He aha ʻo Obinutuzumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻaʻai ʻo Obinutuzumab e kōkua ana i kou ʻōnaehana pale e hakakā i kekahi mau ʻano maʻi koko. No loko kēia lāʻau lapaʻau i kahi hui i kapa ʻia he monoclonal antibodies, e hana ana e like me nā pōkā alakaʻi e ʻimi a hoʻouka i nā pūnaewele maʻi ʻaʻai kikoʻī me ka waiho ʻana i ka hapa nui o nā pūnaewele olakino.

Hiki iā ʻoe ke manaʻo e piʻi nui ana ke aʻo ʻana e pili ana i kahi lāʻau lapaʻau maʻi ʻaʻai hou, a he mea maʻamau loa ia. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o ka obinutuzumab hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu hoʻolālā lapaʻau.

He aha ʻo Obinutuzumab?

He antibody i hana ʻia i loko o ka hale hana ʻo Obinutuzumab e kuhikuhi ana i kahi protein kikoʻī i loaʻa ma nā pūnaewele maʻi ʻaʻai. E noʻonoʻo iā ia he mākaʻi i hoʻomaʻamaʻa nui ʻia e hiki ke ʻike a hōʻailona i nā pūnaewele maʻi ʻaʻai no ka luku ʻia e kou ʻōnaehana pale.

Hāʻawi ʻia kēia lāʻau lapaʻau ma o ka IV infusion, ʻo ia hoʻi, e kahe pololei ana i loko o kou kahe koko ma o ka nila i kou lima a i ʻole ke awa. Hoʻolālā ʻia ka lapaʻau e ʻoi aku ka pololei ma mua o ka chemotherapy kuʻuna, e kālele ana i nā pūnaewele maʻi ʻaʻai ma mua o ka hoʻopilikia ʻana i nā pūnaewele e mahele wikiwiki ana i kou kino.

Ua ʻae ʻia ʻo Obinutuzumab e ka FDA ma ke ʻano he lāʻau lapaʻau breakthrough no ka mea ua hōʻike ʻo ia i nā hoʻomaikaʻi nui i ke kōkua ʻana i ka poʻe me kekahi mau maʻi koko e ola lōʻihi a olakino.

No ke aha e hoʻohana ʻia ai ʻo Obinutuzumab?

Hoʻomaʻamaʻa ʻo Obinutuzumab i nā ʻano maʻi koko kikoʻī, ʻo ia hoʻi ka maʻi leukemia lymphocytic maʻi a me kekahi mau ʻano o ka non-Hodgkin's lymphoma. Ua ʻōlelo paha kāu kauka i kēia lapaʻau no ka mea he hōʻailona protein kikoʻī kāu mau pūnaewele maʻi ʻaʻai e hoʻolilo iā lākou i mea nāwaliwali i kēia lāʻau lapaʻau.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau ma ke ʻano he lapaʻau laina mua, ʻo ia hoʻi, ʻo ia kekahi o nā koho mua e hoʻāʻo ai kāu hui lapaʻau. Hoʻohui pinepine ʻia me nā lāʻau lapaʻau maʻi ʻaʻai ʻē aʻe e hana i kahi ala lapaʻau piha.

I kekahi mau hihia, hiki ke ʻōlelo ʻia ʻo obinutuzumab inā ʻaʻole i hana maikaʻi nā lāʻau lapaʻau ʻē aʻe e like me ka mea i manaʻo ʻia. E wehewehe pono kāu oncologist i ke kumu e kūpono ai kēia lapaʻau no kāu kūlana.

Pehea e hana ai ʻo Obinutuzumab?

Hana ʻo Obinutuzumab ma ka hoʻopili ʻana i kahi protein i kapa ʻia ʻo CD20 e noho ana ma ka ʻili o kekahi mau cella maʻi maʻi. Ke hoʻopili ʻia, hōʻailona ia i kāu ʻōnaehana pale e luku i kēia mau cella i kaha ʻia ma o nā ala he nui.

