He aha ka Paclitaxel: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau chemotherapy ikaika ka Paclitaxel e kōkua ai i ka hakakā ʻana i ka maʻi maʻi ma ka hoʻōki ʻana i nā cell maʻi maʻi mai ka mahele a me ka ulu ʻana. No kēia lāʻau lapaʻau i kahi pūʻulu lāʻau i kapa ʻia ʻo taxanes, e hana ana ma ka hoʻopilikia ʻana i ka hale kūloko o nā cell maʻi maʻi. Hiki i kāu kauka ke ʻōlelo aku i ka paclitaxel inā ua ʻike ʻia ʻoe me kekahi mau ʻano maʻi maʻi, a ʻoiai he lāʻau ikaika ia, hiki i ka hoʻomaopopo ʻana i ke ʻano o kāna hana ke kōkua iā ʻoe e mākaukau no ka mālama ʻana.

He aha ka Paclitaxel?

He lāʻau chemotherapy ka Paclitaxel i loaʻa mai ka ʻili o ka lāʻau yew Pacific. Hāʻawi ʻia ma o ka laina IV (intravenous) pololei i loko o kou kahe koko, maʻamau i ka haukapila a i ʻole ke kikowaena mālama maʻi maʻi. Ua manaʻo ʻia kēia lāʻau lapaʻau kekahi o nā lāʻau lapaʻau maʻi maʻi ikaika loa i loaʻa, ʻo ia hoʻi hiki ke maikaʻi loa akā pono nō hoʻi ka nānā pono ʻana.

Hana ka lāʻau ma ka hoʻopaʻa ʻana i nā hale liʻiliʻi i loko o nā cell i kapa ʻia ʻo microtubules. E noʻonoʻo i kēia mau mea e like me ka scaffolding e kōkua ai i nā cell e mālama i ko lākou ʻano a mahele pono. Ke hoʻopilikia ka paclitaxel i kēia scaffolding, ʻaʻole hiki i nā cell maʻi maʻi ke hoʻopau i kā lākou hana mahele a make hope.

No ke aha e hoʻohana ʻia ai ka Paclitaxel?

Hoʻomaʻamaʻa ʻo Paclitaxel i nā ʻano maʻi maʻi like ʻole, ʻo ka maʻamau ka maʻi maʻi umauma, ka maʻi maʻi ovarian, a me ka maʻi maʻi māmā. Hiki i kāu oncologist ke kuhikuhi iā ia no nā maʻi maʻi ʻē aʻe e like me ka AIDS-related Kaposi's sarcoma. Hiki ke hoʻohana ʻia ka lāʻau lapaʻau wale nō a i hui pū ʻia me nā lāʻau chemotherapy ʻē aʻe, ma muli o kāu kūlana.

I kekahi manawa hoʻohana nā kauka i ka paclitaxel ma ke ʻano he lāʻau mua no ka maʻi maʻi i ʻike hou ʻia. I nā manawa ʻē aʻe, hiki iā lākou ke ʻōlelo aku iā ia inā ua hoʻi mai ka maʻi maʻi ma hope o nā lāʻau lapaʻau mua. E wehewehe kāu hui lapaʻau i ke kumu e pono ai kēia lāʻau lapaʻau no kāu hihia.

Pehea e hana ai ka Paclitaxel?

He lāʻau lapaʻau chemotherapy ikaika ʻo Paclitaxel e hana ana ma ka hoʻōki ʻana i nā pūnaewele maʻi ʻaʻai mai ka hoʻonui ʻana. I loko o kēlā me kēia pūnaewele he mau mea liʻiliʻi e like me nā paipu i kapa ʻia ʻo microtubules e kōkua i ka pūnaewele e māhele i ʻelua pūnaewele hou. Hoʻopili ʻo Paclitaxel i kēia mau microtubules a pale iā lākou mai ka wāwahi ʻana i ka wā e pono ai.

Ke hiki ʻole i nā pūnaewele maʻi ʻaʻai ke hoʻopau i kā lākou hana māhele, paʻa lākou a make hope. ʻO kēia ke kumu e pono ai ʻo paclitaxel i nā pūnaewele maʻi ʻaʻai e māhele wikiwiki ana. Eia naʻe, no ka mea, māhele wikiwiki kekahi mau pūnaewele olakino, e like me nā mea i loko o kou lauoho a me ka ʻōpū digestive, hiki ke hoʻopilikia ʻia lākou, e wehewehe ana i kekahi o nā hopena ʻaoʻao āu e ʻike ai.

