He aha ʻo Pralsetinib: Nā hoʻohana, ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Pralsetinib e ālai ana i nā protein kikoʻī e hoʻokele ana i kekahi mau ʻano o ka ulu ʻana o ka maʻi maʻi. Ua hoʻolālā ʻia e mālama i nā maʻi maʻi me nā loli gene RET, e kū mai ana ke hoʻopilikia ʻia nā hōʻailona ulu maʻamau o kou kino a ʻae i nā cell maʻi maʻi e hoʻonui ʻole ʻia.

Hōʻike kēia lāʻau lapaʻau i kahi ala pololei i ka mālama ʻana i ka maʻi maʻi. Ma kahi o ka hoʻopilikia ʻana i nā cell e mahele wikiwiki ana e like me ka chemotherapy kuʻuna, ua manaʻo ʻia ʻo pralsetinib i ka protein RET abnormal e hoʻoulu ai i kekahi mau maʻi maʻi. Hiki i kēia ala i manaʻo ʻia ke kōkua i ka hoʻolohi a i ʻole ke kāohi ʻana i ka ulu ʻana o ka maʻi maʻi me ka hiki ke hana i nā hopena ʻaoʻao liʻiliʻi ma mua o nā lāʻau lapaʻau ākea.

No ke aha i hoʻohana ʻia ai ʻo Pralsetinib?

Hoʻomaʻamaʻa ʻo Pralsetinib i nā ʻano maʻi maʻi kikoʻī i loaʻa nā loli gene RET a i ʻole nā hoʻonohonoho hou. E hoʻāʻo kāu kauka i kāu mau cell maʻi maʻi e hōʻoia i kēia mau loli genetic ma mua o ke kau ʻana i kēia lāʻau lapaʻau.

Hoʻohana nui ʻia ka lāʻau lapaʻau no ka maʻi maʻi maʻi māmā non-small cell (NSCLC) i laha a ʻaʻole hiki ke wehe ʻia me ke ʻoki. Ua ʻae ʻia nō hoʻi no kekahi mau ʻano o ka maʻi maʻi thyroid, me ka maʻi maʻi thyroid medullary a me nā maʻi maʻi thyroid ʻē aʻe me nā loli RET i pane ʻole i ka mālama ʻana i ka iodine radioactive.

ʻAʻole maʻamau, hiki ke hoʻohana ʻia ʻo pralsetinib no nā ʻōpū paʻa ʻē aʻe i loaʻa nā hoʻololi gene RET. E hoʻoholo kāu oncologist inā kūpono kāu ʻano maʻi maʻi a me ka ʻikepili genetic iā ʻoe no kēia lapaʻau. Aia ka hoʻoholo i ka hana genetic o kāu maʻi maʻi, pehea ka mamao i laha ai, a me kou olakino holoʻokoʻa.

Pehea e hana ai ʻo Pralsetinib?

Hana ʻo Pralsetinib ma ka ālai ʻana i ka protein RET, e hana ana e like me ka hoʻololi hewa i nā cell maʻi maʻi. Ke hoʻololi ʻia nā genes RET, hoʻouna lākou i nā hōʻailona

E manaʻo e like ka RET me ka mea paʻi kinoea i paʻa i ke kūlana i paʻi ʻia. Hana ʻo Pralsetinib e like me ka mea paʻa e hoʻōki i kēia mahele ʻana o ke kelepona i wikiwiki ʻia. Ma ka pale ʻana i kēia mau hōʻailona, hiki i ka lāʻau lapaʻau ke hoʻolohi i ka ulu ʻana o ka maʻi ʻaʻai a hiki paha ke hōʻemi i nā maʻi ʻaʻai e kū nei.

Ua manaʻo ʻia he lāʻau lapaʻau i manaʻo ʻia he ikaika. ʻAʻole like me ka chemotherapy kuʻuna e pili ana i nā ʻano kelepona he nui, ua manaʻo ʻia ʻo pralsetinib i nā kelepona maʻi ʻaʻai me nā hoʻololi RET. ʻO kēia ala pololei e manaʻo ʻia he mea maikaʻi loa ia no nā maʻi kūpono a hiki ke hana i nā hopena ʻaoʻao liʻiliʻi ma mua o nā lāʻau lapaʻau maʻi ʻaʻai ākea.

Pehea e lawe ai au i ka Pralsetinib?

