He aha ʻo Pirfenidone: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Pirfenidone i kuhikuhi ʻia e lohi i ka ʻeha o ka māmā i ka poʻe me ka idiopathic pulmonary fibrosis (IPF). Hana kēia lāʻau lapaʻau waha ma ka hoʻemi ʻana i ka mumū a me ka pale ʻana i kekahi mau protein e hana ai i ka ʻiʻo ʻeha nui i kou māmā. ʻOiai ʻaʻole hiki iā ia ke hoʻōla i ka IPF, kōkua ʻo pirfenidone i ka mālama ʻana i kāu hana māmā a hiki ke hoʻolōʻihi i kou maikaʻi o ke ola ke lawe ʻia ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau piha.

He aha ʻo Pirfenidone?

ʻO Pirfenidone kahi lāʻau anti-fibrotic e pili ana i kahi papa lāʻau lapaʻau kūikawā i kapa ʻia ʻo pyridones. Ua ʻae ʻia e ka FDA e mālama i ka idiopathic pulmonary fibrosis, kahi maʻi māmā e holomua ana kahi e ʻeha ai ka ʻiʻo māmā olakino a mānoanoa i ka manawa.

Hele mai ka lāʻau lapaʻau i ke ʻano capsule a lawe ʻia e ka waha ʻekolu manawa i ka lā me ka meaʻai. E noʻonoʻo iā pirfenidone ma ke ʻano he ʻōnaehana paʻa no kāu hana ʻeha māmā - ʻaʻole ia e hoʻohuli i ka pōʻino i loaʻa, akā hoʻolohi nui ia i ka holomua ʻana o ka hana ʻana o ka ʻiʻo ʻeha hou.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lapaʻau holomua no nā maʻi IPF no ka mea ma mua o kāna ʻae ʻia, he palena palena loa nā koho i loaʻa e lohi i kēia maʻi holomua. Hāʻawi ʻo Pirfenidone iā ʻoe a me kāu hui mālama ola i ka manawa hou e mālama pono ai i kou kūlana.

No ke aha i hoʻohana ʻia ai ʻo Pirfenidone?

Hoʻohana nui ʻia ʻo Pirfenidone e mālama i ka idiopathic pulmonary fibrosis (IPF), kahi maʻi māmā koʻikoʻi kahi e pani mālie ai ka ʻiʻo ʻeha i ka ʻiʻo māmā olakino. ʻO ka huaʻōlelo

He pinepine ka IPF i nā kānaka ma luna o 50 a hoʻokumu i nā hōʻailona e like me ka ʻū maloʻo mau, ka pōkole o ka hanu i ka wā e hana ana, a me ka emi mālie o ka hana o ka māmā. Me ka ʻole o ka lapaʻau, e ʻoi aku ana kēia maʻi i ka wā, e paʻakikī ai ka oxygen e hele mai kou māmā i loko o kou kahe koko.

I kēia manawa, ʻaʻole i ʻae ʻia ka pirfenidone no nā ʻano maʻi ʻē aʻe o ka ʻōpū māmā, ʻoiai ke hoʻomau nei nā mea noiʻi i ke aʻo ʻana i kāna mau pono no nā maʻi pulmonary pili. E hōʻoia kāu kauka i kāu hōʻailona kikoʻī ma o nā hoʻokolohua hana māmā, nā scans CT, a i kekahi manawa ka biopsy māmā ma mua o ke kau ʻana i kēia lāʻau.

Pehea e Hana ai ʻo Pirfenidone?

Hana ʻo Pirfenidone ma ka pahuhopu ʻana i nā ala he nui i pili i ka ʻōpū māmā a me ka mumū. Kāohi ia i ka hana ʻana o ka transforming growth factor-beta (TGF-β), he protein e hōʻailona ana i kou kino e hana i ka ʻiʻo ʻōpū nui i kou māmā.

Hoʻemi pū ka lāʻau lapaʻau i ka mumū ma ka hoʻemi ʻana i ka hana o kekahi mau pūnaewele immune e kōkua ana i ka pōʻino o ka māmā. Eia kekahi, ke keakea nei ka pirfenidone i ka hana ʻana o ka collagen - ʻo ka collagen ka protein nui e hana ana i ka ʻiʻo ʻōpū i kou māmā.

Ua manaʻo ʻia he lāʻau lapaʻau ikaika loa kēia no ka mea e hoʻopilikia nui ana i ka holomua o ka maʻi, akā ʻaʻole ia he lapaʻau ikaika e like me ka chemotherapy. Hana mālie ka lāʻau lapaʻau i nā mahina, a ʻaʻole paha ʻoe e ʻike i nā hoʻomaikaʻi koke ʻana i ke ʻano o kou manaʻo, akā hōʻike pinepine nā hoʻokolohua hana māmā i ka emi lohi o ka holomua o ka maʻi.