Pehea wau e lawe ai iā Paclitaxel?

Hāʻawi mau ʻia ʻo Paclitaxel ma o ka laina IV i loko o kahi hoʻonohonoho lapaʻau, ʻaʻole loa ma ke ʻano he pila āu e lawe ai ma ka home. E hoʻokomo kāu hui mālama ola i kahi paipu liʻiliʻi i loko o kahi vein i kou lima a i ʻole ma o kahi awa inā loaʻa iā ʻoe. Hoʻohui ʻia ka lāʻau lapaʻau me kahi wai kūikawā a hāʻawi mālie ʻia ma luna o kekahi mau hola, maʻamau 3 a 24 mau hola e pili ana i kāu hoʻolālā lapaʻau.

Ma mua o kēlā me kēia lapaʻau, e loaʻa paha iā ʻoe nā lāʻau lapaʻau mua e kōkua i ka pale ʻana i nā hopena maʻi. Hiki i kēia mau mea ke komo i nā antihistamines, steroids, a me nā lāʻau lapaʻau kākoʻo ʻē aʻe. E nānā pono kāu kahu maʻi iā ʻoe i ke kaʻina hana infusion holoʻokoʻa.

ʻAʻole pono ʻoe e ʻai i kekahi mea kūikawā ma mua o ka lapaʻau, akā he mea nui ka noho ʻana i ka wai. E hāʻawi kāu hui lapaʻau iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka ʻai a me ka inu ʻana ma mua o kāu manawa. Manaʻo kekahi poʻe he mea kōkua ka ʻai ʻana i ka meaʻai māmā ma mua e pale aku i ka manaʻo ʻoluʻolu ma ka ʻōpū ʻole.

Pehea ka lōʻihi e lawe ai au iā Paclitaxel?

He lōʻihi ka lōʻihi o ka mālama ʻana i ka paclitaxel ma muli o ke ʻano o kāu maʻi maʻi a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Loaʻa ka hapa nui o nā kānaka i nā lāʻau lapaʻau i nā pōʻaiapuni, me kēlā me kēia pōʻaiapuni e mau ana ma kahi o 3 pule. Hiki paha iā ʻoe ma kahi o 4 a 8 mau pōʻaiapuni, ʻoiai pono kekahi poʻe i nā lāʻau lapaʻau hou aʻe a i ʻole.

E nānā mau kāu oncologist i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau ma o nā hoʻokolohua koko, nā scans, a me nā hoʻokolohua kino. E nānā pū lākou i ke ʻano o kou kino e mālama nei i ka lāʻau lapaʻau. Ma muli o kēia mau hopena, hiki iā lākou ke hoʻoponopono i kāu papa hana lapaʻau a i ʻole e hoʻoholo i ka manawa e pau ai.

Mai hooki i ka lawe ʻana i ka paclitaxel ma kāu iho, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike i nā hopena ʻaoʻao. Pono kāu hui lapaʻau e hoʻolālā pono i ka manawa a me ke ʻano e hoʻopau ai i ka lāʻau lapaʻau e hāʻawi iā ʻoe i ka manawa maikaʻi loa o ka holomua.

He aha nā hopena ʻaoʻao o Paclitaxel?

E like me nā lāʻau lapaʻau ikaika a pau, hiki i ka paclitaxel ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou ma ke ʻano like. He kū hoʻokahi ka pane ʻana o kou kino i ka chemotherapy, a e hana pū kāu hui lapaʻau me ʻoe e mālama i nā hopena i loaʻa.

