He aha ʻo Ripretinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Ripretinib e kōkua i ka mālama ʻana i kahi ʻano maʻi maʻi ʻōpū a me ka ʻōpū i kapa ʻia ʻo gastrointestinal stromal tumor (GIST). Hana kēia lāʻau lapaʻau waha ma ka pale ʻana i kekahi mau protein e hoʻoulu ai i ka ulu ʻana o nā cell maʻi, e hāʻawi ana i kou kino i ka manawa e hakakā ai i ka maʻi.

Inā ua kau ʻia ʻo ripretinib iā ʻoe a i ʻole kekahi āu e mālama ai, nui paha kāu mau nīnau e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai. ʻO ka hoʻomaopopo ʻana i kāu lāʻau lapaʻau hiki ke kōkua iā ʻoe e manaʻoʻiʻo e pili ana i kāu huakaʻi lapaʻau a hana i nā hoʻoholo i ʻike ʻia me kāu hui mālama ola.

He aha ʻo Ripretinib?

He lāʻau lapaʻau maʻi maʻi ʻo Ripretinib i kau ʻia e ke kauka e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo kinase inhibitors. E noʻonoʻo iā ia he lāʻau lapaʻau i manaʻo ʻia e ālai pono i nā hōʻailona e pono ai nā cell maʻi e ulu a hoʻonui.

ʻAʻole like me ka chemotherapy kuʻuna e pili ana i nā ʻano cell he nui, ua hoʻolālā ʻia ʻo ripretinib e kālele ana i nā cell maʻi me nā loli genetic kikoʻī. Hiki i kēia ala i manaʻo ʻia ke kōkua i ka hōʻemi ʻana i kekahi o nā hopena ʻaoʻao koʻikoʻi e pili ana me nā lāʻau lapaʻau maʻi ʻē aʻe.

Hele mai ka lāʻau lapaʻau ma ke ʻano o nā papa waha āu e lawe ai ma ka waha, e maʻalahi ai ma mua o nā lāʻau lapaʻau e koi ai i nā kipa i ka haukapila no nā infusions.

No ke aha i hoʻohana ʻia ai ʻo Ripretinib?

Ua ʻae ʻia ʻo Ripretinib e mālama i nā maʻi gastrointestinal stromal tumors (GIST) i holomua i mālama ʻia me ka liʻiliʻi o ʻekolu mau lāʻau lapaʻau kinase inhibitor. He ʻano maʻi maʻi ʻo GIST i ulu i loko o ka ʻōnaehana digestive, ʻo ka mea maʻamau i ka ʻōpū a i ʻole ka ʻōpū liʻiliʻi.

E kauoha wale kāu kauka iā ripretinib inā ua hoʻomau ka ulu ʻana a i ʻole ka laha ʻana o kāu GIST me ka mālama mua ʻana. Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau ʻehā, ʻo ia hoʻi, hoʻohana pinepine ʻia i ka wā i hana ʻole ai nā lāʻau lapaʻau maʻamau.

ʻAʻole hoʻohana ʻia ka lāʻau lapaʻau ma ke ʻano he koho lapaʻau mua, akā ma ke ʻano he ʻāpana o ke kaʻina o nā lāʻau lapaʻau i hoʻolālā ʻia e mālama i kāu maʻi maʻi no ka lōʻihi e hiki ai.

Pehea e Hana ai ʻo Ripretinib?

Hana ʻo Ripretinib ma ka pale ʻana i nā protein he nui i kapa ʻia ʻo kinases e hoʻohana ai nā sela maʻi maʻi e ulu a ola. Manaʻo ʻia he mea pale kinase ākea, ʻo ia hoʻi hiki iā ia ke kuhikuhi i nā ala like ʻole e hoʻoulu ai i ka ulu ʻana o GIST.

ʻO ka mea e hana ai ʻo ripretinib i mea maikaʻi loa, ʻo ia kona hiki ke hana kūʻē i nā sela maʻi maʻi i kū i ka pale ʻana i nā lāʻau lapaʻau ʻē aʻe. I ka wā lōʻihi, hiki i nā sela maʻi maʻi ke loli a loaʻa nā ala hou e ulu ai, akā ua hoʻolālā ʻia ʻo ripretinib e ālai i kēia mau ala ʻē aʻe.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika, me nā hopena e hiki ke kōkua i ka hoʻolohi ʻana i ka holomua o ka maʻi maʻi i ka wā e hiki ai ke mālama ʻia no ka hapa nui o nā maʻi ke nānā pono ʻia.