Ua manaʻo ʻia kēia lāʻau lapaʻau he koho lapaʻau ikaika a maikaʻi. ʻAʻole like me ka chemotherapy e pili ana i nā ʻano cella like ʻole, ua manaʻo ʻia ʻo obinutuzumab e kuhikuhi ana i nā cella maʻi maʻi, ʻo ia hoʻi ka liʻiliʻi o nā hopena ʻaoʻao.

Hana mālie ke kaʻina hana ma luna o nā pōʻai lapaʻau he nui. Lilo ka ʻōnaehana pale o kou kino i mea maikaʻi i ka ʻike ʻana a me ka hoʻopau ʻana i nā cella maʻi maʻi i ka holomua ʻana o ka lapaʻau.

Pehea wau e lawe ai iā Obinutuzumab?

Hāʻawi mau ʻia ʻo Obinutuzumab ma ke ʻano he infusion IV i kahi hoʻonohonoho mālama ola, ʻaʻole loa ma ke ʻano he pill āu e lawe ai ma ka home. E hoʻokomo kāu hui mālama ola i kahi nila liʻiliʻi i loko o kahi vein i kou lima a i ʻole e komo i kahi awa inā loaʻa iā ʻoe.

Ma mua o kēlā me kēia infusion, e loaʻa iā ʻoe nā lāʻau lapaʻau ma mua e kōkua i ka pale ʻana i nā hopena maʻi. Hiki i kēia mau mea ke komo i nā antihistamines, acetaminophen, a i ʻole corticosteroids. ʻAʻole pono ʻoe e hoʻokē ʻai ma mua o ka lapaʻau ʻana, a ʻo ka ʻai ʻana i ka meaʻai māmā ma mua e hiki ke kōkua iā ʻoe e ʻoluʻolu.

ʻO ka infusion mua ka lōʻihi ma mua o nā mea aʻe, i kekahi manawa a hiki i 6-8 mau hola. ʻO ka maʻamau, lawe nā lāʻau lapaʻau ma hope he 3-4 mau hola. E nānā pono ʻia ʻoe i ke kaʻina hana holoʻokoʻa, a hiki ke hoʻolohi a hoʻomaha paha ka infusion inā ʻike ʻoe i kekahi ʻoluʻolu.

Pehea ka lōʻihi e lawe ai au iā Obinutuzumab?

Aia ka lōʻihi o kāu lapaʻau obinutuzumab i kāu ʻano maʻi maʻi a me ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau. ʻO ka hapa nui o nā hoʻolālā lapaʻau e pili ana i nā pōʻai he nui i nā mahina he nui.

Hiki i kahi papa hana lapaʻau maʻamau ke komo i ʻeono pōʻaiapuni, me kēlā me kēia pōʻaiapuni e mau ana ma kahi o 28 mau lā. I ka wā o ka pōʻaiapuni mua, hiki iā ʻoe ke loaʻa ka lāʻau lapaʻau pinepine, a laila ʻaʻole pinepine i nā pōʻaiapuni ma hope.

E nānā mau kāu kauka i kāu holomua ma o nā hoʻokolohua koko a me nā haʻawina kiʻi. Ma muli o ke ʻano o ka pane ʻana o kāu maʻi maʻi a me ka maikaʻi o kou ʻae ʻana i ka lapaʻau, hiki i kāu hui lapaʻau ke hoʻoponopono i ka lōʻihi a i ʻole ke alapine o kāu infusions.

He aha nā hopena ʻaoʻao o Obinutuzumab?

E like me nā lapaʻau maʻi maʻi a pau, hiki i ka obinutuzumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia ma mua o ka chemotherapy kuʻuna. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻopili ai i kāu hui mālama ola.

Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao, a he ʻike ko kāu hui lapaʻau i ke kōkua ʻana i nā maʻi ma o nā pilikia e kū mai ana. E nānā kākou i nā hopena maʻamau e hiki iā ʻoe ke ʻike.

Nā Hopena ʻAoʻao Maʻamau

Hana pinepine ʻia nā hopena ʻaoʻao ma muli o ka hana nui ʻana o kāu ʻōnaehana pale a ke hana nei kou kino i ka lāʻau lapaʻau. He manawa pōkole kēia mau hopena a hoʻomaikaʻi ma waena o nā pōʻaiapuni lapaʻau.

• Luhi a piʻi ka luhi ma mua o ka maʻamau
• ʻO ka nausea a i ʻole ka ʻōpū ʻoluʻolu
• Nā poʻo
• ʻO nā ʻeha ʻiʻo a i ʻole nā hui
• Fiva a i ʻole nā anu
• ʻO ka ʻū a i ʻole nā hōʻailona hanu māmā
• ʻO ka ʻili ʻili a i ʻole ka ʻū
• Pāpaʻa a i ʻole ka paʻa

Hoʻomaikaʻi pinepine kēia mau hōʻailona i ka wā e hoʻoponopono ai kou kino i ka lapaʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā lāʻau lapaʻau a me nā hoʻolālā e kōkua i ka mālama ʻana i nā pilikia āu e ʻike ai.

Nā Hana e pili ana i ka Infusion

ʻIke kekahi poʻe i nā hopena i ka wā a i ʻole ma hope koke o ka loaʻa ʻana o ka infusion. Nānā pono kāu hui lapaʻau iā ʻoe no kēia mau hopena, ʻo ia ke kumu e loaʻa ai iā ʻoe nā lāʻau lapaʻau mua a noho ma lalo o ka nānā ʻana.

• Ka wela a i ʻole ke anu i ka wā o ka lapaʻau
• Ka pōkole o ka hanu a i ʻole ka pilikia o ka hanu
• Ka paʻa ʻana o ka umauma a i ʻole ka ʻeha
• Ka puʻuwai wikiwiki
• Ka wili a i ʻole ka māmā
• Ka ʻulaʻula a i ʻole ka ʻulaʻula o ka ʻili
• Ka pehu ʻana o ka maka, nā lehelehe, a i ʻole ka ʻāʻī

Inā loaʻa kekahi o kēia mau mea, hiki i kāu kahu hānai ke hoʻolohi a hoʻōki paha i ka hoʻokomo ʻana. ʻO ka hapa nui o nā hopena he maʻalahi a hoʻoponopono koke ʻia me ka mālama kūpono.

Nā hopena ʻaoʻao koʻikoʻi

ʻOiai ʻaʻole maʻamau, pono kekahi mau hopena ʻaoʻao i ka lāʻau lapaʻau koke. E aʻo kāu hui mālama ola iā ʻoe i nā hōʻailona hōʻailona e nānā ai a i ka manawa e kāhea aku ai iā lākou.

• Nā hōʻailona o ka maʻi e like me ke kuni mau, ka luhi nui, a i ʻole nā ​​hōʻailona maʻamau
• Nā pilikia hanu nui a i ʻole ka ʻeha o ka umauma
• Ke kahe ʻana o ke koko a i ʻole ka ʻeha maʻamau
• ʻEha nui o ka ʻōpū
• Huikau a i ʻole nā ​​hoʻololi i ke kūlana noʻonoʻo
• Nā hopena ʻili nui a i ʻole ka ʻōpala ākea
• Melemele o ka ʻili a i ʻole nā ​​maka

He kakaikahi kēia mau hopena koʻikoʻi, akā ʻo ka ʻike ʻana iā lākou i ka wā mua e hōʻoiaʻiʻo ai e loaʻa iā ʻoe ka lāʻau lapaʻau wikiwiki inā pono.