Eia kekahi mau hopena ʻaoʻao maʻamau e ʻike ai ʻoe i ka wā o ka mālama ʻana:

• Luhi a me ka piʻi ʻana o ka luhi ma mua o ka maʻamau
• Nausea a me ka luaʻi i kekahi manawa
• Ka nalowale o ka lauoho, e hoʻomaka ana ma 2-3 pule ma hope o ka hoʻomaka ʻana i ka lāʻau lapaʻau
• Ka ʻūlū a i ʻole ka ʻeha ma kou mau lima a me kou mau wāwae (i kapa ʻia ʻo neuropathy)
• Hoʻonui ʻia ka pilikia o ka maʻi ma muli o ka helu haʻahaʻa o ke keʻena koko keʻokeʻo
• ʻEha ʻiʻo a me nā hui
• Pāpaʻa a i ʻole ka paʻa
• Nā ʻeha waha a i ʻole nā loli i ka ʻono

Hiki ke mālama ʻia kēia mau hopena me ka mālama kūpono a me nā lāʻau lapaʻau kākoʻo. Nui nā mea hana a kāu hui mālama ola e kōkua iā ʻoe e ʻoluʻolu i ka wā o ka mālama ʻana.

Pono kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi i ka lāʻau lapaʻau koke. ʻOiai he mea maʻamau kēia, he mea nui e ʻike iā lākou:

• Nā hopena maʻi koʻikoʻi i ka wā o ka hoʻokomo ʻana
• Nā hōʻailona o ka maʻi koʻikoʻi e like me ke kuni, nā anu, a i ʻole ka ʻūlū mau
• Ke kahe ʻana o ke koko a i ʻole ka ʻeha ʻana
• Ka ʻeha nui a i ʻole ka ʻeha ma nā lima a me nā wāwae
• He paʻakikī ka hanu ʻana a i ʻole ka ʻeha o ka umauma
• Ka puʻuwai ʻole

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau hopena a e aʻo iā ʻoe i nā hōʻailona hōʻailona e nānā ai ma ka home. ʻO ka hapa nui o nā hopena ʻaoʻao he manawa pōkole a e hoʻomaikaʻi ma hope o ka pau ʻana o ka lāʻau.

ʻO wai ka mea pono ʻole e lawe iā Paclitaxel?

ʻAʻole kūpono ʻo Paclitaxel no nā mea a pau, a e loiloi pono kāu oncologist inā palekana ia iā ʻoe. Pono paha ka poʻe me kekahi mau maʻi olakino a i ʻole ka poʻe e lawe ana i nā lāʻau lapaʻau kūikawā i kahi ala lapaʻau ʻē aʻe.

ʻAʻole paha e kauoha kāu kauka iā paclitaxel inā loaʻa iā ʻoe:

• Nā pilikia ate koʻikoʻi
• Haʻahaʻa loa nā helu keʻokeʻo koko
• Nā maʻi maʻi i ʻike ʻia i ka paclitaxel a i ʻole nā lāʻau lapaʻau like
• Nā maʻi puʻuwai
• Nā maʻi koʻikoʻi ʻaʻole i kaohi ʻia

ʻO ka hāpai ʻana kekahi mea nui e noʻonoʻo ai, no ka mea, hiki i ka paclitaxel ke hōʻino i kahi pēpē i hānau ʻole ʻia. Inā hāpai ʻoe, e hoʻolālā ana e hāpai, a i ʻole e hānai ana i ka waiū, e kūkākūkā kāu hui lapaʻau i nā koho lapaʻau ʻē aʻe me ʻoe.

E nānā kāu oncologist i kāu mōʻaukala olakino piha a me nā lāʻau lapaʻau i kēia manawa ma mua o ka ʻōlelo ʻana i ka paclitaxel. E hōʻoia e haʻi iā lākou e pili ana i nā lāʻau lapaʻau a pau, nā lāʻau lapaʻau ma luna o ka pāʻani, a me nā mea hoʻohui āu e lawe nei.

Nā inoa inoa inoa Paclitaxel

Loaʻa ʻo Paclitaxel ma lalo o nā inoa inoa like ʻole, me Taxol ka mana mua i ʻike nui ʻia. Hiki nō hoʻi iā ʻoe ke hālāwai me Abraxane, he hoʻomākaukau kūikawā i hoʻopaʻa ʻia i ka protein albumin. Loaʻa i nā mea ʻelua ka mea hana like akā hāʻawi ʻia i nā ʻano like ʻole.

Hiki i kāu hale kūʻai lāʻau lapaʻau a i ʻole ke kikowaena lapaʻau ke hoʻohana i ka mana generic i kapa ʻia ʻo paclitaxel, e hana like ana me nā mana inoa. ʻO kāu ʻinikua a me nā makemake o ke kikowaena lapaʻau e hoʻoholo pinepine i ka mana kikoʻī āu e loaʻa ai.

