He aha ʻo Rolapitant: Nā Hoʻohana, Ka Leka, Nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Rolapitant i kuhikuhi ʻia e kōkua i ka pale ʻana i ka nausea a me ka luaʻi ʻana i hana ʻia e nā lāʻau lapaʻau chemotherapy. No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo NK1 receptor antagonists, e hana ana ma ka pale ʻana i nā hōʻailona kikoʻī i kou lolo e hoʻomaka ai i kēia mau hōʻailona hōʻoluʻolu ʻole.

Hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano he injection i loko o kou vein (intravenously) ma mua o kou loaʻa ʻana i ka chemotherapy. Hoʻohana nā mea mālama ola kino i ka rolapitant ma ke ʻano he ʻāpana o kahi ala ākea e kōkua iā ʻoe e ʻoluʻolu i ka wā o ka mālama ʻana i ka maʻi maʻi.

No ke aha e hoʻohana ʻia ai ʻo Rolapitant?

Hoʻolālā ʻia ʻo Rolapitant e pale i ka nausea a me ka luaʻi ʻana i hana ʻia e ka chemotherapy (CINV). E kuhikuhi kāu kauka i kēia lāʻau lapaʻau ke loaʻa iā ʻoe kekahi mau ʻano lapaʻau maʻi maʻi i ʻike ʻia e hana i kēia mau hopena ʻaoʻao.

He mea kōkua nui ka lāʻau lapaʻau no nā maʻi e loaʻa ana i ka chemotherapy emetogenic kiʻekiʻe, ʻo ia hoʻi nā lāʻau lapaʻau i loaʻa ka manawa kiʻekiʻe e hana ai i ka nausea a me ka luaʻi ʻana. Hoʻohana ʻia nō hoʻi no nā regimens chemotherapy emetogenic maʻalahi.

Hana maikaʻi ʻo Rolapitant ke hoʻohana ʻia me nā lāʻau anti-nausea ʻē aʻe e like me ka ondansetron a me ka dexamethasone. Hāʻawi kēia hui pū ʻana iā ʻoe i ka pale ikaika loa i ka nausea a me ka luaʻi ʻana e pili ana i ka chemotherapy.

Pehea e hana ai ʻo Rolapitant?

Pale ʻo Rolapitant i nā mea loaʻa NK1 i kou lolo e kuleana no ka hoʻomaka ʻana i ka nausea a me ka luaʻi ʻana. Ke komo ka chemotherapy i kāu ʻōnaehana, hiki iā ia ke hoʻāla i kēia mau mea loaʻa, e alakaʻi ana i kēlā mau manaʻo hōʻoluʻolu ʻole.

Ma ka pale ʻana i kēia mau mea loaʻa kikoʻī, pale ʻo rolapitant i nā hōʻailona nausea mai ka hōʻea ʻana i nā ʻāpana o kou lolo e kāohi ana i ka luaʻi ʻana. Hana kēia i lāʻau lapaʻau i manaʻo ʻia a maikaʻi hoʻi no kēia pilikia.

Ua manaʻo ʻia ka lāʻau lapaʻau he ikaika waena a hāʻawi i ka pale lōʻihi. ʻAʻole like me kekahi mau lāʻau anti-nausea ʻē aʻe, he mea maikaʻi ʻo rolapitant no ka mea e noho ana i loko o kou ʻōnaehana no kekahi mau lā ma hope o ka lāʻau hoʻokahi.

Pehea wau e lawe ai iā Rolapitant?

Hāʻawi ʻia ʻo Rolapitant ma ke ʻano he injection intravenous e kāu hui mālama ola, maʻamau 30 mau minuke a 2 mau hola ma mua o kou loaʻa ʻana o ka chemotherapy. ʻAʻole pono ʻoe e lawe i kēia lāʻau ma ka home a i ʻole e hopohopo e pili ana i ka manawa iā ʻoe iho.

Hāʻawi ʻia ka injection ma o ka laina IV i kou lima a i ʻole ma o ke awa inā loaʻa iā ʻoe kekahi. Maʻamau ka hana ma kahi o 30 mau minuke, a hiki iā ʻoe ke noho ʻoluʻolu i ka wā o ka infusion.