E lawe i ka pralsetinib e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā i ka manawa like i kēlā me kēia lā. Hiki iā ʻoe ke lawe me ka ʻole o ka meaʻai, akā e hoʻāʻo e kūlike me kāu koho e mālama i nā pae paʻa i loko o kou kino.

E ale i nā capsules holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a wehe paha i nā capsules, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka lawe ʻana o ka lāʻau lapaʻau. Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu hui mālama ola e pili ana i nā ala ʻē aʻe.

Hiki i kāu kauka ke ʻōlelo e lawe i ka pralsetinib me kahi meaʻai māmā a i ʻole meaʻai inā loaʻa iā ʻoe ka ʻōpū. Manaʻo kekahi poʻe maʻi e kōkua ka lawe ʻana me ka meaʻai i ka hōʻemi ʻana i ka nausea. Eia naʻe, e pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana i kēia lāʻau lapaʻau, no ka mea, hiki iā lākou ke keakea i ke ʻano o ka hana ʻana o kou kino i ka lāʻau.

E mālama i kāu lāʻau lapaʻau i loko o kāna pahu mua ma ka lumi wela, mai ka wai a me ka wela. E mālama iā ia mai kahi hiki ʻole o nā keiki a me nā holoholona. Mai kaʻana like i kāu lāʻau lapaʻau me nā poʻe ʻē aʻe, ʻoiai inā he maʻi like ko lākou.

Pehea ka lōʻihi e lawe ai au i ka Pralsetinib?

E lawe maʻamau ʻoe i ka pralsetinib no ka lōʻihi e hoʻomau ai ia i ka mālama ʻana i kāu maʻi ʻaʻai a hiki iā ʻoe ke ʻae i nā hopena ʻaoʻao. Hiki i kēia ke lilo i mau mahina a i ʻole mau makahiki, ma muli o ka maikaʻi o ka pane ʻana o kāu maʻi ʻaʻai i ka lāʻau lapaʻau.

E nānā kāu kauka i kou holomua ma o nā scans a me nā hoʻokolohua koko maʻamau. Kōkua kēia mau manawa e hoʻoholo inā e hana ana ka lāʻau a inā e ʻike ana ʻoe i nā hopena ʻaoʻao e hopohopo nei. Ma muli o kēia mau hopena, hiki ke hoʻoponopono ʻia kāu hoʻolālā lapaʻau.

Mai hooki i ka lawe ʻana i ka pralsetinib me ke kūkākūkā ʻole ʻana me kāu oncologist mua. ʻOiai inā maikaʻi kou manaʻo, hiki nō i ka lāʻau ke hana nei e kāohi i ka ulu ʻana o ka maʻi kanesa. ʻO ka hooki ʻana i ka hikiwawe hiki ke ʻae i kāu maʻi kanesa e holomua wikiwiki.

I kekahi mau hihia, hiki i kāu kauka ke hoʻomaha i ka lapaʻau no kekahi manawa inā e loaʻa iā ʻoe nā hopena ʻaoʻao nui. Hāʻawi kēia hoʻomaha i kou kino e ola ma mua o ka hoʻomau ʻana i ka lapaʻau ma ka mahele like a i ʻole ka haʻahaʻa.

He aha nā hopena ʻaoʻao o Pralsetinib?

ʻO ka hapa nui o nā kānaka e lawe ana i ka pralsetinib e ʻike i kekahi mau hopena ʻaoʻao, akā hiki ke mālama ʻia ka nui me ka mālama kūpono a me ka nānā ʻana. E hana pū kāu hui mālama ola me ʻoe e hōʻemi i kēia mau hopena a mālama i kou maikaʻi o ke ola.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Luhi a me ka nāwaliwali e pili ana i kāu mau hana i kēlā me kēia lā
• ʻEha ʻiʻo a me nā hui, ʻoi aku hoʻi i kou kua a me nā lālā
• Ke koko kiʻekiʻe e pono ai ka nānā mau
• Paʻa ʻōpū i hiki ke mālama ʻia me ka ʻai a me ka lāʻau
• Waha maloʻo a me nā loli i ka ʻono
• Pōkole o ka hanu i ka wā o ka hana kino
• ʻO ka ʻili ʻulaʻula a i ʻole nā ​​kūlana ʻili maloʻo
• Hoʻemi ʻia ka ʻai a me ka hiki ke lilo ke kaumaha

