He aha ʻo Plerixafor: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau kūikawā ʻo Plerixafor e kōkua i kou kino e hoʻokuʻu i nā cell stem mai kou iwi i loko o kou kahe koko. He hana nui kēia lāʻau lapaʻau i ka hoʻomākaukau ʻana i nā maʻi no nā transplants cell stem, ʻoiai inā ʻaʻole i hana maikaʻi nā ʻano hana ʻē aʻe. E noʻonoʻo iā ia he mea kōkua e paipai ana i kou iwi e kaʻana like i kāna mau cell stem waiwai me ka manuahi.

He aha ʻo Plerixafor?

ʻO Plerixafor kahi mea hoʻoneʻe cell stem e hana ana ma ka ālai ʻana i kekahi mau mea loaʻa i loko o kou iwi. He mea maopopo, ʻaʻohe kala e hoʻokomo ʻia ma lalo o kou ʻili, e like me ka mea e hoʻokomo ai nā maʻi diabetes i ka insulin. Ua hoʻolālā kūikawā ʻia ka lāʻau lapaʻau e kōkua i nā maʻi e pono ai nā transplants cell stem akā paʻakikī e hana i nā cell stem lawa maoli.

No kēia lāʻau lapaʻau i kahi papa o nā lāʻau i kapa ʻia ʻo CXCR4 antagonists. Ma nā huaʻōlelo maʻalahi, ālai ia i kahi protein e hoʻopaʻa mau i nā cell stem i kou iwi. Ke ālai ʻia kēia protein, hiki i kāu mau cell stem ke neʻe manuahi i loko o kou kahe koko kahi e hiki ai ke hōʻiliʻili ʻia no nā kumu transplant.

No ke aha e hoʻohana ʻia ai ʻo Plerixafor?

Hoʻohana nui ʻia ʻo Plerixafor e kōkua i ka hōʻiliʻili ʻana i nā cell stem mai nā maʻi me nā maʻi koko e like me ka lymphoma a me ka myeloma nui. E kauoha kāu kauka i kēia lāʻau lapaʻau ke pono ʻoe i kahi transplant cell stem akā ʻaʻole e hana ana kou kino i nā cell stem lawa iā ia iho. Hoʻohana mau ʻia ia me kekahi lāʻau lapaʻau i kapa ʻia ʻo G-CSF (granulocyte colony-stimulating factor).

He mea kōkua nui ka lāʻau lapaʻau no nā maʻi i manaʻo ʻia he

I kekahi manawa hoʻohana nā kauka i ka plerixafor no nā maʻi i hāʻule i nā hoʻāʻo hōʻiliʻili keena kumu mua. Hiki nō ke hoʻohana ʻia ma ke ʻano he lapaʻau mua i nā maʻi i manaʻo ʻia e pilikia i ka hoʻoneʻe ʻana i nā keena kumu ma muli o ko lākou mōʻaukala olakino a i ʻole nā lapaʻau mua.

Pehea e hana ai ʻo Plerixafor?

Hana ʻo Plerixafor ma ka hoʻopau ʻana i ka pilina maʻamau ma waena o kāu mau keena kumu a me ka iwi iwi. Loaʻa i kou iwi iwi nā wahi kūikawā i kapa ʻia he niches kahi e makemake ai nā keena kumu e noho pili. Kāohi ka lāʻau i nā hōʻailona kemika e mālama ana i nā keena kumu i kēia mau wahi ʻoluʻolu.

Ke ālai ʻia kēia mau hōʻailona, hoʻomaka kāu mau keena kumu e haʻalele i ka iwi iwi a komo i loko o kou kahe koko. Hana maʻamau kēia kaʻina hana i loko o 6 a 9 mau hola ma hope o ka injection. Manaʻo ʻia ka lāʻau he ikaika a he mea i manaʻo nui ʻia i kāna hana.

