He aha ʻo Quizartinib: Nā Hoʻohana, Nā Kumu, Nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i manaʻo ʻia ʻo Quizartinib i hana ʻia e mālama i kahi ʻano o ka maʻi leukemia myeloid acute (AML). Hana kēia lāʻau lapaʻau waha ma ka pale ʻana i nā protein abnormal e kōkua i nā pūnaewele maʻi e ulu a hoʻonui i loko o kou iwi iwi.

Inā ua kauoha ʻia ʻo quizartinib iā ʻoe a i ʻole kekahi mea aloha, e hana ana paha ʻoe me kahi maʻi maʻi paʻakikī. ʻOiai hiki i kēia ke manaʻo nui, hiki i ka hoʻomaopopo ʻana i ka hana ʻana o kēia lāʻau lapaʻau ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu huakaʻi lapaʻau.

He aha ʻo Quizartinib?

He lāʻau lapaʻau maʻi maʻi ʻo Quizartinib i kuhikuhi ʻia e pili ana i kahi papa o nā lāʻau i kapa ʻia he kinase inhibitors. Hoʻopā a pale pono ia i kahi protein i kapa ʻia ʻo FLT3, hiki ke lilo i mea hana nui i kekahi mau ʻano maʻi koko.

Hele mai kēia lāʻau lapaʻau ma ke ʻano he papa waha, ʻo ia hoʻi hiki iā ʻoe ke lawe ma ka waha ma ka home ma mua o ka pono ʻana i nā lāʻau intravenous ma kahi haukapila. Ua hana kūikawā ʻia ka lāʻau no ka poʻe nona ka maʻi leukemia myeloid acute i kahi loli genetic i kapa ʻia ʻo FLT3-ITD.

E hoʻāʻo kāu kauka i kāu mau pūnaewele maʻi e hōʻoia ua loaʻa iā ʻoe kēia loli kikoʻī ma mua o ke kau ʻana iā quizartinib. Kōkua kēia ala pilikino e hōʻoia i ka maikaʻi loa o ka lāʻau lapaʻau no kāu ʻano leukemia.

No ke aha e hoʻohana ʻia ai ʻo Quizartinib?

Hoʻohana ʻia ʻo Quizartinib e mālama i nā mākua me ka maʻi leukemia myeloid acute (AML) nona ka loli genetic kikoʻī i kapa ʻia ʻo FLT3-ITD mutation. Hoʻohana maʻamau ʻia kēia lāʻau lapaʻau ke hoʻi mai kāu leukemia ma hope o ka mālama ʻana ma mua a i ʻole ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe.

ʻO AML kahi ʻano o ka maʻi koko e pili ana i kou iwi iwi, kahi e hana ai kou kino i nā pūnaewele koko. Ke loaʻa iā ʻoe kēia maʻi, hana kou iwi iwi i nā keʻokeʻo keʻokeʻo abnormal he nui ʻaʻole hana pono, e hoʻopilikia ana i nā pūnaewele koko olakino.

Hana ka loli FLT3-ITD i nā sela maʻi e ulu a hoʻonui ikaika. Ma kahi o 25-30% o nā kānaka me AML i kēia loli kūikawā, ʻo ia ke kumu he mea nui ka hoʻāʻo genetic ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Hiki i kāu oncologist ke noʻonoʻo i ka quizartinib inā ʻaʻole ʻoe he moho no ka chemotherapy ikaika ma muli o kou makahiki a i ʻole nā ​​maʻi olakino ʻē aʻe. Hāʻawi kēia lāʻau lapaʻau i kahi ala i manaʻo ʻia e hiki ke mālie i kou kino me ka hakakā ʻana i ka maʻi maʻi.

Pehea e Hana ai ʻo Quizartinib?

Hana ʻo Quizartinib ma ka pale ʻana i kahi protein kikoʻī i kapa ʻia ʻo FLT3 e hana ana e like me ka

Hiki iā ʻoe ke lawe i ka quizartinib me ka ʻole o ka meaʻai, akā e hoʻāʻo e kūlike me kāu koho. Inā maʻa mau ʻoe e lawe me ka ʻaina kakahiaka, e hoʻomau i ka hana ʻana pēlā i kāu mālama ʻana. Kōkua kēia i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kāu ʻōnaehana.