Pehea wau e lawe ai i ka Pirfenidone?

E lawe i ka pirfenidone e like me ke kau ʻana a kāu kauka, ʻekolu manawa i ka lā me ka meaʻai. ʻO ka lawe ʻana me nā meaʻai e kōkua i ka hōʻemi ʻana i ka ʻōpū a hoʻomaikaʻi i ka maikaʻi o kou kino e komo i ka lāʻau.

E ale i nā capsules holoʻokoʻa me ke aniani wai piha - mai ʻoki, nau, a wehe paha iā lākou. E hoʻokaʻawale i kāu mau lāʻau i ka lā a pau, e like me ka ʻaina kakahiaka, ka ʻaina awakea, a me ka ʻaina ahiahi. Kōkua kēia manawa kūpono i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kou kahe koko.

E hoʻomaka kāu kauka iā ʻoe ma kahi haʻahaʻa haʻahaʻa a e hoʻonui mālie iā ia i nā pule mua. Kōkua kēia ʻano hana i kou kino e hoʻoponopono i ka lāʻau lapaʻau a hoʻemi i ka hiki ʻana o nā hopena ʻaoʻao. ʻO ka hapa nui o nā kānaka e lawe ana i 801 mg ʻekolu manawa i ka lā ma ke ʻano he lāʻau mālama.

Inā ʻoe e ʻai i ka ʻai nui, maikaʻi loa ia no ka lawe ʻana i ka pirfenidone. Eia naʻe, e hoʻāʻo e pale i ka lawe ʻana iā ia ma ka ʻōpū ʻole, no ka mea, hoʻonui nui kēia i kou pilikia o ka nausea a me ka ʻoluʻolu o ka ʻōpū.

Pehea ka lōʻihi e lawe ai au i ka Pirfenidone?

ʻO ka Pirfenidone kahi lapaʻau lōʻihi āu e hoʻomau ai e lawe mau, inā e kōkua ana ia i ka lohi ʻana i ka holomua o kou maʻi a ke ʻae nei ʻoe iā ia. He maʻi maʻi maʻi, holomua ka IPF e pono ai ka mālama mau ma mua o kahi papa lapaʻau pōkole.

E nānā kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau ma o nā hoʻokolohua hana māmā maʻamau, maʻamau i kēlā me kēia 3-6 mahina. Kōkua kēia mau hoʻokolohua e hoʻoholo inā e lohi ana ka pirfenidone i ka emi ʻana o kou hiki i ka māmā a inā pono ʻoe e hoʻomau i ka lapaʻau.

Lawe kekahi poʻe i ka pirfenidone no nā makahiki me nā hopena maikaʻi, a ʻo nā mea ʻē aʻe e pono e hooki inā loaʻa iā lākou nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia a i ʻole e holomua ana kā lākou maʻi me ka mālama ʻana. E hana pū kāu hui mālama ola me ʻoe e ʻimi i ke kaulike kūpono ma waena o nā pōmaikaʻi a me nā pilikia āu e ʻike ai.

He aha nā hopena ʻaoʻao o ka Pirfenidone?

Hiki i ka hoʻomaopopo ʻana i nā hopena ʻaoʻao ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻopili ai i kāu mea mālama ola. ʻO ka hapa nui o nā kānaka e ʻike i kekahi mau hopena ʻaoʻao, akā ʻike ka nui o lākou he hiki ke mālama ʻia me ke kākoʻo kūpono a me nā hoʻoponopono.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, penei:

• Ka maʻi a me ka ʻōpū (e pili ana i ka 1 i 3 mau kānaka)
• Ka ʻili e pane ana i ka lā, e alakaʻi ana i ka ʻōpala a i ʻole ka lā
• Ka luhi a me ka manaʻo e ʻoi aku ka luhi ma mua o ka maʻamau
• Ka nalowale o ka ʻai a me ka emi ʻana o ke kaumaha
• Ka wili, ʻoi loa ke kū koke
• Ke poʻo a me ka huikau māmā
• Ka maʻi palahē a i ʻole nā loli i nā hana o ka ʻōpū

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau i nā pule mua. ʻO ka lawe ʻana i ka pirfenidone me ka meaʻai a me ka noho ʻana i ka wai e hiki ke kōkua i ka hōʻemi ʻana i nā pilikia e pili ana i ka ʻōpū.

