He aha ka Panobinostat: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Panobinostat kahi lāʻau lapaʻau i manaʻo ʻia no ka maʻi kanesa e hana ana ma ka pale ʻana i nā protein kikoʻī e kōkua i nā sela maʻi kanesa e ulu a ola. No ka papa o nā lāʻau i kapa ʻia he histone deacetylase inhibitors, e kōkua ana i nā hana pale maʻi maʻi maʻi o kou kino e hana ʻoi aku ka maikaʻi. Hoʻohana nui ʻia kēia lāʻau lapaʻau no ka mālama ʻana i kekahi mau ʻano maʻi kanesa o ke koko, ʻo ia hoʻi ka multiple myeloma ke hana ʻole nā lāʻau lapaʻau ʻē aʻe e like me ka mea i manaʻo ʻia.

He aha ka Panobinostat?

ʻO Panobinostat kahi lāʻau lapaʻau maʻi kanesa waha e manaʻo ana i nā sela maʻi kanesa ma ke kiʻekiʻe molekala. Hana ia ma ka hoʻopilikia ʻana i nā enzymes i kapa ʻia he histone deacetylases, pono nā sela maʻi kanesa e ulu a hoʻonui.

E noʻonoʻo iā ia he lāʻau lapaʻau e kōkua ana i ka hoʻihoʻi ʻana i ka hiki maoli o kou kino ke kāohi i ka ulu ʻana o nā sela maʻamau. ʻAʻole like me ka chemotherapy e pili ana i nā sela e mahele wikiwiki ana, ʻoi aku ka koho ʻana o ka panobinostat i ke ʻano o ka manaʻo i nā sela maʻi kanesa. Hiki i kēia ala i manaʻo ʻia ke hana pono i ka wā e hoʻoulu ai i nā hopena ʻaoʻao liʻiliʻi ma mua o ka chemotherapy kuʻuna.

Hele mai ka lāʻau lapaʻau i ke ʻano capsule a lawe ʻia e ka waha, e maʻalahi ai ma mua o nā lāʻau lapaʻau e koi ana i nā kipa i ka haukapila no nā infusions. E kauoha kāu kauka iā ia ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau maʻi kanesa piha i hana ʻia no kou kūlana.

No ke aha e hoʻohana ʻia ai ka Panobinostat?

Ua ʻae ʻia ʻo Panobinostat no ka mālama ʻana i ka multiple myeloma, kahi ʻano maʻi kanesa o ke koko e pili ana i nā sela plasma i kou iwi iwi. Hoʻonohonoho ʻia ia ke hoʻāʻo mua ʻoe i ʻelua mau ala lapaʻau ʻē aʻe, me kahi mea immunomodulatory a me kahi mea pale proteasome.

Hiki ke paʻakikī ka mālama ʻana i ka multiple myeloma no ka mea pinepine nā sela maʻi kanesa i ke kūpaʻa ʻana i nā lāʻau lapaʻau i ka manawa. Hāʻawi ʻo Panobinostat i kahi ʻano hana ʻokoʻa, ʻo ia hoʻi hiki iā ia ke kōkua ke pau ka hana ʻana o nā lāʻau lapaʻau ʻē aʻe.

Hiki i kāu kauka oncologist ke ʻōlelo aku i ka panobinostat ma ke ʻano he ʻāpana o ka lāʻau hui pū ʻana, maʻamau i hui pū ʻia me nā lāʻau ʻē aʻe e like me ka bortezomib a me ka dexamethasone. Kōkua kēia hui pū ʻana i ka hoʻouka ʻana i ka maʻi maʻi mai nā ʻaoʻao he nui, e hoʻomaikaʻi ana i nā hopena lapaʻau.

Pehea e Hana ai ʻo Panobinostat?

Hana ʻo Panobinostat ma ka pale ʻana i nā enzymes i kapa ʻia ʻo histone deacetylases (HDACs) e pono ai nā sela maʻi maʻi e kāohi i ka hōʻike gene. Ke ālaina ʻia kēia mau enzymes, ʻaʻole hiki i nā sela maʻi maʻi ke hoʻoponopono pono i kā lākou ulu a me nā hana ola.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau maʻi maʻi ikaika me kahi hana i manaʻo ʻia. Ua hoʻolālā ʻia e lawa ka ikaika e pili ana i nā sela maʻi maʻi i ka wā e koho nui ʻia ma mua o nā lāʻau chemotherapy kuʻuna.

