He aha ka Plazomicin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau antibiotic ikaika ka Plazomicin e hoʻohana ai nā kauka e mālama i nā maʻi bacteria koʻikoʻi i ka wā i hana ʻole ai nā lāʻau antibiotic ʻē aʻe. No kahi hui i kapa ʻia ʻo aminoglycosides kēia lāʻau lapaʻau, he mau lāʻau ikaika e hakakā ana i ka maʻi i hāʻawi ʻia ma o ka IV i ka haukapila. Inā ua ʻōlelo kāu kauka i ka plazomicin, no ka mea e hana ana ʻoe me kahi maʻi bacteria paʻakikī e pono ai kēia lapaʻau kūikawā e kōkua iā ʻoe e ola.

He aha ka Plazomicin?

He ʻano hou ka Plazomicin o ka lāʻau antibiotic aminoglycoside i hoʻolālā ʻia e hakakā i nā bacteria i kūpaʻa i nā lāʻau lapaʻau ʻē aʻe. Hana ia ma ka hoʻōki ʻana i nā bacteria ʻino mai ka hana ʻana i nā protein e pono ai lākou e ola a hoʻonui i kou kino. Hāʻawi mau ʻia kēia lāʻau lapaʻau ma ke ʻano he intravenous infusion, ʻo ia hoʻi, hele pololei ia i loko o kou kahe koko ma o ka vein.

Ua hoʻomohala kūikawā ʻia ka lāʻau lapaʻau e hakakā i kekahi o nā maʻi bacteria paʻakikī loa ʻaʻole e pane i nā lāʻau antibiotic maʻamau. E noʻonoʻo iā ia he mea hana kūikawā e hoʻohana ai nā kauka ke pono lākou i kahi mea ikaika a kuhikuhi ʻia ma mua o nā lāʻau antibiotic maʻamau.

No ke aha e hoʻohana ʻia ai ka Plazomicin?

Hoʻomaʻamaʻa ʻo Plazomicin i nā maʻi maʻi urinary tract paʻakikī a me nā maʻi kahe koko i hana ʻia e kekahi mau bacteria kūpaʻa. E kauoha kāu kauka i kēia lāʻau lapaʻau ke hōʻike nā hoʻokolohua lab i ke kūpaʻa ʻana o nā bacteria e hoʻoulu ana i kāu maʻi i nā lāʻau antibiotic ʻē aʻe. Hiki ke koʻikoʻi kēia mau maʻi a hiki ke hoʻoweliweli i ke ola me ka ʻole o ka lāʻau lapaʻau kūpono.

ʻO nā kūlana maʻamau e hoʻohana ai nā kauka i ka plazomicin, ʻo ia nā maʻi kīkī paʻakikī, nā maʻi ʻōpū koʻikoʻi i laha, a me nā maʻi kahe koko i hana ʻia e nā bacteria kikoʻī e like me carbapenem-resistant Enterobacteriaceae. He mau bacteria paʻakikī loa kēia i hoʻomohala i nā ala e ola ai i ka hapa nui o nā lāʻau antibiotic maʻamau.

Pehea e hana ai ka Plazomicin?

He lāʻau lapaʻau ikaika ʻo Plazomicin e hana ana ma ka hoʻouka ʻana i nā bacteria ma ko lākou kumu. Hoʻopili ia i nā ʻāpana kikoʻī o nā pūnaewele bacteria i kapa ʻia ʻo ribosomes, he mea like me nā hale hana liʻiliʻi e hana ana i nā protein. Ke ālai ʻo plazomicin i kēia mau hale hana protein, ʻaʻole hiki i nā bacteria ke hana i nā protein pono e pono ai lākou e ola a hana hou.

