He aha ka Polatuzumab Vedotin: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

ʻO ka Polatuzumab vedotin he lāʻau lapaʻau maʻi maʻi i manaʻo ʻia e hui pū ana i kahi antibody me kahi lāʻau chemotherapy e mālama ai i kekahi mau ʻano maʻi koko. Hana kēia lapaʻau hana hou e like me ka missile alakaʻi, e hāʻawi ana i ka chemotherapy pololei i nā sela maʻi maʻi me ka mālama ʻana i nā ʻiʻo olakino ma mua o ka chemotherapy kuʻuna.

Hiki paha iā ʻoe ke heluhelu nei i kēia no ka mea ua kauoha ʻia kēia lāʻau lapaʻau iā ʻoe a i ʻole kekahi āu e mālama ai. He mea maʻamau ka loaʻa ʻana o nā nīnau e pili ana i kekahi lapaʻau maʻi maʻi, a ʻo ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi hoʻi i kāu huakaʻi mālama.

He aha ka Polatuzumab Vedotin?

ʻO ka Polatuzumab vedotin he conjugate antibody-drug, ʻo ia hoʻi he ʻelua mau lāʻau lapaʻau e hana pū ana ma ke ʻano he hoʻokahi. Hana ka ʻāpana antibody e like me ka mea hana homing e ʻimi ana i nā sela maʻi maʻi kikoʻī, ʻoiai e luku ka ʻāpana chemotherapy i kēlā mau sela ke loaʻa ka antibody iā lākou.

Hōʻike kēia hana i manaʻo ʻia i kahi holomua nui i ka mālama ʻana i ka maʻi maʻi. Ma kahi o ka hoʻopilikia ʻana i nā sela e mahele wikiwiki ana e like me ka chemotherapy kuʻuna, ua kālele ʻo polatuzumab vedotin i nā sela maʻi maʻi i loaʻa i kahi protein i kapa ʻia ʻo CD79b ma ko lākou ʻili. Kōkua kēia pololei i ka hōʻemi ʻana i kekahi o nā hopena ʻaoʻao āu e ʻike ai me ka chemotherapy maʻamau.

No ka papa o nā lāʻau lapaʻau i kapa ʻia he monoclonal antibodies ka lāʻau lapaʻau. E noʻonoʻo iā ia he kī i hoʻolālā kūikawā ʻia e kūpono wale i nā laka i loaʻa ma kekahi mau sela maʻi maʻi, e hana ana i ka lapaʻau ʻoi aku ka koho a pinepine i ka ʻae ʻia.

No ke aha e hoʻohana ʻia ai ka Polatuzumab Vedotin?

Hoʻomaʻamaʻa ʻo Polatuzumab vedotin i ka lymphoma nui B-cell (DLBCL), kahi ʻano maʻi koko e pili ana i kāu ʻōnaehana pale. E ʻōlelo maʻamau kāu kauka i kēia lāʻau lapaʻau ke hana ʻole nā ​​lapaʻau ʻē aʻe e like me ka mea i manaʻo ʻia, a i ʻole ke hoʻi mai ka maʻi ma hope o ka mālama ʻana.

Ua ʻae ʻia kēia lāʻau lapaʻau no nā pākeke me ka DLBCL i hoʻi hou a i ʻole i kūpaʻa. ʻO ka manaʻo o "Hoʻi hou" ua hoʻi mai ka maʻi ma hope o ka mālama ʻana, a ʻo "kūpaʻa" hoʻi, ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau mua. E hui pū kāu kauka oncologist i ka polatuzumab vedotin me nā lāʻau lapaʻau maʻi ʻē aʻe e hana i kahi hoʻolālā lapaʻau piha.

Hoʻokaʻawale ʻia ka lapaʻau no ka poʻe i hoʻāʻo mua i hoʻokahi lāʻau lapaʻau ʻē aʻe. E loiloi pono kāu hui lapaʻau i kou kūlana kikoʻī, me kou olakino holoʻokoʻa, nā ʻano o kāu maʻi, a me kāu mōʻaukala lapaʻau e hoʻoholo ai inā kūpono kēia lāʻau lapaʻau iā ʻoe.