Hoʻomaikaʻi pinepine kēia mau hopena maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu kauka ke ʻōlelo i nā hoʻolālā e kōkua i ka mālama pono ʻana i kēia mau hōʻailona.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e pono ai ka lāʻau lapaʻau koke. ʻO kēia mau hopena kakaʻikahi akā koʻikoʻi e komo pū ana:

• Nā pilikia nui o ka māmā, me ka mumū e hoʻoulu ai i ka ʻūlū mau a me nā pilikia hanu
• Nā pilikia o ke ake i hōʻailona ʻia e ka melemele o ka ʻili a i ʻole nā maka, ka mimi ʻeleʻele, a i ʻole ka ʻeha nui o ka ʻōpū
• Nā loli o ka puʻuwai e hiki ke hoʻoulu i ka wili a i ʻole ka ʻū
• Ke koko kiʻekiʻe nui e alakaʻi ana i nā ʻeha poʻo a i ʻole nā loli o ka ʻike
• Nā pilikia koko, ʻoi loa inā ʻoe e ʻike i ka ʻeha ʻokoʻa a i ʻole ke koko
• Nā hopena ʻili nui me ka ʻōhū a i ʻole ka ʻili

E kelepona koke i kāu mea mālama ola inā ʻoe e ʻike i kekahi o kēia mau hōʻailona koʻikoʻi. Hiki i ka ʻike mua a me ka mālama ʻana i nā hopena ʻaoʻao ke pale i nā pilikia nui aʻe.

ʻO wai ka mea pono ʻole e lawe iā Pralsetinib?

ʻAʻole kūpono ʻo Pralsetinib no nā mea a pau, a hiki i kekahi mau maʻi olakino a i ʻole nā lāʻau lapaʻau ke hoʻolilo iā ia i mea palekana ʻole iā ʻoe. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe iā pralsetinib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mea hana. ʻO nā hōʻailona o nā hopena maʻi e komo pū ana me nā hives, nā pilikia hanu, a i ʻole ka pehu ʻana o kou maka, nā lehelehe, ke alelo, a i ʻole ka ʻāʻī.

Pono kekahi mau maʻi olakino i ka noʻonoʻo kūikawā ma mua o ka hoʻomaka ʻana iā pralsetinib:

• Ke koko kiʻekiʻe i paʻakikī ke kāohi
• Nā pilikia o ka puʻuwai a i ʻole ka maʻi puʻuwai
• Maʻi ake a i ʻole nā enzyme ake kiʻekiʻe
• Maʻi māmā a i ʻole nā pilikia hanu
• Nā maʻi koko a i ʻole ka lawe ʻana i nā lāʻau e lahilahi ai ke koko
• Nā pilikia o ka puʻupaʻa e pili ana i ke ʻano o ka hana ʻana o kou kino i nā lāʻau lapaʻau

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, hiki i ka pralsetinib ke hōʻeha i kāu pēpē e ulu ana. Pono ʻoe e hoʻohana i ka mana hānau kūpono i ka wā o ka mālama ʻana a no kekahi mau pule ma hope o ka hoʻōki ʻana i ka lāʻau. Pēlā nō, inā ʻoe e hānai ana i ka umauma, pono ʻoe e kūkākūkā i nā koho ʻē aʻe me kāu kauka.

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka pralsetinib, a hiki ke hoʻemi i kona pono a i ʻole e hoʻonui i nā hopena ʻaoʻao. E hōʻike mau i kāu hui mālama ola e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei.

Nā inoa inoa o Pralsetinib

Loaʻa ka Pralsetinib ma lalo o ka inoa inoa Gavreto ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa kalepa nui āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau lapaʻau.

Ke kūkākūkā ʻana i kāu mālama ʻana me nā mea mālama ola a i ʻole nā ​​ʻoihana ʻinikua, hiki iā ʻoe ke lohe i nā inoa ʻelua i hoʻohana ʻia. ʻO ka inoa generic pralsetinib e pili ana i ka mea hana, ʻoiai ʻo Gavreto ka inoa kikoʻī i hana ʻia e ka hui lāʻau lapaʻau.

I kēia manawa, ʻo Gavreto wale nō ka inoa i ʻae ʻia e ka FDA o pralsetinib. ʻAʻole i loaʻa nā mana generic, ʻo ia hoʻi, ʻokoʻa paha kāu ʻinikua a me ke kumukūʻai mai nā lāʻau lapaʻau maʻi ʻaʻai ʻē aʻe i loaʻa nā koho generic.