Nā Koho ʻē aʻe o Paclitaxel

Inā ʻaʻole kūpono ʻo paclitaxel iā ʻoe, he nui nā koho chemotherapy ʻē aʻe a kāu oncologist e noʻonoʻo ai. ʻO Docetaxel kekahi lāʻau taxane e hana like me paclitaxel akā ʻoi aku ka maikaʻi o ka hoʻomanawanui ʻana e kekahi poʻe. ʻO Carboplatin a me cisplatin nā lāʻau i hoʻokumu ʻia i ka platinum e hana ʻokoʻa akā hiki ke mālama i nā maʻi maʻi like.

No kekahi mau ʻano maʻi maʻi, hiki i nā lāʻau lapaʻau i manaʻo ʻia a i ʻole nā lāʻau immunotherapy hou ke kūpono i nā koho ʻē aʻe. Aia kēia mau lāʻau lapaʻau e like me trastuzumab no ka maʻi umauma HER2-positive a i ʻole pembrolizumab no kekahi mau maʻi maʻi maʻi.

E noʻonoʻo kāu hui lapaʻau i kāu ʻano maʻi maʻi kikoʻī, ke kahua, ke olakino holoʻokoʻa, a me nā lāʻau lapaʻau i hala i ka wā e ʻōlelo ai i ke koho maikaʻi loa. He kū hoʻokahi ke kūlana o kēlā me kēia kanaka, no laila ʻaʻole paha ka mea e hana maikaʻi ai no kekahi mea ʻo ia ke koho kūpono iā ʻoe.

ʻOi aku ka maikaʻi o Paclitaxel ma mua o Docetaxel?

He mau lāʻau chemotherapy maikaʻi ʻo Paclitaxel a me docetaxel mai ka ʻohana like, akā ʻaʻole ʻoi aku kekahi ma mua o kekahi. ʻO ke koho ma waena o lākou e pili ana i kāu ʻano maʻi maʻi kikoʻī, ka pane ʻana o kou kino i ka lāʻau lapaʻau, a me kou mau kumu olakino pilikino.

ʻO Paclitaxel ke kumu pinepine i ka pōʻino o ke aʻalolo (neuropathy) akā hiki ke maʻalahi ma kāu helu koko. Hiki i ka Docetaxel ke hoʻoulu i ka wai hou a me nā loli kui akā ʻaʻole paha e hoʻoulu i nā pilikia aʻalolo koʻikoʻi. Pane maikaʻi kekahi mau maʻi maʻi i kekahi lāʻau ma mua o kekahi.

E noʻonoʻo ana kāu kauka oncologist i nā haʻawina noiʻi e pili ana i ke ʻano o kāu maʻi kanesa, kāu moʻolelo olakino, a me kāu mau pahuhopu lapaʻau i ke koho ʻana ma waena o kēia mau lāʻau. I kekahi manawa, hiki iā lākou ke ʻōlelo aku e hoʻololi mai kekahi i kekahi inā pau ka pane ʻana o kāu maʻi kanesa a i ʻole inā lilo nā hopena ʻaoʻao i mea paʻakikī loa ke mālama.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Paclitaxel

He Palekana ʻo Paclitaxel no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana ʻia ʻo Paclitaxel i ka poʻe me ka maʻi diabetes, akā pono ia i ka nānā ʻana a me ka mālama hou. ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kōpaʻa koko, akā hiki iā ia ke hoʻonui i ka pōʻino o nā aʻalolo (neuropathy) i loaʻa i kekahi poʻe me ka maʻi diabetes. E hana pū kāu hui lapaʻau me ʻoe e nānā i kāu lapaʻau maʻi kanesa a me ka mālama ʻana i ka maʻi diabetes.

Pono ʻoe e nānā i kāu kōpaʻa koko i nā manawa pinepine i ka wā o ka lapaʻau ʻana, no ka mea, hiki i ke koʻikoʻi o ka chemotherapy a me kekahi o nā lāʻau lapaʻau kākoʻo ke hoʻopilikia i kāu mau pae glucose. Pono paha e hoʻoponopono ʻia kāu mau lāʻau lapaʻau diabetes, a e hoʻopili kāu hui mālama ola ma waena o kāu oncologist a me ka loea diabetes.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Paclitaxel?