Pehea e Hana ai ʻo Polatuzumab Vedotin?

Hana ʻo Polatuzumab vedotin ma ka hāʻawi ʻana i ka chemotherapy pololei i nā sela maʻi ma o kahi kaʻina hana ʻelua ʻanuʻu. ʻO ka mea mua, hele ka ʻāpana antibody ma kou kahe koko a pili i nā protein CD79b i loaʻa ma ka ʻili o kekahi mau sela lymphoma.

Ke paʻa ka antibody i ka sela maʻi, hoʻokuʻu ia i ka lāʻau chemotherapy i loko o ka sela. ʻO kēia ʻōnaehana hāʻawi i manaʻo ʻia e hiki ai i ka chemotherapy ke hana ma kahi e pono ai, me ka hiki ke hoʻoulu i nā hopena ʻaoʻao liʻiliʻi i nā sela olakino ma kou kino.

Manaʻo ʻia he lāʻau lapaʻau maʻi ikaika. ʻOiai ua ʻoi aku ka pahuhopu ma mua o ka chemotherapy kuʻuna, he lāʻau lapaʻau koʻikoʻi nō ia e pono ai ka nānā pono. E nānā pono kāu hui mālama ola iā ʻoe i ka wā o ka lapaʻau e hōʻoia ai e hana pono ana a e mālama i nā hopena ʻaoʻao e hiki ke hana.

Pehea e Lawe ai au i ka Polatuzumab Vedotin?

Hāʻawi ʻia ʻo Polatuzumab vedotin ma ke ʻano he intravenous (IV) infusion ma kahi kikowaena lapaʻau maʻi a i ʻole ka haukapila. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home - pono ia i ka lawelawe ʻana e nā mea mālama ola i hoʻomaʻamaʻa ʻia e loea i ka mālama maʻi.

He 90 mau minuke ka hoʻokomo ʻana no kāu mahele mua, a maʻa mau ka lōʻihi o nā mahele ma hope ma kahi o 30 mau minuke. E loaʻa iā ʻoe ka lāʻau lapaʻau ma o kahi paipu liʻiliʻi i hoʻokomo ʻia i loko o kahi vein, maʻa mau i kou lima. E nānā pono kāu kahu hānai iā ʻoe i ka wā o ke kaʻina hana hoʻokomo.

Ma mua o kēlā me kēia lapaʻau, hiki iā ʻoe ke loaʻa nā lāʻau lapaʻau ma mua e kōkua i ka pale ʻana i nā hopena maʻi a i ʻole ka nausea. Hiki i kēia mau mea ke komo i nā antihistamines, steroids, a i ʻole nā lāʻau anti-nausea. E wehewehe kāu hui mālama ola i ka mea e manaʻo ai a kōkua iā ʻoe e ʻoluʻolu e like me ka hiki i ka wā o ke kaʻina hana.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau me ka meaʻai no ka mea e hele pololei ana i loko o kou kahe koko. Eia naʻe, hiki i ka ʻai ʻana i ka ʻai māmā ma mua o ka lapaʻau ke kōkua iā ʻoe e ʻoluʻolu a hiki ke hōʻemi i ka nausea. E noho maikaʻi i ka wai ma mua a ma hope o kāu hoʻokomo ʻana ke ʻole e ʻōlelo kāu kauka.

Pehea ka lōʻihi e lawe ai au i ka Polatuzumab Vedotin?

Loaʻa ka polatuzumab vedotin i ka hapa nui o nā kānaka no nā pōʻai a hiki i ʻeono, me kēlā me kēia pōʻai e mau ana i 21 mau lā. ʻO ia hoʻi, e loaʻa iā ʻoe ka lāʻau lapaʻau i hoʻokahi manawa i kēlā me kēia ʻekolu pule no kahi o ʻehā a ʻelima mau mahina, ʻoiai paha e ʻokoʻa kāu papa manawa kikoʻī ma muli o kāu hoʻolālā lapaʻau.

