He aha ka Rifampin a me Isoniazid: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Rifampin a me isoniazid he lāʻau lapaʻau hui e hakakā ana i nā maʻi tuberculosis (TB). Hana pū kēia mau lāʻau antibiotic ikaika ʻelua e pepehi i ka bacteria e hoʻoulu ai i ka TB, e hana ana i ka mālama ʻana i ʻoi aku ka maikaʻi ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau.

ʻO kēia hui pū ʻana he kumu nui ia o ka mālama ʻana i ka TB no nā makahiki he nui. Ua kauoha kāu kauka iā ia no ka mea he paʻakikī loa ka bacteria TB a pono i nā lāʻau lapaʻau he nui e pale iā lākou mai ka hoʻomohala ʻana i ke kūpaʻa i ka mālama ʻana.

He aha ka Rifampin a me Isoniazid?

Hoʻohui ʻo Rifampin a me isoniazid i ʻelua mau lāʻau anti-TB i hoʻokahi pila maʻalahi. No ka papa o nā antibiotics i kapa ʻia ʻo rifamycins ʻo Rifampin, ʻoiai ʻo isoniazid he ʻāpana o ka ʻohana hydrazide o nā lāʻau anti-TB.

ʻO ka hui pū ʻana, hana kēia mau lāʻau lapaʻau i kahi paʻi ikaika hoʻokahi-ʻelua e kūʻē i ka bacteria TB. Hoʻopilikia ʻo Rifampin i ka hiki o ka bacteria ke hana i nā protein koʻikoʻi, ʻoiai ʻo isoniazid e pale iā lākou mai ke kūkulu ʻana i ko lākou mau paia cell pale.

Hele mai kēia hui pū ʻana i ke ʻano papa a lawe ʻia i hoʻokahi manawa i ka lā. Loaʻa ka lāʻau lapaʻau i nā ikaika like ʻole e kūlike i kāu mau pono lapaʻau kikoʻī e pili ana i kou kaumaha a me ke koʻikoʻi o kāu maʻi.

No ke aha e hoʻohana ʻia ai ka Rifampin a me Isoniazid?

Hoʻomaʻamaʻa kēia lāʻau lapaʻau hui i nā maʻi tuberculosis ikaika a kōkua i ka pale ʻana i ka TB i ka poʻe i hōʻike ʻia i ka bacteria. Hiki i kāu kauka ke kauoha iā ia inā loaʻa iā ʻoe ka maʻi TB e pili ana i kou mau māmā, nā lymph nodes, a i ʻole nā ​​ʻāpana ʻē aʻe o kou kino.

He mea maikaʻi loa ka lāʻau lapaʻau no ka mālama ʻana i ka pulmonary TB, e pili ana i nā māmā a ʻo ia ke ʻano maʻamau o ka maʻi. Hiki iā ia ke mālama i ka extrapulmonary TB, e kū mai ana ke laha ka maʻi ma waho o nā māmā i nā ʻōkana ʻē aʻe.

I kekahi manawa, kuhikuhi nā kauka i kēia hui ʻana no ka maʻi TB latent, kahi e lawe ai ʻoe i ka bacteria akā ʻaʻole ʻoe e maʻi. ʻO ka mālama ʻana i ka TB latent e pale ai i ka lilo ʻana i maʻi ikaika ma hope o ke ola.

Hiki nō hoʻi i kāu mea mālama ola ke ʻōlelo aku i kēia lāʻau lapaʻau inā ua pili kokoke ʻoe me kekahi mea i loaʻa ka TB ikaika, ʻoiai inā he mau mea pilikia kāu e hiki ai iā ʻoe ke loaʻa i ka maʻi.

Pehea e Hana ai ʻo Rifampin a me Isoniazid?

Hana kēia hui ʻana ma ka hoʻouka ʻana i ka bacteria TB ma o nā ʻano hana ʻelua, e paʻakikī ai i nā germs ke ola a hoʻonui. Kāohi ʻo Rifampin i kahi enzyme i kapa ʻia ʻo RNA polymerase e pono ai ka bacteria TB e hana i nā protein e pono ai no ko lākou ola.