Mai ʻoki, nau, a i ʻole e wāwahi i nā papa, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka lawe ʻia ʻana o ka lāʻau lapaʻau. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai, akā ʻaʻole loa e hoʻololi i nā papa iho.

He mea nui e lawe i ka quizartinib ma kahi o ka manawa like i kēlā me kēia lā e mālama i nā pae kūlike i loko o kou kahe koko. ʻO ka hoʻonohonoho ʻana i kahi alarm i kēlā me kēia lā a i ʻole ka hoʻopili ʻana iā ia i kahi hana maʻamau e like me ka palaki ʻana i kou mau niho hiki ke kōkua iā ʻoe e hoʻomanaʻo.

E mālama i kāu lāʻau lapaʻau ma ka lumi wela, mai ka makū a me ka wela. E mālama i loko o kāna pahu mua a mai nā keiki a me nā holoholona.

Pehea ka lōʻihi e pono ai au e lawe i ka Quizartinib?

ʻO ka lōʻihi o ka mālama ʻana i ka quizartinib e ʻokoʻa loa mai kēlā me kēia kanaka a hilinaʻi i ka maikaʻi o ka pane ʻana o kou kino i ka lāʻau lapaʻau. E nānā kāu kauka i kāu holomua ma o nā hoʻokolohua koko maʻamau a me nā biopsies iwi iwi e hoʻoholo ai i ka lōʻihi kūpono.

He nui ka poʻe e hoʻomau i ka lawe ʻana i ka quizartinib no kekahi mau mahina a i ʻole mau makahiki, inā e hoʻomalu pono ana i kā lākou leukemia a hiki ke mālama ʻia nā hopena ʻaoʻao. Hiki i kekahi poʻe maʻi ke lawe iā ia no ka manawa pau ʻole ma ke ʻano he lāʻau lapaʻau e mālama ai i kā lākou maʻi maʻi i ke kala ʻana.

E loiloi mau kāu oncologist inā e hana ana ka lāʻau lapaʻau ma ka nānā ʻana i kāu helu koko a me ka ʻimi ʻana i nā cell leukemia i loko o kou iwi iwi. Inā pane maikaʻi kāu maʻi maʻi, e hoʻomau paha ʻoe i ka mālama ʻana no ka manawa lōʻihi.

Mai hooki i ka lawe ʻana i ka quizartinib i ka pō a i ʻole e hoʻololi i kāu papa hana dosing me ka ʻole e kūkākūkā me kāu hui mālama ola. ʻOiai inā ʻoe e ʻoi aku ka maikaʻi, hiki nō i ka lāʻau lapaʻau ke hakakā ikaika nei i nā cell maʻi ʻaʻole e hōʻike ana i nā hōʻailona.

He aha nā hopena ʻaoʻao o Quizartinib?

E like me nā lāʻau lapaʻau maʻi āpau, hiki i ka quizartinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka nānā pono ʻana a me ke kākoʻo mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe i ka wā e lawe ana i ka quizartinib:

• Nausea a me ka luaʻi
• Pāpaʻa a i ʻole ka paʻa ʻana
• Luhi a me ka nāwaliwali
• Hoʻemi ʻia ka ʻai
• ʻEha ʻiʻo a me nā hui
• Poʻo
• ʻĀwili
• Nā loli i ka ʻono

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā hoʻolālā a me nā lāʻau lapaʻau e kōkua i ka mālama pono ʻana i kēia mau hōʻailona.

Hiki ke loaʻa nā hopena ʻaoʻao koʻikoʻi, ʻoiai ʻaʻole maʻamau lākou. He mea nui e ʻike i kēia mau mea i hiki iā ʻoe ke ʻimi i ka lāʻau lapaʻau inā pono:

• Nā pilikia o ka puʻuwai (QT prolongation)
• Nā maʻi koʻikoʻi ma muli o ka helu haʻahaʻa o ke keʻokeʻo koko
• Ke kahe ʻana a i ʻole ka ʻeha ma muli o ka helu platelet haʻahaʻa
• Nā pilikia o ke akepaʻa
• Ka mālama wai a me ka pehu
• Paʻakikī ka hanu
• Nā hopena ʻili koʻikoʻi

E nānā pono kāu kauka iā ʻoe me nā hoʻokolohua koko maʻamau a me ka nānā ʻana i ka puʻuwai e hopu i nā hopena ʻaoʻao koʻikoʻi i ka wā mua. Hiki i ka hapa nui o nā kānaka ke hoʻomau i ka mālama ʻana me ka palekana me ka mālama olakino kūpono.

