He aha ka Omadacycline: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau antibiotic hou ka Omadacycline i pili i ka ʻohana tetracycline o nā lāʻau lapaʻau. Ua hoʻolālā ʻia e hakakā i nā maʻi bacteria koʻikoʻi i lilo i mea kūʻē i nā lāʻau antibiotic ʻē aʻe, e lilo ana i mea hana waiwai i ka wā ʻaʻole e hana pono nā lāʻau lapaʻau kuʻuna.

Hāʻawi ʻia kēia lāʻau lapaʻau ma o ka laina IV (intravenous) pololei i loko o kou kahe koko, e hiki ai iā ia ke hiki i nā kiʻekiʻe kiʻekiʻe ma kou kino i ka wikiwiki. E nānā pono kāu hui mālama ola iā ʻoe i ka wā o ka mālama ʻana e hōʻoia e pane maikaʻi ana ʻoe a ʻike i nā hopena ʻaoʻao liʻiliʻi.

No ke aha e hoʻohana ʻia ai ka Omadacycline?

Hoʻomaʻamaʻa ʻo Omadacycline i ʻelua ʻano nui o nā maʻi bacteria koʻikoʻi. Ua ʻae ʻia no ka maʻi pneumonia bacterial i loaʻa i ke kaiāulu a me nā maʻi ʻili a me nā maʻi ʻili bacterial acute i ka wā ʻaʻole e hana pono nā lāʻau antibiotic ʻē aʻe.

ʻO ka maʻi pneumonia bacterial i loaʻa i ke kaiāulu he maʻi māmā hiki iā ʻoe ke hopu ma waho o nā haukapila a i ʻole nā ​​hale mālama ola. Hiki ke paʻakikī ke mālama ʻana i kēia ʻano pneumonia no ka mea ua hoʻomohala pinepine nā bacteria e hana ana i ka mea kūʻē i nā lāʻau antibiotic i hoʻohana pinepine ʻia.

Hoʻomaʻamaʻa pū ka lāʻau lapaʻau i nā maʻi ʻili a me nā maʻi ʻiʻo palupalu, me ka cellulitis, nā abscesses, a me nā maʻi ʻeha. Hiki i kēia mau maʻi ke laha wikiwiki a lilo i mea hoʻoweliweli i ke ola inā ʻaʻole i mālama ʻia me ka antibiotic kūpono, ʻo ia ke kumu e koho ai kāu kauka i ka omadacycline no kēia mau kūlana koʻikoʻi.

Pehea e hana ai ka Omadacycline?

Hana ʻo Omadacycline ma ka hoʻōki ʻana i nā bacteria mai ka hana ʻana i nā protein e pono ai lākou e ola a hoʻonui. Ua manaʻo ʻia he antibiotic ikaika no ka mea hiki iā ia ke lanakila i nā ʻano hana pale e hoʻohana ai nā bacteria e kūʻē i nā lāʻau antibiotic tetracycline ʻē aʻe.

E manaʻo e like me kahi mana i holomua o nā lāʻau antibiotic tetracycline kahiko. ʻOiai ua aʻo nā bacteria e pale aku i nā lāʻau antibiotic kuʻuna he nui, he mau hiʻohiʻona kūikawā ko ka omadacycline e kōkua iā ia e paheʻe i nā pale bacteria a hana pono i kāna hana.

Hoʻopā ka lāʻau i ka ribosome bacterial, e like me kahi hale hana liʻiliʻi i loko o nā bacteria e hana ana i nā protein pono. Ma ka pani ʻana i kēia hale hana, hoʻopōloli ka omadacycline i nā bacteria a pale iā lākou mai ka hana hou ʻana, e ʻae ana i kāu ʻōnaehana pale e hoʻomaʻemaʻe i ka maʻi.

Pehea wau e lawe ai i ka Omadacycline?

Hāʻawi ʻia ka Omadacycline ma o ka laina IV e nā poʻe loea mālama ola i loko o kahi haukapila a i ʻole ke keʻena lapaʻau. ʻAʻole ʻoe e lawe i kēia lāʻau ma ka home, no ka mea, pono ia i ka nānā pono ʻana a me ka mālama olakino kūpono i ka wā e lawelawe ʻia ai.