Nā hopena ʻaoʻao kakaikahi akā koʻikoʻi

Hiki i kekahi mau hopena ʻaoʻao kakaikahi loa ke hana i nā pule a i ʻole nā ​​mahina ma hope o ka lapaʻau. ʻOiai ʻaʻole maʻamau kēia mau mea, ʻo ka ʻike ʻana iā lākou e kōkua iā ʻoe e makaʻala i kou olakino i ka manawa.

• Progressive multifocal leukoencephalopathy (PML) - he maʻi lolo kakaikahi
• Nā pilikia ate nui
• Nā maʻamau o ka puʻuwai
• Tumor lysis syndrome - i ka wā e wāwahi koke ai nā cella maʻi maʻi
• Nā helu koko haʻahaʻa nui e mau ana no nā pule he nui
• Hoʻāla hou ʻia o ka maʻi hepatitis B i ka poʻe i loaʻa mua

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau pilikia kakaikahi ma o nā hoʻokolohua koko maʻamau a me nā nānā.

ʻO wai ka mea pono ʻole e lawe iā Obinutuzumab?

ʻAʻole kūpono ʻo Obinutuzumab no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka ʻōlelo ʻana i kēia lapaʻau. ʻO ka ʻoiaʻiʻo e pili ana i kou olakino e kōkua i ka hōʻoia ʻana i ka palekana o kēia lāʻau lapaʻau iā ʻoe.

Pono ka poʻe me nā maʻi koʻikoʻi, ikaika e kali a hiki i ka pau ʻana o ka maʻi ma mua o ka hoʻomaka ʻana i ka lapaʻau. Pono e lawa ka ikaika o kāu ʻōnaehana pale e mālama pono i ka lāʻau lapaʻau.

Inā he moʻolelo kou o ka hepatitis B, ʻoiai inā ʻaʻole i hana no nā makahiki, pono ʻoe i ka nānā kūikawā. Hiki i ka lāʻau lapaʻau ke hoʻāla hou i kēia maʻi ma kekahi manawa, akā ua ʻike kāu hui lapaʻau i ka nānā ʻana a me ka pale ʻana i kēia pilikia.

ʻAʻole pono nā wahine hāpai e loaʻa iā obinutuzumab, no ka mea, hiki iā ia ke hōʻeha i ka pēpē e ulu ana. Inā ʻoe e hoʻolālā nei e hāpai, e kūkākūkā kāu kauka i nā lapaʻau ʻē aʻe a i ʻole nā koho manawa me ʻoe.

Nā inoa inoa ʻo Obinutuzumab

Kūʻai ʻia ʻo Obinutuzumab ma lalo o ka inoa inoa ʻo Gazyva ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. Hiki nō hoʻi iā ʻoe ke ʻike iā ia i kapa ʻia ʻo Gazyvaro ma kekahi mau ʻāina ʻEulopa.

He like ka lāʻau lapaʻau me ka nānā ʻole i ka inoa inoa. E hōʻoia kāu hale kūʻai lāʻau lapaʻau a i ʻole ke kikowaena lapaʻau e loaʻa iā ʻoe ka hoʻomākaukau kūpono i kauoha ʻia e kāu oncologist.

Nā koho ʻē aʻe ʻo Obinutuzumab

Nui nā lāʻau lapaʻau ʻē aʻe e hana like me obinutuzumab no ka mālama ʻana i nā maʻi koko. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe e pili ana i kāu kūlana kikoʻī, nā lapaʻau mua, a i ʻole ka uhi ʻinikua.

ʻO Rituximab kekahi antibody monoclonal e kuhikuhi ana i ka protein CD20 like. Ua hoʻohana ʻia no ka lōʻihi ma mua o obinutuzumab a loaʻa kahi ʻano palekana i hoʻokumu ʻia, ʻoiai ua hōʻike nā haʻawina e ʻoi aku ka maikaʻi o obinutuzumab no kekahi mau kūlana.