Na kāu oncologist e hoʻoholo i ka lōʻihi pololei ma muli o ka maikaʻi o ka pane ʻana o ka maʻi kanesa i ka lapaʻau a me ka maikaʻi o kou ʻae ʻana i ka lāʻau lapaʻau. Hiki i kekahi poʻe ke loaʻa nā pōʻai liʻiliʻi inā pane wikiwiki ka maʻi kanesa, aʻo nā mea ʻē aʻe e pono paha i nā hoʻoponopono i kā lākou papa manawa inā koi nā hopena ʻaoʻao i ka manawa hoʻōla hou.

I loko o kāu lapaʻau, e nānā mau kāu hui lapaʻau i kāu helu koko, e nānā i kou mau ʻōkana, a e loiloi i ka pane ʻana o ka maʻi kanesa. Kōkua kēia mau hoʻokolohua i ka hōʻoia ʻana e hana pono ana ka lāʻau lapaʻau a palekana hoʻi iā ʻoe e hoʻomau i ka lapaʻau.

He aha nā hopena ʻaoʻao o Polatuzumab Vedotin?

E like me nā ʻano lapaʻau maʻi ʻaʻai a pau, hiki i ka polatuzumab vedotin ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi ana. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e ʻike i nā hōʻailona i ka wā mua a loaʻa ke kākoʻo āu e pono ai.

Eia nā hopena ʻaoʻao maʻamau loa e hiki iā ʻoe ke ʻike i ka wā o ka lapaʻau:

• Luhi a me ka manaʻo nui o ka luhi ma mua o ka maʻamau
• Nausea a i kekahi manawa ka luaʻi
• Pāpaʻa a i ʻole nā ʻōpala palupalu
• Hoʻemi ʻia ka ʻai
• Nā helu koko haʻahaʻa, hiki ke hoʻonui i ka pilikia o ka maʻi
• Neuropathy peripheral (ka ʻūlū a i ʻole ke ʻano o ka ʻūlū ʻana i nā lima a me nā wāwae)
• Fiva a me nā anu
• ʻEha ʻiʻo a me nā hui

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao me ka mālama kūpono a me ka lāʻau lapaʻau. E hāʻawi kāu hui mālama ola iā ʻoe i nā hoʻolālā kikoʻī e kōkua i ka hōʻemi ʻana i ka hōʻoluʻolu a mālama i kou maikaʻi o ke ola i ka wā o ka lapaʻau.

ʻOiai ʻaʻole maʻamau, hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke:

• Nā maʻi koʻikoʻi ma muli o nā helu keʻokeʻo koko haʻahaʻa
• Tumor lysis syndrome, kahi e wāwahi koke ai nā sela maʻi ʻaʻai
• Nā hopena maʻi maʻi koʻikoʻi i ka wā o ka infusion
• Nā pilikia ate nui
• Progressive multifocal leukoencephalopathy (PML), kahi maʻi lolo kakaʻikahi akā koʻikoʻi

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau pilikia kakaʻikahi akā koʻikoʻi. E aʻo lākou iā ʻoe i nā hōʻailona ʻōlelo aʻo e nānā ai a hāʻawi i nā ʻōlelo kuhikuhi maopopo i ka wā e hoʻopili koke ai iā lākou.

ʻO wai ka mea pono ʻole e lawe i ka Polatuzumab Vedotin?

ʻAʻole kūpono ka Polatuzumab vedotin no nā mea a pau, a e loiloi pono kāu oncologist inā palekana ia iā ʻoe. Pono paha ka poʻe me kekahi mau maʻi olakino a i ʻole nā kūlana i nā lapaʻau ʻē aʻe.

ʻAʻole pono ʻoe e loaʻa i kēia lāʻau lapaʻau inā he maʻi koʻikoʻi ʻoe i ka polatuzumab vedotin a i ʻole kekahi o kāna mau mea. E akahele nō hoʻi kāu kauka inā he maʻi koʻikoʻi ʻoe, no ka mea, hiki i ka lāʻau lapaʻau ke kāohi hou i kāu ʻōnaehana pale.