Hāʻawi ʻia ka maʻamau maʻamau i hoʻokahi manawa i ka lā, a lawe ʻia kēlā me kēia infusion ma kahi o 30 mau minuke e hoʻopau. E hoʻoholo kāu hui mālama ola i ka nui pololei e pili ana i kou kaumaha, ka hana o ka puʻupaʻa, a me ke koʻikoʻi o kāu maʻi.

ʻAʻole pono ʻoe e hopohopo e lawe me ka meaʻai a i ʻole ma ka ʻōpū ʻole no ka mea e hele pololei ana i loko o kou kahe koko. Eia naʻe, he mea nui e noho maikaʻi i ka wai i ka wā o ka mālama ʻana, no laila e inu i ka wai nui ke ʻole e ʻōlelo kāu kauka.

E nānā pono kāu hui lapaʻau iā ʻoe i ka wā o kēlā me kēia infusion no nā hopena koke. E mālama pū lākou i ka pane ʻana o ʻoe i ka lāʻau lapaʻau ma o nā loiloi maʻamau a me nā hoʻokolohua koko.

Pehea ka lōʻihi e lawe ai au i ka Omadacycline?

ʻO ka lōʻihi o ka mālama ʻana ma waena o 7 a 14 mau lā, ma muli o ke ʻano a me ke koʻikoʻi o kāu maʻi. E hoʻoholo kāu kauka i ka lōʻihi pololei o ka mālama ʻana ma muli o ka wikiwiki o kou pane ʻana a me ka maikaʻi o kou kino e hoʻomaʻemaʻe i ka maʻi.

No ka maʻi pneumonia, pono paha ʻoe i ka lāʻau no 7 a 14 mau lā, a ʻo nā maʻi ʻili paha e koi i ka manawa like. E loiloi kāu hui mālama ola i kāu holomua i kēlā me kēia lā a hiki ke hoʻololi i ka hoʻolālā lapaʻau inā pono.

He mea nui e hoʻopau i ka papa holoʻokoʻa o ka lāʻau lapaʻau, ʻoiai inā hoʻomaka ʻoe e maikaʻi ma mua o ka pau ʻana. ʻO ka hoʻōki ʻana i ka antibiotic ma mua loa hiki ke ʻae i nā bacteria e koe e hoʻonui hou a hiki ke kūʻē i ka lāʻau.

He aha nā hopena ʻaoʻao o Omadacycline?

E like me nā lāʻau lapaʻau a pau, hiki i ka omadacycline ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hiki ke mālama ʻia me ka mālama olakino kūpono.

Eia nā hopena ʻaoʻao āu e ʻike ai, i hui pū ʻia e like me ka pinepine o ko lākou hana ʻana:

Nā hopena ʻaoʻao maʻamau

Hana ʻia kēia mau hopena ʻaoʻao ma mua o 10% o ka poʻe e lawe ana i ka omadacycline:

• Nausea a me ka luaʻi - ʻO kēia ka hopena ʻaoʻao pinepine, e pili ana i ka 1 i 4 mau kānaka
• Diarrhea - Maʻamau ka maʻalahi akā hiki ke ʻoi aku ka paʻakikī
• Nā hopena ma ka wahi injection - ʻEha, ʻulaʻula, a i ʻole pehu kahi i waiho ʻia ai ka IV
• Poʻo - Maʻamau ka maʻalahi a me ka manawa
• Luhi - ʻOi aku ka luhi ma mua o ka maʻamau i ka wā o ka lāʻau

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā lāʻau lapaʻau e kōkua i ka mālama ʻana i ka nausea a i ʻole nā ​​hōʻailona ʻoluʻolu ʻole.

ʻAʻole maʻamau akā he hopena ʻaoʻao nui

Hana ʻia kekahi mau hopena ʻaoʻao i ka liʻiliʻi pinepine akā pono e nānā:

• Clostridium difficile-associated diarrhea (CDAD) - He maʻi ʻōpū koʻikoʻi e hiki ke ulu i nā lā a i ʻole mau pule ma hope o ka lapaʻau
• Nā enzyme ate kiʻekiʻe - E nānā kāu kauka i kēia ma o nā hoʻokolohua koko
• Ka helu platelet haʻahaʻa - Hoʻopilikia kēia i ka hiki ke hoʻopaʻa i ke koko
• Pōpō a i ʻole ka māmā - Maʻamau ka maʻalahi akā he mea nui e hōʻike
• ʻEha ʻōpū - Ma waho aʻe o ka ʻōpū maʻamau

E nānā kāu hui lapaʻau i kēia mau hopena ma o ka nānā mau ʻana a me nā hoʻokolohua koko ke pono.

Nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi

ʻOiai ʻaʻole maʻamau, pono kekahi mau hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke:

• Nā hopena maʻi maʻi koʻikoʻi - Paʻakikī ka hanu ʻana, ka pehu ʻana o ka maka a i ʻole ka ʻāʻī, ka ʻūhū nui
• Nā pilikia ate koʻikoʻi - Melemele o ka ʻili a i ʻole nā maka, mimi ʻeleʻele, luhi nui
• Nā hopena ʻili koʻikoʻi - ʻO ka ʻūhū ākea, ka ʻōpū, a i ʻole ka ʻili ʻili
• ʻO ka maʻi hypertension intracranial - ʻEha poʻo nui, nā loli ʻike, a i ʻole ka huikau
• Pancreatitis - ʻEha ʻōpū nui e hiki ke pā i ke kua

He kakaʻikahi kēia mau hopena ʻaoʻao koʻikoʻi, akā ua aʻo ʻia kāu hui mālama ola e ʻike a mālama koke iā lākou inā loaʻa.

ʻO wai ka mea pono ʻole e lawe iā Omadacycline?

Pono kekahi poʻe e pale i ka omadacycline ma muli o ka piʻi ʻana o nā pilikia a i ʻole ka emi ʻana o ka pono. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e loaʻa iā omadacycline inā he maʻi ʻoe i nā lāʻau antibiotic tetracycline. Aia kēia i nā maʻi i ka doxycycline, minocycline, a i ʻole nā ​​lāʻau ʻē aʻe i loko o kēia ʻohana, no ka mea hiki ke hana nā hopena keʻa.

Pono nā wāhine hāpai e pale i kēia lāʻau, ʻoiai i ka lua a me ke kolu o ka trimester. Hiki i nā lāʻau antibiotic tetracycline ke hoʻopilikia i nā niho a me nā iwi e ulu ana i loko o ka ʻōpū, e hiki ai ke hoʻololi mau i ke kala a i ʻole nā pilikia o ka ulu ʻana.

ʻAʻole pono nā keiki ma lalo o 8 mau makahiki e loaʻa i ka omadacycline no ka mea hiki iā ia ke hoʻololi mau i ke kala o nā niho a hoʻopilikia i ka ulu ʻana o nā iwi. Eia naʻe, i nā kūlana e hoʻoweliweli ana i ke ola, hiki i nā kauka ke ana i nā pōmaikaʻi e kūʻē i kēia mau pilikia.

Pono nā ʻōlelo akahele kūikawā no:

Hiki i kekahi poʻe ke lawe i ka omadacycline akā pono lākou i ka nānā hou a me nā ʻano lāʻau i hoʻoponopono ʻia:

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• ʻO ka poʻe me ka maʻi kīkī koʻikoʻi - Pono paha e hoʻoponopono i ka lāʻau
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• ʻO ka poʻe me nā pilikia o ke ake - Pono ka nānā pono ʻana i ka hana o ke ake
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• Nā makuahine e hānai ana i ka waiū - Hiki i ka lāʻau ke hele i loko o ka waiū umauma
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• ʻO ka poʻe me ka mōʻaukala o ka hypertension intracranial - Hiki ke pilikia i ka hoʻi hou ʻana
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• ʻO ka poʻe e lawe ana i nā mea lahilahi koko - Pono paha e nānā i nā manawa clotting
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E loiloi kāu hui mālama ola i kēia mau mea a hoʻoponopono i kāu hoʻolālā lapaʻau e like me ia e hōʻoia i kou palekana.

Nā inoa inoa o Omadacycline

Loaʻa ka Omadacycline ma lalo o ka inoa inoa Nuzyra ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa inoa nui e loaʻa iā ʻoe i ka hapa nui o nā wahi mālama ola.

Hana ʻia ka lāʻau e Paratek Pharmaceuticals a he mea hou ia i ka mākeke, ua ʻae ʻia e ka FDA i ka makahiki 2018. No ka mea he antibiotic hou ia, ʻaʻole i loaʻa nā mana generic.