ʻO ka mea e hana ai ʻo plazomicin i mea kūikawā, ʻo ia ka hiki ke lanakila i nā ʻano hana pale e hoʻohana ai nā bacteria e pale aku i nā lāʻau lapaʻau ʻē aʻe. Ua hoʻomohala nā bacteria he nui i nā enzymes hiki ke wāwahi i nā lāʻau lapaʻau aminoglycoside kahiko, akā ua hoʻolālā ʻia ʻo plazomicin e pale aku i kēia mau pale bacteria. Hāʻawi kēia iā ia i kahi pono i ka hakakā ʻana i nā maʻi i hiki ʻole i nā lāʻau lapaʻau ʻē aʻe ke mālama.

Pehea wau e lawe ai iā Plazomicin?

Hāʻawi mau ʻia ʻo Plazomicin ma ke ʻano he intravenous infusion i loko o kahi haukapila a i ʻole kahi hoʻonohonoho lapaʻau e nā poʻe loea mālama ola i hoʻomaʻamaʻa ʻia. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha. Hoʻohui ʻia ka lāʻau lapaʻau me kahi hopena sterile a hāʻawi mālie ʻia ma o kahi laina IV ma luna o 30 mau minuke a 2 mau hola, ma muli o kou kūlana.

E nānā pono kāu hui mālama ola iā ʻoe i ka wā o kēlā me kēia infusion e nānā i nā hopena a i ʻole nā hopena ʻaoʻao. ʻO ka papa hana dosing e pili ana i ka loaʻa ʻana o ka lāʻau lapaʻau i hoʻokahi manawa i ka lā, ʻoiai e hoʻoholo kāu kauka i ka manawa kūpono e pili ana i kāu hana kīkī a me ke koʻikoʻi o kāu maʻi. ʻAʻole pono ʻoe e hopohopo e pili ana i ka lawe ʻana me ka meaʻai no ka mea e hele pololei ana i loko o kou kahe koko.

Pehea ka lōʻihi e lawe ai au iā Plazomicin?

ʻO ka lōʻihi o ka mālama ʻana me ka plazomicin maʻamau mai 4 a 14 mau lā, ma muli o ke ʻano a me ke koʻikoʻi o kāu maʻi. E hoʻoholo kāu kauka i ka lōʻihi kūpono e pili ana i ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau a me nā hopena laboratory e hōʻike ana e hoʻomaʻemaʻe ana ka maʻi. Pono paha kekahi poʻe i nā papa pōkole, aʻo nā poʻe ʻē aʻe me nā maʻi paʻakikī e koi i ka mālama lōʻihi.

He mea nui e hoʻopau i ka papa lapaʻau holoʻokoʻa, ʻoiai inā e hoʻomaka ana ʻoe e maikaʻi ma mua o ka pau ʻana. ʻO ka hoʻōki ʻana i nā lāʻau antibiotic ma mua o ka manawa hiki ke ʻae i ka bacteria e ola a e kūʻē paha, e paʻakikī ai ka mālama ʻana i nā maʻi i ka wā e hiki mai ana. E nānā kāu hui lapaʻau i kou holomua ma o nā hoʻokolohua koko a me nā loiloi lapaʻau e hōʻoia i ka hana pono ʻana o ka lapaʻau.

He aha nā hopena ʻaoʻao o Plazomicin?

E like me nā lāʻau ikaika a pau, hiki i ka plazomicin ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e makaʻala ai i kāu hui mālama ola e pili ana i nā hopohopo.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka nausea, ka maʻi maʻi, a me ka ʻeha māmā a i ʻole ka huhū ma ke kahua IV kahi e hāʻawi ʻia ai ka lāʻau. Hiki ke mālama ʻia kēia mau hopena a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lapaʻau.