Kōkua ka lāʻau lapaʻau i ka hoʻihoʻi ʻana i nā hana cellular maʻamau i hoʻopilikia ʻia e nā sela maʻi maʻi. Ma ka hoʻopilikia ʻana i kēia mau ala kikoʻī, hiki i ka panobinostat ke hoʻōki i nā sela maʻi maʻi mai ka ulu ʻana a i ʻole ka make ʻana, ʻoiai e liʻiliʻi ka hopena i nā sela olakino ma kou kino.

Pehea wau e lawe ai i ka Panobinostat?

E lawe i ka panobinostat e like me ke kauoha a kāu kauka, maʻamau ʻekolu manawa i ka pule i nā lā kikoʻī. ʻO ka papa manawa maʻamau ʻo ka Pōʻakahi, Pōʻakolu, a me ka Pōʻalima o nā pule 1 a me 2 o kēlā me kēia pōʻai lapaʻau 21 lā.

Pono ʻoe e lawe i nā capsules me ka wai, a hiki iā ʻoe ke lawe me ka ʻole o ka meaʻai. Eia naʻe, ʻo ka lawe ʻana me ka meaʻai e kōkua paha i ka hōʻemi ʻana i ka ʻōpū inā ʻoe e ʻike i ka nausea. Mai ʻoki, nau, a wehe paha i nā capsules - e ale iā lākou i mea e hōʻoia ai i ka absorption kūpono.

He mea nui e lawe i kāu mau lāʻau i ka manawa like i kēlā me kēia lā e mālama i nā pae kūlike o ka lāʻau lapaʻau i kāu ʻōnaehana. Inā ʻoe e luaʻi i loko o hoʻokahi hola o ka lawe ʻana i kahi lāʻau, mai lawe i kekahi lāʻau ʻē aʻe i kēlā lā - e kali a hiki i kāu lāʻau i hoʻonohonoho ʻia.

Ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, e ʻōlelo paha kāu kauka e ʻai i ka ʻai māmā a i ʻole ka ʻai māmā ma kahi o 30 mau minuke ma mua o ka lawe ʻana i ka lāʻau. Hiki i kēia ke kōkua i ka hōʻemi ʻana i nā hopena ʻaoʻao gastrointestinal e ʻike ai kekahi poʻe.

Pehea ka lōʻihi e lawe ai au i ka Panobinostat?

ʻO ka lōʻihi o ka lāʻau lapaʻau panobinostat e ʻokoʻa nui mai kēlā me kēia kanaka a hilinaʻi i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau no kāu kūlana kikoʻī. Hoʻomau ka hapa nui o nā kānaka i ka lāʻau lapaʻau no ka lōʻihi e kōkua ana i ka mālama ʻana i kā lākou maʻi maʻi a hiki ke mālama ʻia nā hopena ʻaoʻao.

E nānā kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau ma o nā hoʻokolohua koko maʻamau, nā haʻawina kiʻi, a me nā hoʻokolohua kino. Kōkua kēia mau loiloi i ka hoʻoholo ʻana inā e hana pono ana ka lāʻau lapaʻau a inā palekana ke hoʻomau ʻoe.

Hiki i kekahi poʻe ke lawe i ka panobinostat no kekahi mau mahina, aʻo nā mea ʻē aʻe e hoʻomau no hoʻokahi makahiki a ʻoi aku paha. ʻO ke kī ka loaʻa ʻana o ke kaulike kūpono ma waena o ka mālama ʻana i ka maʻi maʻi a me ka maikaʻi o ke ola. E hana pū kāu hui mālama ola me ʻoe e hana i nā hoʻoponopono e like me ka mea e pono ai i kāu huakaʻi lapaʻau.