Hoʻopā ʻo Isoniazid i kahi ʻāpana ʻokoʻa o ka ʻōnaehana ola o ka bacteria ma ka pale ʻana iā lākou mai ka hana ʻana i ka waikawa mycolic, kahi mea nui o ko lākou paia cell. Me ka ʻole o ka paia cell ikaika, nāwaliwali ka bacteria a make hope loa.

ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau ʻelua e hana i ka mea a nā kauka e kapa ai he

Inā pilikia kou ʻōpū, hiki iā ʻoe ke lawe i ka lāʻau me ka meaʻai liʻiliʻi, akā e hōʻemi iki paha kēia i kona pono. Manaʻo kekahi poʻe e kōkua ka lawe ʻana me nā pahū a i ʻole ka toast e hōʻemi i ka nausea.

E hoʻāʻo e lawe i kāu lāʻau i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i loko o kou kahe koko. Hiki i ka hoʻonohonoho ʻana i kahi alarm i kēlā me kēia lā ke kōkua iā ʻoe e hoʻomanaʻo, ʻoiai pono ka mālama ʻana i ka TB i ka hoʻohana mau ʻana no nā mahina he nui.

E hōʻalo i ka waiʻona i ka wā e lawe ana i kēia lāʻau, no ka mea, hiki i ka rifampin a me ka isoniazid ke hoʻopilikia i kou ate, a hoʻonui ka waiʻona i kēia pilikia. E nānā paha kāu kauka i kāu hana ate me nā hoʻokolohua koko maʻamau.

Pehea ka lōʻihi e lawe ai au i ka Rifampin a me ka Isoniazid?

Lawe ka hapa nui o nā kānaka i kēia hui ʻana no ʻeono a ʻeiwa mahina, ma muli o ke ʻano a me ke koʻikoʻi o kā lākou maʻi TB. E hoʻoholo kāu kauka i ka lōʻihi pololei e pili ana i kāu kūlana kikoʻī a me ka maikaʻi o kāu pane ʻana i ka lāʻau.

No ka TB pulmonary ikaika, ʻo ke ʻano lapaʻau maʻamau he ʻeono mahina, a ʻo ka TB extrapulmonary e koi aku i ka lapaʻau lōʻihi. Pono paha ka poʻe me ka TB kūʻē i ka lāʻau a i ʻole nā ​​pūnaehana pale i hoʻopilikia ʻia i ka lāʻau lōʻihi.

He mea nui e hoʻopau i ke ʻano lapaʻau holoʻokoʻa, ʻoiai inā hoʻomaka ʻoe e maikaʻi ma hope o kekahi mau pule. ʻO ka hooki ʻana i ka wā mua hiki ke ʻae i ka bacteria e ola nei e hoʻonui a hiki ke hoʻomohala i ke kūʻē ʻana i nā lāʻau.

E nānā kāu kauka i kāu holomua me nā nānā maʻamau a hiki ke hoʻololi i ka lōʻihi o kāu lapaʻau e pili ana i ka maikaʻi o ka pane ʻana o ka maʻi. Pono paha kekahi poʻe i nā mahina hou o ka lapaʻau inā paʻakikī ko lākou TB.

He aha nā hopena ʻaoʻao o Rifampin a me Isoniazid?

E like me nā lāʻau lapaʻau a pau, hiki i ka rifampin a me ka isoniazid ke hana i nā hopena ʻaoʻao, ʻoiai e ʻae maikaʻi ka nui o nā kānaka. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka wā e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a maʻa mau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Eia nā hopena āu e ʻike nui ai:

• ʻO ke kala ʻalani a ʻulaʻula paha o kou mimi, nā waimaka, ka wai, a me ka hou
• ʻO ka nausea maʻalahi a i ʻole ka ʻōpū
• Ka nalowale o ka ʻai
• ʻO ke poʻo maʻalahi
• ʻO ka wili
• ʻO ka luhi a i ʻole ka manaʻo e luhi pinepine

He maʻamau a palekana loa ka hoʻololi ʻana i ke kala ʻalani, ʻoiai hiki iā ia ke hoʻoluhi i nā aniani pili a me nā lole. E nalowale kēia hopena ke hooki ʻoe i ka lawe ʻana i ka lāʻau.