ʻO nā koho ʻē aʻe e komo pū ana me ka ofatumumab, kekahi antibody anti-CD20, a i ʻole nā ʻano lapaʻau i manaʻo ʻia e like me nā mea pale BTK. E wehewehe ana kāu oncologist i ke kumu e manaʻoʻiʻo ai lākou ʻo obinutuzumab ke koho maikaʻi loa no kāu ʻano maʻi maʻi a me ke kūlana.

Ua ʻoi aku ka maikaʻi o Obinutuzumab ma mua o Rituximab?

Ua hōʻike nā haʻawina e hiki i ka obinutuzumab ke ʻoi aku ka maikaʻi ma mua o ka rituximab no kekahi mau ʻano maʻi koko, ʻo ia hoʻi ka leukemia lymphocytic maʻi. Eia naʻe, "ʻoi aku ka maikaʻi" e hilinaʻi ana i kou kūlana pilikino a me ka mōʻaukala olakino.

Ua hoʻolālā kūikawā ʻia ʻo Obinutuzumab e ʻoi aku ka ikaika ma mua o ka rituximab i ka luku ʻana i nā sela maʻi. Ua hōʻike nā hoʻokolohua lapaʻau e ola lōʻihi ana nā kānaka me kekahi mau maʻi maʻi me ka ʻole o ka holomua o ko lākou maʻi ke mālama ʻia me obinutuzumab i hoʻohālikelike ʻia me rituximab.

Eia naʻe, ua hoʻohana maikaʻi ʻia ka rituximab no nā makahiki he nui a he moʻolelo lōʻihi o ka ʻikepili palekana. E noʻonoʻo kāu kauka i nā mea e like me kou makahiki, ke olakino holoʻokoʻa, nā lapaʻau mua, a me nā ʻano maʻi maʻi kikoʻī i ka wā e hoʻoholo ai i ka lāʻau lapaʻau e hāʻawi iā ʻoe i ka manawa maikaʻi loa o ka holomua.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Obinutuzumab

Q1. He palekana anei ʻo Obinutuzumab no ka poʻe me nā pilikia o ka naʻau?

Hiki i nā poʻe me nā maʻi puʻuwai ke loaʻa mau iā obinutuzumab, akā pono lākou i ka nānā pono ʻana i ka wā o ka mālama ʻana. E hana pū kāu cardiologist a me oncologist e hōʻoia i ka hiki i kou puʻuwai ke mālama i ka lāʻau lapaʻau me ka palekana.

Hiki ke hoʻololi ʻia ke kaʻina hana infusion no ka poʻe me nā pilikia o ka naʻau, me nā helu hoʻokele lohi a me ka nānā pinepine ʻana. Hiki nō hoʻi i kāu hui lapaʻau ke hoʻoponopono i nā lāʻau lapaʻau mua āu e loaʻa ai e hōʻemi i ke kaumaha ma kāu ʻōnaehana cardiovascular.

Inā he mōʻaukala kou o ka maʻi puʻuwai, e hōʻoia e kūkākūkā pono i kēia me kāu oncologist. Hiki iā lākou ke wehewehe i nā pilikia a me nā pōmaikaʻi kikoʻī i kou kūlana a me ka mea e nānā ʻia.

Q2. He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Obinutuzumab?

Mai ka mea e hāʻawi ʻia ana ka obinutuzumab e nā poʻe loea mālama ola i loko o kahi keʻena lapaʻau, he mea kakaʻikahi loa nā mea i hana ʻia me ka nui. Hoʻohālikelike ʻia ka lāʻau lapaʻau e pili ana i kou kaumaha kino a hāʻawi ʻia e nā limahana lapaʻau i aʻo ʻia.

Inā manaʻo ʻoe ua hana hewa ʻia i ka wā o kāu mālama ʻana, e ʻōlelo koke. Lawe ko kāu hui lapaʻau i kēia mau hopohopo me ka koʻikoʻi a e noiʻi koke lākou i nā pilikia e hiki mai ana.