ʻAʻole maʻamau akā ʻoi aku ka nui o nā hopena ʻaoʻao e pono ai ka lāʻau lapaʻau koke:

• Nā hopena ʻili koʻikoʻi a i ʻole ka ʻōpala ākea
• Nā hōʻailona o nā pilikia o ke ake e like me ka melemele o ka ʻili a i ʻole nā maka, ka mimi ʻeleʻele, a i ʻole ka ʻeha o ka ʻōpū mau
• Ka pilikia o ka hanu a i ʻole ka hōʻino ʻana i nā hōʻailona o ka māmā
• Ka wili nui a i ʻole nā hanana fainting
• ʻO ka ʻehaʻeha a i ʻole ke kahe ʻana o ke koko

ʻO nā pilikia kakaʻikahi akā koʻikoʻi e hiki ke komo i ka pōʻino o ke ake nui a i ʻole nā loli maʻamau o ka puʻuwai. E nānā kāu kauka i ka hana o kou ake me nā hoʻokolohua koko maʻamau a hiki ke hoʻoponopono i kāu mahele a i ʻole e hooki i ka lāʻau inā loaʻa nā loli e pili ana.

ʻO wai ka mea ʻaʻole pono e lawe i ka Pirfenidone?

ʻAʻole pono kekahi poʻe e lawe i ka pirfenidone ma muli o ka piʻi ʻana o nā pilikia koʻikoʻi. E nānā pono kāu kauka i kāu mōʻaukala olakino a me nā lāʻau lapaʻau i kēia manawa ma mua o ke kau ʻana i kēia lapaʻau.

ʻAʻole pono ʻoe e lawe i ka pirfenidone inā loaʻa iā ʻoe:

• Ka maʻi ate koʻikoʻi a i ʻole ka mōʻaukala o nā pilikia o ke ake
• Ka maʻi kīkī hope e pono ai ka dialysis
• ʻIke ʻia ka maʻi i ka pirfenidone a i ʻole kekahi o kāna meaʻai
• Ka hoʻohana ʻana i ka fluvoxamine (he antidepressant) i kēia manawa e hiki ke hoʻonui i nā pae pirfenidone

Pono ka makaʻala kūikawā inā ʻoe e lawe ana i kekahi mau lāʻau lapaʻau e launa pū me ka pirfenidone, me kekahi mau lāʻau antibiotic, nā lāʻau antifungal, a me nā lāʻau lapaʻau puʻuwai. E hōʻike mau i kāu mea mālama ola e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e hoʻohana nei.

ʻAʻole pono nā wahine hāpai e lawe i ka pirfenidone no ka mea hiki ke hōʻeha i ka pēpē e ulu ana. Inā ʻoe e hoʻolālā ana e hāpai a i ʻole e hānai ana i ka waiū, e kūkākūkā i nā koho lapaʻau ʻē aʻe me kāu kauka. Pono nā kāne e lawe ana i ka pirfenidone e kamaʻilio pū me kā lākou mea mālama ola e pili ana i nā manaʻo hoʻolālā ʻohana.

Nā inoa inoa o Pirfenidone

Loaʻa ka Pirfenidone ma lalo o ka inoa inoa ʻo Esbriet ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka mea i kauoha pinepine ʻia a ʻo ia ka mea i ʻike nui ʻia e nā hoʻolālā ʻinikua.

Ma nā ʻāina ʻē aʻe, loaʻa paha ka pirfenidone ma lalo o nā inoa inoa like ʻole, akā like ka mea hana a me ka dosage maʻamau. Ke loaʻa nei nā mana generic o ka pirfenidone ma kekahi mau wahi, hiki ke hāʻawi i ka mālama kālā ʻoiai e hāʻawi ana i nā pōmaikaʻi therapeutic like.

E nānā mau me kāu lāʻau lapaʻau e hōʻoia e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono, ʻoiai inā ʻoe e hele ana a i ʻole e hoʻopiha ana i nā kauoha ma nā wahi like ʻole. Hiki ke ʻokoʻa ke ʻano o nā capsules ma waena o nā mea hana, akā pono e like ka ʻike o ka mea hana.

Nā koho ʻē aʻe o Pirfenidone

ʻO Nintedanib (inoa inoa Ofev) ke koho nui i ka pirfenidone no ka mālama ʻana i ka IPF. Hana ʻokoʻa nā lāʻau lapaʻau ʻelua akā loaʻa nā pahuhopu like o ka hoʻolohi ʻana i ka holomua o ka maʻi a me ka mālama ʻana i ka hana o ka māmā.

Hoʻopaʻa ʻo Nintedanib i nā ala like ʻole e pili ana i ka ʻōpala māmā a lawe ʻia i ʻelua manawa i ka lā me ka meaʻai. ʻOi aku ka maikaʻi o kekahi poʻe i kekahi lāʻau lapaʻau ma mua o kekahi, a hiki i kāu kauka ke ʻōlelo e hoʻololi inā ʻike ʻoe i nā hopena ʻaoʻao koʻikoʻi me kāu lapaʻau i kēia manawa.

