He aha ʻo Pasireotide: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Pasireotide he lāʻau lapaʻau hormone synthetic e like me ka hormone maoli i kapa ʻia ʻo somatostatin i loko o kou kino. Ua hoʻolālā ʻia e kōkua i ka mālama ʻana i nā pae hormone i ka poʻe me kekahi mau maʻi endocrine laha ʻole, ʻo ia hoʻi nā mea e pili ana i ka ʻōpū pituitary a me nā ʻōpū adrenal.

Hana kēia lāʻau lapaʻau ma ka hoʻopaʻa ʻana i nā mea hoʻokipa kikoʻī i loko o kou kino e hōʻemi i ka hana ʻana i nā hormones nui. E noʻonoʻo iā ia he hoʻololi hoʻoponopono e kōkua ana i ka hoʻihoʻi ʻana i nā cell hana hormone i ke kaulike ke hana ʻole nā ​​ʻōnaehana hoʻomalu maoli o kou kino.

No ke aha e hoʻohana ʻia ai ʻo Pasireotide?

Hoʻonohonoho mua ʻia ʻo Pasireotide no ka maʻi ʻo Cushing, kahi maʻi laha ʻole kahi e hana ai kou ʻōpū pituitary i ka nui o ka hormone i kapa ʻia ʻo ACTH. Ke alakaʻi nei kēia i kāu mau ʻōpū adrenal e hana i nā mea nui o ka cortisol, hiki ke hoʻoulu i nā pilikia olakino koʻikoʻi i loko o kou kino.

Hiki i kāu kauka ke kuhikuhi iā pasireotide no ka acromegaly, kahi maʻi laha ʻole kahi e hana ai kou ʻōpū pituitary i ka nui o ka hormone ulu. Hana maʻamau kēia i nā pākeke a hiki ke hoʻoulu i nā loli kino like ʻole a me nā pilikia olakino inā waiho ʻole ʻia.

I kekahi mau hihia, hoʻohana nā mea mālama ola i ka pasireotide e mālama i kekahi mau ʻano o nā maʻi neuroendocrine. He mau maʻi laha ʻole kēia e hiki ke hana i nā hormones nui a hoʻoulu i nā hōʻailona ʻoluʻolu ʻole e like me ka ʻulaʻula, ka maʻi maʻi, a i ʻole ka ʻeha o ka ʻōpū.

Pehea e hana ai ʻo Pasireotide?

Ua manaʻo ʻia ʻo Pasireotide he lāʻau lapaʻau ikaika e hana ana ma ka hoʻohālike ʻana i ka hormone maoli o kou kino somatostatin. Hoʻopili ia i nā mea hoʻokipa kikoʻī ma nā cell hana hormone, e haʻi ana iā lākou e hoʻolohi i kā lākou hana.

I ka wā e loaʻa ai nā maʻi e like me ka maʻi o Cushing a i ʻole acromegaly, lilo kekahi mau keena i loko o kou ʻōpū pituitary i mea hana nui a hana i ka nui o ka hormone. Hana ʻo Pasireotide e like me ka pedal brake, e kōkua ana i ka hōʻemi ʻana i kēia hana hormone nui a lawe mai i nā pae kokoke i ka maʻamau.

He mea maikaʻi loa ka lāʻau lapaʻau no ka mea e kuhikuhi ana i nā ʻano mea hoʻokipa somatostatin. Kōkua kēia ala ākea iā ia e hana ma nā ʻano keena hana hormone like ʻole, e lilo ana i mea pono no nā kūlana endocrine like ʻole.

Pehea wau e lawe ai iā Pasireotide?

Loaʻa ʻo Pasireotide i nā ʻano ʻelua: nā injections subcutaneous āu e hāʻawi ai iā ʻoe iho ma lalo o ka ʻili, a me nā injections intramuscular i hāʻawi ʻia i loko o ka ʻiʻo e kekahi mea mālama ola. ʻO ke ʻano āu e hoʻohana ai e pili ana i kou kūlana kikoʻī a me ka ʻōlelo aʻoaʻo a kāu kauka.