He aha nā hopena ʻaoʻao o Panobinostat?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka panobinostat ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. ʻO nā hopena ʻaoʻao maʻamau ka mea hiki ke mālama ʻia me ke kākoʻo olakino kūpono a me ka nānā ʻana.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Luhi a me ka nāwaliwali
• Nausea a me ka luaʻi
• Pāpaʻa
• Hoʻemi ʻia ka ʻai
• Haʻahaʻa nā helu koko
• Pehu i nā lima, nā wāwae, a i ʻole nā wāwae
• ʻO ka ʻeha ʻiʻo a i ʻole ka hui

He maʻalahi a maʻalahi kēia mau hopena ʻaoʻao a pinepine e hoʻomaikaʻi i ka hoʻoponopono ʻana o kou kino i ka lāʻau lapaʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā hoʻolālā a me nā lāʻau lapaʻau e kōkua i ka mālama ʻana i kēia mau hōʻailona.

ʻO nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e komo pū ana me nā maʻi koʻikoʻi ma muli o ka helu haʻahaʻa o nā keʻena koko keʻokeʻo, nā pilikia o ka puʻuwai, a i ʻole ka maʻi maʻi nui e alakaʻi ana i ka maloʻo. ʻOiai he mea maʻamau kēia, he mea nui e hōʻike i nā hōʻailona e pili ana i kāu kauka i ka wā hiki.

Hiki i kekahi poʻe ke loaʻa i nā koko koko, ka luhi nui, a i ʻole nā pilikia o ke ake. E nānā pono kāu kauka iā ʻoe me nā hoʻokolohua koko maʻamau e hopu i nā pilikia hiki ke hiki i ka wā mua a hoʻoponopono i kāu lapaʻau inā pono.

ʻO wai ka mea ʻaʻole pono e lawe iā Panobinostat?

ʻAʻole kūpono ʻo Panobinostat no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. ʻO ka poʻe me kekahi mau maʻi puʻuwai, ʻo ia hoʻi ka poʻe me ka mōʻaukala o ka puʻuwai ʻole a i ʻole nā pilikia o ka puʻuwai, ʻaʻole paha he mau moho maikaʻi no kēia lāʻau.

Inā loaʻa iā ʻoe nā pilikia o ke ake nui a i ʻole nā maʻi ikaika a ʻaʻole i mālama ʻia, e ʻōlelo paha kāu kauka e kali a hiki i ka wā e mālama maikaʻi ʻia ai kēia mau maʻi ma mua o ka hoʻomaka ʻana iā panobinostat. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i kāu ʻōnaehana pale, e hoʻolilo ana i nā maʻi i mea koʻikoʻi.

ʻAʻole pono nā wahine hāpai a i ʻole nā wahine e hānai ana i ka waiū e lawe iā panobinostat, no ka mea, hiki iā ia ke hōʻeha i nā pēpē e ulu ana. Inā ʻoe i ka makahiki hānau keiki, pono ʻoe e hoʻohana i ka mana hānau kūpono i ka wā o ka lapaʻau a no kekahi mau mahina ma hope o ka hoʻōki ʻana i ka lāʻau.

ʻO ka poʻe me nā pilikia kīkī nui a i ʻole ka poʻe e lawe ana i kekahi mau lāʻau e pili ana i ka puʻuwai, pono paha lākou i nā lāʻau ʻē aʻe. E nānā kāu kauka i kāu mau lāʻau lapaʻau a me nā maʻi olakino e hōʻoia i ka palekana o panobinostat iā ʻoe.

Nā inoa inoa Panobinostat

Loaʻa ʻo Panobinostat ma lalo o ka inoa inoa ʻo Farydak ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa inoa mua āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau.

I kēia manawa, ʻo Farydak ka inoa nui i loaʻa, no ka mea, he lāʻau lapaʻau hou ʻo panobinostat i lalo o ka pale ʻana i ka palapala. ʻAʻole i loaʻa nā mana generic, akā e loli paha kēia i ka wā e pau ai nā palapala.

