He aha ʻo Repotrectinib: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Repotrectinib e hana ana ma ka pale ʻana i nā protein kikoʻī e kōkua ana i nā sela maʻi e ulu a laha. No ka papa o nā lāʻau i kapa ʻia he kinase inhibitors kēia lāʻau lapaʻau waha, ʻo ia hoʻi ke keakea nei i nā hōʻailona e haʻi ana i nā sela maʻi e hoʻonui.

Hiki i kāu kauka ke kuhikuhi iā repotrectinib ke hana ʻole nā lāʻau lapaʻau maʻi maʻi ʻē aʻe e like me ka mea i manaʻo ʻia. He hōʻike ia i kahi ala hou i ka mālama ʻana i ka maʻi maʻi e kālele ana i nā loli genetic kikoʻī e hoʻokele ana i kāu maʻi maʻi.

No ke aha i hoʻohana ʻia ai ʻo Repotrectinib?

Ua hoʻolālā kūikawā ʻia ʻo Repotrectinib e mālama i kekahi mau ʻano maʻi maʻi maʻi ʻole (NSCLC) i loaʻa nā loli genetic. Pono nā sela maʻi maʻi i ka mea a nā kauka e kapa ai he ROS1 a i ʻole NTRK gene fusions no kēia lāʻau lapaʻau e hana pono.

Hoʻomaʻamaʻa ʻia kēia lāʻau lapaʻau ke hoʻāʻo mua ʻoe i nā lāʻau lapaʻau i manaʻo ʻia ʻaʻole i hana a i ʻole i pau ka hana ʻana. E hana kāu kauka i nā hoʻokolohua kūikawā ma kāu ʻiʻo maʻi e hōʻoia i ka repotrectinib ke koho kūpono no kāu kūlana.

I kekahi mau hihia, hiki i nā kauka ke noʻonoʻo i ka repotrectinib no nā ʻōpū paʻa ʻē aʻe i loaʻa nā NTRK gene fusions, ʻoiai ʻaʻole maʻamau kēia. E kūkākūkā kāu oncologist inā ʻo kāu ʻano maʻi maʻi a me ka genetic makeup e lilo ʻoe i moho maikaʻi no kēia lapaʻau.

Pehea e hana ai ʻo Repotrectinib?

Hana ʻo Repotrectinib ma ka ʻimi ʻana a me ka pale ʻana i nā protein kikoʻī i kapa ʻia he kinases e hana e like me nā kuapo i loko o nā sela maʻi. Ke hoʻā ʻia kēia mau kuapo, haʻi lākou i nā sela maʻi e ulu, mahele, a laha i kou kino.

E noʻonoʻo e like me ka ʻoki ʻana i nā laina mana i kahi hale hana - ke pale ʻo repotrectinib i kēia mau kuapo protein, ʻaʻole hiki i nā sela maʻi ke loaʻa nā hōʻailona e pono ai lākou e hoʻomau i ka ulu ʻana. Kōkua kēia i ka hoʻolohi ʻana a i ʻole ka hoʻōki ʻana i ka maʻi mai ka laha ʻana i nā ʻāpana ʻē aʻe o kou kino.

Ma ke ʻano he lāʻau lapaʻau i manaʻo ʻia, ua manaʻo ʻia ʻo repotrectinib he mea ikaika loa no nā ʻano genetic kikoʻī o ka maʻi ʻaʻai e mālama ai. Eia naʻe, ua hoʻolālā ʻia e ʻoi aku ka pololei ma mua o ka chemotherapy kuʻuna, e kālele ana i nā pūnaewele maʻi ʻaʻai ma mua o ka hoʻopilikia ʻana i nā pūnaewele e māhele wikiwiki ana i kou kino.

Pehea wau e lawe ai iā Repotrectinib?

E lawe ʻoe i ka repotrectinib ma ka waha, maʻamau hoʻokahi manawa i ka lā me ka ʻole o ka meaʻai. E hoʻomaka kāu kauka iā ʻoe ma kahi mahele kikoʻī e pili ana i kou kūlana pilikino, a he mea nui e lawe iā ia i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i kou kino.