Nā koho ʻē aʻe o Pralsetinib

Nui nā lāʻau lapaʻau i manaʻo ʻia he koho inā ʻaʻole kūpono ka pralsetinib iā ʻoe a i ʻole e pau ka hana ʻana. Aia ke koho i kāu ʻano maʻi maʻi a me ka ʻikepili genetic.

No nā maʻi maʻi RET-altered, ʻo selpercatinib (Retevmo) kekahi mea hoʻopaʻa RET e hana like me ka pralsetinib. Hiki i kāu oncologist ke noʻonoʻo e hoʻololi ma waena o kēia mau lāʻau lapaʻau inā pau kekahi i ka hana a i ʻole e hana i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia.

No nā maʻi maʻi maʻi maʻi maʻi, hiki i nā lāʻau lapaʻau ʻē aʻe ke komo:

• Nā mea hoʻopaʻa ALK e like me alectinib a i ʻole crizotinib inā loaʻa i kāu maʻi maʻi nā loli ALK
• Nā mea hoʻopaʻa EGFR e like me erlotinib a i ʻole osimertinib no nā maʻi maʻi EGFR-mutated
• Nā lāʻau lapaʻau immunotherapy e like me pembrolizumab a i ʻole nivolumab
• Nā hui chemotherapy kuʻuna

No ke kanesa thyroid, hiki i nā koho ʻē aʻe ke komo i ka lenvatinib, sorafenib, a i ʻole ka lāʻau lapaʻau iodine radioactive, ma muli o kou kūlana kikoʻī. E noʻonoʻo kāu kauka i ke ʻano genetic o kāu maʻi kanesa, nā lāʻau lapaʻau i hala, a me ke olakino holoʻokoʻa i ka wā e ʻōlelo ai i nā koho ʻē aʻe.

Ua ʻoi aku ka maikaʻi o Pralsetinib ma mua o Selpercatinib?

He mea maikaʻi ʻo Pralsetinib a me selpercatinib i nā mea pale RET, akā he mau ʻokoʻa ko lākou e hiki ai ke kūpono kekahi iā ʻoe ma mua o kekahi. ʻAʻole maopopo ka

E kauoha paha kāu kauka i nā hoʻokolohua hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau a e nānā pono iā ʻoe i ka wā o ka lāʻau. Hiki i kēia ke komo i nā electrocardiograms (ECGs) maʻamau e nānā i kou puʻuwai a me nā ana koko. Inā he mōʻaukala kou o nā pilikia puʻuwai, e hana pū kāu cardiologist a me ka oncologist e hōʻoia i ka ʻoi aku o nā pōmaikaʻi ma mua o nā pilikia.

Hiki i ka nui o nā kānaka me nā maʻi puʻuwai maʻalahi a i ʻole ka maʻi maʻi ke lawe palekana i ka pralsetinib me ka nānā pono. Eia naʻe, inā he maʻi puʻuwai koʻikoʻi kou a i ʻole ke koko kiʻekiʻe ʻole, pono paha i kāu kauka e hoʻoponopono i kēia mau pilikia ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau maʻi kanesa.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Pralsetinib?

Inā lawe hewa ʻoe i ka pralsetinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawaʻawa, ʻoiai inā maikaʻi ʻoe. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi nā pilikia puʻuwai a me ke koko haʻahaʻa.

Mai hoʻāʻo e hoʻoponopono i ka overdose ma ka lele ʻana i kāu mahele aʻe a i ʻole ka lawe ʻana i ka lāʻau liʻiliʻi. Akā, e kelepona koke i kāu mea mālama ola e loaʻa ai ke alakaʻi kikoʻī e pili ana i ka nui o ka lāʻau lapaʻau keu āu i lawe ai a i ka manawa āu i lawe ai.

ʻOiai e kali ana i ka ʻōlelo aʻo lapaʻau, e nānā iā ʻoe iho no nā hōʻailona e like me ka ʻūlū, ka ʻūlū, ka puʻuwai ʻole, a i ʻole ka luhi nui. Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​e ʻimi koke i ka mālama olakino pilikia. E mālama i ka hue lāʻau me ʻoe i hiki i nā mea mālama ola ke ʻike pololei i ka mea a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Pralsetinib?