Hoʻopaʻa pono ka lāʻau i nā mea hoʻokipa CXCR4, e like me nā kikowaena docking no nā keena kumu. Ma ka noho ʻana i kēia mau kikowaena docking, hoʻoikaika ʻo plerixafor i nā keena kumu e lana manuahi i loko o kou koko kahi e hiki ai ke hōʻiliʻili ʻia ma o ke kaʻina hana i kapa ʻia ʻo apheresis.

Pehea wau e lawe ai iā Plerixafor?

Hāʻawi ʻia ʻo Plerixafor ma ke ʻano he subcutaneous injection, ʻo ia hoʻi, hele ia ma lalo o kou ʻili ma mua o ke komo ʻana i loko o ke aʻa. E hoʻokomo kāu mea mālama ola iā ia i loko o kou ʻōpū, ʻūhā, a i ʻole ka lima luna. Hāʻawi ʻia ka injection ma kahi o 11 mau hola ma mua o kāu manawa hōʻiliʻili keena kumu.

ʻAʻole pono ʻoe e lawe i kēia lāʻau me ka meaʻai a i ʻole ka wai no ka mea ua hoʻokomo ʻia ma mua o ka ʻai ʻana. Eia naʻe, pono ʻoe e noho hydrated ma mua a ma hope o ka loaʻa ʻana o ka injection. E hāʻawi kāu hui lapaʻau i nā ʻōlelo kikoʻī e pili ana i ka ʻai ʻana a me ka inu ʻana ma mua o kāu kaʻina hana hōʻiliʻili keena kumu.

Pono e maʻemaʻe a maloʻo kahi e hoʻokomo ai ma mua o ka lawelawe ʻana. E hoʻololi kāu mea mālama ola i nā wahi e hoʻokomo ai inā pono ʻoe i nā lāʻau he nui. E loaʻa iā ʻoe kēia lāʻau lapaʻau ma kahi hoʻonohonoho lapaʻau kahi e hiki ai i nā poʻe loea lapaʻau ke nānā iā ʻoe no nā hopena koke.

Pehea ka lōʻihi e lawe ai au i ka Plerixafor?

Hoʻohana maʻamau ʻia ka Plerixafor no kahi manawa pōkole loa, maʻamau mai 1 a 4 mau lā. Aia ka lōʻihi pololei i ka maikaʻi o ka pane ʻana o kou kino i ka lāʻau lapaʻau a me ka nui o nā cell stem e pono ai ke hōʻiliʻili ʻia. Loaʻa i ka hapa nui o nā maʻi hoʻokahi injection i kēlā me kēia lā i ka wā o kā lākou manawa hoʻoneʻe cell stem.

E nānā kāu kauka i kāu helu koko i kēlā me kēia lā e ʻike i ka nui o nā cell stem e holo ana i loko o kou kahe koko. Inā lawa nā cell stem i hōʻiliʻili ʻia ma hope o hoʻokahi a ʻelua paha lā, ʻaʻole pono ʻoe i nā lāʻau hou. Pono paha kekahi poʻe maʻi i ʻehā mau lā o ka mālama ʻana.

Hoʻopilikino ʻia ka papa hana lapaʻau e pili ana i kou kūlana olakino kikoʻī a me ke ʻano o ka pane ʻana o kou kino. E hoʻoholo kāu hui mālama ola i ka manawa e hoʻōki ai i ka lāʻau lapaʻau ma muli o ka hōʻiliʻili ʻana o nā cell stem kūleʻa ma mua o kahi manawa i hoʻonohonoho mua ʻia.

He aha nā hopena ʻaoʻao o Plerixafor?