E ale i nā capsules holoʻokoʻa me ke aniani wai piha - mai ʻoki, nau, a wehe paha iā lākou. Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai, akā ʻaʻole e hoʻololi i nā capsules iā lākou iho.

Hiki iā ʻoe ke lawe i ka repotrectinib me nā meaʻai a i ʻole ma ka ʻōpū ʻole, ʻo ia ka mea e ʻoluʻolu ai iā ʻoe. ʻIke kekahi poʻe i ka lawe ʻana me ka meaʻai e kōkua i ka hōʻemi ʻana i ka ʻōpū, a ʻo nā mea ʻē aʻe e makemake e lawe iā ia ma ka ʻōpū ʻole no ka maikaʻi o ka absorption.

Inā luaʻi ʻoe ma hope koke o ka lawe ʻana i kāu mahele, mai lawe i kahi mahele hou i kēlā lā. E hoʻomau wale me kāu papa manawa maʻamau i ka lā aʻe a e haʻi i kāu kauka i ka mea i hana ʻia.

Pehea ka lōʻihi e lawe ai au iā Repotrectinib?

E hoʻomau ʻoe i ka lawe ʻana iā repotrectinib i ka wā e kōkua ana i ka mālama ʻana i kāu maʻi ʻaʻai a ke ʻae maikaʻi nei ʻoe iā ia. ʻAʻole like me kekahi mau lāʻau lapaʻau āu e lawe ai no ka helu kikoʻī o nā lā a i ʻole nā pule, ʻo ka mālama ʻana i ka maʻi ʻaʻai e hoʻomau pinepine ʻia no nā mahina a i ʻole nā makahiki.

E nānā kāu kauka i kāu pane ma o nā scans maʻamau a me nā hoʻokolohua koko e ʻike i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. Inā hoʻomaka hou kāu maʻi ʻaʻai e ulu a i ʻole e hoʻomohala ʻoe i nā hopena ʻaoʻao paʻakikī loa e mālama ai, hiki i kāu kauka ke hoʻoponopono i kāu mahele a i ʻole e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe.

Hiki i kekahi poʻe ke lawe i ka repotrectinib no nā mahina he nui me nā hopena maikaʻi, aʻo nā mea ʻē aʻe e pono paha e hooki koke ma muli o nā hopena ʻaoʻao a i ʻole nā loli i kā lākou maʻi maʻi. E kū hoʻokahi kāu manawa lapaʻau i kāu kūlana a me ke ʻano o ka pane ʻana o kou kino i ka lāʻau.

He aha nā hopena ʻaoʻao o Repotrectinib?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka repotrectinib ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā mea a pau e ʻike iā lākou. ʻO nā hopena ʻaoʻao maʻamau ka mea maʻamau e mālama ʻia me ka nānā pono ʻana a me ka mālama kākoʻo mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao āu e ʻike ai, e hoʻomaka ana me nā mea maʻamau:

• Luhi a me ka manaʻo luhi ma mua o ka maʻamau
• Nausea a me nā loli i ka ʻai
• Pāpaʻa a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū
• ʻO ka wili a i ʻole ka manaʻo māmā
• Nā loli i ka ʻono (ʻokoʻa paha nā meaʻai)
• ʻO ka pehu ʻana i kou mau lima, nā wāwae, a i ʻole nā wāwae
• ʻO ka ʻeha ʻiʻo a i ʻole ka hui
• ʻO ke poʻo

ʻO kēia mau hopena ʻaoʻao maʻamau ka mea maʻamau i ka maʻalahi a i ka maʻalahi a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu hui mālama ola ke hōʻike i nā ala e mālama ai i kēia mau hōʻailona a kōkua iā ʻoe e ʻoluʻolu.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e pono ai ka lāʻau lapaʻau koke. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike iā lākou:

• Nā pilikia hanu koʻikoʻi a i ʻole ka pōkole o ka hanu
• ʻEha umauma a i ʻole ka puʻuwai ʻole
• Nā hōʻailona o nā pilikia o ke ake (melemele o ka ʻili a i ʻole nā maka, mimi ʻeleʻele, ʻeha ʻōpū nui)
• ʻO ka wili nui a i ʻole ka hāʻule
• Nā hōʻailona o ka maʻi (fiva, nā anu, ka ʻū mau)
• Ke kahe ʻana a i ʻole ka ʻeha ʻana

Inā ʻike ʻoe i kekahi o kēia mau hōʻailona koʻikoʻi, e kelepona koke i kāu mea mālama ola a i ʻole e ʻimi i ka lāʻau lapaʻau pilikia. ʻO kou palekana ka mea nui, a aia kāu hui lapaʻau e kōkua iā ʻoe ma nā pilikia.

