o ka ʻili a i ʻole nā maka, a i ʻole ka hanu ʻole maʻamau.

ʻO kekahi mau hopena ʻaoʻao laha akā koʻikoʻi e komo pū ana me nā hopena ʻili koʻikoʻi, ka mumū o ka māmā, a me nā loli nui i ka hana o ke ake. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e hele i nā manawa nānā i hoʻonohonoho ʻia i hiki i kāu kauka ke hopu i nā pilikia i ka wā mua.

ʻO wai ka mea pono ʻole e lawe i ka Neratinib?

ʻAʻole kūpono ka Neratinib no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kuhikuhi ʻana. ʻAʻole pono ʻoe e lawe i ka neratinib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mea ʻai.

Hiki i kekahi mau maʻi olakino ke palekana ʻole ka neratinib iā ʻoe. E makaʻala loa kāu kauka inā loaʻa iā ʻoe:

• He maʻi ate nui a i ʻole nā pilikia o ka hana ate
• Nā pilikia o ka naʻau a i ʻole ka hāʻule ʻana o ka naʻau
• He maʻi kīkī nui
• Nā maʻi e hana nei
• He maʻi ʻāʻī ʻāʻī
• He moʻolelo o ka maʻi palahē nui me nā lāʻau ʻē aʻe

He mea nui nō hoʻi ka hāpai ʻana a me ka hānai ʻana i ka waiū. Hiki i ka Neratinib ke hōʻeha i ka pēpē i hānau ʻole ʻia, no laila pono ʻoe e hoʻohana i ka mana hānau pono i ka wā e mālama ʻia ai a no hoʻokahi mahina ma hope o kāu lāʻau hope loa.

Inā ʻoe e hānai ana i ka waiū, pono ʻoe e hooki i ka wā e lawe ana i ka neratinib a no hoʻokahi mahina ma hope o kāu lāʻau hope loa. Hiki i ka lāʻau lapaʻau ke hele i loko o ka waiū umauma a hiki ke hōʻeha i ka pēpē e hānai ana.

Nā inoa inoa o Neratinib

Loaʻa ka Neratinib ma lalo o ka inoa inoa ʻo Nerlynx ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia ke ʻano i kauoha pinepine ʻia o ka lāʻau lapaʻau.

Hiki i kekahi mau ʻāina ke loaʻa nā inoa inoa like ʻole a i ʻole nā mana generic. E nānā mau me kāu kauka lapaʻau e hōʻoia e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono, a mai hoʻololi i nā inoa inoa like ʻole me ka ʻole o ka ʻae ʻana o kāu kauka.

Nā koho ʻē aʻe o Neratinib

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i ka maʻi ʻaʻai umauma HER2-positive, akā ʻo ke koho maikaʻi loa e hilinaʻi ana i kāu kūlana kikoʻī. ʻO nā koho maʻamau e pili ana i ka trastuzumab (Herceptin), pertuzumab (Perjeta), a me T-DM1 (Kadcyla).

No ka lāʻau lapaʻau adjuvant hoʻonui, hiki i kāu kauka ke noʻonoʻo e hoʻomau i ka trastuzumab no hoʻokahi makahiki hou ma mua o ka hoʻololi ʻana i ka neratinib. Hiki i kekahi poʻe maʻi ke lilo i mau moho no nā hoʻokolohua lapaʻau e hoʻāʻo ana i nā lāʻau lapaʻau hou a i ʻole nā hui.

ʻO ke koho ʻana ma waena o kēia mau koho e hilinaʻi ana i nā mea e like me nā ʻano o kāu maʻi ʻaʻai, nā lāʻau lapaʻau i hala, ke olakino holoʻokoʻa, a me nā makemake pilikino. E kōkua kāu oncologist iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia o kēlā me kēia koho.

Ua ʻoi aku ka maikaʻi o Neratinib ma mua o Trastuzumab?

He hana ʻokoʻa ʻo Neratinib a me trastuzumab a hoʻohana pinepine ʻia i nā pae lapaʻau like ʻole, no laila ʻaʻole maʻalahi ka hoʻohālikelike pololei ʻana iā lākou. Hoʻohana maʻamau ʻia ʻo Trastuzumab ma ke ʻano he ʻāpana o ka lapaʻau mua, ʻoiai hāʻawi ʻia ʻo neratinib ma hope ma ke ʻano he lapaʻau hoʻonui.

Hōʻike ka noiʻi ʻana i ka hoʻohui ʻana i ka neratinib ma hope o ka pau ʻana o ka lapaʻau trastuzumab hiki ke hōʻemi hou i ka pilikia o ka hoʻi hou ʻana o ka maʻi maʻi i hoʻohālikelike ʻia me ka trastuzumab wale nō. Eia naʻe, hoʻoulu maʻamau ʻo neratinib i nā hopena ʻaoʻao hou aʻe, ʻo ia hoʻi ka maʻi maʻi.

Aia ka koho

He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Neratinib?

Inā ua hala ʻoe i kahi mahele o neratinib, e lawe koke iā ia ke hoʻomanaʻo ʻoe i ka lā like. Eia naʻe, inā kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia e hiki mai ana, e lele i ka mahele i hala a hoʻomau me kāu papa maʻamau.

Mai lawe ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i nā mea hoʻomanaʻo kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e noho ma ke ala.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Neratinib?

Pono ʻoe e hooki i ka lawe ʻana iā neratinib ke haʻi aku kāu kauka iā ʻoe, ma hope o ka pau ʻana o ka makahiki piha o ka mālama ʻana. ʻO ka hooki ʻana i ka wā mua e hōʻemi paha i ka pono o ka lāʻau lapaʻau i ka pale ʻana i ka hoʻi hou ʻana o ka maʻi kanesa.

Inā ʻoe e ʻike nei i nā hopena ʻaoʻao koʻikoʻi, e kamaʻilio me kāu kauka e pili ana i ka hoʻoponopono ʻana i kāu mahele a i ʻole ka lawe ʻana i kahi hoʻomaha manawa ma mua o ka hooki ʻana. Hiki i kāu hui mālama ola ke kōkua iā ʻoe e ʻimi i nā ala e mālama ai i nā hopena ʻaoʻao ʻoiai e loaʻa ana ka pōmaikaʻi piha o ka mālama ʻana.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Neratinib?

ʻOiai ʻaʻohe pilina pololei ma waena o neratinib a me ka waiʻona, ʻoi aku ka maikaʻi o ka kaupalena ʻana a i ʻole ka pale ʻana i ka waiʻona i ka wā o ka mālama ʻana. Hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka nausea a me ka ʻōpū, a hiki ke hoʻopilikia i ka hiki o kou kino ke hana i ka lāʻau lapaʻau.

Eia kekahi, hiki i ka waiʻona ke hoʻokahe i ka wai, he mea hopohopo nui ia no ka mea he hopena ʻaoʻao maʻamau ka maʻi maʻi o neratinib. Inā koho ʻoe e inu i kekahi manawa, e hana me ka maʻalahi a e hōʻoia e noho maikaʻi ʻoe.