ʻOiai ʻaʻole maʻamau, ʻike kekahi poʻe i nā hopena ʻaoʻao nui e pono ai ka mālama ʻana i ka lāʻau. Hiki kēia i kahi pākēneka liʻiliʻi o nā maʻi akā he mea nui e ʻike:

• ʻO ka nausea mau a me ka luaʻi
• ʻO ka ʻeha nui o ka ʻōpū
• ʻO ka melemele o ka ʻili a i ʻole nā maka (jaundice)
• ʻO ka mimi ʻeleʻele ma mua o ke kala ʻalani i manaʻo ʻia
• ʻO ka nāwaliwali a i ʻole ka luhi maʻamau
• ʻO ka ʻeha a i ʻole ka ʻūlū ʻana i nā lima a i ʻole nā wāwae
• ʻO ke kuni mau a i ʻole nā hōʻailona e like me ka maʻi flu

Hiki i kēia mau hōʻailona ke hōʻike i nā pilikia o ke ake a i ʻole ka pōʻino o ke aʻalolo, ʻo ia nā pilikia kakaʻikahi akā koʻikoʻi e pono ai ka loiloi olakino koke.

I nā manawa kakaʻikahi, ʻike paha kekahi poʻe i nā hopena maʻi maʻi koʻikoʻi a i ʻole ka pōʻino nui o ke ake. ʻOiai ʻo kēia mau pilikia koʻikoʻi e pili ana i ka liʻiliʻi ma mua o 1% o nā maʻi, pono lākou i ka mālama olakino pilikia inā loaʻa lākou.

ʻO wai ka mea ʻaʻole pono e lawe iā Rifampin a me Isoniazid?

Pono kekahi poʻe e pale i kēia lāʻau hui ʻana ma muli o ka piʻi ʻana o nā pilikia. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana i kēia lapaʻau.

ʻAʻole pono ka poʻe me ka maʻi ate koʻikoʻi a i ʻole ka moʻolelo o nā pilikia o ke ake e lawe i kēia hui ʻana, no ka mea, hiki i nā lāʻau ʻelua ke hoʻopilikia i ka hana o ke ake. Inā loaʻa iā ʻoe ka hepatitis a i ʻole nā maʻi ate ʻē aʻe, hiki i kāu kauka ke koho i nā lāʻau ʻē aʻe.

ʻAʻole i ʻōlelo ʻia kēia lāʻau lapaʻau i ka wā e hāpai ana, ʻoiai i ka trimester mua, ke ʻole ka maikaʻi e ʻoi aku ka nui ma mua o nā pilikia. Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, e kūkākūkā i nā koho palekana me kāu mea mālama ola.

ʻAʻole pono ka poʻe i loaʻa i ka maʻi maʻi nui i ka rifampin a i ʻole isoniazid e lawe i kēia hui pū ʻana. ʻO ka poʻe me kekahi mau maʻi genetic e pili ana i ke ʻano o ke kino e hana ai i kēia mau lāʻau lapaʻau e pono paha i nā lāʻau lapaʻau like ʻole.

Inā loaʻa iā ʻoe ka maʻi kīkī, ka maʻi diabetes, a i ʻole e lawe i kekahi mau lāʻau lapaʻau ʻē aʻe, pono paha i kāu kauka e hoʻoponopono i kāu mahele a i ʻole e nānā pono iā ʻoe. Hiki i kekahi mau pilina lāʻau lapaʻau ke koʻikoʻi, no laila e haʻi mau i kāu mea mālama ola e pili ana i nā lāʻau lapaʻau a pau āu e lawe nei.

Nā inoa inoa o Rifampin a me Isoniazid

ʻO ka inoa inoa maʻamau no kēia hui pū ʻana ʻo Rifamate, i loaʻa nui ma ʻAmelika Hui Pū ʻIa. Aia kēia inoa i ka rifampin a me ka isoniazid i nā mahele i hoʻopaʻa ʻia i hoʻolālā ʻia no ka maʻalahi o ka hoʻohana ʻana i hoʻokahi manawa i ka lā.