No nā injections subcutaneous, e hoʻokomo maʻamau ʻoe i ka lāʻau lapaʻau ʻelua i ka lā i nā wahi e like me kou ʻūhā, ka ʻōpū, a i ʻole ka lima luna. E aʻo kāu hui mālama ola iā ʻoe i ke ʻano o ka injection kūpono a kōkua iā ʻoe e hoʻololi i nā wahi injection e pale ai i ka huhū o ka ʻili.

Inā loaʻa iā ʻoe nā injections intramuscular, hāʻawi ʻia kēia mau mea i hoʻokahi manawa i kēlā me kēia mahina ma ke keʻena o kāu kauka a i ʻole ke keʻena. Hoʻokomo ʻia ka lāʻau lapaʻau i loko o kou ʻiʻo ʻūhā e kekahi mea mālama ola i aʻo ʻia.

Hiki iā ʻoe ke lawe iā pasireotide me ka ʻole o ka meaʻai, akā e hoʻāʻo e mālama i ke kūlike me kāu hana maʻamau. Manaʻo kekahi poʻe he mea kōkua ke lawe iā ia i nā manawa like i kēlā me kēia lā e mālama i nā pae hormone paʻa i ko lākou kino.

Pehea ka lōʻihi o kaʻu lawe ʻana iā Pasireotide?

ʻO ka lōʻihi o ka mālama ʻana iā pasireotide e ʻokoʻa loa ma muli o kou kūlana kikoʻī a me ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau. No ka nui o nā poʻe me ka maʻi o Cushing a i ʻole acromegaly, lilo kēia i lapaʻau lōʻihi e hiki ke hoʻomau no nā makahiki.

E nānā mau kāu kauka i nā pae hormone o kou kino ma o nā hoʻokolohua koko e ʻike ai i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. Hana ʻia kēia mau nānā ʻana i kēlā me kēia mau mahina i ka wā mua, a laila e emi pinepine ana ke paʻa nā pae o kou kino.

Pono paha kekahi poʻe e lawe i ka pasireotide no ka manawa pau ʻole e mālama i nā pae hormone o ko lākou kino. Hiki i nā poʻe ʻē aʻe ke hoʻohana ia mea ma ke ʻano he lapaʻau alahaka i ka wā e hoʻomākaukau ana no ke ʻoki a i ʻole nā hana ʻē aʻe. E hana pū kāu hui mālama ola me ʻoe e hoʻoholo i ke ala maikaʻi loa no kou kūlana.

He aha nā hopena ʻaoʻao o Pasireotide?

E like me nā lāʻau lapaʻau a pau, hiki i ka pasireotide ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau e maʻalahi ke mālama ʻia a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau:

• Nā pae kō koko kiʻekiʻe (hyperglycemia) - ʻo kēia ka hopena ʻaoʻao pinepine
• Nausea a me ka ʻoluʻolu ʻole o ka ʻōpū
• Pāpaʻa a i ʻole nā noho palupalu
• Nā hopena ma ka pūnaewele injection e like me ka ʻulaʻula a i ʻole ka pehu
• Nā poʻo
• ʻO ka luhi a i ʻole ka piʻi ʻana o ka luhi ma mua o ka maʻamau
• ʻO ka noʻonoʻo
• ʻEha o ka ʻōpū

ʻO kēia mau hopena maʻamau e lilo pinepine i mea ʻoluʻolu ʻole i ka wā e hoʻopili ai kou kino i ka lāʻau lapaʻau.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao nui e koi ai i ka nānā ʻana:

• Diabetes a i ʻole ka ʻino ʻana o ka maʻi diabetes
• Nā pilikia o ka gallbladder a i ʻole nā pōhaku gall
• Nā loli o ka puʻuwai
• Nā loli o ka hana ate
• Ke koko haʻahaʻa
• Nā loli o ka hana kīkī

E nānā mau kāu kauka iā ʻoe no kēia mau hopena koʻikoʻi ma o nā hoʻokolohua koko a me nā hoʻokolokolo ʻē aʻe.

Hiki i nā hopena ʻaoʻao laha ʻole akā koʻikoʻi ke komo i nā hopena maʻi maʻi koʻikoʻi, nā pilikia nui o ka puʻuwai, a i ʻole nā pilikia ate koʻikoʻi. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike i nā hōʻailona ʻōlelo aʻo a e ʻimi koke i ka lāʻau lapaʻau inā loaʻa lākou.

ʻO wai ka mea ʻaʻole pono e lawe iā Pasireotide?