Hiki i nā hopena ʻaoʻao koʻikoʻi ke hoʻopilikia i kou mau puʻupaʻa a me ka lohe ʻana, ʻo ia ke kumu e nānā pono ai kāu hui lapaʻau iā ʻoe me nā hoʻokolohua koko maʻamau a me nā loiloi lohe. Eia nā hopena ʻaoʻao nui e makaʻala ai:

• Nā pilikia o ka puʻupaʻa, hiki ke hōʻike ʻia ma ke ʻano he loli i ka mimi a i ʻole ka pehu
• Nā loli lohe, me ke kani ʻana i nā pepeiao a i ʻole ka pilikia o ka lohe
• ʻO ka noʻonoʻo ʻole a i ʻole nā pilikia kaulike
• ʻO ka maʻi maʻi koʻikoʻi e hōʻike ana i kahi maʻi lua
• Nā hopena maʻi, ʻoiai he kakaikahi kēia

E hana kāu hui mālama ola i nā hoʻokolohua koko maʻamau e nānā i ka hana o kou puʻupaʻa a hiki ke hana i nā hoʻokolohua lohe e hopu i nā pilikia i ka wā mua. Inā ʻike ʻoe i nā hōʻailona e pili ana, he mea nui e haʻi koke i kāu kahu hānai a i ʻole kauka i hiki iā lākou ke hoʻoponopono i kāu lapaʻau inā pono.

ʻO wai ka mea pono ʻole e lawe i ka Plazomicin?

ʻAʻole kūpono ʻo Plazomicin no nā mea a pau, a e loiloi pono kāu kauka inā ʻo ia ke koho kūpono no kāu kūlana kikoʻī. ʻAʻole pono e loaʻa i nā poʻe me nā maʻi maʻi i nā lāʻau antibiotic aminoglycoside i ka plazomicin, no ka mea, hiki i kēia ke hoʻoulu i nā hopena maʻi maʻi koʻikoʻi.

E mālama pū kāu kauka i ka mālama nui inā loaʻa iā ʻoe kekahi mau maʻi olakino. ʻO ka poʻe me nā pilikia o ka puʻupaʻa, ka lohe ʻana, a i ʻole nā maʻi kaulike e pono paha i nā koho lapaʻau like ʻole a i ʻole ka nānā pono ʻana inā pono ka plazomicin. Pono nā wahine hāpai a me nā makuahine e hānai ana i ka manaʻo kūikawā, no ka mea, hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka makuahine a me ka pēpē.

Eia kekahi, ʻaʻole kūpono paha ka poʻe e lawe ana i kekahi mau lāʻau lapaʻau ʻē aʻe no ka mālama ʻana i ka plazomicin. E nānā kāu hui mālama ola i kāu mau lāʻau lapaʻau a me ka mōʻaukala olakino e hōʻoia i ka palekana o kēia antibiotic iā ʻoe.

Nā inoa inoa inoa Plazomicin

Loaʻa ka Plazomicin ma lalo o ka inoa inoa Zemdri ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa kalepa āu e ʻike ai ma nā moʻolelo lāʻau lapaʻau o ka haukapila a me nā palapala ʻinikua. ʻO ka inoa generic, plazomicin, e pili ana i ka mea hana maoli i ka lāʻau lapaʻau.

No ka mea he lāʻau lapaʻau haukapila kūikawā kēia, ʻaʻole ʻoe e ʻike iā ia ma nā hale kūʻai lāʻau maʻamau. Loaʻa wale ia ma o nā haukapila a me nā keʻena mālama ola kūikawā e mālama ana i nā maʻi koʻikoʻi e koi ana i nā antibiotics intravenous.

Nā koho ʻē aʻe o Plazomicin

Ke ʻaʻole kūpono ka plazomicin a i ʻole ʻaʻole loaʻa, he nui nā lāʻau lapaʻau ʻē aʻe i nā kauka no nā maʻi bacteria kūpaʻa. Aia ke koho ʻē aʻe i ke ʻano o ka bacteria e hoʻoulu ai i kāu maʻi a me nā antibiotics e ʻike ai kēlā mau bacteria.