Pono paha ka poʻe me nā pilikia ate koʻikoʻi i nā hoʻoponopono ʻana i ka lāʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe, no ka mea, ua hana ʻia ka lāʻau lapaʻau ma o ke ake. E nānā kāu hui mālama ola i kāu hana ate ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a nānā iā ia i ka wā o kāu mālama ʻana.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, hiki i kēia lāʻau lapaʻau ke hōʻeha i kāu pēpē. E kūkākūkā kāu kauka i nā ʻano hana pale palekana inā he makahiki hānau keiki ʻoe, a pono ʻoe e hoʻohana i ka mana hānau kūpono i ka wā o ka lāʻau lapaʻau a no kekahi mau mahina ma hope.

Nā inoa inoa Polatuzumab Vedotin

Kūʻai ʻia ʻo Polatuzumab vedotin ma lalo o ka inoa inoa Polivy. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau lapaʻau, no ka mea, he lāʻau lapaʻau kūikawā i hana ʻia e hoʻokahi hui lāʻau lapaʻau.

Hiki iā ʻoe ke ʻike i ka inoa piha i kākau ʻia ʻo

He hui pū ʻia nā lāʻau lapaʻau maʻamau e like me R-ICE a i ʻole R-DHAP he mau koho nui, ʻoi loa no ka poʻe i kūpono no ka hoʻololi ʻana i nā cell stem. Hoʻohana kēia mau lapaʻau i nā hui lāʻau like ʻole i kūpono paha no kou kūlana.

Hiki nō hoʻi i nā hoʻokolohua lapaʻau ke hāʻawi i ke komo ʻana i nā lapaʻau hoʻokolohua hou. Hiki i kāu hui mālama ola ke kōkua iā ʻoe e hoʻomaopopo inā he kūpono kekahi mau haʻawina e holo nei no kou kūlana.

Ua ʻoi aku ka maikaʻi o Polatuzumab Vedotin ma mua o Rituximab?

Hana ʻokoʻa ʻo Polatuzumab vedotin a me rituximab a hoʻohana pinepine ʻia pū kekahi me kekahi ma mua o nā koho ʻē aʻe. He antibody monoclonal ʻo Rituximab e kuhikuhi ana i nā protein CD20 ma nā lymphomas B-cell, ʻoiai ʻo polatuzumab vedotin e kuhikuhi ana i nā protein CD79b.

Ma mua o ka maikaʻi a i ʻole ka ʻino, hoʻopili kēia mau lāʻau i kekahi i kekahi. Nui nā protocols lapaʻau e hui pū ana i ka polatuzumab vedotin me ka rituximab a me ka chemotherapy e hoʻouka i ka maʻi kanesa mai nā kihi he nui. Hāʻawi pinepine kēia hui pū ʻana i nā hopena maikaʻi aʻe ma mua o ka hoʻohana ʻana i kekahi lāʻau.

E hoʻolālā kāu oncologist i kahi hoʻolālā lapaʻau e komo pū ana i nā lāʻau ʻelua, ma muli o kāu ʻano lymphoma a me kou olakino holoʻokoʻa. ʻO ka pahuhopu ka hana ʻana i ka hui lapaʻau maikaʻi loa i ka wā e mālama pono ai i nā hopena ʻaoʻao.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Polatuzumab Vedotin

He palekana anei ʻo Polatuzumab Vedotin no ka poʻe me nā pilikia o ka puʻuwai?

Hiki i ka poʻe me nā maʻi puʻuwai ke loaʻa pinepine i ka polatuzumab vedotin, akā pono kāu cardiologist a me ka oncologist e hana pū e nānā pono iā ʻoe. ʻAʻole maʻamau ka lāʻau lapaʻau i nā pilikia puʻuwai pololei, akā hiki i nā lapaʻau maʻi kanesa ke hoʻopilikia i ka hana o ka puʻuwai.

E hana paha kāu hui lapaʻau i nā hoʻokolohua hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a hiki ke nānā i kou puʻuwai i ka wā o ka lāʻau lapaʻau. Inā he maʻi puʻuwai koʻikoʻi kou, hiki iā lākou ke hoʻoponopono i kāu papa hana lapaʻau a i ʻole e hāʻawi i ke kākoʻo hou e pale ai i ke olakino o kou puʻuwai.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Polatuzumab Vedotin?