Inā haʻalele ʻoe i kahi mahele o pralsetinib, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, ke ʻole kokoke i ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i haʻalele ʻia a lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe i nā lāʻau ʻelua i ka manawa hoʻokahi e pani ai i ka lāʻau i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole e hāʻawi i ka pōmaikaʻi hou. Inā ʻaʻole ʻoe maopopo e pili ana i ka manawa, ʻoi aku ka maikaʻi o ka lele ʻana i ka lāʻau i hala a hoʻomau me kāu papa manawa maʻamau.

Inā poina pinepine ʻoe i nā lāʻau, e noʻonoʻo e hoʻonohonoho i nā ʻōhua kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo. Kōkua ka hoʻohana ʻana i kēlā me kēia lā i ka mālama ʻana i nā pae paʻa o ka lāʻau i loko o kou kino, he mea nui kēia no ka mālama pono ʻana i kāu maʻi kanesa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Pralsetinib?

Pono ʻoe e hooki i ka lawe ʻana iā pralsetinib ma lalo o ke alakaʻi a kāu kauka, maʻamau i ka wā e holomua ai kāu maʻi kanesa me ka mālama ʻana a i ʻole inā loaʻa iā ʻoe nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia. E hana kāu oncologist i kēia hoʻoholo e pili ana i nā scans maʻamau a me nā hoʻokolohua koko e nānā ana i ka maikaʻi o ka hana ʻana o ka lāʻau.

ʻOiai inā maikaʻi ʻoe a ʻaʻohe ou hōʻailona, ​​hiki nō i ka lāʻau ke mālama i ka ulu ʻana o ka maʻi kanesa. ʻO ka hooki ʻana me ka nānā ʻole ʻana i ka lāʻau lapaʻau hiki ke ʻae i kāu maʻi kanesa e holomua wikiwiki. E noʻonoʻo pono kāu kauka i nā pōmaikaʻi o ka mālama ʻana i ka hoʻomau ʻana i nā hopena ʻaoʻao āu e ʻike nei.

Inā holomua kāu maʻi kanesa i ka wā e lawe ana iā pralsetinib, e kūkākūkā kāu kauka i nā koho lapaʻau ʻē aʻe. I kekahi manawa, hiki ke maikaʻi ka hoʻomaha lapaʻau pōkole a ukali ʻia e ka hoʻomau ʻana i kahi lāʻau haʻahaʻa. I nā manawa ʻē aʻe, hiki ke ʻōlelo ʻia ka hoʻololi ʻana i kahi lāʻau lapaʻau i manaʻo ʻia a i ʻole ke ala lapaʻau.

Hiki iaʻu ke lawe iā Pralsetinib me nā lāʻau lapaʻau maʻi kanesa ʻē aʻe?

Hāʻawi ʻia ʻo Pralsetinib ma ke ʻano he mea hoʻokahi ma mua o ka hui pū ʻana me nā lāʻau lapaʻau maʻi kanesa ʻē aʻe, akā pili kēia i kāu kūlana kikoʻī. E hoʻoholo kāu oncologist i ke ala lapaʻau maikaʻi loa e pili ana i kāu ʻano maʻi kanesa, ke kahua, a me nā lāʻau lapaʻau i hala.

I kekahi mau hihia, hiki ke hui pū ʻia ʻo pralsetinib me nā lāʻau lapaʻau kākoʻo ʻē aʻe e mālama i nā hopena ʻaoʻao a i ʻole e hoʻoikaika i kou ʻōnaehana pale. Eia naʻe, ʻo ka hui pū ʻana me nā lāʻau lapaʻau maʻi ʻaʻai ʻē aʻe e koi ana i ka noʻonoʻo pono ʻana i nā pilina kūpono a me ka hoʻonui ʻia ʻana o nā hopena ʻaoʻao.

E hōʻike mau i kāu hui mālama ola e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e loaʻa nei, me nā hoʻokolohua lapaʻau, nā mea hoʻohui, a i ʻole nā lāʻau lapaʻau ʻē aʻe. Hiki i kekahi mau hui ke keakea i ka pono o pralsetinib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi. E hoʻopili kāu hui lapaʻau i nā ʻano āpau o kāu mālama ʻana e hōʻoia i ka palekana a me ka maikaʻi o ka hoʻolālā lapaʻau.