Hiki i nā lāʻau antibiotic aminoglycoside ʻē aʻe e like me amikacin a i ʻole gentamicin ke lilo i mau koho inā hiki i nā bacteria ke maʻalahi i kēia mau lāʻau. No kekahi mau maʻi, hiki i nā lāʻau hui pū me ka hoʻohana ʻana i nā antibiotic he nui ke kūpono. ʻO nā antibiotic hou e like me meropenem-vaborbactam a i ʻole ceftazidime-avibactam he mau koho ʻē aʻe nō hoʻi no kekahi mau maʻi bacteria kūʻē.

E koho kāu kauka i ke koho maikaʻi loa e pili ana i nā hopena moʻomeheu e hōʻike ana i nā antibiotic e hana kūʻē i kāu maʻi kikoʻī. ʻO kēia ala pilikino e hōʻoiaʻiʻo ana e loaʻa iā ʻoe ka lāʻau lapaʻau maikaʻi loa me ka hōʻemi ʻana i nā hopena ʻaoʻao pono ʻole.

Ua ʻoi aku ka maikaʻi o Plazomicin ma mua o Amikacin?

ʻO Plazomicin a me amikacin he mau antibiotic aminoglycoside, akā he mau mea maikaʻi ko lākou i nā kūlana like ʻole. ʻOi aku ka hou o Plazomicin a ua hoʻolālā ʻia e lanakila i nā mīkini kūʻē e hoʻemi ai i ka maikaʻi o amikacin i kekahi mau bacteria. ʻO kēia ka mea e waiwai nui ai ka plazomicin no ka mālama ʻana i nā maʻi i hana ʻia e nā bacteria i kūʻē i ka amikacin a me nā aminoglycosides kahiko ʻē aʻe.

Eia naʻe,

Pono e noʻonoʻo pono ʻia ka Plazomicin inā he pilikia kou mau puʻupaʻa, no ka mea, hiki i nā lāʻau antibiotic aminoglycoside ke hoʻopilikia i ka hana o nā puʻupaʻa. E loiloi kāu kauka i ke olakino o kou mau puʻupaʻa ma o nā hoʻokolohua koko ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a hiki ke hoʻoponopono i ka nui a i ʻole ke alapine o ka lawelawe ʻana ma muli o ka maikaʻi o ka hana ʻana o kou mau puʻupaʻa.

Inā he pilikia liʻiliʻi kou mau puʻupaʻa, hiki nō paha iā ʻoe ke loaʻa ka plazomicin me ka nānā pono ʻana a me nā lāʻau haʻahaʻa paha. Eia naʻe, inā he maʻi puʻupaʻa koʻikoʻi kou, hiki i kāu kauka ke koho i kahi antibiotic ʻē aʻe i ʻoi aku ka palekana no kou mau puʻupaʻa. Aia ka hoʻoholo i ka loiloi ʻana i nā pōmaikaʻi o ka mālama ʻana i kāu maʻi koʻikoʻi e kūʻē i nā pilikia e hiki ke hana i ka hana o kou mau puʻupaʻa.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao mai Plazomicin?

No ka mea, hāʻawi ʻia ka plazomicin i loko o kahi haukapila, e loaʻa koke iā ʻoe ke komo i ka mālama olakino inā loaʻa nā hopena ʻaoʻao. E haʻi koke i kāu kahu hānai a i ʻole ke kauka inā loaʻa iā ʻoe kekahi mau hōʻailona e like me ka loli ʻana o ka lohe, ka ʻūlū, ka ʻeha maʻamau, a i ʻole ka pilikia o ka hanu ʻana. Mai kali e ʻike inā e hoʻomaikaʻi nā hōʻailona iā lākou iho.

Ua aʻo ʻia kāu hui lapaʻau e ʻike a mālama i nā hopena ʻaoʻao mai kēia lāʻau lapaʻau. Hiki iā lākou ke hoʻoponopono i kāu lāʻau, hoʻololi i ka helu infusion, a i ʻole e hāʻawi i nā lāʻau lapaʻau hou e kōkua i ka mālama ʻana i nā hopena ʻaoʻao āu e ʻike ai. I kekahi mau hihia, pono paha lākou e hoʻololi i kahi antibiotic ʻē aʻe inā he koʻikoʻi nā hopena ʻaoʻao.