Mai ka wā i hāʻawi ʻia ai ka polatuzumab vedotin e nā poʻe loea mālama ola i kahi hoʻonohonoho lapaʻau i mālama ʻia, he mea maʻamau loa nā overdoses ulia pōpilikia. Hoʻohālikelike ʻia ka lāʻau lapaʻau e pili ana i kou kaumaha kino a hāʻawi ʻia e nā kahu hānai i aʻo ʻia e nānā pālua i ka hoʻohana ʻana.

Inā hopohopo ʻoe e pili ana i kāu mahele a i ʻole e ʻike i nā hōʻailona maʻamau ma hope o ka lāʻau lapaʻau, e hoʻokaʻaʻike koke i kāu hui mālama ola. Hiki iā lākou ke loiloi i kou kūlana a hāʻawi i ka mālama kūpono inā pono. E loaʻa i ke kikowaena lapaʻau nā protocols e mālama ai i nā hopohopo e pili ana i ka hoʻohana ʻana.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Polatuzumab Vedotin?

Inā hala ʻoe i kahi manawa i hoʻonohonoho ʻia no ka polatuzumab vedotin, e hoʻokaʻaʻike i kāu kikowaena lapaʻau maʻi maʻi i ka hiki wawe e hoʻonohonoho hou. E hana pū lākou me ʻoe e hoʻi i ke ala me kāu hoʻolālā lapaʻau me ka ʻole e hoʻopilikia i kona pono.

Pono paha kāu hui mālama ola e hoʻoponopono iki i kāu papa hana, akā ʻaʻole pono ka hala ʻana i hoʻokahi mahele e hoʻomaka hou. E loiloi lākou i ka hopena o ka lohi i kāu lāʻau lapaʻau a hana i nā hoʻololi e pono ai e hōʻoia e loaʻa iā ʻoe ka pōmaikaʻi piha o kāu lāʻau lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Polatuzumab Vedotin?

E hoʻopau maʻamau ʻoe i kāu papa hana i hoʻolālā ʻia o ka polatuzumab vedotin ma hope o nā pōʻai ʻeono, akā e hana kāu oncologist i ka hoʻoholo hope loa e pili ana i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau a me ka maikaʻi o kou ʻae ʻana. Hiki i kekahi poʻe ke hooki i mua inā loaʻa iā lākou kahi pane maikaʻi loa a i ʻole inā lilo nā hopena ʻaoʻao i mea paʻakikī loa e mālama.

E hoʻohana kāu kauka i nā scans, nā hoʻokolohua koko, a me nā hoʻokolohua kino e hoʻoholo ai i ka wā kūpono e hooki ai i ka lapaʻau. E kūkākūkā pū lākou i ka mea e hiki mai ana i kāu hoʻolālā mālama, inā he nānā ʻana, ka mālama ʻana, a i ʻole nā lapaʻau ʻē aʻe.

Hiki iaʻu ke hana i ka wā e lawe ana i ka Polatuzumab Vedotin?

Hiki i nā kānaka he nui ke hoʻomau i ka hana ʻoiai e loaʻa ana ka polatuzumab vedotin, akā pono paha ʻoe e hana i kekahi mau hoʻoponopono i kāu papa manawa. Hāʻawi ʻia ka lapaʻau i hoʻokahi manawa i kēlā me kēia ʻekolu pule, no laila pono ʻoe i ka manawa hoʻomaha no nā manawa infusion a makemake paha e hoʻolālā i nā lā māmā ma hope koke o ka lapaʻau.

He hopena ʻaoʻao maʻamau ka luhi, no laila e ʻike paha ʻoe e pono ana ʻoe i ka hoʻomaha hou aʻe ma mua o ka maʻamau. E kamaʻilio me kāu mea hana e pili ana i nā hoʻonohonoho maʻalahi inā hiki, a e hoʻolohe i kou kino e pili ana i ka mea e manaʻo ʻia he hiki ke mālama ʻia. Hiki i kāu hui mālama ola ke hāʻawi i ke alakaʻi e pili ana i nā palena hana inā pono.