E like me nā lāʻau lapaʻau a pau, hiki i ka plerixafor ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a he manawa pōkole, e hana ana i ka wā o ka manawa lapaʻau pōkole.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e hiki iā ʻoe ke ʻike:

• Ka maʻi maʻi, hiki ke hele mai ka maʻalahi a i ka waena
• Nausea a i kekahi manawa ka luaʻi
• Nā hopena ma ka pūnaewele injection e like me ka ʻulaʻula, ka pehu, a i ʻole ka ʻeha maʻalahi
• ʻO ka luhi a i ʻole ka piʻi ʻana o ka luhi ma mua o ka maʻamau
• Poʻo
• ʻO ka wili
• Hihia i ka hiamoe

Hoʻoponopono maʻamau kēia mau hopena ʻaoʻao maʻamau i loko o hoʻokahi a ʻelua paha lā ma hope o ka pau ʻana o ka mālama ʻana. E nānā pono kāu hui mālama ola iā ʻoe a hiki ke hāʻawi i ka mālama kākoʻo e kōkua i ka mālama ʻana i kekahi ʻoluʻolu.

ʻAʻole maʻamau akā ʻoi aku ka koʻikoʻi o nā hopena ʻaoʻao, ʻoiai he kakaikahi lākou. Penei:

• Nā hopena maʻi maʻi koʻikoʻi me ka pilikia o ka hanu ʻana a i ʻole ka pehu ʻana
• Hāʻule nui i ke koko
• Nā loli o ka puʻuwai
• ʻEha nui o ka ʻōpū
• Nā hōʻailona o ka maʻi a i ʻole ka ʻeha ʻana

Inā loaʻa iā ʻoe kekahi mau hōʻailona koʻikoʻi a i ʻole nā hōʻailona e hopohopo ai, e pane koke kāu hui lapaʻau iā lākou. ʻO ke kahua lapaʻau kahi e loaʻa ai iā ʻoe ka plerixafor e hōʻoiaʻiʻo ana i ka wikiwiki i ka mālama ulia pōpilikia inā pono.

ʻO wai ka mea pono ʻole e lawe i ka Plerixafor?

ʻAʻole kūpono ka Plerixafor no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia no ʻoe. ʻAʻole kūpono paha nā kānaka me kekahi mau maʻi olakino a i ʻole ka poʻe e lawe ana i nā lāʻau lapaʻau kūikawā no kēia lapaʻau.

ʻAʻole pono ʻoe e loaʻa i ka plerixafor inā he maʻi ʻoe i ka lāʻau lapaʻau a i ʻole kekahi o kāna mau mea. E makaʻala nō hoʻi kāu kauka inā loaʻa iā ʻoe kekahi mau maʻi puʻuwai, nā pilikia o ka puʻupaʻa, a i ʻole ka mōʻaukala o nā koko koko.

ʻAʻole pono nā wahine hāpai a i ʻole nā wahine e hānai ana i ka waiū e hoʻohana i ka plerixafor ke ʻole ka maikaʻi o nā pōmaikaʻi ma mua o nā pilikia. Hiki i ka lāʻau lapaʻau ke hōʻino i kahi pēpē i hānau ʻole ʻia, no laila he mea nui ka pale ʻana i ka hāpai ʻana i ka wā o ka mālama ʻana. Inā ʻoe e hoʻolālā nei e hāpai, e kūkākūkā i kēia me kāu hui mālama ola ma mua o ka hoʻomaka ʻana i ka mālama ʻana.

Pono paha nā kānaka me ka maʻi puʻupaʻa koʻikoʻi i nā hoʻoponopono ʻana i ka maʻi a i ʻole ʻaʻole kūpono paha no ka plerixafor. E nānā kāu kauka i kāu hana puʻupaʻa ma mua o ke kau ʻana i kēia lāʻau.

Nā inoa inoa Plerixafor

Loaʻa ka Plerixafor ma lalo o ka inoa inoa Mozobil ma ka hapa nui o nā ʻāina. ʻO kēia ke ʻano i kauoha pinepine ʻia o ka lāʻau lapaʻau a ʻo ka mea e mālama ai kāu hale kūʻai lāʻau lapaʻau.

Ma kekahi mau ʻāina, e ʻike paha ʻoe i ka inoa maʻamau, plerixafor injection. Hana ʻia ka lāʻau lapaʻau e Sanofi a loaʻa ma ka hapa nui o nā ʻāina kahi e hana ʻia ai nā transplants stem cell.