ʻO nā hopena ʻaoʻao laha akā koʻikoʻi paha e pili ana i nā pilikia o ka puʻuwai koʻikoʻi, nā maʻi e hoʻoweliweli ana i ke ola, a i ʻole ka maʻi lysis tumor (i ka wā e wāwahi koke ai nā sela maʻi). ʻOiai ʻaʻole maʻamau kēia mau pilikia, e nānā kāu hui lapaʻau i nā hōʻailona mua a hana wikiwiki inā loaʻa lākou.

ʻO wai ka mea ʻaʻole pono e lawe i ka Quizartinib?

ʻAʻole kūpono ʻo Quizartinib no nā mea a pau, a e loiloi pono kāu kauka inā he koho kūpono ia nāu. ʻAʻole kūpono paha nā kānaka me kekahi mau maʻi puʻuwai no kēia lāʻau lapaʻau ma muli o kona hopena i ka puʻuwai.

ʻAʻole pono ʻoe e lawe i ka quizartinib inā he maʻi ʻoe i ka lāʻau lapaʻau a i ʻole kekahi o kāna mea ʻai. E akahele nō hoʻi kāu kauka i ka ʻōlelo ʻana inā he pilikia koʻikoʻi kou ate a i ʻole nā pilikia o ka puʻupaʻa, no ka mea, kōkua kēia mau ʻōkana i ka hana ʻana i ka lāʻau lapaʻau.

ʻAʻole hiki i nā kānaka me kekahi mau maʻi puʻuwai, ʻo ia hoʻi ka poʻe me ka maʻi QT lōʻihi, ke lawe palekana i ka quizartinib. E hana paha kāu kauka i ka electrocardiogram (ECG) ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau e nānā i kou puʻuwai.

He mea nui ka hāpai ʻana a me ka hānai ʻana i ka waiū. Hiki i ka Quizartinib ke hōʻeha i kahi pēpē i hānau ʻole ʻia, no laila he mea nui ka pale ʻana i ka hāpai ʻana i ka wā o ka lāʻau lapaʻau a no kekahi manawa ma hope o ka hoʻōki ʻana i ka lāʻau lapaʻau. Inā hānai ʻoe i ka waiū, pono ʻoe e kūkākūkā i nā koho hānai ʻē aʻe me kāu hui mālama ola.

E noʻonoʻo pū kāu kauka i kou kūlana olakino holoʻokoʻa, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me kekahi mōʻaukala o nā maʻi koʻikoʻi ma mua o ka ʻōlelo ʻana i ka quizartinib. Kōkua kēia loiloi akahele i ka hōʻoia ʻana i ka palekana a me ke kūpono o ka lāʻau lapaʻau no kou kūlana.

Inoa Brand Quizartinib

Loaʻa ʻo Quizartinib ma lalo o ka inoa brand Vanflyta ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia ka inoa kalepa āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau lapaʻau.

Ua hoʻomohala ʻia ka lāʻau lapaʻau e Daiichi Sankyo a ua loaʻa ka ʻae mai ka FDA no ka mālama ʻana i ka FLT3-ITD positive AML. Ke kauoha kāu kauka i ka quizartinib, e hāʻawi maʻamau ka hale kūʻai lāʻau lapaʻau iā ia ma ke ʻano he Vanflyta ke ʻole lākou e kuhikuhi.

ʻAʻole i loaʻa nā ʻano generic o ka quizartinib, no ka mea, he mea hou ka lāʻau lapaʻau a aia ma lalo o ka pale palapala. ʻO ia hoʻi, ʻo Vanflyta wale nō ke ʻano o ka quizartinib i loaʻa no ke kau ʻana.

Nā Koho ʻē aʻe no Quizartinib

Nui nā lāʻau lapaʻau ʻē aʻe i loaʻa no ka mālama ʻana i ka FLT3-positive AML, me nā ʻano hana like ʻole a me nā hopena ʻaoʻao. E kōkua kāu oncologist e hoʻoholo i ke koho maikaʻi loa no kāu kūlana.

