Ofatumumab (alaloa intravenous, alaloa subcutaneous)
Nā mea hōʻailona e loaʻa ana
Arzerra, Kesimpta
E pili ana i kēia lāʻau
Hoʻohana ʻia ka inikini Ofatumumab me ka chlorambucil e mālama i kekahi ʻano o ka maʻi kanesa o nā keʻokeʻo koko i kapa ʻia ʻo ka leukemia lymphocytic maʻi (CLL) i nā mea maʻi ʻaʻole i loaʻa kekahi lāʻau lapaʻau ma mua. Hoʻohana ʻia pū keia me ka fludarabine a me ka cyclophosphamide e mālama i nā mea maʻi me ka CLL i hoʻi hou mai. Hoʻohana ʻia kēia lāʻau lapaʻau i nā mea maʻi me ka CLL i mālama mua ʻia me nā lāʻau lapaʻau ʻē aʻe (e laʻa, alemtuzumab, fludarabine) i hana ʻole maikaʻi. Hoʻohana ʻia pū ka inikini Ofatumumab e mālama i nā ʻano hoʻi hou o ka maʻi multiple sclerosis (MS), me ka clinically isolated syndrome, ka relapsing-remitting disease, a me ka maʻi holomua lua ikaika. ʻAʻole e ho'ōla kēia lāʻau i ka MS, akā hiki iā ia ke hoʻomāmā i kekahi o nā hopena hōʻino a hoʻemi i ka nui o nā hoʻi hou ʻana o ka maʻi. Hoʻopilikia ka Ofatumumab i ka ulu ʻana o nā cell kanesa, kahi i luku ʻia e ke kino. ʻOiai hiki ke hoʻopilikia ʻia ka ulu ʻana o nā cell kino maʻamau e ka ofatumumab, e loaʻa pū nā hopena ʻē aʻe i makemake ʻole ʻia. Hiki i kekahi o kēia mau mea ke koʻikoʻi a pono e hōʻike ʻia i kāu kauka. ʻAʻole koʻikoʻi kekahi o nā hopena makemake ʻole ʻia, e like me ka ʻili ʻili, akā hiki ke hopohopo. ʻAʻole loaʻa kekahi o nā hopena makemake ʻole ʻia a hiki i nā mahina a i ʻole nā makahiki ma hope o ka hoʻohana ʻana i ka lāʻau lapaʻau. Ma mua o kou hoʻomaka ʻana i ka mālama ʻana me ka ofatumumab, pono ʻoe a me kāu kauka e kamaʻilio e pili ana i nā pono o kēia lāʻau lapaʻau a me nā pilikia o ka hoʻohana ʻana iā ia. Pono e hāʻawi ʻia ʻo Arzerra® e ke kauka a i ʻole ma lalo o ka nānā pololei o kāu kauka. Loaʻa wale ʻo Kesimpta® me ka palapala kauka. Loaʻa kēia huahana i nā ʻano dosage penei:
Ma mua o ka hoʻohana ʻana i kēia lāʻau
I ka hoʻoholo ʻana e hoʻohana i kahi lāʻau lapaʻau, pono e kaulike i nā pilikia o ka lawe ʻana i ka lāʻau lapaʻau me ka pono e hana ai. He hoʻoholo kēia āu a me kāu kauka e hana ai. No kēia lāʻau lapaʻau, pono e noʻonoʻo i nā mea aʻe: E haʻi aku i kāu kauka inā ua loaʻa iā ʻoe kekahi hopena maʻamau ʻole a i ʻole nā hopena ʻē aʻe i kēia lāʻau lapaʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe. E haʻi pū aku i kāu limahana mālama ola inā loaʻa iā ʻoe nā ʻano ʻē aʻe o nā maʻi ʻiliʻili, e like me nā meaʻai, nā kala, nā mea mālama, a i ʻole nā holoholona. No nā huahana ʻole-prescription, e heluhelu pono i ka lepili a i ʻole nā mea hoʻohui pūʻolo. ʻAʻohe mau haʻawina kūpono i hana ʻia ma ka pilina o ka makahiki i nā hopena o ka inikini ofatumumab i ka heluna keiki. ʻAʻole i hoʻokumu ʻia ka palekana a me ka pono. ʻAʻohe mau