ʻO wai ka mea pono ʻole e lawe i ka Repotrectinib?

ʻAʻole kūpono ʻo Repotrectinib no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Hiki i kekahi mau maʻi olakino a i ʻole nā lāʻau lapaʻau ke hoʻemi i ka palekana a i ʻole ka pono o repotrectinib no ʻoe.

Pono ʻoe e kūkākūkā i kēia mau mea me kāu hui mālama ola ma mua o ka hoʻomaka ʻana i ka mālama ʻana:

• Maʻi ate koʻikoʻi a i ʻole nā pilikia o ka hana ate
• Nā maʻi puʻuwai a i ʻole nā maʻi puʻuwai koʻikoʻi
• Hāpai i kēia manawa a i ʻole nā hoʻolālā e hāpai
• Hānai ʻana a i ʻole nā hoʻolālā e hānai
• Maʻi kīkī koʻikoʻi
• Ke lawe nei i kekahi mau lāʻau lapaʻau e launa pū me repotrectinib

Inā ʻoe i ka makahiki hānau keiki, e kūkākūkā kāu kauka i nā ʻano hana hoʻomalu hānau kūpono no ka mea hiki i ka repotrectinib ke hōʻeha i kahi pēpē e ulu ana. Pono nā kāne a me nā wahine e hoʻohana i ka contraception hilinaʻi i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope o ka hoʻōki ʻana i ka lāʻau.

E nānā pū kāu kauka i kāu mau lāʻau lapaʻau i kēia manawa, me nā lāʻau lapaʻau a me nā mea hoʻohui, e nānā i nā pilina hiki. Hiki i kekahi mau lāʻau lapaʻau ke hoʻopilikia i ka hana ʻana o repotrectinib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao.

Nā inoa inoa inoa ʻo Repotrectinib

Loaʻa ʻo Repotrectinib ma lalo o ka inoa inoa ʻo Augtyro. ʻO kēia ka inoa kalepa āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau.

No ka mea he lāʻau lapaʻau hou ʻo repotrectinib, i kēia manawa aia wale nō ma ke ʻano inoa inoa. Hiki ke loaʻa nā mana generic i ka wā e hiki mai ana, akā i kēia manawa, ʻo Augtyro wale nō ke ʻano o ka repotrectinib ma ka mākeke.

Ke kūkākūkā ʻana i kāu mālama ʻana me nā mea mālama ola a i ʻole nā hui ʻinikua, hiki iā lākou ke kuhikuhi i ka inoa generic (repotrectinib) a i ʻole ka inoa inoa (Augtyro), akā he lāʻau lapaʻau like lākou.

Nā koho ʻē aʻe ʻo Repotrectinib

Inā ʻaʻole kūpono ʻo repotrectinib iā ʻoe, aia kekahi mau lāʻau lapaʻau i manaʻo ʻia he mau koho ʻē aʻe e pili ana i ke ʻano genetic o kāu maʻi ʻaʻai. E kōkua kāu oncologist e hoʻoholo i nā koho ʻē aʻe e hana maikaʻi loa no kou kūlana.

No nā maʻi ʻaʻai māmā ROS1-positive, nā lāʻau lapaʻau i manaʻo ʻia e komo pū ana:

• Crizotinib (Xalkori) - hoʻohana pinepine ʻia ma ke ʻano he lapaʻau laina mua
• Ceritinib (Zykadia) - he koho ʻē aʻe no nā maʻi ʻaʻai ROS1-positive
• Entrectinib (Rozlytrek) - hana no nā hui ROS1 a me NTRK

No nā maʻi ʻaʻai NTRK fusion-positive, ʻo entrectinib (Rozlytrek) kekahi koho i manaʻo ʻia e hana like me repotrectinib. Hiki i kāu kauka ke noʻonoʻo i ka immunotherapy a i ʻole ka chemotherapy kuʻuna e pili ana i kou olakino holoʻokoʻa a me ka mōʻaukala lapaʻau.