No ka mea, hāʻawi ʻia ʻo paclitaxel e nā poʻe lapaʻau i hoʻomaʻamaʻa ʻia i loko o kahi haukapila a i ʻole ke keʻena lapaʻau, he mea maʻamau loa ka overdose ulia pōpilikia. Hoʻohālikelike ʻia ka lāʻau lapaʻau me ka akahele e pili ana i ka nui o kou kino a hāʻawi ʻia mālie ma o ka IV me ka nānā mau.

Inā he hopohopo kāu e pili ana i kāu mahele lapaʻau a i ʻole e ʻike i nā hōʻailona maʻamau i ka wā a i ʻole ma hope o ka infusion, e hoʻokaʻaʻike koke i kāu hui mālama ola. Loaʻa iā lākou nā protocols i kahi e mālama ai i nā pilikia e pili ana i ka lāʻau lapaʻau a hiki ke hāʻawi i ka mālama kūpono inā pono.

He aha kaʻu e hana ai inā hala wau i kahi mahele o Paclitaxel?

Inā ʻoe e hala i kahi lapaʻau paclitaxel i hoʻonohonoho ʻia, e kelepona i kāu hui oncology i ka wā hiki wawe e hoʻonohonoho hou. Mai ho'āʻo e hoʻoponopono i kahi mahele i hala ma ka loaʻa ʻana o nā lapaʻau kokoke. E hoʻoholo kāu hui lapaʻau i ke ala maikaʻi loa e hoʻoponopono ai i kāu papa hana lapaʻau.

I kekahi manawa pono nā lohi lapaʻau ma muli o nā helu koko haʻahaʻa, nā maʻi, a i ʻole nā pilikia olakino ʻē aʻe. E nānā kāu oncologist i kou kūlana a hoʻoholo i ka wā e palekana ai e hoʻomau i ka lapaʻau. ʻO ka hala ʻana i hoʻokahi lapaʻau ʻaʻole ia he manaʻo ua hāʻule kāu lapaʻau maʻi kanesa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Paclitaxel?

ʻO ka hoʻoholo e hooki i ka paclitaxel e hana mau ʻia e kāu oncologist ma muli o ka maikaʻi o ka hana ʻana o ka lapaʻau a me ke ʻano o ka pane ʻana o kou kino. Hoʻopau ka hapa nui o nā kānaka i ka helu i hoʻonohonoho mua ʻia o nā pōʻai lapaʻau, akā hiki ke loli kēia ma muli o nā hopena scan a me ke ʻano o kou manaʻo.

Hiki i kāu kauka ke hooki i ka lapaʻau i ka wā mua inā hōʻike nā scans ua hala ke kanesa, inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā ʻaʻole e pane hou ke kanesa i ka lāʻau lapaʻau. Mai hooki i ka lapaʻau ma kāu iho, ʻoiai inā ʻoe e manaʻo maikaʻi ana, no ka mea, hiki i kēia ke ʻae i nā cell cancer e ulu hou.

Hiki iaʻu ke hana i ka wā e lawe ana i ka Paclitaxel?

Nui ka poʻe e hoʻomau i ka hana i ka wā o ka lapaʻau paclitaxel, ʻoiai paha e pono ʻoe e hana i kekahi mau hoʻoponopono i kāu papa hana. Hāʻawi ʻia ka lāʻau lapaʻau i hoʻokahi manawa i kēlā me kēia ʻekolu pule, no laila pono ʻoe e hoʻolālā a puni nā lā lapaʻau a me nā lā ma hope iho e ʻ piʻi ai ʻoe i ka luhi.

E hilinaʻi kāu pae ikehu a me ka hiki ke hana i ke ʻano o ka pane ʻana o kou kino i ka lapaʻau. Manaʻo kekahi poʻe ua lawa ka maikaʻi e mālama i kā lākou hana maʻamau, ʻoiai pono ka poʻe ʻē aʻe e hōʻemi i kā lākou mau hola a i ʻole e hoʻomaha. E kamaʻilio me kāu mea hana e pili ana i nā hoʻonohonoho maʻalahi a e noʻonoʻo e kūkākūkā i kou kūlana me kahi limahana pilikanaka hiki ke kōkua iā ʻoe e hoʻomaopopo i kou mau pono a me nā koho.