Hiki i kāu ʻinikua a me ka hale kūʻai lāʻau lapaʻau ke hoʻopilikia i ka brand a i ʻole ka formulation āu e loaʻa ai, akā like ka mea hana a me ka pono me ka nānā ʻole i ka inoa brand.

Nā Koho ʻē aʻe o Plerixafor

ʻOiai he mea kū hoʻokahi ʻo plerixafor i kāna hana, aia nā ala ʻē aʻe i ka hoʻoneʻe ʻana i ka stem cell e noʻonoʻo ai kāu kauka. ʻO ka koho maʻamau ka hoʻohana ʻana i nā kiʻekiʻe kiʻekiʻe o G-CSF wale nō, ʻoiai ʻaʻole maikaʻi kēia no nā mea a pau.

Hiki i kekahi poʻe maʻi ke pōmaikaʻi mai kahi hui pū ʻana me ka hoʻohana ʻana i ka G-CSF me nā lāʻau lapaʻau ʻē aʻe e like me nā lāʻau chemotherapy e hoʻoneʻe i nā stem cell. Eia naʻe, he ʻokoʻa pinepine kēia mau koho i nā hopena ʻaoʻao a ʻaʻole paha e like ka maikaʻi no nā mea hoʻoneʻe maikaʻi ʻole.

I nā hihia i loaʻa ʻole ai ʻo plerixafor a i ʻole kūpono ʻole, hiki i kāu kauka ke noʻonoʻo i ka ʻohi ʻana i ka iwi iwi ma ke ʻano he koho i ka hōʻiliʻili ʻana i ka stem cell koko peripheral. He hana ʻoi aku ka invasive kēia akā hiki nō ke hāʻawi i nā stem cell e pono ai no ka transplant.

ʻOi aku ka maikaʻi o Plerixafor ma mua o G-CSF wale nō?

ʻOi aku ka maikaʻi o ka plerixafor i hui pū ʻia me ka G-CSF ma mua o ka G-CSF wale nō no ka hoʻoneʻe ʻana i ka stem cell, ʻoi aku hoʻi i nā maʻi maʻi maikaʻi ʻole. Hōʻike nā haʻawina e hoʻonui ka hui pū ʻana i ka helu kūleʻa o ka hōʻiliʻili ʻana i nā stem cell lawa no ka transplant.

Eia naʻe, ʻaʻole pono ka plerixafor i ka maikaʻi no nā mea a pau. ʻAʻole pono paha nā maʻi e pane maikaʻi i ka G-CSF wale nō i ka lāʻau lapaʻau hou. E noʻonoʻo kāu kauka i kāu mau mea pilikia a me ka mōʻaukala olakino i ka wā e hoʻoholo ai i ke ala maikaʻi loa.

Hele mai ka hui pū ʻana o ka plerixafor a me ka G-CSF me nā kumukūʻai hou a me nā hopena ʻaoʻao e pili ana i ka G-CSF wale nō. E loiloi kāu hui mālama ola i kēia mau mea i nā pōmaikaʻi i ka wā e hana ai i nā ʻōlelo aʻoaʻo lapaʻau.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Plerixafor

He palekana anei ʻo Plerixafor no nā maʻi me ka maʻi puʻuwai?

Pono ka plerixafor i ka noʻonoʻo pono i nā maʻi me ka maʻi puʻuwai. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai a me ke koko, no laila e hana pū kāu cardiologist a me ka oncologist e loiloi i kou pilikia pilikino. Inā he moʻolelo kou o nā pilikia puʻuwai, pono paha ʻoe i ka nānā ʻana i ka wā o ka mālama ʻana.

Hiki i ka hapa nui o nā maʻi me nā maʻi puʻuwai paʻa ke loaʻa palekana i ka plerixafor ma lalo o ka mālama olakino kokoke. Eia naʻe, ʻo ka poʻe me ka maʻi puʻuwai nui a i ʻole nā ​​puʻuwai puʻuwai hou e pono paha i nā ala ʻē aʻe i ka hōʻiliʻili ʻana i nā cell stem.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao koʻikoʻi?

Inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻeha o ka umauma, a i ʻole nā ​​hopena maʻi maʻi koʻikoʻi, e ʻimi koke i ka lāʻau lapaʻau pilikia. Ma muli o ka hāʻawi ʻia ʻana o ka plerixafor i kahi hoʻonohonoho lapaʻau, e loaʻa nā poʻe loea lapaʻau e kōkua i ka mālama ʻana i nā hopena koʻikoʻi.

No nā hōʻailona ʻaʻole koʻikoʻi akā e pili ana e like me ka luaʻi mau ʻana a i ʻole ka maʻi maʻi nui, e hoʻokaʻaʻike koke i kāu hui mālama ola. Hiki iā lākou ke hāʻawi i ka mālama kākoʻo a hoʻoholo inā pono e hana i nā hoʻololi i kāu hoʻolālā lapaʻau.

He aha ka mea e hana ai inā ʻaʻole holomua kaʻu hōʻiliʻili ʻana i nā cell stem?

Inā ʻaʻole i loaʻa i ka hoʻāʻo mua ʻana i ka hōʻiliʻili ʻana i nā cell stem i nā cell lawa, hiki i kāu kauka ke ʻōlelo i nā mea hou aku o ka plerixafor a i ʻole nā ​​hoʻolālā hōʻiliʻili ʻē aʻe. I kekahi manawa ʻoi aku ka holomua o ka hoʻāʻo ʻana i ka hōʻiliʻili ʻana i ka lua a i ʻole ke kolu.

I nā hihia kakaʻikahi ʻaʻole e hana pono ka plerixafor, e ʻimi kāu hui lapaʻau i nā koho ʻē aʻe e like me ka ʻohi ʻana i ka iwi iwi a i ʻole ka hoʻohana ʻana i nā cell stem donor ma kahi o kāu. ʻO ka pahuhopu ka hōʻoia mau i ka loaʻa ʻana o nā cell stem olakino lawa no kāu kaʻina hana transplant.

Hiki iaʻu ke kalaiwa ma hope o ka loaʻa ʻana o Plerixafor?

Hiki iā ʻoe ke ʻike i ka noʻonoʻo ʻole a i ʻole ka luhi ma hope o ka loaʻa ʻana o ka plerixafor, no laila, ua ʻōlelo ʻia e loaʻa i kekahi e kalaiwa iā ʻoe i kāu mau manawa a me waho. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i kou makaʻala a me ka manawa pane no ka manawa.

E loiloi kāu hui mālama ola i kou manaʻo ma mua o ka hoʻomaʻemaʻe ʻana iā ʻoe e kalaiwa. Inā ʻoe e manaʻo makaʻala a ʻoluʻolu, a ʻaʻole i ʻike i nā hopena ʻaoʻao nui, hiki iā ʻoe ke kalaiwa iā ʻoe iho i ka home, akā ʻoi aku ka palekana e hoʻonohonoho i ka halihali ma mua.

Pono anei au i nā palena meaʻai kūikawā i ka wā e lawe ana i ka Plerixafor?

ʻAʻohe palena meaʻai kikoʻī i ka wā e lawe ana i ka plerixafor, akā he mea nui ka noho ʻana i ka wai maikaʻi. Hiki i ka inu ʻana i ka wai nui ke kōkua i kou kino e hana i ka lāʻau lapaʻau a hiki ke hōʻemi i kekahi mau hopena ʻaoʻao e like me ka nausea.

Inā ʻoe e ʻike i ka nausea a i ʻole ka luaʻi, hiki i ka ʻai ʻana i nā meaʻai liʻiliʻi a palupalu ke kōkua. Hiki i kāu hui mālama ola ke hāʻawi i nā ʻōlelo aʻoaʻo meaʻai kikoʻī e pili ana i kou manaʻo a me nā hopena ʻaoʻao āu e ʻike ai i ka wā o ka mālama ʻana.