ʻO ke koho ma waena o kēia mau koho ʻē aʻe e pili ana i nā mea e like me kāu mau lapaʻau mua, ke olakino holoʻokoʻa, ka ʻae ʻana i nā hopena ʻaoʻao, a me ke ʻano o ka pane ʻana o kāu maʻi ʻaʻai i nā lāʻau lapaʻau ʻē aʻe. E hana pū kāu oncologist me ʻoe e ʻimi i ka hoʻolālā lapaʻau kūpono loa.

Ua ʻoi aku ka maikaʻi o Repotrectinib ma mua o Crizotinib?

Hoʻomaʻamaʻa ʻo Repotrectinib a me crizotinib i nā maʻi ʻaʻai māmā ROS1-positive, akā hana lākou i nā ʻano like ʻole a hoʻohana pinepine ʻia i nā pae lapaʻau like ʻole. Hoʻohana pinepine ʻia ʻo Crizotinib ma ke ʻano he lāʻau lapaʻau i manaʻo ʻia mua, aʻo repotrectinib e mālama ʻia no ka wā i pau ai nā lapaʻau ʻē aʻe i ka hana.

Hōʻike ka noiʻi e ʻoi aku ka maikaʻi o repotrectinib no nā maʻi ʻaʻai i kūkulu i ke kūʻē ʻana iā crizotinib. ʻO ia hoʻi, inā ua ulu kāu maʻi ʻaʻai me ka mālama ʻana iā crizotinib, he koho maikaʻi paha ʻo repotrectinib iā ʻoe.

Ua hoʻolālā ʻia ʻo Repotrectinib e hana maikaʻi i ka maʻi ʻaʻai i laha i ka lolo, he mea nui ia no kekahi mau maʻi. Eia naʻe, loaʻa i nā lāʻau lapaʻau ʻelua kā lākou mau hopena ʻaoʻao a me nā mea e noʻonoʻo ai.

E noʻonoʻo kāu kauka i kāu mōʻaukala lapaʻau, ke kūlana olakino o kēia manawa, a me ke ʻano o ka pane ʻana o kāu maʻi maʻi i nā lāʻau lapaʻau ma mua i ka wā e hoʻoholo ai ma waena o kēia mau koho. ʻAʻole maikaʻi loa kekahi lāʻau lapaʻau - pili ka koho maikaʻi loa i kou mau kūlana pilikino.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Repotrectinib

He palekana anei ʻo Repotrectinib no ka poʻe me nā pilikia o ka naʻau?

Hiki i ka Repotrectinib ke hoʻopilikia i ka puʻuwai o kekahi poʻe, no laila e loiloi pono kāu kauka i kou olakino puʻuwai ma mua o ke kau ʻana. Inā he pilikia kou puʻuwai, pono ʻoe e nānā pono i ka wā o ka lapaʻau.

E hana paha kāu hui mālama ola i ka electrocardiogram (EKG) ma mua o ka hoʻomaka ʻana i ka lapaʻau a me kēlā me kēia manawa i ka wā o ka lāʻau lapaʻau e nānā i kou puʻuwai. Hiki iā lākou ke nānā i kāu pae electrolyte, no ka mea, hiki i nā kaulike ʻole ke hoʻopilikia i ke ʻano o ka hopena o ka lāʻau lapaʻau i kou puʻuwai.

Inā he mōʻaukala kou o nā maʻi puʻuwai, hiki i kāu kauka ke ʻōlelo aku e hoʻomaka me ka haʻahaʻa haʻahaʻa a i ʻole e hōʻike i kahi koho lapaʻau ʻē aʻe. He mea nui ka kamaʻilio hāmama e pili ana i kāu mōʻaukala olakino puʻuwai no ka lapaʻau palekana.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o Repotrectinib?

Inā ua lawe hewa ʻoe i ka nui o ka repotrectinib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole ke kikowaena mana ʻawaʻawa. Mai kali e ʻike inā ʻoe e ʻike i nā hōʻailona - he mea nui ka loaʻa ʻana o ke alakaʻi wikiwiki no kou palekana.