Pehea e Lawe ai au i ka Ripretinib?

E lawe i ka ripretinib e like me ke kauoha a kāu kauka, maʻamau i hoʻokahi manawa i ka lā me ka meaʻai. ʻO ka lawe ʻana me ka ʻai e kōkua i kou kino e komo maikaʻi i ka lāʻau lapaʻau a hiki ke hōʻemi i ka ʻōpū.

Hiki iā ʻoe ke lawe i ka ripretinib me kekahi meaʻai maʻamau, akā e hoʻāʻo e lawe iā ia i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i loko o kāu ʻōnaehana. ʻAʻohe pono e pale i nā meaʻai kikoʻī, akā ʻo ka mālama ʻana i ka meaʻai kaulike e kōkua iā ʻoe e manaʻo maikaʻi i ka wā o ka mālama ʻana.

E ale i nā papa holoʻokoʻa me ka wai - mai ʻoki, haki, a nau paha iā lākou. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai.

Pehea ka lōʻihi e lawe ai au i ka Ripretinib?

E hoʻomau ʻoe i ka lawe ʻana i ka ripretinib no ka lōʻihi e kōkua ana i ka mālama ʻana i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe. Hiki i kēia ke mau mahina a i ʻole mau makahiki, ma muli o ke ʻano o kou kino e pane ai i ka lāʻau lapaʻau.

E nānā kāu kauka i kou holomua ma o nā scans maʻamau a me nā hoʻokolohua koko e ʻike ai i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. E nānā pū lākou i nā hopena ʻaoʻao e pono ai ka hoʻololi ʻana i kāu hoʻolālā lapaʻau.

Mai hooki i ka lawe ʻana iā ripretinib me ka ʻole e kūkākūkā mua me kāu hui mālama ola. ʻOiai inā maikaʻi kou manaʻo, hiki nō i ka lāʻau lapaʻau ke hana nei e mālama i kāu maʻi maʻi.

He aha nā hopena ʻaoʻao o Ripretinib?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka ripretinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i ʻike nā kānaka a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ke kākoʻo kūpono a me ka nānā ʻana mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e hiki ai iā ʻoe ke ʻike:

• Luhi a me ka luhi maʻalahi ma mua o ka maʻamau
• Ka nalowale o ka lauoho a i ʻole ka lahilahi, he mea pōkole maʻamau
• Nausea a me ka emi ʻana o ka ʻai
• Diarrhea a i ʻole nā ​​hoʻololi i nā neʻe ʻana o ka ʻōpū
• ʻO ka ʻeha ʻiʻo a me nā hui
• ʻO ka ʻili ʻili a i ʻole ka ʻili maloʻo
• ʻO ka pehu ʻana i nā lima, nā wāwae, a i ʻole a puni nā maka

ʻO kēia mau hopena ʻaoʻao maʻamau he maʻalahi a me ka maʻalahi a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

ʻOiai ʻaʻole maʻamau, pono kekahi mau hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke a hiki ke hana ʻia i kahi pākēneka liʻiliʻi o nā maʻi:

• Nā pilikia ate koʻikoʻi, e nānā kāu kauka ma o nā hoʻokolohua koko
• Nā hoʻololi ʻana i ka puʻuwai e hiki ke ʻike ʻia ma ka electrocardiogram
• Nā hopena ʻili koʻikoʻi me ka ʻōpala a i ʻole ka ʻili
• Nā hōʻailona o ka maʻi ma muli o ka helu haʻahaʻa o ke keʻokeʻo koko
• Ke kahe ʻana a i ʻole ka ʻeha maʻamau

E nānā pono kāu hui mālama ola iā ʻoe no kēia mau hopena koʻikoʻi a hoʻoponopono i kāu lapaʻau inā pono.

ʻO wai ka mea ʻaʻole pono e lawe iā Ripretinib?

ʻAʻole kūpono ʻo Ripretinib no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. Pono paha ka poʻe me kekahi mau maʻi puʻuwai i ka nānā hou ʻana a i ʻole nā ​​lapaʻau ʻē aʻe.

Pono ʻoe e kūkākūkā i kāu mōʻaukala olakino piha me kāu kauka, ʻoiai inā he maʻi ate kou, nā pilikia o ka naʻau, a i ʻole ka mōʻaukala o nā maʻi koko. ʻAʻole pono kēia mau kūlana e pale iā ʻoe mai ka lawe ʻana i ka ripretinib, akā pono lākou i ka nānā pono.

Inā hāpai ʻoe, e hoʻolālā ana e hāpai, a i ʻole e hānai ana i ka waiū, ʻaʻole ʻōlelo ʻia ka ripretinib no ka mea hiki ke hōʻino i kahi pēpē e ulu ana. E kūkākūkā kāu kauka i nā koho mana hānau kūpono me ʻoe i ka wā o ka mālama ʻana.

Inoa Brand Ripretinib

Kūʻai ʻia ʻo Ripretinib ma lalo o ka inoa brand Qinlock. Inā ʻōlelo kāu kauoha lapaʻau

Hōʻike nā haʻawina he ʻoi aku ka maikaʻi o ka ripretinib ma mua o ka regorafenib i nā maʻi i holomua ko lākou maʻi ma hope o nā lāʻau lapaʻau he nui. He ʻokoʻa nō hoʻi ka hopena ʻaoʻao o ka ripretinib, a ʻoi aku ka maikaʻi o kekahi mau maʻi.

Na kāu kauka e hoʻoholo i ke kaʻina o nā lāʻau lapaʻau maikaʻi loa e pili ana i nā ʻano maʻi kikoʻī a me ke ʻano o kou pane ʻana i nā lāʻau lapaʻau ma mua.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana i ka Ripretinib

He Palekana anei ka Ripretinib no ka poʻe me ka maʻi puʻuwai?

Hiki i ka Ripretinib ke hoʻopilikia i ka puʻuwai, no laila pono ka poʻe me nā maʻi puʻuwai e nānā pono. E hana paha kāu kauka i ka electrocardiogram (ECG) ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a me ka wā o ka lāʻau lapaʻau.

Inā loaʻa iā ʻoe ka maʻi puʻuwai, ʻaʻole ia e kāpae iā ʻoe mai ka lawe ʻana i ka ripretinib, akā e hana pū kāu cardiologist a me ka oncologist e hōʻoia i kou palekana. Hiki iā lākou ke hoʻoponopono i kāu mahele lāʻau a i ʻole e nānā pinepine iā ʻoe.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Ripretinib?

Inā lawe hewa ʻoe i ka nui o kāu mahele lāʻau i kuhikuhi ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā maikaʻi ʻoe, no ka mea, ʻaʻole ʻike koke ʻia kekahi mau hopena o ka overdose.

E lawe mai i kāu ʻōmole lāʻau lapaʻau me ʻoe inā pono ʻoe e hele i ka lumi pilikia, no ka mea, e kōkua kēia i nā mea mālama ola e hoʻomaopopo pono i ka mea āu i lawe ai a me ka manawa.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele lāʻau o Ripretinib?

Inā haʻalele ʻoe i kahi mahele lāʻau a ua hala ma lalo o 8 mau hola mai kou manawa maʻamau, e lawe koke iā ia ke hoʻomanaʻo ʻoe. Inā ua hala ma mua o 8 mau hola, e lele i ka mahele lāʻau i haʻalele ʻia a lawe i kāu mahele lāʻau aʻe i ka manawa maʻamau.

Mai lawe ʻelua mahele lāʻau i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele lāʻau i haʻalele ʻia. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole o ka hāʻawi ʻana i ka pōmaikaʻi hou.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Ripretinib?

Pono ʻoe e hooki i ka lawe ʻana i ka ripretinib ma lalo o ke alakaʻi a kāu kauka. ʻOiai inā maikaʻi kou manaʻo, hiki nō i ka lāʻau lapaʻau ke hana nei e kāohi i kāu maʻi kanesa.

E loiloi mau kāu kauka inā he pono nō ka ripretinib ma o nā scans a me nā hoʻokolohua koko. E kūkākūkā lākou i ka hooki ʻana i ka lāʻau lapaʻau inā e holomua nui ana kāu maʻi kanesa a i ʻole inā lilo nā hopena ʻaoʻao i mea paʻakikī loa ke mālama.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Ripretinib?

ʻOiai ʻaʻohe pāpā kikoʻī i ka waiʻona me ka ripretinib, ʻoi aku ka maikaʻi o ka kaupalena ʻana i ka inu waiʻona i ka wā o ka mālama ʻana i ka maʻi kanesa. Hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka luhi a me ka nausea, a hiki ke hoʻopilikia i ka hiki o kou kino ke hana i ka lāʻau lapaʻau.

E kūkākūkā ʻoiaʻiʻo i kāu inu waiʻona me kāu hui mālama ola kino i hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kou olakino holoʻokoʻa a me ka hoʻolālā lapaʻau.