I kekahi mau ʻāina, hiki iā ʻoe ke loaʻa kēia hui pū ʻana ma lalo o nā inoa inoa like ʻole, ʻoiai e mau ana nā mea hana. Hiki i kāu kauka lāʻau ke kōkua iā ʻoe e ʻike i nā huahana like inā e hele ana ʻoe a pono paha e hoʻopiha i nā palapala kauoha ma nā wahi like ʻole.

Loaʻa nō hoʻi nā mana generic o ka rifampin a me ka isoniazid a hana like ka maikaʻi e like me nā mana inoa. ʻO kēia mau koho generic e uku pinepine i ka liʻiliʻi ʻoiai e hāʻawi ana i nā pono therapeutic like.

Nā koho ʻē aʻe o Rifampin a me Isoniazid

Inā ʻaʻole hiki iā ʻoe ke lawe i ka rifampin a me ka isoniazid, hiki i kekahi mau lāʻau lapaʻau ʻē aʻe ke mālama pono i nā maʻi TB. E koho kāu kauka i ke koho maikaʻi loa e pili ana i kāu kūlana kikoʻī a me ka mōʻaukala olakino.

Hāʻawi ʻo Ethambutol i hui pū ʻia me nā lāʻau anti-TB ʻē aʻe i kahi koho maikaʻi no ka poʻe i hiki ʻole ke ʻae i ka rifampin a i ʻole isoniazid. Hana ʻokoʻa kēia hui pū ʻana akā hiki ke like ka maikaʻi no nā ʻano TB he nui.

No nā kānaka me ka TB kūʻē i ka lāʻau, pono paha nā lāʻau lapaʻau hou e like me ka bedaquiline a i ʻole linezolid. Hoʻokaʻawale ʻia kēia mau lapaʻau no nā hihia i hana ʻole ai ka lāʻau lapaʻau maʻamau a i ʻole ʻaʻole kūpono.

Pono paha kekahi poʻe e lawe i nā lāʻau lapaʻau pākahi i kaʻawale ma mua o ka hui pū ʻana. Hāʻawi kēia ala i nā hoʻoponopono ʻana i ka dosage pololei inā loaʻa iā ʻoe nā hopena ʻaoʻao mai kekahi mea akā ʻaʻole mai kekahi.

Ua ʻoi aku ka maikaʻi o ka Rifampin a me Isoniazid ma mua o nā lāʻau lapaʻau TB ʻē aʻe?

ʻO ka hui pū ʻana o Rifampin a me isoniazid ka maʻamau gula no ka mālama ʻana i ka TB no nā makahiki he nui ma muli o kona pono i hōʻoia ʻia a me ka hopena ʻaoʻao hiki ke mālama ʻia. Hōʻike mau nā haʻawina lapaʻau i nā helu hoʻōla kiʻekiʻe ke hoʻopau ka poʻe i ka papa lapaʻau piha.

Ke hoʻohālikelike ʻia me ka lawe ʻana i nā lāʻau lapaʻau ʻokoʻa he nui, hāʻawi kēia hui i ka maʻalahi o nā pila liʻiliʻi a me nā papa hana dosing i maʻalahi ʻia. ʻO kēia maʻalahi ke alakaʻi pinepine i ka hoʻokō maikaʻi ʻana, he mea nui ia no ka mālama ʻana i ka TB.

Eia naʻe, pili ka

Hiki i ka Rifampin ke launa pū me kekahi mau lāʻau lapaʻau maʻi diabetes, ʻo ia hoʻi nā mea i hana ʻia e ke akepaʻa. Pono paha kāu mea mālama ola e hoʻoponopono i nā ʻano lāʻau lapaʻau maʻi diabetes a i ʻole e nānā pono iā ʻoe i ka wā o ka mālama ʻana i ka TB.

Inā loaʻa iā ʻoe ka maʻi diabetes, e haʻi i kāu kauka ma mua o ka hoʻomaka ʻana i kēia hui pū ʻana. Hiki iā lākou ke kōkua iā ʻoe e hoʻomohala i kahi hoʻolālā nānā e hōʻoia i ka mālama ʻana i ka TB a me ka mālama ʻana i ka maʻi diabetes e noho ma ke ala.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Rifampin a me ka Isoniazid?