ʻO Midostaurin (Rydapt) kekahi mea hoʻopaʻa FLT3 i hoʻohana pinepine ʻia me ka chemotherapy no ka AML FLT3-positive i hōʻike ʻia. Hana like ia me ka quizartinib akā hoʻohana pinepine ʻia i ka wā mua o ka mālama ʻana.

ʻO Gilteritinib (Xospata) kekahi lāʻau lapaʻau i manaʻo ʻia no ka FLT3-positive AML i hoʻohana ʻia i ka wā i hoʻi hou ai ka maʻi a i ʻole ke kūpaʻa ʻana i nā lāʻau lapaʻau ʻē aʻe. Pākuʻi ia i nā protein he nui i pili i ka ulu ʻana o nā cella maʻi.

He mea nui nā hana chemotherapy kuʻuna, ʻoi aku hoʻi no ka poʻe i lawa ke olakino e ʻae i ka mālama ʻana. Hiki i kēia mau mea ke komo i nā hui pū ʻana o ka cytarabine a me nā anthracyclines.

Hiki ke noʻonoʻo ʻia ka hoʻololi ʻana i nā cella stem no kekahi mau maʻi, ʻoi aku hoʻi nā poʻe ʻōpio me ke olakino maikaʻi. Hiki i kēia mālama ʻana ke hoʻōla i ka AML akā pono ka koho ʻana a me ka hoʻomākaukau ʻana.

E noʻonoʻo kāu kauka i nā mea e like me kou makahiki, ke olakino holoʻokoʻa, nā lāʻau lapaʻau i hala, a me nā ʻano genetic kikoʻī o kou leukemia i ka wā e ʻōlelo ai i nā koho ʻē aʻe i ka quizartinib.

ʻOi aku ka maikaʻi o Quizartinib ma mua o Midostaurin?

He mea maikaʻi nā mea hoʻopaʻa FLT3 ʻo Quizartinib a me midostaurin, akā hoʻohana pinepine ʻia lākou i nā kūlana like ʻole ma mua o ka hoʻohālikelike pololei ʻana. Aia ke koho

Hoʻohana pinepine ʻia ʻo Midostaurin ma ke ʻano he ʻāpana o ka mālama mua ʻana no ka FLT3-positive AML i hōʻike ʻia, maʻamau i hui pū ʻia me ka chemotherapy maʻamau. Ua hōʻike ʻia e hoʻomaikaʻi i ke ola ke hoʻohui ʻia i nā papa hana lapaʻau maʻamau.

ʻO Quizartinib, ma kekahi ʻaoʻao, hoʻohana nui ʻia no ka relapsed a i ʻole refractory FLT3-positive AML. Hoʻolālā ʻia ia no nā kūlana i hoʻi mai ai ka leukemia ma hope o ka mālama ʻana a i ʻole ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe.

Ma ke ʻano o ka pono, ua hōʻike nā lāʻau lapaʻau ʻelua i nā pōmaikaʻi nui i nā hoʻokolohua lapaʻau. Ua hōʻike ʻo Quizartinib i ka hana ikaika loa e kūʻē i kekahi mau loli FLT3 a ʻoi aku paha ka ikaika i kekahi mau haʻawina lab.

He ʻokoʻa nā ʻano hopena ʻaoʻao ma waena o nā lāʻau lapaʻau ʻelua. ʻOiai hiki i nā mea ʻelua ke hoʻoulu i nā hopena ʻaoʻao maʻamau e like me ka nausea a me ka luhi, loaʻa paha iā lākou nā pilikia like ʻole no nā pilikia koʻikoʻi e like me nā pilikia o ka puʻuwai a i ʻole nā maʻi.

E noʻonoʻo kāu oncologist i kāu mōʻaukala lapaʻau, ke kūlana olakino o kēia manawa, a me nā ʻano kikoʻī o kāu leukemia i ke koho ʻana ma waena o kēia mau lāʻau lapaʻau. ʻAʻole pili ka hoʻoholo i ka mea i

ʻAʻole paha he mau kānaka me nā maʻi puʻuwai i kūpono no ka quizartinib, akā hiki nō i ka poʻe me nā maʻi puʻuwai i mālama maikaʻi ʻia ke lawe palekana me ka nānā pono.

He aha kaʻu e hana ai inā ua lawe au i ka nui loa o ka Quizartinib?