Ke kūkākūkā ʻana i kāu lapaʻau me nā mea mālama ola a i ʻole nā ​​kānaka lapaʻau, hiki iā ʻoe ke kuhikuhi i ka lāʻau lapaʻau ma kekahi inoa - panobinostat a i ʻole Farydak - a e ʻike lākou i ka mea āu e kamaʻilio nei.

Nā koho ʻē aʻe o Panobinostat

Inā ʻaʻole kūpono ʻo panobinostat iā ʻoe a i ʻole e pau ka hana ʻana, aia kekahi mau lapaʻau ʻē aʻe no ka myeloma lehulehu. Hiki i kāu kauka ke noʻonoʻo i nā mea pale deacetylase histone ʻē aʻe a i ʻole nā ​​lāʻau lapaʻau me nā ʻano hana like ʻole.

ʻO kekahi mau koho ʻē aʻe e pili ana i nā lāʻau lapaʻau i manaʻo ʻia e like me carfilzomib, pomalidomide, a i ʻole daratumumab. Hana kēia mau lāʻau lapaʻau ma nā ala like ʻole e hoʻouka i nā sela maʻi, e hāʻawi ana i nā koho inā ʻaʻole kūpono ʻo panobinostat no kou kūlana.

ʻO nā ala immunotherapy hou, me ka CAR-T cell therapy, he mau koho paha ia e pili ana i kāu mau kūlana kikoʻī. Hiki i nā hoʻokolohua lapaʻau e noiʻi ana i nā lapaʻau hoʻokolohua ke hāʻawi i nā mea hou aʻe no ka poʻe i hoʻāʻo i nā lāʻau lapaʻau maʻamau he nui.

ʻO ke koho maikaʻi loa e pili ana i kāu mau lapaʻau mua, ke olakino holoʻokoʻa, a me nā ʻano kikoʻī o kāu maʻi maʻi. E hana kāu oncologist me ʻoe e hoʻoholo i nā hana kūpono e hiki mai ana inā ʻaʻole hana ʻo panobinostat a i ʻole ke kumu o nā hopena ʻaoʻao ʻae ʻole.

Ua ʻoi aku ka maikaʻi o Panobinostat ma mua o Bortezomib?

Hana ʻo Panobinostat a me bortezomib ma nā ʻano hana like ʻole, no laila ʻaʻole maʻalahi ka hoʻohālikelike ʻana iā lākou. He mea pale proteasome ʻo Bortezomib i hoʻohana pinepine ʻia i ka hoʻomaka ʻana o ka lapaʻau myeloma lehulehu, ʻoiai ua mālama ʻia ʻo panobinostat no nā laina lapaʻau ma hope.

I nā haʻawina lapaʻau, hoʻohana pinepine ʻia ka panobinostat me ka bortezomib ma mua o ka pani ʻana iā ia. Ua hōʻike kēia hana hui i nā hopena maikaʻi aʻe ma mua o kekahi lāʻau lapaʻau wale nō i ka poʻe me ka myeloma nui i hoʻi hou.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i kāu mōʻaukala lapaʻau, pehea ka pane ʻana o kāu maʻi kanesa i nā lāʻau lapaʻau ma mua, a me kou kūlana olakino holoʻokoʻa. E noʻonoʻo kāu kauka i nā mea e like me nā hopena ʻaoʻao ma mua, nā hōʻailona o kēia manawa, a me nā ʻano kikoʻī o kāu maʻi kanesa i ka wā e hana ai i nā ʻōlelo aʻoaʻo lapaʻau.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana i ka Panobinostat

He Palekana anei ka Panobinostat no ka poʻe me nā pilikia o ka puʻuwai?

Pono ka panobinostat i ka nānā pono ʻana i ka poʻe me nā maʻi puʻuwai no ka mea hiki iā ia ke hoʻopilikia i ka puʻuwai. E hana kāu kauka i kahi electrocardiogram (ECG) ma mua o ka hoʻomaka ʻana i ka lapaʻau a me ka wā o ka lapaʻau e nānā i ka hana uila o kou puʻuwai.

Inā he mōʻaukala kou o nā pilikia o ka puʻuwai, ka hāʻule ʻana o ka puʻuwai, a i ʻole nā maʻi puʻuwai koʻikoʻi ʻē aʻe, hiki i kāu kauka ke ʻōlelo aku i nā lāʻau lapaʻau ʻē aʻe a i ʻole e mālama i nā hana hou inā ʻo ka panobinostat kāu koho maikaʻi loa. E hana pū lākou me kahi cardiologist e hōʻoia i ka pale ʻia o kou olakino puʻuwai i ka wā o ka lapaʻau.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Panobinostat?

Inā lawe hewa ʻoe i ka nui o ka panobinostat ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā e ulu nā hōʻailona - ʻoi aku ka maikaʻi o ka ʻimi ʻana i ka ʻōlelo aʻoaʻo lapaʻau.

ʻO ka lawe ʻana i ka nui o ka panobinostat hiki ke hoʻonui i ka pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi nā pilikia o ka puʻuwai a me nā hāʻule nui i nā helu o nā cell koko. Makemake paha kāu hui mālama ola e nānā pono iā ʻoe a hiki ke hoʻoponopono i kāu mau lāʻau e hiki mai ana e hōʻoia i kou palekana.

He aha kaʻu e hana ai inā haʻalele au i kahi lāʻau o Panobinostat?

Inā ʻoe e hala i ka lāʻau panobinostat, mai lawe inā ua hala ma mua o 12 hola mai kou manawa i hoʻonohonoho ʻia. Akā, e lele i ka lāʻau i hala a lawe i kāu lāʻau aʻe i ka manawa i hoʻonohonoho ʻia.

Mai lawe i ʻelua lāʻau i ka manawa hoʻokahi e hoʻoponopono ai i ka lāʻau i hala, no ka mea, hiki i kēia ke hoʻonui i ka pilikia o nā hopena ʻaoʻao koʻikoʻi. Inā ʻoe e hala pinepine ana i nā lāʻau, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua iā ʻoe e hoʻomanaʻo, e like me ka hoʻonohonoho ʻana i nā ʻōhua kelepona a i ʻole ka hoʻohana ʻana i ka mea hoʻonohonoho pila.

Iāhea Hiki iaʻu ke Hooki i ka Lawe ʻana i ka Panobinostat?

Pono ʻoe e hooki i ka lawe ʻana i ka panobinostat ma lalo o ke alakaʻi a kāu kauka. ʻO ka hoʻoholo e hooki i ka lapaʻau e hilinaʻi ana i ka maikaʻi o ka hana ʻana o ka lāʻau, nā hopena ʻaoʻao āu e ʻike nei, a me kou kūlana olakino holoʻokoʻa.

Pono paha kekahi poʻe e hooki no ka manawa inā loaʻa iā lākou nā hopena ʻaoʻao koʻikoʻi, aʻo nā mea ʻē aʻe e hooki mau inā holomua ka maʻi kanesa a i ʻole lilo nā hopena ʻaoʻao i mea hiki ʻole ke mālama. E kōkua kāu kauka iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia e hana i ka hoʻoholo maikaʻi loa no kou kūlana.

Hiki iaʻu ke Lawe i nā Lāʻau ʻē aʻe i ka wā e lawe ana i ka Panobinostat?

Hiki i nā lāʻau he nui ke launa pū me ka panobinostat, no laila he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau i kūʻai ʻia me ka ʻole o ka palapala kauoha, a me nā mea hoʻohui āu e lawe nei. Hiki i kekahi mau lāʻau lapaʻau ke hoʻonui i nā pae panobinostat i loko o kou koko, e hiki ai ke hoʻoulu i nā hopena ʻaoʻao hou.

E nānā kāu kauka i nā lāʻau lapaʻau a pau a pono paha e hoʻoponopono i nā lāʻau a i ʻole e ʻōlelo i nā mea ʻē aʻe no kekahi mau lāʻau. Mai hoʻomaka i nā lāʻau lapaʻau hou a i ʻole nā mea hoʻohui me ka ʻole e kūkākūkā mua me kāu hui mālama ola, no ka mea, hiki i nā huahana i ʻike ʻia he mea ʻole ke launa pū me nā lapaʻau maʻi kanesa.