I ka hanana hiki ʻole o ka nui, e nānā pono ʻia ʻoe no ka hoʻonui ʻia ʻana o nā hopena ʻaoʻao, a e hāʻawi kāu hui lapaʻau i ke kākoʻo e kōkua i kou kino e hana i ka lāʻau lapaʻau keu me ka palekana.

Q3. He aha kaʻu e hana ai inā hala iaʻu kahi mahele o ka Obinutuzumab?

Inā hala ʻoe i kahi infusion obinutuzumab i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui oncology i ka wā hiki loa e hoʻonohonoho hou. E hoʻoholo lākou i ka manawa maikaʻi loa no kāu mālama ʻana e pili ana i kāu protocol mālama a me ka nui o ka manawa i hala.

Ma keʻano maʻamau, he mea nui e noho kokoke i kāu hoʻolālā mālama i hoʻonohonoho ʻia no nā hopena maikaʻi loa. Eia naʻe, maopopo i kāu hui lapaʻau i kekahi manawa e hiki ke hoʻopilikia ʻia nā maʻi, nā pilikia, a i ʻole nā kūlana ʻē aʻe me kāu mau manawa.

Mai ho'āʻo e hana i nā mahele i hala ma ka hoʻonohonoho ʻana i nā mālama kokoke loa. E hoʻoponopono kāu oncologist i kāu papa hana mālama me ka palekana e hōʻoia e loaʻa iā ʻoe ka pōmaikaʻi piha o ka lāʻau lapaʻau.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Obinutuzumab?

ʻAʻole pono ʻoe e hooki i ka mālama ʻana i ka obinutuzumab me ka ʻole e kūkākūkā mua me kāu oncologist. ʻO ka hoʻoholo e hooki i ka mālama ʻana e pili ana i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi a inā e ʻike nei ʻoe i nā hopena ʻaoʻao hiki ke mālama ʻia.

E loiloi mau kāu kauka i kou holomua ma o nā hoʻokolohua koko, nā kiʻi, a me nā hoʻokolohua kino. Inā e pane maikaʻi ana kāu maʻi 'aʻai a ua hoʻopau ʻoe i kāu mau pōʻai lapaʻau i hoʻolālā ʻia, e kūkākūkā lākou i ka manawa kūpono e hooki ai.

Pono paha kekahi poʻe e hooki i ka lapaʻau ma mua ma muli o nā hopena ʻaoʻao koʻikoʻi, a e pōmaikaʻi paha kekahi poʻe mai nā pōʻai hou. E hana kāu hui lapaʻau i kēia mau hoʻoholo e pili ana i kāu pane pilikino a me ke olakino holoʻokoʻa.

Q5. Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Obinutuzumab?

Pono e pale ʻia nā lāʻau lapaʻau ola i ka wā e loaʻa ana iā obinutuzumab a no kekahi mau mahina ma hope o ka pau ʻana o ka lapaʻau. Eia naʻe, hiki ke ʻōlelo ʻia kekahi mau lāʻau lapaʻau non-live e pale iā ʻoe mai nā maʻi.

E hāʻawi kāu hui mālama ola i ke alakaʻi kikoʻī e pili ana i nā lāʻau lapaʻau palekana a pono i ka wā o kāu lapaʻau. Hiki iā lākou ke ʻōlelo i nā pana flu a i ʻole nā lāʻau lapaʻau ʻē aʻe e kōkua iā ʻoe ke hana ikaika nei kāu ʻōnaehana pale e hakakā i ka maʻi 'aʻai.

E nānā mau me kāu oncologist ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau, ʻoiai nā mea maʻamau. E hoʻopili lākou me kāu kauka mālama mua e hōʻoia i ka loaʻa ʻana o nā immunizations kūpono me ka palekana.