Inā ua lawe ʻoe i ka nui loa o ka quizartinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu mea mālama ola a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā e ulu ana nā hōʻailona, no ka mea, he mea nui ka mālama olakino wikiwiki.

ʻO ka lawe ʻana i ka nui loa o ka quizartinib hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi nā pilikia o ka puʻuwai. Hiki i kāu hui lapaʻau ke makemake e nānā pono iā ʻoe a hiki ke hana i nā hoʻokolohua hou e like me ka electrocardiogram.

No ka pale ʻana i nā overdoses ulia pōpilikia, e mālama i kāu lāʻau lapaʻau i loko o kāna pahu mua me ka lepili maopopo, a e noʻonoʻo e hoʻohana i kahi mea hoʻonohonoho pila inā ʻoe e lawe i nā lāʻau he nui. Mai pāpālua i nā lāʻau inā ua hala ʻoe i hoʻokahi.

He aha kaʻu e hana ai inā ua hala au i kahi lāʻau o ka Quizartinib?

Inā ua hala ʻoe i kahi lāʻau o ka quizartinib, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu lāʻau i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka lāʻau i hala a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua lāʻau i ka manawa like e hoʻoponopono ai i kahi lāʻau i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā ʻaʻole ʻoe maopopo e pili ana i ka manawa, e kelepona i kāu mea mālama ola no ke alakaʻi.

ʻO ka hoʻonohonoho ʻana i nā mea hoʻomanaʻo i kēlā me kēia lā ma kāu kelepona a i ʻole ka hoʻopili ʻana i kāu lāʻau lapaʻau i kahi hana maʻamau hiki ke kōkua iā ʻoe e hoʻomanaʻo e lawe mau i ka quizartinib. He mea nui ka hoʻohana mau ʻana no ka mālama ʻana i nā pae kūpono i kāu ʻōnaehana.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Quizartinib?

Pono ʻoe e hooki i ka lawe ʻana i ka quizartinib ke hoʻoholo kāu oncologist he kūpono ke hana pēlā. E hoʻokumu ʻia kēia hoʻoholo i ka maikaʻi o ka lāʻau lapaʻau e kāohi ana i kou leukemia a inā e ʻike nei ʻoe i nā hopena ʻaoʻao hiki ke mālama ʻia.

He nui paha ka poʻe e pono e lawe i ka quizartinib no nā mahina a i ʻole nā makahiki, aʻo nā mea ʻē aʻe e hoʻololi i nā lāʻau lapaʻau ʻē aʻe a i ʻole e loaʻa ka hoʻōla lōʻihi. E hoʻohana kāu kauka i nā hoʻokolohua koko maʻamau a me nā loiloi iwi iwi e alakaʻi i kēia mau hoʻoholo.

Mai hooki i ka lawe ʻana i ka quizartinib ma kāu iho, ʻoiai inā ʻoe e manaʻo maikaʻi ana. Hiki nō i ka lāʻau lapaʻau ke hakakā ikaika nei i nā pūnaewele maʻi maʻi, a ʻo ka hooki ʻana i ka hikiwawe hiki ke ʻae i kāu leukemia e hoʻi mai a i ʻole e ʻino.

Hiki iaʻu ke lawe i nā lāʻau lapaʻau ʻē aʻe i ka wā e lawe ana i ka Quizartinib?

He nui nā lāʻau lapaʻau e hiki ke launa pū me ka quizartinib, no laila he mea nui e haʻi aku i kāu mea mālama ola e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei. Hiki i kekahi mau launa pū ke hoʻopilikia i ka maikaʻi o ka quizartinib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao.

Pono e hoʻohana ʻia kekahi mau lāʻau lapaʻau e pili ana i ka puʻuwai me ka akahele nui a i ʻole e pale loa ʻia i ka wā e lawe ana i ka quizartinib. E nānā kāu kauka i kāu papa inoa lāʻau lapaʻau me ka akahele a pono paha e hoʻoponopono a pani paha i kekahi mau lāʻau lapaʻau.

E nānā mau me kāu mea mālama ola ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou, me nā lāʻau lapaʻau a me nā mea hoʻohui. Hiki iā lākou ke kōkua iā ʻoe e hoʻomaopopo i nā launa pū ʻana a e hōʻoia i ka palekana a me ka pono o kāu lāʻau lapaʻau.