ʻAʻole kūpono ʻo Pasireotide no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. ʻO nā kānaka me kekahi mau maʻi puʻuwai, ʻo ia hoʻi ka poʻe me nā puʻuwai puʻuwai maʻamau ʻole, ʻaʻole paha he moho maikaʻi no kēia lāʻau.

Inā loaʻa iā ʻoe ka maʻi ate koʻikoʻi, e pale paha kāu kauka i ka kuhikuhi ʻana i ka pasireotide a i ʻole e hoʻohana me ka akahele loa. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana ate, no laila hiki ke ʻoi aku ka maikaʻi o nā pilikia ate.

Pono ka poʻe me ka maʻi diabetes i mālama ʻole ʻia e mālama pono i ko lākou kō koko ma mua o ka hoʻomaka ʻana i ka pasireotide. Mai ka wā e hiki ai i ka lāʻau lapaʻau ke hoʻonui i nā pae kō koko, hiki i ka hoʻomaka ʻana me ka maʻi diabetes i mālama ʻole ʻia ke alakaʻi i nā pilikia koʻikoʻi.

ʻAʻole pono nā wahine hāpai e lawe i ka pasireotide ke ʻole ka maikaʻi ma mua o nā pilikia. Inā ʻoe e hoʻolālā nei e hāpai a i ʻole e hānai ana i ka waiū, e kūkākūkā pono i kēia me kāu mea mālama ola.

Nā inoa inoa o Pasireotide

Loaʻa ʻo Pasireotide ma lalo o ka inoa inoa ʻo Signifor no nā formulations subcutaneous a me intramuscular. Kapa pinepine ʻia ka mana subcutaneous ʻo Signifor, ʻoiai ʻo ka mana intramuscular lōʻihi e ʻike ʻia ʻo Signifor LAR.

Loaʻa i nā formulations ʻelua ka mea hana like akā ua hoʻolālā ʻia no nā papa hana dosing like ʻole. E koho kāu kauka i ke ʻano kūpono loa e pili ana i kāu mau pono a me nā manaʻo ola.

Nā koho ʻē aʻe o Pasireotide

Inā ʻaʻole kūpono ʻo pasireotide iā ʻoe a i ʻole ʻaʻole e hāʻawi i ka mana kūpono o kou kūlana, hiki ke noʻonoʻo ʻia kekahi mau koho ʻē aʻe. ʻO Octreotide kekahi analog somatostatin e hana like ana akā loaʻa paha nā ʻaoʻao ʻokoʻa.

No Cushing's disease, hiki i nā lāʻau lapaʻau e like me ketoconazole, metyrapone, a i ʻole mifepristone nā koho. Hana kēia mau mea ma o nā ʻano hana like ʻole e kāohi i nā pae cortisol.

Hiki ke noʻonoʻo ʻia nā koho ʻoki, e like me ke ʻoki pituitary no ka maʻi o Cushing a i ʻole acromegaly, ma ke ʻano he mea ʻē aʻe i ka lāʻau lapaʻau a i ʻole i hui pū ʻia me ka lāʻau lapaʻau. E kōkua kāu endocrinologist e hoʻoholo i ke ala maikaʻi loa no kāu kūlana.

Ua ʻoi aku ka maikaʻi o Pasireotide ma mua o Octreotide?

ʻO Pasireotide a me octreotide nā analog somatostatin, akā hana lākou i nā mea like ʻole i kou kino. Hoʻopaʻa ʻo Pasireotide i nā ʻano mea hoʻokipa somatostatin, hiki ke ʻoi aku ka maikaʻi no kekahi mau maʻi.

No ka maʻi o Cushing, makemake pinepine ʻia ʻo pasireotide no ka mea he hana maikaʻi aʻe ma nā mea hoʻokipa kikoʻī i loaʻa i nā ʻōpū pituitary e hoʻoulu ai i kēia maʻi. ʻAʻole maikaʻi ʻo Octreotide no ka maʻi o Cushing.

Eia naʻe, no ka acromegaly a me nā ʻōpū neuroendocrine, hiki ke maikaʻi nā lāʻau lapaʻau ʻelua. ʻO ke koho pinepine e pili ana i nā mea e like me ka ʻae ʻana i ka hopena ʻaoʻao, ka maʻalahi o ka hoʻopaʻa ʻana, a me ka pane pilikino i ka lāʻau lapaʻau.