Inā lawe hewa ʻoe i ka nui ma mua o kāu kauoha, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi ka pōʻino o ke akepaʻa.

Mai ho'āʻo e hoʻopuka iā ʻoe iho ke ʻole i kuhikuhi ʻia e nā poʻe loea lapaʻau. Akā, e inu i ka wai nui a e ʻimi i ka lāʻau lapaʻau i kēia manawa, ʻoiai inā ʻoe e ʻike i ka nausea nui, ka luaʻi, a i ʻole ka ʻeha o ka ʻōpū.

E lawe mai i ka hue lāʻau lapaʻau me ʻoe i ka lumi pilikia i hiki i nā mea mālama ola ke ʻike pololei i ka mea a me ka nui āu i lawe ai. Hiki i ka lāʻau lapaʻau wikiwiki ke kōkua i ka pale ʻana a i ʻole ka hōʻemi ʻana i nā pilikia mai ka overdose.

He aha kaʻu e hana ai inā hala au i kahi mahele o Rifampin a me Isoniazid?

Inā hala ʻoe i kahi mahele, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, ke ʻole kokoke i ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i hala a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i nā alarms kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo.

ʻAʻole e hōʻino ka hala ʻana i nā mahele i kāu mālama ʻana, akā he mea nui ka kūlike no ka lāʻau lapaʻau TB. Inā hala ʻoe ma mua o kekahi mau mahele, e hoʻokaʻaʻike i kāu kauka e kūkākūkā pehea e hoʻi ai i ke ala me ka palekana.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Rifampin a me ka Isoniazid?

Mai hooki i ka lawe ʻana i kēia lāʻau lapaʻau me ka ʻae ʻole o kāu kauka, ʻoiai inā manaʻo ʻoe ua maikaʻi loa. Hiki i ka bacteria TB ke ola i loko o kou kino no nā mahina, a ʻo ka hooki ʻana i ka lāʻau lapaʻau i ka wā mua hiki ke alakaʻi i ka hāʻule ʻana o ka lāʻau lapaʻau a i ʻole ke kūpaʻa ʻana i ka lāʻau.

Na kāu kauka e hoʻoholo i ka manawa e palekana ai ke hooki ʻana ma muli o kāu pane ʻana i ka lāʻau lapaʻau, nā hoʻokolohua hahai, a me ke ʻano kikoʻī o ka TB āu i loaʻa. Pono ka hapa nui o nā kānaka e hoʻopau i ka liʻiliʻi o ʻeono mahina o ka lāʻau lapaʻau.

Inā lilo nā hopena ʻaoʻao i mea hiki ʻole ke ʻae ʻia, e kamaʻilio me kāu kauka e pili ana i ka hoʻoponopono ʻana i kāu lāʻau lapaʻau ma mua o ka hooki ʻana iā ʻoe iho. Hiki iā lākou ke hoʻololi i kāu mahele a i ʻole e hoʻololi iā ʻoe i nā lāʻau lapaʻau ʻē aʻe me ka hōʻoia ʻana e mau ana kāu lāʻau lapaʻau TB.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Rifampin a me Isoniazid?

Paipai ikaika ʻia e pale loa i ka waiʻona i ka wā e lawe ana i kēia hui pū ʻana o nā lāʻau lapaʻau. Hiki i ka rifampin a me ka isoniazid ke hoʻopilikia i kou ate, a hoʻonui nui ka waiʻona i ka pilikia o ka pōʻino ate koʻikoʻi.

Hiki i nā mea liʻiliʻi o ka waiʻona ke pilikia i ka hui pū ʻana me kēia mau lāʻau lapaʻau. ʻAʻole pono ka pilikia, ʻoiai ke mau nei ka lāʻau lapaʻau TB no nā mahina.

Inā he hopohopo kāu e pili ana i ka hoʻohana ʻana i ka waiʻona a i ʻole pono ke kākoʻo e pale aku i ka waiʻona i ka wā o ka lāʻau lapaʻau, e kūkākūkā ākea me kāu mea mālama ola. Hiki iā lākou ke hāʻawi i nā kumuwaiwai a me nā hoʻolālā e kōkua iā ʻoe e noho ʻole i ka waiʻona i ka wā o kāu lāʻau lapaʻau TB.