ʻAʻole pono ʻoe e ʻai a inu i kekahi mea kūikawā ma mua o ka loaʻa ʻana o ka rolapitant. Eia naʻe, hiki i kāu hui mālama ola ke ʻōlelo aku e ʻai i ka meaʻai māmā ma mua inā ʻoe e manaʻo ana e hana, no ka mea, hiki i kēia ke kōkua i ka hōʻoluʻolu holoʻokoʻa i ka wā o ka mālama ʻana.

Pehea ka lōʻihi e lawe ai au iā Rolapitant?

E loaʻa iā ʻoe ka rolapitant ma mua o kēlā me kēia pōʻai chemotherapy e koi ana i ka pale anti-nausea. Aia ka papa manawa pololei i kāu hoʻolālā lapaʻau maʻi maʻi a me ka pinepine o kou loaʻa ʻana o ka chemotherapy.

Loaʻa ka hapa nui o nā maʻi i ka rolapitant i nā lā wale nō e loaʻa ana iā lākou nā lāʻau chemotherapy e hiki ke hoʻoulu i ka nausea. E hoʻoholo kāu oncologist i ka papa manawa kūpono e pili ana i kāu regimen lapaʻau.

Hiki i nā hopena o ka lāʻau rolapitant hoʻokahi ke mau no kekahi mau lā, ʻo ia hoʻi ua pale ʻia ʻoe i ka wā e hiki mai ai ka nausea i hoʻokumu ʻia e ka chemotherapy. ʻO kēia pale lōʻihi kekahi o nā pōmaikaʻi nui o ka lāʻau.

He aha nā hopena ʻaoʻao o Rolapitant?

E like me nā lāʻau lapaʻau a pau, hiki i ka rolapitant ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hiki ke mālama ʻia.

Eia nā hopena ʻaoʻao pinepine e hiki iā ʻoe ke ʻike:

• Ua emi ka ʻai
• Pōniuniu a i ʻole ka māmā o ke poʻo
• Hiccups
• Luhi a i ʻole ka ʻūlū
• ʻEha o ka ʻōpū
• Nā maʻi o ka ʻōnaehana mimi
• Stomatitis (nā ʻeha o ka waha)

Hoʻoponopono maʻamau kēia mau hopena ʻaoʻao iā lākou iho a ʻaʻole pono e hoʻōki i ka lāʻau. Hiki i kāu hui mālama ola ke kōkua iā ʻoe e mālama i nā pilikia āu e ʻike ai.

Hiki ke loaʻa nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi, ʻoiai he mea maʻamau lākou. Pākuʻi ʻia kēia mau mea i nā hopena maʻi maʻi koʻikoʻi, nā loli nui i ka puʻuwai, a i ʻole ka pōniuniu nui ʻaʻole e hoʻomaikaʻi.

Inā ʻoe e ʻike i ka pilikia o ka hanu ʻana, ka pehu nui, ka ʻeha o ka umauma, a i ʻole ke ʻano maikaʻi ʻole ma hope o ka loaʻa ʻana o ka rolapitant, e hōʻike koke i kāu hui mālama ola. ʻAʻole maʻamau kēia mau hōʻailona akā pono e nānā koke.

ʻO wai ka mea pono ʻole e lawe i ka Rolapitant?

ʻAʻole kūpono ka Rolapitant no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Pono paha ka poʻe me kekahi mau maʻi a i ʻole ka poʻe e lawe ana i nā lāʻau lapaʻau kūikawā i nā lāʻau lapaʻau ʻē aʻe.

ʻAʻole pono ʻoe e loaʻa i ka rolapitant inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mea ʻai. E nīnau kāu hui mālama ola e pili ana i nā hopena i hala i nā lāʻau anti-nausea ma mua o kāu mahele mua.

Pono paha ka poʻe e lawe ana i kekahi mau lāʻau lapaʻau i ka nānā kūikawā a i ʻole nā hoʻoponopono mahele. Pākuʻi ʻia kēia mau mea i kekahi mau mea hoʻoheheʻe koko, nā lāʻau lapaʻau hopu, a me nā lāʻau e pili ana i ka puʻuwai.

Inā he pilikia nui kou ate, hiki i kāu kauka ke koho i kahi lāʻau anti-nausea ʻē aʻe a i ʻole e hoʻoponopono i kāu hoʻolālā lapaʻau. Hoʻoponopono ʻia ka Rolapitant e ke ake, no laila hiki i ka maʻi ate koʻikoʻi ke hoʻopilikia i ke ʻano o kou kino e mālama ai i ka lāʻau.

Pono nā wahine hāpai a me nā wahine hānai i ka noʻonoʻo kūikawā. ʻOiai ʻaʻole i aʻo nui ʻia ka rolapitant i ka wā hāpai, e kaupaona kāu oncologist i nā pōmaikaʻi e kūʻē i nā pilikia hiki ke loaʻa inā ʻoe e kali ana a i ʻole e hānai ana.

Nā inoa inoa Rolapitant

Loaʻa ʻo Rolapitant ma lalo o ka inoa inoa ʻo Varubi ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa i ʻike nui ʻia no ka lāʻau lapaʻau i nā wahi lapaʻau.

Hiki i kāu haukapila a i ʻole ke kikowaena lapaʻau ke kuhikuhi iā ia ma kona inoa maʻamau, rolapitant, a i ʻole ma ka inoa inoa ʻo Varubi. Hoʻopili nā mea ʻelua i ka lāʻau lapaʻau like me ka mea hana like.

Ke kūkākūkā ʻana i kāu lapaʻau me kāu hui mālama ola, ua ʻae ʻia kekahi inoa a e ʻike lākou i ka lāʻau lapaʻau āu e kuhikuhi nei.

Nā Koho ʻē aʻe o Rolapitant

Hiki i kekahi mau lāʻau lapaʻau ʻē aʻe ke kōkua i ka pale ʻana i ka nausea a me ka luaʻi i hoʻokumu ʻia e ka chemotherapy inā ʻaʻole kūpono ʻo rolapitant iā ʻoe. Hiki i kāu oncologist ke ʻōlelo i nā koho ʻē aʻe e pili ana i kāu mau pono kikoʻī a me ka mōʻaukala olakino.

ʻO nā mea ʻē aʻe o ka NK1 receptor antagonists me aprepitant (Emend) a me fosaprepitant (Emend for injection). Hana like kēia mau mea me rolapitant akā he mau papa hana ʻokoʻa a me nā ʻaoʻao hopena.

Hiki i kāu kauka ke noʻonoʻo i nā papa ʻē aʻe o nā lāʻau anti-nausea e like me ondansetron (Zofran), granisetron (Kytril), a i ʻole metoclopramide (Reglan). Hana kēia mau lāʻau lapaʻau ma o nā ʻano hana like ʻole akā hiki ke maikaʻi no ka pale ʻana i ka nausea e pili ana i ka chemotherapy.

ʻO ke koho ʻana i kahi koho ʻē aʻe e pili ana i nā mea e like me kāu mau lāʻau lapaʻau ʻē aʻe, nā maʻi olakino, a me ke ʻano kikoʻī o ka chemotherapy āu e loaʻa nei. E hana pū kāu hui mālama ola me ʻoe e ʻimi i ke koho kūpono loa.

Ua ʻoi aku ka maikaʻi o Rolapitant ma mua o Ondansetron?

Hana ʻokoʻa ʻo Rolapitant a me ondansetron a hoʻohana pinepine ʻia pū kekahi ma mua o nā koho ʻē aʻe i kekahi i kekahi. Hoʻopili lākou i nā hopena o kekahi i kekahi ma ka pale ʻana i nā ala like ʻole e hoʻoulu ai i ka nausea a me ka luaʻi.

Hana ʻo Ondansetron ma ka pale ʻana i nā mea hoʻokipa serotonin, ʻoiai ʻo rolapitant e pale i nā mea hoʻokipa NK1. ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau ʻelua e hāʻawi i ka pale ākea i ka nausea i hoʻokumu ʻia e ka chemotherapy ma mua o kekahi lāʻau.

Ma ke ʻano o ka pono, hōʻike nā haʻawina i ka hui pū ʻana o ka rolapitant me ka ondansetron a me ka dexamethasone e hāʻawi ana i ka mana maikaʻi o ka nausea ma mua o ka hoʻohana ʻana i ka ondansetron wale nō. ʻO kēia ala hui pū ʻana i kēia manawa ke kūlana maʻamau no nā ʻano chemotherapy he nui.

ʻO ke koho ma waena o ka hoʻohana ʻana i ka rolapitant wale nō a i ʻole i ka hui pū ʻana e hilinaʻi ana i kāu ʻano chemotherapy kikoʻī a me kāu mau mea pilikia pilikino no ka hoʻomohala ʻana i ka nausea a me ka luaʻi.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana i ka Rolapitant

Q1. Palekana anei ka Rolapitant no ka poʻe me ka maʻi puʻuwai?

He palekana ka Rolapitant no ka poʻe me ka maʻi puʻuwai, akā pono kāu cardiologist a me oncologist e hoʻopili i kāu mālama. Hiki i ka lāʻau lapaʻau ke launa pū me kekahi mau lāʻau lapaʻau puʻuwai, no laila pono paha ka nānā pono ʻana.

Inā he moʻolelo kou o nā pilikia o ka puʻuwai a i ʻole e lawe i nā lāʻau lapaʻau no nā maʻi puʻuwai, e hōʻoia i ka ʻike o kāu hui mālama maʻi maʻi a me ka cardiologist i nā lāʻau lapaʻau a pau āu e lawe nei. Pono paha lākou e hoʻoponopono i nā dosages a i ʻole e nānā pono iā ʻoe i ka wā o ka mālama ʻana.

Q2. He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Rolapitant?

No ka mea, hāʻawi ʻia ka rolapitant e nā poʻe loea mālama ola i kahi hoʻonohonoho i mālama ʻia, he mea maʻamau loa nā overdoses ulia pōpilikia. Inā hopohopo ʻoe no ka loaʻa ʻana o ka nui o ka lāʻau lapaʻau, e kamaʻilio koke me kāu kahu hānai a i ʻole kauka.

ʻO nā hōʻailona o ka loaʻa ʻana o ka nui o ka rolapitant e komo paha i ka dizziness koʻikoʻi, ka luhi nui, a i ʻole ka maikaʻi ʻole. Ua aʻo ʻia kāu hui mālama ola e ʻike a mālama i kēia mau kūlana inā loaʻa.

Q3. He aha kaʻu e hana ai inā hala iaʻu kahi mahele o ka Rolapitant?

Inā hala ʻoe i kahi mahele rolapitant i hoʻonohonoho ʻia ma mua o ka chemotherapy, e hoʻokaʻaʻike i kāu hui mālama ola i ka hiki wawe. E hoʻoholo lākou i ke ala maikaʻi loa e pili ana i kāu papa hana lapaʻau.

Hiki i kāu hui ke hoʻololi i kāu chemotherapy e hōʻoia e loaʻa iā ʻoe ka pale kūpono i ka nausea, a i ʻole hiki iā lākou ke ʻōlelo i nā lāʻau lapaʻau ʻē aʻe no kēlā pōʻai lapaʻau. Mai hoʻāʻo e hoʻoponopono i nā mea i hala iā ʻoe iho.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Rolapitant?

E hooki maʻamau ʻoe i ka loaʻa ʻana o ka rolapitant ke hoʻopau ʻoe i kāu mau lapaʻau chemotherapy a i ʻole inā hoʻololi kāu kauka iā ʻoe i kahi regimen anti-nausea ʻē aʻe. Hoʻoholo mau ʻia ka hoʻoholo e hooki ʻia e kāu hui mālama ola.

Inā ʻike ʻoe i nā hopena ʻaoʻao e hoʻopilikia nei iā ʻoe, e kūkākūkā me kāu oncologist ma mua o ka hooki ʻana i ka lāʻau lapaʻau iā ʻoe iho. Hiki iā lākou ke hoʻololi pinepine i kāu hoʻolālā lapaʻau a i ʻole e hāʻawi i ke kākoʻo hou e mālama i kekahi ʻoluʻolu.

Q5. Hiki iaʻu ke kalaiwa ma hope o ka loaʻa ʻana o Rolapitant?

Hiki i ka Rolapitant ke hoʻoulu i ka dizziness i kekahi poʻe, no laila pono ʻoe e pale i ke kalaiwa ʻana ma hope koke o ka loaʻa ʻana o ka lāʻau lapaʻau. ʻOi aku ka maikaʻi e loaʻa i kekahi e hoʻokele iā ʻoe i a mai kāu mau manawa chemotherapy.

E kali a hiki i kou manaʻo paʻa a makaʻala ma mua o ke kalaiwa hou ʻana. ʻO ka maʻamau, ʻo ia hoʻi ka kali ʻana ma kahi o kekahi mau hola ma hope o kāu lapaʻau, akā e hoʻolohe i kou kino a mai wikiwiki e komo i ka huila inā ʻaʻole ʻoe maikaʻi.