He aha ka mea e hana ai inā e haʻalele wau i kahi lāʻau o Plazomicin?

No ka mea, hāʻawi ʻia ka plazomicin i loko o kahi haukapila e nā poʻe loea mālama ola, he mea maʻamau ka haʻalele ʻana i nā lāʻau. E hahai ana kāu hui lapaʻau i kahi papa hana koʻikoʻi e hōʻoiaʻiʻo e loaʻa iā ʻoe kēlā me kēia lāʻau i ka manawa kūpono. Inā hoʻopaneʻe ʻia kahi lāʻau ma muli o nā kaʻina hana lapaʻau a i ʻole nā hana haukapila ʻē aʻe, e hoʻoponopono kāu hui mālama ola i ka papa hana.

Inā he hopohopo kāu e pili ana i ka manawa o kāu mau lāʻau, e ʻoluʻolu e nīnau i kāu kahu hānai a i ʻole kauka e pili ana i kāu papa lāʻau. Hiki iā lākou ke wehewehe i ka manawa e loaʻa ai iā ʻoe kēlā me kēia lāʻau a kōkua i ka hoʻoponopono ʻana i nā hopohopo āu e pili ana i kāu manawa lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Plazomicin?

ʻAʻole pono ʻoe e hooki i ka lapaʻau plazomicin ma kāu iho, ʻoiai inā ʻoe e manaʻo maikaʻi loa. E hoʻoholo kāu kauka i ka manawa e hooki ai i ka lāʻau lapaʻau ma muli o nā mea he nui, me ke ʻano o kou pane ʻana i ka lapaʻau, nā hopena o ka hoʻāʻo koko, a inā ua hoʻomaʻemaʻe loa ʻia ka maʻi.

ʻO ka hooki ʻana i ka lapaʻau antibiotic ma mua o ka manawa hiki ke ʻae i ka bacteria e ola a hiki ke hoʻomohala i ke kūʻē ʻana, e paʻakikī ai nā maʻi i ka wā e hiki mai ana. E nānā kāu hui lapaʻau i kāu holomua a e hōʻike iā ʻoe i ka wā e palekana ai ke hoʻopau i ka papa lapaʻau. Hoʻokumu ʻia kēia hoʻoholo ma nā hōʻike lapaʻau ua hoʻoponopono piha ʻia ka maʻi.

Hiki iā Plazomicin ke launa pū me nā lāʻau ʻē aʻe?

ʻAe, hiki i ka plazomicin ke launa pū me kekahi mau lāʻau ʻē aʻe, ʻo ia ke kumu e nānā ai kāu kauka i kāu mau lāʻau i kēia manawa ma mua o ka hoʻomaka ʻana i ka lapaʻau. Hiki i kekahi mau lāʻau ke hoʻonui i ka pilikia o nā pilikia o ka puʻupaʻa a i ʻole ka lohe ʻana i ka wā e hui pū ʻia me ka plazomicin, aʻo nā mea ʻē aʻe e pili ana i ka maikaʻi o ka hana ʻana o ka antibiotic.

ʻO nā lāʻau maʻamau e launa pū ana me kekahi mau diuretics, nā antibiotics ʻē aʻe, a me kekahi mau lāʻau ʻeha. E mālama pono kāu hui mālama ola i nā lāʻau lapaʻau e pono ai ʻoe e lawe nei a hiki ke hoʻololi i nā lāʻau a i ʻole ka manawa e hōʻemi ai i nā pilina. E hōʻike mau i kāu hui lapaʻau e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā lāʻau lapaʻau herbal āu e lawe nei, ʻoiai inā ʻaʻole pili lākou i kāu maʻi.