haʻawina kūpono i hana ʻia a hiki i kēia lā i hōʻike ʻole i nā pilikia geriatric-kūikawā e kaupalena ai i ka pono o ka inikini ofatumumab i nā ʻelemakule. Eia naʻe, ʻoi aku ka nui o nā poʻe ʻelemakule i loaʻa nā hopena ʻaoʻao makemake ʻole (e laʻa, neutropenia, pneumonia) e pono ai ke akahele. ʻAʻohe mau haʻawina lawa i nā wāhine no ka hoʻoholo ʻana i ka pilikia o ka pēpē i ka hoʻohana ʻana i kēia lāʻau lapaʻau i ka wā hānai. E kaulike i nā pono hiki ke loaʻa me nā pilikia hiki ke loaʻa ma mua o ka lawe ʻana i kēia lāʻau lapaʻau i ka wā hānai. ʻOiai ʻaʻole pono e hoʻohana pū ʻia kekahi mau lāʻau lapaʻau, i nā hihia ʻē aʻe, hiki ke hoʻohana pū ʻia ʻelua mau lāʻau lapaʻau ʻokoʻa ʻoiai inā hiki ke loaʻa kahi pilina. I kēia mau hihia, makemake paha kāu kauka e hoʻololi i ka nui, a i ʻole nā ʻano palekana ʻē aʻe paha e pono ai. I ka wā e lawe ana ʻoe i kēia lāʻau lapaʻau, he mea nui loa ia i kāu limahana mālama ola e ʻike inā ke lawe nei ʻoe i kekahi o nā lāʻau lapaʻau i helu ʻia ma lalo nei. Ua koho ʻia nā pilina aʻe ma muli o ko lākou nui hiki ke loaʻa a ʻaʻole pono nā mea āpau. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe. Hiki i kāu kauka ke hoʻoholo ʻaʻole e mālama iā ʻoe me kēia lāʻau lapaʻau a hoʻololi paha i kekahi o nā lāʻau lapaʻau ʻē aʻe āu e lawe nei. ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe, akā hiki ke koi ʻia i kekahi mau hihia. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua. ʻAʻole pono e hoʻohana ʻia kekahi mau lāʻau lapaʻau ma a kokoke paha i ka manawa o ka ʻai ʻana i ka meaʻai a i ʻole ka ʻai ʻana i kekahi mau ʻano meaʻai ʻoiai hiki ke loaʻa nā pilina. Hiki i ka hoʻohana ʻana i ka waiʻona a i ʻole ka paka me kekahi mau lāʻau lapaʻau ke hoʻokumu pū i nā pilina. E kūkākūkā me kāu limahana mālama ola i ka hoʻohana ʻana i kāu lāʻau lapaʻau me ka meaʻai, ka waiʻona, a i ʻole ka paka. Hiki i ka loaʻa ʻana o nā pilikia olakino ʻē aʻe ke hoʻopilikia i ka hoʻohana ʻana i kēia lāʻau lapaʻau. E hōʻoia e haʻi aku i kāu kauka inā loaʻa iā ʻoe nā pilikia olakino ʻē aʻe, ʻoiai:
Pehea e hoʻohana ai i kēia lāʻau
E hāʻawi aku ana kekahi nēnē a i ʻole kekahi limahana ola kino i aʻo ʻia iā ʻoe i kēia lāʻau lapaʻau ma kahi halemai. Hāʻawi ʻia ia ma o kahi catheter IV i hoʻokomo ʻia i loko o kekahi o kou mau veins a i ʻole ma ke ʻano he pana ma lalo o kou ʻili, maʻamau ma ke alo o kou mau ʻūhā, ʻōpū, a i ʻole nā lima kiʻekiʻe. Pono e hāʻawi mālie ʻia ʻo Arzerra®, no laila e noho mau ana ka IV no ka liʻiliʻi loa o hoʻokahi hola. Hiki nō hoʻi iā ʻoe ke loaʻa nā lāʻau lapaʻau e kōkua ai i ka pale ʻana i nā maʻi ʻaliki. Hiki mai kēia lāʻau lapaʻau me kahi Alakaʻi Lāʻau Lapaʻau a me nā ʻōlelo aʻo no nā mea maʻi. E heluhelu a hahai pono i nā ʻōlelo aʻo. E nīnau i kāu kauka inā he nīnau kāu. Hiki ke hāʻawi ʻia ʻo Kesimpta® i kekahi manawa ma ka home i nā mea maʻi ʻaʻole pono e noho ma ka haukapila a i ʻole ke keʻena lapaʻau. Inā hoʻohana ʻoe i kēia lāʻau lapaʻau ma ka home, e aʻo aku kāu kauka a i ʻole nēnē iā ʻoe pehea e hoʻomākaukau ai a hoʻopili ai i ka lāʻau lapaʻau. E hōʻoia ʻoe i kou hoʻomaopopo ʻana i ka hoʻohana ʻana i ka lāʻau lapaʻau. Inā hoʻohana ʻoe i kēia lāʻau lapaʻau ma ka home, e hōʻike ʻia nā wahi o ke kino kahi e hiki ai ke hāʻawi ʻia kēia pana. E hoʻohana i kahi wahi kino ʻē aʻe i kēlā me kēia manawa āu e hāʻawi ai iā ʻoe iho a i kāu keiki paha i ka pana. E mālama i kahi āu e hāʻawi ai i kēlā me kēia pana e hōʻoia i kāu hoʻololi ʻana i nā wahi o ke kino. E kōkua kēia i ka pale ʻana i nā pilikia ʻili. No ka hoʻohana ʻana i ka syringe a i ʻole peni i hoʻopiha mua ʻia: E ʻokoʻa ka nui o kēia lāʻau lapaʻau no nā mea maʻi like ʻole. E hahai i nā kauoha a kāu kauka a i ʻole nā kuhikuhi ma ka lepili. ʻO ka ʻike ma lalo nei e komo wale i nā nui awelika o kēia lāʻau lapaʻau. Inā ʻokoʻa kāu nui, mai hoʻololi ia ke ʻole kāu kauka i haʻi aku iā ʻoe e hana pēlā. ʻO ka nui o ka lāʻau lapaʻau āu e lawe ai e hilinaʻi ana i ka ikaika o ka lāʻau lapaʻau. Eia kekahi, ʻo ka nui o nā nui āu e lawe ai i kēlā me kēia lā, ka manawa i ʻae ʻia ma waena o nā nui, a me ka lōʻihi o ka manawa āu e lawe ai i ka lāʻau lapaʻau e hilinaʻi ana i ka pilikia olakino āu e hoʻohana nei i ka lāʻau lapaʻau. Pono e hāʻawi ʻia kēia lāʻau lapaʻau ma kahi papa hana paʻa. Inā poina ʻoe i kahi nui, e kāhea i kāu kauka, mea mālama ola home, a i ʻole ke keʻena lapaʻau no nā ʻōlelo aʻo. E mālama i kahi i hiki ʻole ai i nā keiki ke kiʻi. Mai mālama i ka lāʻau lapaʻau kahiko a i ʻole ka lāʻau lapaʻau ʻaʻole pono hou. E nīnau i kāu limahana olakino pehea ʻoe e hoʻolei ai i kekahi lāʻau lapaʻau āu ʻaʻole e hoʻohana. E mālama i loko o ka pahu hau. Mai hoʻoilo. E mālama i ka lāʻau lapaʻau i loko o kāna pahu kumu e pale aku ai i ka mālamalama. Hiki iā ʻoe ke mālama i kēia lāʻau lapaʻau ma ka mahana o ka lumi no 7 mau lā. Inā mālama ʻia ma ka mahana o ka lumi, hiki iā ʻoe ke hoʻihoʻi i ka lāʻau lapaʻau i hoʻohana ʻole ʻia i loko o ka pahu hau a hoʻohana i loko o 7 mau lā. E hoʻolei i ka lāʻau lapaʻau inā ʻaʻole i hoʻohana ʻia i loko o kēlā mau 7 mau lā. E hoʻolei i nā peni a me nā syringes i hoʻohana ʻia i loko o kahi pahu paʻa, pani ʻia e hiki ʻole i nā nila ke houluulu. E mālama i kēia pahu mamao aku i nā keiki a me nā holoholona.
Hōʻole: He kahua ʻike olakino ʻo ʻAukake a ʻaʻole hōʻike kāna mau pane i ka ʻōlelo aʻoaʻo lapaʻau. E kūkākūkā mau me kahi ʻoihana lapaʻau laikini kokoke iā ʻoe ma mua o ka hana ʻana i nā hoʻololi.
Hana ʻia i India, no ka honua