E noʻonoʻo kāu kauka i kāu maʻi kikoʻī, ka mōʻaukala olakino, a me nā pahuhopu lapaʻau i ke koho ʻana ma waena o kēia mau lāʻau lapaʻau. I kekahi manawa, ʻo ka poʻe i pane ʻole i hoʻokahi lāʻau lapaʻau e ʻoi aku ka maikaʻi me kekahi.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Pasireotide

He palekana ʻo Pasireotide no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana ʻia ʻo Pasireotide i ka poʻe me ka maʻi diabetes, akā pono ia i ka nānā pono ʻana a me nā hoʻoponopono pinepine i nā lāʻau lapaʻau diabetes. Hoʻonui pinepine ka lāʻau lapaʻau i nā pae kō koko, no laila pono paha kāu hoʻolālā hoʻokele diabetes.

E hana pū kāu kauka me ʻoe e nānā pinepine i kāu mau pae kō koko i ka hoʻomaka ʻana iā pasireotide. Pono paha ʻoe i nā loli i kāu ʻai, hana maʻamau, a i ʻole nā ​​lāʻau lapaʻau diabetes e mālama i ka mana kō koko maikaʻi.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o ka Pasireotide?

Inā ua hoʻokomo hewa ʻoe i ka nui o ka pasireotide, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole e ʻimi i ka lāʻau lapaʻau pilikia. Hiki i ka overdose ke hoʻohaʻahaʻa nui i ke kō koko, ke koko, a me ka puʻuwai.

I ka wā e kali ana i ke kōkua olakino, e nānā iā ʻoe iho no nā hōʻailona e like me ka ʻūlū nui, ka maʻi, ka nausea, a i ʻole ka maikaʻi ʻole. Mai hoʻāʻo e mālama iā ʻoe iho i ka overdose - pono ka loiloi olakino ʻoihana.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Pasireotide?

Inā ua hala ʻoe i kahi injection subcutaneous, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, ke ʻole kokoke ka manawa no kāu mahele aʻe. I kēlā hihia, e lele i ka mahele i hala a e hoʻomau me kāu papa manawa maʻamau. Mai lawe i kahi mahele pālua e hana ai no kahi mea i hala.

No ka injection intramuscular lōʻihi, e hoʻokaʻaʻike i kāu mea mālama ola inā ua hala ʻoe i kahi manawa. E kōkua lākou iā ʻoe e hoʻonohonoho hou a pono paha e hoʻoponopono i kāu hoʻolālā lapaʻau no ka manawa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Pasireotide?

Mai hooki i ka lawe ʻana i ka pasireotide me ka ʻole e kūkākūkā me kāu mea mālama ola. ʻO ka hooki koke ʻana hiki ke hoʻonui i kāu mau pae hormone, e alakaʻi ana i ka hoʻihoʻi ʻana o nā hōʻailona a i ʻole nā pilikia.

E alakaʻi kāu kauka iā ʻoe ma nā loli i kāu hoʻolālā lapaʻau. Inā pono ʻoe e hooki i ka pasireotide, hana maʻamau ʻia me ka nānā ʻana i kāu mau pae hormone e hōʻoia i ka mālama ʻia ʻana o kou kūlana.

Hiki iaʻu ke hele i ka wā e lawe ana i ka Pasireotide?

ʻAe, hiki iā ʻoe ke hele i ka wā e lawe ana i ka pasireotide, akā pono ia i kekahi hoʻolālā. Inā ʻoe e hoʻohana ana i nā injections subcutaneous, pono ʻoe e lawe i kāu lāʻau lapaʻau me ʻoe, me nā lako mālama kūpono e mālama ai i ka mahana kūpono.

E lawe mau i ka palapala mai kāu kauka e wehewehe ana i kou maʻi a me ka pono no ka lāʻau lapaʻau injectable. Kōkua kēia i ka palekana o ke kahua mokulele a me nā dute. No nā huakaʻi lōʻihi, e hoʻonohonoho me kāu mea mālama ola e pili ana i nā mea hou o ka lāʻau lapaʻau a me nā hoʻoponopono manawa e pono ai no kāu papa hana.