ʻO nā lapaʻau kākoʻo ʻē aʻe no ka IPF e komo pū ana me ka oxygen therapy, ka hoʻoponopono ʻana i ka pulmonary, a me ka hoʻololi ʻana i ka māmā no nā moho kūpono. Hana pū kēia mau ala me nā lāʻau anti-fibrotic e kōkua i ka mālama ʻana i nā hōʻailona a mālama i kou maikaʻi o ke ola.

E kōkua kāu hui mālama ola kino e hoʻoholo i ke ala lapaʻau maikaʻi loa no kou kūlana kikoʻī, me ka noʻonoʻo ʻana i nā mea e like me kou olakino holoʻokoʻa, nā maʻi olakino ʻē aʻe, a me nā makemake pilikino.

Ua ʻoi aku ka maikaʻi o Pirfenidone ma mua o Nintedanib?

ʻAʻole ʻo pirfenidone a ʻo nintedanib paha i

Ua manaʻo ʻia ʻo Pirfenidone he palekana no ka poʻe me ka maʻi puʻuwai paʻa, akā pono kāu kauka puʻuwai a me ka pulmonologist e hana pū e nānā i kāu lapaʻau. ʻAʻole pili pololei ka lāʻau i ka hana o ka puʻuwai, akā hiki i kekahi mau hopena ʻaoʻao e like me ka ʻūlū ke hopohopo nui inā loaʻa iā ʻoe kekahi mau maʻi puʻuwai.

Inā he pilikia kou puʻuwai, e nānā pono kāu kauka iā ʻoe no ka mea hiki i ka pirfenidone ke hoʻopilikia i ka puʻuwai i nā manawa kakaikahi. Hiki i ka hapa nui o ka poʻe me ka maʻi puʻuwai i mālama maikaʻi ʻia ke lawe palekana i ka pirfenidone me ka mālama olakino kūpono.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Pirfenidone?

Inā lawe hewa ʻoe i kahi mahele hou o ka pirfenidone, mai hopohopo, akā e hoʻokaʻaʻike i kāu mea mālama ola a i ʻole ka mea kūʻai lāʻau lapaʻau no ke alakaʻi. ʻO ka lawe ʻana i kahi mea liʻiliʻi ma mua o ka mea i kauoha ʻia i kekahi manawa ʻaʻole ia he mea weliweli, akā hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao e like me ka nausea a i ʻole ka ʻūlū.

Mai ho'āʻo e

E pono ʻoe e hooki i ka lawe ʻana i ka pirfenidone ma lalo o ke alakaʻi a kāu kauka, no ka mea, he maʻi holomua ka IPF e maʻa mau ana me ka ʻole o ka lāʻau. Hoʻomau ka hapa nui o nā kānaka i ka lawe ʻana i ka pirfenidone no ka wā lōʻihi ke ʻole lākou e loaʻa i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia a i ʻole e holomua ana kā lākou maʻi me ka ʻole o ka lāʻau.

E loiloi mau kāu kauka inā e pōmaikaʻi ana ka pirfenidone iā ʻoe ma o nā hoʻokolohua hana māmā a me ka nānā ʻana i nā hōʻailona. Inā pono ʻoe e hooki i ka lāʻau lapaʻau, e kūkākūkā kāu hui mālama ola i nā lāʻau lapaʻau ʻē aʻe a kōkua iā ʻoe e hoʻololi palekana i kāu hoʻolālā lapaʻau e hiki mai ana.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Pirfenidone?

ʻOi aku ka maikaʻi e kaupalena i ka inu ʻana i ka waiʻona i ka wā e lawe ana i ka pirfenidone, no ka mea, hiki i nā mea ʻelua ke hoʻopilikia i kāu hana ate. Hiki ke ʻae ʻia ka inu māmā i kekahi manawa no kekahi poʻe, akā pono ʻoe e kūkākūkā i kēia me kāu mea mālama ola e pili ana i kou kūlana olakino.

No ka mea, hiki i ka pirfenidone ke hoʻoulu i ka ʻōpū a hiki i ka waiʻona ke hoʻonui i kēia hopena, hiki i ka hui ʻana iā lākou ke hoʻonui i kou pilikia o ka hāʻule a i ʻole nā ​​pōʻino. E nānā mau kāu kauka i kāu hana ate a hiki ke hāʻawi i ke alakaʻi pilikino e pili ana i ka inu ʻana i ka waiʻona e pili ana i nā hopena o kāu hoʻokolohua a me ke olakino holoʻokoʻa.