I ka wā e kali ana i ka ʻōlelo aʻo lapaʻau, e pale i ka lawe ʻana i nā lāʻau lapaʻau hou a e hoʻāʻo e hoʻomanaʻo pono i ka nui o ka mea āu i lawe ai a me ka manawa. E kōkua kēia ʻike i nā mea mālama ola e hoʻoholo i ke ala maikaʻi loa o ka hana.

ʻO nā hōʻailona e hōʻike ana ua lawe paha ʻoe i ka nui, ʻo ia ka ʻūlū nui, ka ʻūlū, ka puʻuwai wikiwiki, a i ʻole ka nausea nui. Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​e ʻimi koke i ka mālama olakino pilikia.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Repotrectinib?

Inā ua hala ʻoe i ka lāʻau a ua hala ma lalo o 12 hola mai kou manawa maʻamau, e lawe koke aku i ka lāʻau ke hoʻomanaʻo ʻoe. Akā naʻe, inā ua hala ma mua o 12 hola, e lele i ka lāʻau i hala a e lawe i kāu lāʻau aʻe i ka manawa maʻamau.

Mai lawe i ʻelua lāʻau i ka manawa hoʻokahi e pani i ka lāʻau i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. ʻOi aku ka maikaʻi o ka lele ʻana i hoʻokahi lāʻau ma mua o ka pāpālua ʻana a me ka hiki ke hōʻeha.

E noʻonoʻo e hoʻonohonoho i kahi ʻala i kēlā me kēia lā a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo i kāu lāʻau. ʻO ka hoʻomau ʻana i ka manawa e kōkua i ka mālama ʻana i nā pae paʻa o ka lāʻau i loko o kou kino no nā hopena maikaʻi loa.

Iāhea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Repotrectinib?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana iā repotrectinib me ka ʻole e kūkākūkā mua me kāu oncologist. ʻOiai inā ʻoe e manaʻo maikaʻi ana a i ʻole e ʻike ana i nā hopena ʻaoʻao, ʻo ka hooki ʻana koke ʻana hiki ke ʻae i kāu maʻi ʻaʻai e hoʻomaka hou e ulu.

E loiloi mau kāu kauka i ka maikaʻi o ka hana ʻana o ka lāʻau ma o nā scans a me nā hoʻokolohua koko. Inā hooki kāu maʻi ʻaʻai i ka pane ʻana iā repotrectinib a i ʻole inā e hoʻomohala ʻoe i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, e hana lākou me ʻoe e hoʻololi i kahi hoʻolālā lapaʻau ʻokoʻa.

Ke hoʻomau nei kekahi poʻe i ka lawe ʻana iā repotrectinib no nā mahina he nui a i ʻole nā makahiki inā e kāohi maikaʻi ana i kā lākou maʻi ʻaʻai. Pono paha kekahi poʻe e hooki koke ma muli o ka holomua a i ʻole nā hopena ʻaoʻao. E hoʻopilikino ʻia kāu manawa lapaʻau e pili ana i kāu pane a me ke olakino holoʻokoʻa.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Repotrectinib?

ʻOi aku ka maikaʻi o ka kaupalena ʻana i ka ʻai ʻana i ka waiʻona i ka wā e lawe ana iā repotrectinib, no ka mea, hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka noʻonoʻo ʻole a me ka luhi. Eia kekahi, ua hana ʻia ka waiʻona a me ka repotrectinib e kou ate, no laila, ʻo ka inu ʻana e pili paha i ka maikaʻi o kou kino e mālama ai i ka lāʻau.

Inā koho ʻoe e inu i kekahi manawa, e hana pēlā me ke ana a e nānā i kou manaʻo. ʻIke kekahi poʻe i ka liʻiliʻi o ka waiʻona e ʻoi aku ka luhi a i ʻole ka wili ʻana ma mua o ka maʻamau i ka wā e lawe ana i ka repotrectinib.

E kūkākūkā mau i kāu hoʻohana ʻana i ka waiʻona me kāu hui mālama ola i hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kou olakino holoʻokoʻa a me ka pane ʻana i ka lāʻau. Hiki iā lākou ke kōkua iā ʻoe e hana i nā koho palekana loa no kou kūlana.