Ke loaʻa iā ʻoe ka lapaʻau, hiki iā ʻoe ke ʻike i ka

He nui nā lāʻau antibiotic ʻē aʻe i hiki ke hoʻohana ʻia ma ke ʻano he koho ʻē aʻe i ka omadacycline, ma muli o kāu maʻi kikoʻī a me nā kūlana olakino. E koho kāu kauka i ke koho maikaʻi loa e pili ana i nā hopena moʻomeheu bacteria a me kou kūlana pilikino.

No ka maʻi pneumonia, hiki i nā koho ʻē aʻe ke komo i nā lāʻau antibiotic ikaika ʻē aʻe e like me linezolid, vancomycin, a i ʻole ceftaroline. He mau ikaika like ʻole ko kēlā me kēia a ua koho ʻia ma muli o nā bacteria e hoʻoulu nei i kāu maʻi a me ke kūpaʻa ʻana i nā ʻano lapaʻau like ʻole.

No nā maʻi ʻili, hiki i nā koho ʻē aʻe ke komo i ka daptomycin, clindamycin, a i ʻole nā ​​tetracyclines ʻē aʻe e like me doxycycline. Aia ke koho i ke koʻikoʻi o kāu maʻi a inā paha he kūpaʻa nā bacteria i nā lāʻau antibiotic ʻē aʻe.

E hana maʻamau kāu hui mālama ola i nā hoʻokolohua e ʻike pono i nā bacteria e hoʻoulu nei i kāu maʻi ma mua o ka hoʻoholo ʻana i ke ala lapaʻau maikaʻi loa. E hōʻoia kēia e loaʻa iā ʻoe ka lāʻau antibiotic maikaʻi loa no kāu kūlana kikoʻī.

Ua ʻoi aku ka maikaʻi o Omadacycline ma mua o nā lāʻau antibiotic ʻē aʻe?

ʻAʻole pono ʻo Omadacycline i

Akā, no ka mea he mea hou a ʻoi aku ka ikaika, mālama ʻia ka omadacycline no nā maʻi koʻikoʻi kahi i hana ʻole ai nā lāʻau antibiotic ʻē aʻe a i ʻole ʻaʻole paha e pono. ʻAʻole pono ia ka koho mua no nā maʻi bacteria a pau.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Omadacycline

Q1. Palekana anei ʻo Omadacycline no ka poʻe me ka maʻi kīkī?

Hiki ke hoʻohana ʻia ʻo Omadacycline i ka poʻe me ka maʻi kīkī, akā pono ia i ka nānā pono ʻana a me ka hoʻoponopono ʻana i ka dosage. ʻAʻole like me kekahi mau lāʻau antibiotic ʻē aʻe, hoʻopau ʻia ia mai ke kino ma nā ala he nui, ʻaʻole wale nō nā kīkī.

Inā he mau pilikia kīkī maʻalahi a kūpono paha, ʻaʻole pono ʻoe e hoʻoponopono i ka dosage. Eia naʻe, pono paha ka poʻe me ka maʻi kīkī koʻikoʻi i ka hoʻololi ʻana i ka dosage e pale ai i ka hōʻiliʻili ʻana o ka lāʻau i loko o kā lākou ʻōnaehana.

E nānā kāu kauka i kāu hana kīkī ma o nā hoʻokolohua koko ma mua a i ka wā o ka mālama ʻana. E hoʻoponopono lākou i kāu dosage inā pono e hōʻoia e loaʻa iā ʻoe ka nui kūpono o ka lāʻau me ka pilikia ʻole o nā hopena ʻaoʻao.

Q2. He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao koʻikoʻi?

Inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻūlū koʻikoʻi, a i ʻole ka ʻeha o ka ʻōpū nui, e hoʻomaopopo koke i kāu hui mālama ola. No ka mea e loaʻa ana iā ʻoe kēia lāʻau i loko o kahi keʻena lapaʻau, kokoke mau ke kōkua.

No nā kūlana pilikia e like me nā hopena maʻi koʻikoʻi, e hoʻōki koke kāu hui lapaʻau i ka hoʻokomo ʻana a hāʻawi i ka lāʻau kūpono. Loaʻa iā lākou nā lāʻau a me nā lako i mākaukau e mālama i kēia mau kūlana me ka wikiwiki a me ka maikaʻi.

