Olaparib (ma ka waha)

Lynparza

Hoʻohana ʻia ka Olaparib ma ke ʻano he lāʻau mālama mālama i nā mea maʻi me ka maʻi kanesa ovaria holomua, ka maʻi kanesa o ka puka fallopian, a i ʻole ka maʻi peritoneal mua me ke ʻano o ka ʻano hoʻoilina (germline) a i ʻole ka loaʻa ʻana (somatic) o ka gene BRCA ʻino. E hoʻokolohua kāu kauka no ka loaʻa ʻana o kēia gene. Hoʻohana ʻia ia i nā mea maʻi i loaʻa ka mālama piha a i ʻole hapa me nā lāʻau kanesa platinum-based. Hoʻohana pū ʻia ka Olaparib me ka bevacizumab ma ke ʻano he lāʻau mālama mālama i nā mea maʻi me ka maʻi kanesa ovaria holomua, ka maʻi kanesa o ka puka fallopian, a i ʻole ka maʻi peritoneal mua me ke ʻano o ka gene BRCA ʻino a i ʻole ka hoʻokolohua maikaʻi o ka tumor no ka genomic instability i kapa ʻia ʻo HRD. E hoʻokolohua kāu kauka no ka loaʻa ʻana o kēia gene. Hoʻohana ʻia ia i nā mea maʻi i loaʻa ka mālama piha a i ʻole hapa me nā lāʻau kanesa platinum-based. Hoʻohana pū ʻia ka Olaparib e mālama i ka maʻi kanesa ovaria, ka maʻi kanesa o ka puka fallopian, a i ʻole ka maʻi peritoneal mua me ke ʻano o ka ʻano hoʻoilina (germline) a i ʻole ka loaʻa ʻana (somatic) o ka gene BRCA ʻino i hoʻi mai. E hoʻokolohua kāu kauka no ka loaʻa ʻana o kēia gene. Hoʻohana ʻia ia i nā mea maʻi i loaʻa ka mālama piha a i ʻole hapa me nā lāʻau kanesa platinum-based. Hoʻohana pū ʻia ka Olaparib e mālama i ka maʻi umauma mua HER2-negative i nā mea maʻi i mālama ʻia me nā lāʻau kanesa ʻē aʻe. Hoʻohana ʻia inā loaʻa i nā cell kanesa nā mutation germline BRCA. E hoʻohana kāu kauka i kahi hoʻokolohua kūikawā e ʻimi i kēia mau mutation. Hāʻawi ʻia ia i nā mea maʻi ma hope o ka ʻoki ʻana e wehe i ka tumor. Hoʻohana pū ʻia ka Olaparib e mālama i ka maʻi umauma metastatic HER2-negative (ka maʻi kanesa i pālahalaha) i nā mea maʻi i mālama ʻia me nā lāʻau kanesa ʻē aʻe. Hoʻohana ʻia inā loaʻa i nā cell kanesa nā mutation germline BRCA. E hoʻohana kāu kauka i kahi hoʻokolohua kūikawā e ʻimi i kēia mau mutation. Hoʻohana pū ʻia ka Olaparib ma ke ʻano he lāʻau mālama mālama i nā mea maʻi me ka maʻi kanesa pancreas metastatic (ka maʻi kanesa i pālahalaha) me ke ʻano o ka ʻano hoʻoilina (germline) o ka gene BRCA ʻino, ʻaʻole i holomua ka maʻi a ua mālama ʻia me nā lāʻau kanesa platinum-based no ka liʻiliʻi o 16 mau wiki. Hoʻohana pū ʻia ka Olaparib e mālama i ka maʻi kanesa prostate metastatic castration-resistant (ka maʻi kanesa prostate i pālahalaha a kūʻē i nā mālama lapaʻau a i ʻole nā ʻoki e hoʻoemi i ka testosterone) i nā mea maʻi i mālama ʻia me nā lāʻau kanesa ʻē aʻe (e laʻa, abiraterone, enzalutamide). Hoʻohana ʻia inā loaʻa i nā cell kanesa ke ʻano o ka gene HRR ʻino hoʻoilina (germline) a i ʻole ka loaʻa ʻana (somatic). E hoʻokolohua kāu kauka no ka loaʻa ʻana o kēia gene. Hoʻohana ʻia ka Olaparib me ka abiraterone a me ka prednisone a i ʻole prednisolone e mālama i ka maʻi kanesa prostate metastatic castration-resistant (ka maʻi kanesa prostate i pālahalaha a kūʻē i nā mālama lapaʻau a i ʻole nā ʻoki e hoʻoemi i ka testosterone) me ke ʻano o ka gene BRCA ʻino hoʻoilina a i ʻole ka loaʻa ʻana. E hoʻokolohua kāu kauka no ka loaʻa ʻana o kēia gene. Loaʻa wale kēia lāʻau me ka palapala kauoha a kāu kauka. Loaʻa kēia huahana i nā ʻano dosage e like me kēia:

I ka hoʻoholo ʻana e hoʻohana i kahi lāʻau lapaʻau, pono e kaulike i nā pilikia o ka lawe ʻana i ka lāʻau lapaʻau me ka pono e hana ai. He hoʻoholo kēia āu a me kāu kauka e hana ai. No kēia lāʻau lapaʻau, pono e noʻonoʻo i kēia mau mea: E haʻi aku i kāu kauka inā ua loaʻa iā ʻoe kekahi hopena maʻamau ʻole a i ʻole nā ​​hopena ʻē aʻe i kēia lāʻau lapaʻau a i ʻole nā ​​lāʻau lapaʻau ʻē aʻe. E haʻi aku pū i kāu limahana mālama ola inā loaʻa iā ʻoe nā ʻano ʻē aʻe o nā maʻi ʻiliʻili, e like me nā meaʻai, nā kala, nā mea mālama, a i ʻole nā ​​holoholona. No nā huahana ʻole-prescription, e heluhelu pono i ka lepili a i ʻole nā ​​mea hoʻohui pūʻolo. ʻAʻohe mau haʻawina kūpono i hana ʻia ma ka pilina o ka makahiki i nā hopena o ka olaparib i ka heluna keiki. ʻAʻohe palekana a me ka pono i hoʻokumu ʻia. ʻAʻohe mau haʻawina kūpono i hana ʻia a hiki i kēia lā i hōʻike i nā pilikia geriatric-kūikawā e kaupalena i ka pono o ka olaparib i nā ʻelemakule. ʻAʻohe mau haʻawina lawa i nā wāhine no ka hoʻoholo ʻana i ka pilikia o ka pēpē i ka wā e hoʻohana ana i kēia lāʻau lapaʻau i ka wā hānai. E kaulike i nā pono hiki ke loaʻa me nā pilikia hiki ke loaʻa ma mua o ka lawe ʻana i kēia lāʻau lapaʻau i ka wā hānai. ʻOiai ʻaʻole pono e hoʻohana pū ʻia kekahi mau lāʻau lapaʻau, i nā hihia ʻē aʻe, hiki ke hoʻohana pū ʻia ʻelua mau lāʻau lapaʻau ʻokoʻa ʻoiai inā hiki ke loaʻa kahi pilina. I kēia mau hihia, makemake paha kāu kauka e hoʻololi i ka nui, a i ʻole nā ​​ʻano palekana ʻē aʻe paha e pono ai. I ka wā e lawe ana ʻoe i kēia lāʻau lapaʻau, he mea nui loa ia i kāu limahana mālama ola e ʻike inā ke lawe nei ʻoe i kekahi o nā lāʻau lapaʻau i helu ʻia ma lalo nei. Ua koho ʻia nā pilina aʻe ma muli o ko lākou koʻikoʻi hiki ke loaʻa a ʻaʻole pono e hoʻokomo piha ʻia. ʻO ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe ʻaʻole i ʻōlelo pinepine ʻia, akā hiki ke koi ʻia i kekahi mau hihia. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā ​​lāʻau lapaʻau ʻelua. ʻAʻole pono e hoʻohana ʻia kekahi mau lāʻau lapaʻau i ka wā a i ʻole kokoke i ka wā e ʻai ai i ka meaʻai a i ʻole ka ʻai ʻana i kekahi mau ʻano meaʻai ʻoiai hiki ke loaʻa nā pilina. ʻO ka hoʻohana ʻana i ka waiʻona a i ʻole ka paka me kekahi mau lāʻau lapaʻau hiki ke hoʻokumu i nā pilina. Ua koho ʻia nā pilina aʻe ma muli o ko lākou koʻikoʻi hiki ke loaʻa a ʻaʻole pono e hoʻokomo piha ʻia. ʻO ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā mea aʻe ʻaʻole i ʻōlelo pinepine ʻia, akā hiki ke hiki ʻole ke pale ʻia i kekahi mau hihia. Inā hoʻohana pū ʻia, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i kēia lāʻau lapaʻau, a i ʻole e hāʻawi iā ʻoe i nā ʻōlelo kuhikuhi kūikawā e pili ana i ka hoʻohana ʻana i ka meaʻai, ka waiʻona, a i ʻole ka paka. Hiki i ke alo o nā pilikia olakino ʻē aʻe ke hoʻopilikia i ka hoʻohana ʻana i kēia lāʻau lapaʻau. E hōʻoia e haʻi aku i kāu kauka inā loaʻa iā ʻoe nā pilikia olakino ʻē aʻe, ʻoiai: