He aha ʻo Palifermin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau protein i hoʻolālā kūikawā ʻia ʻo Palifermin e kōkua i ka pale a me ka hoʻōla ʻana i nā ʻiʻo palupalu i loko o kou waha a me kou ʻāʻī i ka wā o nā lāʻau lapaʻau maʻi ʻaʻai ikaika. Inā ʻoe a i ʻole kekahi āu e mālama nei e kū ana i kekahi mau ʻano o ka lāʻau lapaʻau maʻi ʻaʻai, hiki i kāu hui lapaʻau ke ʻōlelo aku i kēia lāʻau lapaʻau kākoʻo e kōkua i ka pale ʻana i nā ʻeha waha ʻeha a me nā pilikia ʻē aʻe.

Hana kēia lāʻau lapaʻau e like me ke kiaʻi mālie no nā ʻiʻo palupalu e laina ana i kou waha, ʻāʻī, a me ka ʻōnaehana digestive. Hāʻawi ʻia ma o ka IV ma mua a ma hope o nā lāʻau lapaʻau maʻi ʻaʻai kikoʻī e kōkua i nā hana hoʻōla maoli o kou kino e noho ikaika i ka wā e pilikia ai lākou.

He aha ʻo Palifermin?

ʻO Palifermin kahi mana i hana ʻia e ke kanaka o kahi protein maoli i kapa ʻia ʻo keratinocyte growth factor (KGF) a kou kino e hana maʻamau ai. E noʻonoʻo iā ia he hui hoʻoponopono kūikawā e kuhikuhi pono ana i nā cell e laina ana i kou waha, ʻāʻī, a me ka ʻōnaehana digestive.

No ka papa o nā mea ulu ka lāʻau lapaʻau, ʻo ia nā protein e kōkua i nā cell e ulu, māhele, a hoʻoponopono iā lākou iho. Ua hana nā ʻepekema iā palifermin ma ka hoʻololi ʻana i ka KGF maoli e ʻoi aku ka paʻa a me ka maikaʻi ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau.

ʻAʻole kēia he lāʻau lapaʻau maʻi ʻaʻai iā ia iho, akā he lāʻau lapaʻau kākoʻo e kōkua i ka pale ʻana i nā ʻiʻo olakino i ka wā e loaʻa ana iā ʻoe nā lāʻau lapaʻau pono ʻē aʻe. He mea like ia me ka loaʻa ʻana o ka hoʻoikaika hou no nā ʻāpana o kou kino i nā mea maʻalahi loa i ka wā o nā kaʻina hana lapaʻau ikaika.

No ke aha e hoʻohana ʻia ai ʻo Palifermin?

Hoʻohana nui ʻia ʻo Palifermin e pale i nā ʻeha waha koʻikoʻi (i kapa ʻia ʻo oral mucositis) i ka poʻe e loaʻa ana i ka chemotherapy kiʻekiʻe a me ka radiation therapy ma mua o nā transplants iwi iwi. Hiki i kēia mau lāʻau lapaʻau ke hoʻopakele i ke ola akā pinepine lākou e hōʻino i nā cell olakino e laina ana i kou waha a me kou ʻāʻī.

Hiki i kāu kauka ke ʻōlelo aku iā palifermin inā ʻoe e hoʻomākaukau ana no kahi transplant cell stem hematopoietic, ʻoi aku hoʻi inā he maʻi koko kou e like me ka leukemia, lymphoma, a i ʻole multiple myeloma. Ua ʻae ʻia ka lāʻau lapaʻau no nā maʻi e loaʻa ana i nā lāʻau lapaʻau e ʻike ʻia e hoʻoulu ai i nā pilikia nui o ka waha a me ka ʻāʻī.

ʻO ka pahuhopu ke kōkua iā ʻoe e hele i kāu mālama maʻi maʻi me ka liʻiliʻi o ka ʻeha a me nā pilikia liʻiliʻi. Ke pale ʻia a hoʻemi ʻia paha nā ʻeha o ka waha, ʻoi aku ka nui o kou mālama ʻana i ka meaʻai kūpono, loaʻa nā maʻi liʻiliʻi, a ʻike i ka liʻiliʻi o ka hōʻoluʻolu maʻamau i ka wā o kou ola hou ʻana.

Pehea e hana ai ʻo Palifermin?

Hana ʻo Palifermin ma ka hoʻoulu ʻana i ka ulu a me ka pale ʻana o nā cell epithelial, ʻo ia nā cell e hana ai i ka uhi pale o kou waha, ʻāʻī, a me ka ʻōnaehana digestive. Ke olakino kēia mau cell a ke hoʻohou nei iā lākou iho, ʻoi aku ka maikaʻi o lākou e kū i nā hopena o nā lāʻau lapaʻau maʻi maʻi.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau kākoʻo i manaʻo ʻia ma mua o ka lāʻau lapaʻau ikaika a nāwaliwali paha ma ke ʻano kuʻuna. Ua hoʻolālā ʻia e hana ma nā ʻano cell nhất mà ʻaʻole e pili ana i ka pono o kāu mālama maʻi maʻi.

Hoʻopili ka protein i nā mea hoʻokipa kikoʻī ma kāu mau cell epithelial, e hoʻouna ana i nā hōʻailona e paipai iā lākou e ulu, hoʻonui, a hoʻoponopono iā lākou iho me ka wikiwiki. Kōkua kēia hana i ka hana ʻana i kahi pale ikaika a paʻa i kou waha a me ka ʻāʻī ma mua o ka hoʻomaka ʻana o nā lāʻau lapaʻau paʻakikī.

Ma hope o ka ʻōlelo ʻana, kōkua pū ʻo palifermin i kēia mau cell like e ola hou me ka wikiwiki ma hope o ka pōʻino o ka lāʻau lapaʻau. He like ia me ka loaʻa ʻana o kahi hui hoʻoponopono mākaukau e hana ana e hoʻoikaika i kou pale ʻana ma mua o ka manawa a e hoʻoponopono i nā pōʻino e hiki mai ana.

Pehea wau e lawe ai iā Palifermin?

Hāʻawi ʻia ʻo Palifermin ma o ka laina intravenous (IV) e nā poʻe loea mālama ola i hoʻomaʻamaʻa ʻia i loko o kahi haukapila a i ʻole ke keʻena lapaʻau. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha.

ʻO ka papa hana maʻamau e pili ana i ka loaʻa ʻana o ʻekolu mau lāʻau ma mua o ka hoʻomaka ʻana o kāu lapaʻau hoʻoponopono, a laila ʻekolu mau lāʻau hou aʻe ma hope o kāu transplant stem cell. E hoʻokaʻawale kāu hui lapaʻau i kēia mau lāʻau me ka mālama pono, e hāʻawi pinepine ana iā lākou i nā lā e pili ana.

ʻAʻole pono ʻoe e hana i kekahi mea kūikawā e hoʻomākaukau ai no kāu palifermin infusion. ʻAʻole like me kekahi mau lāʻau lapaʻau, ʻaʻole ia e koi iā ʻoe e ʻai a pale paha i ka ʻai ma mua. ʻO ka infusion IV ponoʻī e lawe ma kahi o 15-30 mau minuke.

E nānā kāu hui mālama ola iā ʻoe i ka wā a ma hope o kēlā me kēia lāʻau e hōʻoia e ʻae maikaʻi ana ʻoe i ka lāʻau. E hoʻonohonoho pū lākou i ka manawa me kāu mau lapaʻau ʻē aʻe e hōʻoia i ka pale maikaʻi loa no kou waha a me nā ʻiʻo ʻāʻī.

Pehea ka lōʻihi e lawe ai au i ka Palifermin?

Hoʻopau ʻia ke ʻano maʻamau o ka lapaʻau palifermin i loko o ʻelua pule, e loaʻa ana i ʻeono mau lāʻau i hāʻawi ʻia i nā manawa kikoʻī. ʻAʻole kēia he lāʻau lapaʻau āu e lawe ai no nā mahina a i ʻole nā makahiki.

E hāʻawi kāu kauka iā ʻoe i ʻekolu mau lāʻau ma mua o ka hoʻomaka ʻana o kāu lapaʻau hoʻoponopono, a laila ʻekolu mau lāʻau hou aʻe ma hope o kāu transplant stem cell. Aia ke kikoʻī manawa i kāu papa hana lapaʻau kikoʻī a me ke ʻano o ka pane ʻana o kou kino.

Ua manaʻo ʻia ka lōʻihi o ka lapaʻau a ua hoʻolālā pono ʻia. Hoʻolālā ʻia ʻo Palifermin e hāʻawi i ka pale i ka wā nāwaliwali loa o kāu lapaʻau maʻi maʻi, i ka wā e pilikia nui ai kou waha a me nā ʻiʻo ʻāʻī.

Ke hoʻopau ʻoe i ke ala piha a ua hoʻōla ʻia kou mau ʻiʻo waha, ʻaʻole pono ʻoe i nā lapaʻau palifermin hou ke ʻole ʻoe e hana i nā lāʻau lapaʻau ikaika like i ka wā e hiki mai ana.

He aha nā hopena ʻaoʻao o Palifermin?

ʻAe ka hapa nui o nā kānaka iā palifermin, ʻoiai ke noʻonoʻo nei i ka ikaika o nā lapaʻau i manaʻo ʻia e kākoʻo. ʻO nā hopena ʻaoʻao e mālama ʻia a me ka manawa, e hoʻoponopono ana i ka pau ʻana o kāu papa lapaʻau.

E hoʻomaka kākou me nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike, e pili ana i ka nui o nā kānaka e loaʻa ana i kēia lāʻau lapaʻau:

• Pāpaʻa ʻili a i ʻole ʻulaʻula, e ʻike pinepine ʻia e like me ka hopena e like me ka lā
• Hoʻololi ke kala o ka waha a i ʻole ke alelo, e ʻike pinepine ʻia e like me nā ʻāpana keʻokeʻo a i ʻole ka uhi
• Hoʻololi i nā manaʻo ʻono, kahi e ʻono ʻokoʻa ai nā meaʻai a i ʻole ke metala
• Hoʻomāmā ka pehu ʻana o ka waha a i ʻole nā ʻiʻo alelo
• ʻEha hui a i ʻole nā ʻiʻo, e like me nā hōʻailona e like me ka maʻi flu

ʻO kēia mau hopena maʻamau ke ala o kou kino e pane aku ai i ka hoʻonui ʻia ʻana o ka ulu ʻana o ke kelepona a me ka hana hoʻoponopono. ʻO ka hapa nui o nā kānaka e ʻike i kēia mau hopena he mea hiki ke ʻae ʻia a he manawa pōkole.

ʻIke kekahi poʻe i nā hopena ʻaoʻao ʻaʻole maʻamau akā hiki ke mālama ʻia e nānā ʻia e kāu hui lapaʻau:

• Fiva a i ʻole nā anu i ka wā a i ʻole ma hope o ka hoʻokomo ʻana
• Nausea a i ʻole ka ʻōpū
• ʻEha poʻo a i ʻole ka wili
• Nā hopena ma kahi o ka injection e like me ka ʻulaʻula a i ʻole ka pehu
• Nā loli i nā waiwai koko o ka hale hana

I kēia manawa, e kūkākūkā kākou i nā hopena ʻaoʻao laha akā ʻoi aku ka koʻikoʻi e pono ai ka lāʻau lapaʻau koke. ʻOiai ʻaʻole pinepine kēia mau mea, he mea nui e ʻike iā lākou:

• Nā hopena maʻi koʻikoʻi me ka pilikia o ka hanu ʻana, ka paʻa o ka umauma, a i ʻole ka pāpaʻa ākea
• Ka pehu nui ʻana o ka maka, nā lehelehe, ke alelo, a i ʻole ka ʻāʻī
• Nā hopena ʻili koʻikoʻi me ka ʻōpū a i ʻole ka ʻili ʻana
• Nā hōʻailona o ka maʻi e like me ka fiva mau, nā anu, a i ʻole ka nāwaliwali ʻole
• ʻEha ʻōpū nui a i ʻole ka luaʻi mau

E nānā pono kāu hui mālama ola iā ʻoe no nā hopena e pili ana a e ʻike pono lākou pehea e mālama ai iā lākou inā loaʻa. E hoʻomanaʻo i nā pōmaikaʻi o ka pale ʻana i nā ʻeha waha koʻikoʻi e ʻoi aku ka nui ma mua o kēia mau pilikia no ka hapa nui o nā maʻi.

ʻO wai ka mea ʻaʻole pono e lawe iā Palifermin?

ʻAʻole kūpono ʻo Palifermin no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia no kou kūlana kikoʻī. Pono ka hoʻoholo ʻana i ke kaupaona ʻana i nā pōmaikaʻi e kūʻē i nā pilikia hiki ke hana ʻia ma muli o kāu ʻikepili olakino.

ʻAʻole pono ʻoe e loaʻa iā palifermin inā he maʻi ʻoe i ka lāʻau lapaʻau ponoʻī, kekahi o kāna mau mea, a i ʻole i nā protein i loaʻa mai E. coli. No ka mea, ua hana ʻia ʻo palifermin me ka hoʻohana ʻana i ka bacteria E. coli, pono nā kānaka me nā maʻi koʻikoʻi i nā huahana i loaʻa mai E. coli i nā ala ʻē aʻe.

E mālama pū ana kāu hui lapaʻau i ka mālama nui inā loaʻa iā ʻoe kekahi mau ʻano maʻi maʻi. Hiki i ka Palifermin ke hoʻoulu i ka ulu ʻana o kekahi mau pūnaewele maʻi maʻi i loaʻa nā mea hoʻokipa kikoʻī, no laila ʻaʻole ia i ʻōlelo ʻia no kekahi mau maʻi maʻi koko ʻole.

Pono paha ka poʻe me nā maʻi maʻi ikaika, ʻaʻole i mālama ʻia e kali a hiki i ka mālama ʻia ʻana o kā lākou maʻi ma mua o ka hoʻomaka ʻana i ka palifermin. Pono kāu ʻōnaehana pale e loaʻa i ke kūlana maikaʻi loa e pōmaikaʻi ai mai kēia lāʻau lapaʻau kākoʻo.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, pono kāu kauka e noʻonoʻo pono i nā pilikia a me nā pōmaikaʻi. ʻOiai he ʻikepili palena ʻia e pili ana i ka hoʻohana ʻana i ka palifermin i ka wā hāpai, ua mālama ʻia ka lāʻau lapaʻau no nā kūlana hoʻoweliweli i ke ola kahi e ʻoi aku ai nā pōmaikaʻi ma mua o nā pilikia hiki ke hana ʻia.

Nā inoa inoa Palifermin

Loaʻa ʻo Palifermin ma lalo o ka inoa inoa Kepivance, ʻo ia ka inoa i ʻike nui ʻia no kēia lāʻau lapaʻau. Hana ʻia ʻo Kepivance e Sobi (Swedish Orphan Biovitrum) a ʻo ia ka inoa nui i loaʻa ma ka hapa nui o nā ʻāina.

Hiki iā ʻoe ke ʻike i kēia lāʻau lapaʻau i kapa ʻia e kona inoa generic, palifermin, a i ʻole e kona inoa inoa, Kepivance, ma muli o kāu hoʻonohonoho mālama ola. E pili ana nā inoa ʻelua i ka lāʻau lapaʻau like me ka mea hana like.

Ma kekahi mau ʻāina, hiki ke loaʻa ka lāʻau lapaʻau ma lalo o nā inoa inoa like ʻole a i ʻole ma o nā mea hana like ʻole, akā ua like ka mea hana a me nā hopena therapeutic. E hōʻoia kāu hui mālama ola e loaʻa iā ʻoe ka formulation kūpono me ka nānā ʻole i ka inoa inoa kikoʻī i hoʻohana ʻia.

Nā Koho ʻē aʻe o Palifermin

I kēia manawa, ʻaʻohe koho pololei i ka palifermin e hana like ana. ʻO ia wale nō ka lāʻau lapaʻau i ʻae ʻia e ka FDA i hoʻolālā ʻia e pale i ka oral mucositis i nā maʻi e loaʻa ana i ka chemotherapy kiʻekiʻe a me ka radiation ma mua o nā transplants stem cell.

Eia naʻe, hiki i kāu hui lapaʻau ke hoʻohana i nā ala kākoʻo ʻē aʻe me ka palifermin a i ʻole ma kahi o ia mea, ma muli o kāu kūlana kikoʻī. Ke kālele nei kēia mau hoʻolālā ʻē aʻe i ka mālama ʻana i nā hōʻailona a me ka hoʻolaha ʻana i ka hoʻōla ʻana ma o nā ʻano hana like ʻole.

Hoʻohana kekahi mau mea mālama ola i nā protocols mālama waha e pili ana i nā mouthwashes kūikawā, nā mea uhi, a i ʻole nā ​​hoʻolālā hoʻokele ʻeha. Hiki ke kōkua kēia mau ala akā ʻaʻole lākou e hāʻawi i ka pale cellular i manaʻo ʻia e hāʻawi ai ka palifermin.

Ua hōʻike ka therapy laser haʻahaʻa a me kekahi mau mea hoʻohui meaʻai i ka hoʻohiki ʻana i kekahi mau haʻawina, akā ʻaʻole i hōʻoia ʻia lākou e like me ka palifermin no ka pale ʻana i nā ʻeha waha koʻikoʻi i nā maʻi pilikia nui.

E ʻōlelo kāu kauka i ke ala maikaʻi loa e pili ana i kāu hoʻolālā lapaʻau kikoʻī, nā mea pilikia, a me ke kūlana olakino holoʻokoʻa. I kekahi manawa, ʻoi aku ka maikaʻi o ka hui pū ʻana o nā hoʻolālā ma mua o ka hilinaʻi ʻana i kekahi ala hoʻokahi.

ʻOi aku ka maikaʻi o Palifermin ma mua o nā lāʻau lapaʻau pale ʻē aʻe?

I kēia manawa, ua manaʻo ʻia ʻo Palifermin ke kūlana gula no ka pale ʻana i ka oral mucositis koʻikoʻi i nā maʻi e loaʻa ana i nā lāʻau lapaʻau hoʻomaʻemaʻe kiʻekiʻe ma mua o nā transplants stem cell. Ua hōʻike mau nā haʻawina lapaʻau i kona pono i ka hōʻemi ʻana i ka paʻakikī a me ka lōʻihi o nā ʻeha waha.

I ka hoʻohālikelike ʻana me ka mālama waha maʻamau wale nō, hoʻēmi nui ʻo palifermin i ka pinepine o nā ʻeha waha nui mai kahi 98% a i kahi 63% ma nā maʻi pilikia nui. Hōʻike kēia i kahi hoʻomaikaʻi nui i ka maikaʻi o ke ola i ka wā o kahi manawa lapaʻau paʻakikī.

Ua hōʻike ʻia nō hoʻi ka lāʻau lapaʻau e hoʻēmi i ka pono no nā lāʻau ʻeha narcotic a hoʻēmi i ka lōʻihi o ka ʻeha waha nui. Nui nā maʻi i loaʻa iā palifermin e hōʻike ana i ka hiki ke ʻai a inu me ka ʻoluʻolu i ka wā o kā lākou hoʻōla lapaʻau.

Eia naʻe,

Mai ka mea e hāʻawi ʻia ana ʻo palifermin e nā poʻe loea mālama ola i loko o kahi wahi lapaʻau i mālama ʻia, he mea maʻamau loa ka loaʻa ʻana o ka overdose. Hoʻohālikelike pono a nānā pālua kāu hui lapaʻau i kāu mahele ma mua o kēlā me kēia hāʻawi ʻana.

Inā hopohopo ʻoe e pili ana i ka loaʻa ʻana o ka lāʻau lapaʻau nui loa, mai kānalua e nīnau i kāu hui mālama ola e pili ana i ke kaʻina hana dosing. Hiki iā lākou ke wehewehe pehea lākou e helu ai i kāu mahele kikoʻī a me nā hana palekana i kahi.

I ka hanana hiki ʻole o kahi hewa dosing, ua aʻo ʻia kāu hui lapaʻau e ʻike a mālama koke i nā pilikia. Loaʻa iā lākou nā protocols i kahi e nānā ai a hoʻoponopono i nā hopena maikaʻi ʻole.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Palifermin?

Inā poina iā ʻoe kahi mahele palifermin i hoʻonohonoho ʻia, e hoʻokaʻaʻike koke i kāu hui mālama ola e kūkākūkā i ka hoʻonohonoho hou ʻana. Hoʻopili pono ʻia ka manawa o nā mahele palifermin me kāu mau lāʻau lapaʻau ʻē aʻe, no laila pono e mālama ʻia nā loli e kāu poʻe loea lapaʻau.

Hiki i kāu kauka ke hoʻoponopono i kāu papa manawa e hoʻokō i ka mahele i poina, a i ʻole e ʻōlelo lākou e hoʻomau me kāu hoʻolālā lapaʻau a nānā pono iā ʻoe no nā ʻeha waha. Aia ka hoʻoholo i ka manawa i poina ai ka mahele a me kahi āu i loko o kāu manawa lapaʻau.

Mai hoʻāʻo e hana i kahi mahele i poina iā ʻoe iho. Hoʻolālā kūikawā ʻia ka papa manawa lāʻau lapaʻau e hāʻawi i ka pale maikaʻi loa, a pono e hana ʻia nā loli ma lalo o ka mālama ʻana i ka lāʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Palifermin?

ʻAʻole pono ʻoe e hana i ka hoʻoholo e pili ana i ka manawa e hooki ai iā palifermin no ka mea e hāʻawi ʻia ana ma ke ʻano he papa hana i hoʻoholo mua ʻia. Aia ka protocol maʻamau i ʻeono mau mahele i ka huina, a i ka manawa i hoʻopau ai ʻoe i kēia papa, ua pau ka lapaʻau.

E nānā kāu hui mālama ola i nā ʻiʻo o kou waha a me kou ʻāʻī i ka wā o kāu mālama ʻana i ka maʻi kanesa e hōʻoia i ka hāʻawi ʻana o ka palifermin i ka pale i manaʻo ʻia. E nānā pū lākou i nā hōʻailona e pono ai ka mālama kākoʻo hou.

Inā loaʻa iā ʻoe nā hopena ʻaoʻao e pili ana, hiki i kāu kauka ke hoʻololi i kāu hoʻolālā lapaʻau, akā e hana ʻia kēia hoʻoholo ma ke kūkākūkā ʻana me kāu hui lapaʻau holoʻokoʻa e hōʻoia i kou palekana a me ka holomua o ka lapaʻau.

Hiki iaʻu ke loaʻa iā Palifermin i ka wā e hāpai ana?

Pono ka hoʻohana ʻana i ka palifermin i ka wā e hāpai ana i ka noʻonoʻo pono e kāu hui lapaʻau. He palena nā ʻikepili e pili ana i ka hopena o ka lāʻau lapaʻau i nā wahine hāpai a me nā pēpē e ulu ana, no laila, mālama ʻia ia no nā kūlana kahi e ʻoi aku ai nā pōmaikaʻi ma mua o nā pilikia hiki.

Inā hāpai ʻoe a pono i ka mālama ʻana i ka maʻi kanesa ikaika, e hana kāu mau kauka me nā loea i ka hāpai ʻana i ka pilikia nui e hoʻomohala i ka hoʻolālā lapaʻau palekana loa. Hiki i kēia ke komo i nā ala ʻē aʻe e pale ai i nā ʻeha waha a i ʻole nā ​​protocol lapaʻau i hoʻololi ʻia.

E hilinaʻi ka hoʻoholo i nā mea e like me ke ʻano a me ke kahua o kāu maʻi kanesa, pehea ka lōʻihi o kou hāpai ʻana, a me nā koho lapaʻau ʻē aʻe i loaʻa. E hōʻoia kāu hui lapaʻau iā ʻoe i nā ʻike a pau e pono ai e hana i ka hoʻoholo maikaʻi loa no ʻoe a me kāu pēpē.