He aha ka Sacubitril a me Valsartan: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Sacubitril a me valsartan he lāʻau lapaʻau puʻuwai hui pū e kōkua i kou puʻuwai e pauma i ke koko me ka maikaʻi. Hana kēia lāʻau lapaʻau hana pālua ma ka hoʻomaha ʻana i kou mau kīʻaha koko a kōkua i kou puʻuwai e mālama maikaʻi i ka wai, e maʻalahi ai i kou puʻuwai nāwaliwali e hana i kāna hana.

Hiki i kāu kauka ke kuhikuhi i kēia lāʻau lapaʻau inā he puʻuwai puʻuwai kou, kahi maʻi kahi e hakakā ai kou puʻuwai e pauma i ke koko lawa e hoʻokō i nā pono o kou kino. Ua hoʻolālā ʻia e kōkua iā ʻoe e ʻoi aku ka maikaʻi, e noho i waho o ka haukapila, a e ola lōʻihi me ka puʻuwai puʻuwai.

He aha ka Sacubitril a me Valsartan?

Hoʻohui ʻo Sacubitril a me valsartan i ʻelua mau lāʻau lapaʻau puʻuwai like ʻole i hoʻokahi pila. E noʻonoʻo iā ia he ala hui kahi e hoʻoponopono ai kēlā me kēia lāʻau lapaʻau i ka puʻuwai puʻuwai mai kahi kihi ʻokoʻa e hāʻawi iā ʻoe i nā hopena maikaʻi aʻe ma mua o ka hiki ʻana o kekahi.

Hana ʻo Sacubitril ma ka pale ʻana i kahi enzyme e wāwahi i nā mea kōkua i kou kino. Kōkua maoli kēia mau mea i kou puʻuwai a me nā kīʻaha koko e hana maikaʻi. No kahi hui i kapa ʻia ʻo ARBs (angiotensin receptor blockers) ʻo Valsartan e kōkua i ka hoʻomaha ʻana i kou mau kīʻaha koko.

Kapa ʻia kēia hui ʻana he ARNI, ʻo ia hoʻi ka angiotensin receptor neprilysin inhibitor. ʻO ka inoa inoa āu e ʻike ai ʻo Entresto, ʻoiai e loaʻa ana nā mana generic.

No ke aha e hoʻohana ʻia ai ka Sacubitril a me Valsartan?

Hoʻohana nui ʻia kēia lāʻau lapaʻau no ka mālama ʻana i ka puʻuwai puʻuwai maʻi i nā pākeke. ʻAʻole manaʻo ka puʻuwai puʻuwai ua pau kāu puʻuwai i ka hana, akā ʻaʻole ia e pauma maikaʻi e like me ka mea pono.

E kuhikuhi maʻamau kāu kauka i kēia inā he puʻuwai puʻuwai kou me ka hōʻemi ʻia o ka ejection fraction. ʻO ia hoʻi, ʻaʻole e ʻomi ikaika ana ke keʻena pauma nui o kou puʻuwai (ventricle hema) e pauma i ke koko kūpono i kou kino.

I kekahi manawa hoʻohana nā kauka i kēia lāʻau lapaʻau no kekahi mau keiki me ka maʻi puʻuwai, ʻoiai ʻaʻole maʻamau kēia. E hoʻoholo kāu hui mālama ola inā kūpono kēia lāʻau lapaʻau no kāu ʻano maʻi puʻuwai.

Pehea e hana ai ʻo Sacubitril a me Valsartan?

Hana kēia lāʻau lapaʻau ma o kahi ala pālua akamai e kamaʻilio ana i ka maʻi puʻuwai mai nā kihi ʻelua koʻikoʻi. Manaʻo ʻia he lāʻau lapaʻau puʻuwai ikaika, hiki ke hoʻomaikaʻi nui i ka hana ʻana o kou puʻuwai.

Pale ka ʻāpana sacubitril i kahi enzyme i kapa ʻia ʻo neprilysin, ka mea e wāwahi maʻamau i nā mea pono i kou kino. Ma ka pale ʻana i kēia enzyme, ʻoi aku ka nui o kēia mau mea kōkua e noho ikaika no ka lōʻihi. Kōkua kēia mau mea i kou mau kīʻaha koko e hoʻomaha, e hōʻemi i ka wai, a e hoʻemi i ka hana ma kou puʻuwai.

I kēia manawa, pale ʻo valsartan i nā mea hoʻokipa no kahi hormone i kapa ʻia ʻo angiotensin II. ʻO kēia hormone ka mea e hoʻopaʻa ai i kou mau kīʻaha koko a haʻi i kou kino e paʻa i ka paʻakai a me ka wai. Ma ka pale ʻana i kēia mau hopena, kōkua ʻo valsartan i kou mau kīʻaha koko e hoʻomaha a hoʻemi i ka wai.

ʻO ka hui pū ʻana, kōkua kēia mau hana i kou puʻuwai e pauma ʻoi aku ka maikaʻi i ka wā e hōʻemi ana i ke kaumaha ma kēia ʻōpū koʻikoʻi. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā pōmaikaʻi i loko o kekahi mau pule, ʻoiai e hiki ke lawe i kekahi mau mahina e hoʻomohala i nā hopena piha.

Pehea e lawe ai au i ka Sacubitril a me Valsartan?

Pono ʻoe e lawe i kēia lāʻau lapaʻau e like me ke kauoha a kāu kauka, ʻelua manawa i ka lā me ka ʻole o ka meaʻai. ʻO ka lawe ʻana i nā manawa like i kēlā me kēia lā e kōkua i ka mālama ʻana i nā pae paʻa i kāu ʻōnaehana.

Hiki iā ʻoe ke lawe i kēia mau papa me ka wai, ka waiū, a i ʻole ka wai, ʻo nā mea a pau e ʻoluʻolu loa iā ʻoe. Inā ʻoe e ʻike i ka ʻōpū, hiki ke kōkua ka lawe ʻana me ka meaʻai. ʻAʻohe koi meaʻai kikoʻī, no laila hiki iā ʻoe ke hoʻoponopono e pili ana i kāu hana maʻamau i kēlā me kēia lā a me ke ʻano o ka pane ʻana o kou kino.

E ʻai i nā papa holoʻokoʻa ma mua o ka ʻoki ʻana, ka nau ʻana, a i ʻole ka wāwahi ʻana iā lākou. E hōʻoia kēia e loaʻa iā ʻoe ka mahele kūpono a e hana ana ka lāʻau lapaʻau e like me ka mea i manaʻo ʻia. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu kauka lāʻau e pili ana i nā koho.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi mahele haʻahaʻa a e hoʻonui mālie ia i nā pule he nui. Kōkua kēia ala i kāu kino e hoʻoponopono i ka lāʻau lapaʻau a hoʻemi i ka manawa o nā hopena ʻaoʻao e like me ka ʻūlū a i ʻole ke koko haʻahaʻa.

Pehea ka lōʻihi e lawe ai au i ka Sacubitril a me Valsartan?

He lāʻau lapaʻau lōʻihi kēia e pono ai ʻoe e hoʻomau mau. He maʻi maʻi ka maʻi puʻuwai, a ʻo ka hooki ʻana i kēia lāʻau lapaʻau, ʻo ia hoʻi ka nalowale ʻana o nā pōmaikaʻi e hāʻawi ai no kāu hana puʻuwai.

Pono ka hapa nui o nā kānaka e lawe i kēia lāʻau lapaʻau no ke koena o ko lākou ola e mālama i nā hoʻomaikaʻi ʻana i kā lākou mau hōʻailona maʻi puʻuwai. E nānā mau kāu kauka iā ʻoe e hōʻoia e hana maikaʻi ana a e hoʻoponopono i ka mahele inā pono.

Mai hooki i ka lawe ʻana i kēia lāʻau lapaʻau me ka ʻole e kamaʻilio mua me kāu kauka. ʻO ka hooki koke ʻana hiki ke hoʻihoʻi a hoʻonui paha i kāu mau hōʻailona maʻi puʻuwai. Inā pono ʻoe e hooki iā ia no kekahi kumu, e hana kāu kauka i kahi hoʻolālā e hana palekana.

Pono paha kekahi poʻe i nā wā hoʻomaha mai ka lāʻau lapaʻau inā loaʻa iā lākou kekahi mau hopena ʻaoʻao, akā pono e hana mau ʻia kēia ma lalo o ka mālama olakino. E kōkua kāu hui mālama ola iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia o ka hoʻomau ʻana i ka lāʻau.

He aha nā hopena ʻaoʻao o Sacubitril a me Valsartan?

E like me nā lāʻau lapaʻau a pau, hiki i ka sacubitril a me ka valsartan ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e manaʻoʻiʻo i kāu lāʻau.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka wili, ke koko haʻahaʻa, ka nui o ka potassium, a me ka ʻū. Hana pinepine kēia no ka mea e hana ana ka lāʻau lapaʻau e hoʻololi i ka hana ʻana o kou puʻuwai a me nā kīʻaha koko.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e nā kānaka:

• Wili a i ʻole ka māmā, ʻoi loa ke kū i luna
• Ke koko haʻahaʻa (hypotension)
• Hoʻonui ʻia ka pae potassium i loko o kou koko
• ʻŪ ʻaʻole e pau
• Luhi a i ʻole ka manaʻo luhi ma mua o ka maʻamau
• Nā loli hana o ka puʻupaʻa

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā pule mua o ka mālama ʻana.

Aia kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e pono ai ka lāʻau lapaʻau koke. ʻOiai ʻaʻole pinepine kēia mau mea, he mea nui e ʻike i ka mea e nānā ai.

E kelepona koke i kāu kauka inā ʻoe e ʻike:

• Wili nui a i ʻole nā ʻōpala
• Pehu o kou maka, nā lehelehe, ke alelo, a i ʻole ka ʻāʻī (angioedema)
• Paʻakikī ka hanu a i ʻole ka ʻai ʻana
• Nausea nui a i ʻole ka luaʻi
• Nāwaliwali ʻole a i ʻole nā pilikia ʻiʻo
• Nā hōʻailona o nā pilikia o ka puʻupaʻa e like me ka hoʻemi ʻia o ka mimi a i ʻole ka pehu

He kakaikahi kēia mau hopena koʻikoʻi, akā pono lākou i ka mālama olakino wikiwiki e hōʻoia i kou palekana a hoʻoponopono i kāu mālama ʻana.

ʻO wai ka mea ʻaʻole pono e lawe iā Sacubitril a me Valsartan?

ʻAʻole kūpono kēia lāʻau lapaʻau no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻO kekahi mau maʻi e palekana ʻole ai a i ʻole ka liʻiliʻi o ka hoʻohana ʻana.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau inā he maʻi ʻoe i ka sacubitril, valsartan, a i ʻole nā mea ʻē aʻe i loko o nā papa. Inā ua loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi i nā mea pale ACE a i ʻole ARB i ka wā ma mua, ʻaʻole palekana kēia lāʻau lapaʻau iā ʻoe.

Pono nā kānaka me kekahi mau maʻi olakino e pale loa i kēia lāʻau lapaʻau:

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• Mōʻaukala o ka angioedema (pehu nui) me nā mea pale ACE a i ʻole ARB
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• Hāpai a i ʻole e hoʻolālā ana e hāpai
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• Maʻi kīkī koʻikoʻi a i ʻole ka hāʻule ʻana o ke kīkī
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• Ke koko haʻahaʻa loa
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• Nā pae potassium kiʻekiʻe ʻaʻole hiki ke mālama ʻia
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• Nā kūlana genetic kakaʻikahi e pili ana i ka metabolism lāʻau
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Hiki i kēia mau kūlana ke hoʻoweliweli i ka lāʻau lapaʻau a i ʻole ke pale ʻana mai ka hana pono ʻana, no laila ʻoi aku ka maikaʻi o nā lāʻau lapaʻau ʻē aʻe.

E akahele loa kāu kauka inā he maʻi diabetes kāu, nā pilikia kīkī maʻalahi a i ʻole, maʻi ate, a i ʻole inā ʻoe e lawe ana i kekahi mau lāʻau lapaʻau ʻē aʻe. ʻAʻole pono kēia mau kūlana e kāpae i ka lāʻau lapaʻau, akā pono lākou i ka nānā ʻana a me ka hoʻoponopono ʻana i ka mahele.

Nā inoa inoa o Sacubitril a me Valsartan

ʻO ka inoa inoa kaulana loa no kēia hui pū ʻana o ka lāʻau lapaʻau ʻo Entresto, i hana ʻia e Novartis. ʻO kēia ka mana mua i ʻae ʻia a ke mau nei ka ʻano i kauoha pinepine ʻia.

Loaʻa nā mana generic o sacubitril a me valsartan mai nā mea hana like ʻole. Loaʻa i kēia mau mea nā mea hana like i nā mea like me ka mana inoa inoa, akā ʻokoʻa paha lākou a ʻoi aku ka liʻiliʻi.

Hiki i kāu lāʻau lapaʻau ke pani i kahi mana generic ke ʻole kāu kauka e kākau pono

Hoʻohana pinepine ʻia nā mea pale ACE e like me lisinopril a i ʻole enalapril no ka puʻuwai a hana like me ka mea valsartan. ʻO nā ARB e like me losartan a i ʻole candesartan kekahi koho e ālai i nā mea hoʻokipa like me valsartan.

ʻO nā lāʻau lapaʻau puʻuwai ʻē aʻe e noʻonoʻo ai kāu kauka:

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• Nā mea pale beta e like me metoprolol a i ʻole carvedilol
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• Nā diuretics (pill wai) e hōʻemi i ka wai
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• Nā mea kūʻē aldosterone e like me spironolactone
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• Nā lāʻau lapaʻau hou e like me nā mea pale SGLT2
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• Digoxin no kekahi ʻano o ka puʻuwai
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ʻO ka pinepine, pili ka mālama ʻana i ka puʻuwai i ka hui ʻana i nā lāʻau lapaʻau like ʻole e loaʻa ai nā hopena maikaʻi loa. E hana pū kāu kauka me ʻoe e ʻimi i ka hui kūpono e kāohi ai i kāu mau hōʻailona me ka hōʻemi ʻana i nā hopena ʻaoʻao.

ʻOi aku ka maikaʻi o Sacubitril a me Valsartan ma mua o Lisinopril?

Hōʻike nā haʻawina ʻoi aku ka maikaʻi o ka sacubitril a me valsartan ma mua o nā mea pale ACE e like me lisinopril no ka mālama ʻana i ka puʻuwai me ka hōʻemi ʻia o ka ejection fraction. Ua hōʻike ʻia kēia lāʻau lapaʻau hui e hōʻemi i nā halemai a hoʻomaikaʻi i ke ola ʻana ma mua o nā mea pale ACE wale nō.

ʻO ka hoʻokolokolo lapaʻau nui i alakaʻi i ka ʻae ʻia o kēia lāʻau lapaʻau i ʻike ʻia he 20% ka haʻahaʻa o ka poʻe e lawe ana i ka sacubitril a me valsartan i ka make ʻana mai ka puʻuwai i hoʻohālikelike ʻia me ka poʻe e lawe ana i kahi mea pale ACE. He liʻiliʻi nō hoʻi kā lākou halemai no ka puʻuwai.

Eia naʻe,

Nīnau pinepine ʻia e pili ana iā Sacubitril a me Valsartan

He palekana anei ʻo Sacubitril a me Valsartan no ka maʻi kīkī?

Hiki ke hoʻohana akahele ʻia kēia lāʻau lapaʻau i ka poʻe me ka maʻi kīkī maʻalahi a i ʻole waena, akā pono e nānā pono ʻia. E nānā kāu kauka i ka hana o kou kīkī i nā manawa a pau no ka mea hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana o kou kīkī.

Inā loaʻa iā ʻoe ka maʻi kīkī koʻikoʻi a i ʻole ka maʻi kīkī, ʻaʻole i ʻōlelo ʻia kēia lāʻau lapaʻau. Hiki i ka hui ʻana ke hoʻonui i ka hana o ka kīkī i kekahi poʻe, ʻoi aku ka nui inā e maloʻo ʻoe a i ʻole e lawe i kekahi mau lāʻau lapaʻau ʻē aʻe.

E nānā pono kāu hui mālama ola i kāu mau hoʻokolohua koko, ʻoi aku hoʻi i nā mahina mua o ka mālama ʻana. Inā ʻoi aku ka maikaʻi ʻole o ka hana o kou kīkī, pono paha lākou e hoʻoponopono i kāu mahele a i ʻole e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o Sacubitril a me Valsartan?

Inā ua lawe hewa ʻoe i ka nui o kēia lāʻau lapaʻau, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. ʻO ka lawe ʻana i ka nui hiki ke hoʻohaʻahaʻa i ke koko, ka ʻūlū, ka hāʻule ʻana, a i ʻole nā pilikia o ka kīkī.

Mai hoʻāʻo e mālama iā ʻoe iho i ka overdose ma ka inu ʻana i nā wai hou a i ʻole e moe ana. Hiki i nā hopena o ka nui o ka lāʻau lapaʻau ke koʻikoʻi a pono e loiloi ʻia e ka lāʻau lapaʻau. E kelepona i nā lawelawe pilikia inā manaʻo ʻoe i ka ʻūlū nui, ʻaʻole hiki ke noho ʻike, a i ʻole he pilikia i ka hanu ʻana.

No ka pale ʻana i nā overdose ulia pōpilikia, e hoʻohana i kahi mea hoʻonohonoho pila a hoʻonohonoho i nā mea hoʻomanaʻo ma kāu kelepona. E mālama i kāu lāʻau lapaʻau i loko o kāna hue mua me ka lepili maopopo, a mai lawe i nā mahele hou e

Mai lawe i nā mea ʻelua i ka manawa hoʻokahi e pani ai i ka mea i hala. Hiki i kēia ke hoʻohaʻahaʻa loa i kou koko a hoʻoluhi iā ʻoe a i ʻole e nāwaliwali. Hiki i nā mea pālua ke hoʻonui i kou pilikia o nā hopena ʻē aʻe.

Inā poina pinepine ʻoe i nā mea, e hoʻāʻo e hoʻonohonoho i nā ʻōhua kelepona, e hoʻohana i ka mea hoʻonohonoho pila, a i ʻole e lawe i kāu lāʻau i ka manawa like me kekahi hana i kēlā me kēia lā e like me ka palaki ʻana i kou niho. Kōkua ka hoʻohana mau ʻana i ka lāʻau i ka hana pono.

Iāhea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Sacubitril a me Valsartan?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana i kēia lāʻau me ka ʻole e kamaʻilio mua me kāu kauka. He maʻi maʻi mau ka maʻi puʻuwai e koi pinepine ai i ka mālama ʻana i ke ola, a ʻo ka hooki ʻana i ka wā koke hiki ke hoʻihoʻi a hoʻonui paha i kāu mau hōʻailona.

Hiki i kāu kauka ke noʻonoʻo e hooki a hoʻololi paha i kāu lāʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, inā e ʻino nui ana kāu hana kīkī, a i ʻole inā e hoʻomaikaʻi nui ana kāu maʻi puʻuwai. Eia naʻe, pono e hana mau ʻia kēia mau hoʻoholo me kāu hui mālama ola.

Inā pono ʻoe e hooki no ke ʻoki a i ʻole nā hana lapaʻau ʻē aʻe, e hāʻawi kāu kauka iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka manawa e hooki ai a me ka manawa e hoʻomaka hou ai. Hiki nō hoʻi iā lākou ke kuhikuhi i nā lāʻau ʻē aʻe e hoʻohana no ka manawa.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Sacubitril a me Valsartan?

ʻOi aku ka maikaʻi e kaupalena i ka inu ʻana i ka waiʻona i ka wā e lawe ana i kēia lāʻau, no ka mea, hiki i ka waiʻona ke hoʻonui i nā hopena hoʻohaʻahaʻa koko a hoʻoluhi iā ʻoe a i ʻole e māmā ke poʻo. He maikaʻi nā mea liʻiliʻi o ka waiʻona no ka hapa nui o nā kānaka, akā ʻo ka hoʻohaʻahaʻa ke kī.

Hiki nō hoʻi i ka waiʻona ke hoʻonui i nā hōʻailona o ka maʻi puʻuwai a keakea i ka pono o kāu lāʻau. Inā loaʻa iā ʻoe ka maʻi puʻuwai, ua kūkākūkā paha kāu kauka i ka kaupalena ʻana i ka waiʻona ma ke ʻano he ʻāpana o kāu hoʻolālā lapaʻau holoʻokoʻa.

E kūkākūkā me kāu mea mālama ola e pili ana i ka nui o ka waiʻona, inā he mea, he palekana iā ʻoe. Hiki iā lākou ke hāʻawi iā ʻoe i ka ʻōlelo aʻo pilikino e pili ana i kou kūlana kikoʻī, nā lāʻau lapaʻau ʻē aʻe, a me ke olakino holoʻokoʻa.