ʻOiai nā hōʻailona liʻiliʻi akā hopohopo e like me ka nausea mau, ka luhi maʻamau, a i ʻole nā ​​hoʻololi i ka ʻike pono e hōʻike koke ʻia. Hiki i kāu hui mālama ola ke hoʻoponopono i kāu mālama ʻana a i ʻole e hāʻawi i ka mālama kākoʻo e kōkua iā ʻoe e ʻoluʻolu.

Q3. Hiki iaʻu ke kalaiwa a i ʻole e hana i nā mīkini i ka wā e lawe ana iā Omadacycline?

Pono ʻoe e pale i ka hoʻokele a i ʻole ka hana ʻana i nā mīkini inā ʻoe e ʻike i ka ʻūlū, ka luhi, a i ʻole nā hopena ʻē aʻe e hiki ke hoʻopilikia i kou hiki ke hana i kēia mau hana me ka palekana. No ka mea e loaʻa ana iā ʻoe ka lāʻau IV, aia paha ʻoe i loko o kahi hale mālama ola.

ʻIke kekahi poʻe i ka ʻūlū māmā a i ʻole ka luhi i ka wā o ka lāʻau, hiki ke hoʻopilikia i kou hoʻonohonoho ʻana a me nā manawa pane. ʻOi aku ka maikaʻi e loaʻa i kekahi e hoʻokele iā ʻoe i ka home ma hope o kāu mau kau lapaʻau.

Ke pau kāu papa lapaʻau a ua pau nā hopena ʻaoʻao, hiki iā ʻoe ke hoʻomau i nā hana maʻamau e like me ka hoʻokele. Eia naʻe, e nānā me kāu mea mālama ola e pili ana i ka manawa e palekana ai ke hana pēlā.

Q4. E launa pū anei ʻo Omadacycline me kaʻu mau lāʻau ʻē aʻe?

Hiki i ka Omadacycline ke launa pū me kekahi mau lāʻau, no laila he mea nui e haʻi i kāu hui mālama ola e pili ana i nā lāʻau a pau āu e lawe nei. Aia kēia i nā lāʻau lapaʻau, nā lāʻau lapaʻau ma luna o ka pāʻani, a me nā mea hoʻohui.

Hiki i ka lāʻau lapaʻau ke launa pū me nā mea lahilahi koko e like me ka warfarin, e hoʻonui ana i kou pilikia o ke kahe ʻana. Pono paha kāu kauka e nānā i kou manawa hoʻopaʻa koko i ka wā o ka lāʻau.

Hiki i kekahi mau lāʻau e hōʻemi i ka waikawa o ka ʻōpū, e like me nā antacids a i ʻole nā mea pale pauma proton, ke hoʻopilikia i ka maikaʻi o ka hana ʻana o ka omadacycline. Eia naʻe, no ka mea e loaʻa ana iā ʻoe ma ke ala intravenous, ʻaʻole i hopohopo nui kēia mau pilina ma mua o nā lāʻau antibiotic waha.

Q5. Pehea wau e ʻike ai inā e hana ana ka lāʻau?

E nānā kāu hui mālama ola i kekahi mau hōʻailona e hoʻoholo ai inā e mālama pono ana ʻo omadacycline i kāu maʻi. Aia kēia i nā hoʻomaikaʻi ʻana i kāu mau hōʻailona, nā hōʻailona koʻikoʻi, a me nā hopena o ka hale hana.

No ka pneumonia, hiki iā ʻoe ke ʻike i ka hanu maʻalahi, ka emi ʻana o ke kuni, a me ka liʻiliʻi o ka ʻū ʻana i loko o kekahi mau lā ma hope o ka hoʻomaka ʻana o ka lāʻau. No nā maʻi ʻili, pono ʻoe e ʻike i ka emi ʻana o ka ʻulaʻula, ka pehu, a me ka ʻeha ma ka wahi maʻi.

E nānā pū ana kāu hui lapaʻau i nā ana i manaʻo ʻia e like me kou mahana, ka helu o nā keʻena koko keʻokeʻo, a me nā mea hōʻailona maʻi ʻē aʻe ma o nā hoʻokolohua koko. Kōkua kēia mau mea i ka hāʻawi ʻana i kahi kiʻi piha o ka maikaʻi o kou pane ʻana i ka lapaʻau.