He aha ʻo Sarilumab: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Sarilumab e kōkua ana i ka hōʻemi ʻana i ka mumū i ka poʻe me ka maʻi ʻaʻa rheumatoid a me nā maʻi autoimmune ʻē aʻe. Hāʻawi ʻia ia ma ke ʻano he injection ma lalo o ka ʻili, e like me ke ʻano o ka poʻe me ka maʻi diabetes e hāʻawi iā lākou iho i nā pana insulin.

No kahi hui i kapa ʻia ʻo IL-6 inhibitors kēia lāʻau lapaʻau, e hana ana ma ka pale ʻana i nā hōʻailona kikoʻī i loko o kāu ʻōnaehana pale e hoʻoulu ai i ka ʻeha hui a me ka pehu. E noʻonoʻo e like me ka hoʻohaʻahaʻa ʻana i ka leo ma ka pane immune overactive o kou kino.

He aha ʻo Sarilumab?

He lāʻau lapaʻau olaola ʻo Sarilumab e manaʻo ana i ka interleukin-6 (IL-6), kahi protein e hoʻokele i ka mumū i loko o kou kino. Ke loaʻa iā ʻoe ka maʻi ʻaʻa rheumatoid, hana kou ʻōnaehana pale i ka nui o ka IL-6, e alakaʻi ana i nā hui ʻeha a pehu.

Hele mai ka lāʻau lapaʻau ma ke ʻano he peni i hoʻopiha mua ʻia a i ʻole ka syringe āu e hoʻokomo ai ma lalo o kou ʻili i kēlā me kēia pule ʻelua. Hana ʻia me ka hoʻohana ʻana i ka ʻenehana biotechnology kiʻekiʻe, ʻo ia hoʻi, hana ʻia mai nā cell ola ma mua o nā kemika kuʻuna.

E kauoha maʻamau kāu kauka iā sarilumab ke ʻaʻole i hāʻawi nā lāʻau lapaʻau arthritis ʻē aʻe i ka hoʻomaha lawa. Manaʻo ʻia he lāʻau lapaʻau i manaʻo ʻia no ka mea e kālele ana i kahi ʻāpana kikoʻī o ka ʻōnaehana pale ma mua o ka hoʻopaʻa ʻana i kāu pane immune holoʻokoʻa.

No ke aha e hoʻohana ʻia ai ʻo Sarilumab?

Hoʻohana nui ʻia ʻo Sarilumab e mālama i ka maʻi ʻaʻa rheumatoid maʻalahi a koʻikoʻi i nā pākeke. Kōkua ia i ka hōʻemi ʻana i ka ʻeha hui, ka ʻoʻoleʻo, a me ka pehu e hiki ke paʻakikī i nā hana i kēlā me kēia lā.

Hiki i kāu kauka ke ʻōlelo iā sarilumab inā ʻaʻole ʻoe i pane maikaʻi i ka methotrexate a i ʻole nā ​​lāʻau lapaʻau antirheumatic e hoʻololi ana i ka maʻi (DMARDs). Hiki ke hoʻohana ʻia wale nō a i hui pū ʻia me ka methotrexate no nā hopena maikaʻi.

Ke aʻo ʻia nei ka lāʻau lapaʻau no nā maʻi mumū ʻē aʻe, akā ʻo ka maʻi ʻaʻaʻa rheumatoid ka mea nui i ʻae ʻia. Na kāu mea mālama ola e hoʻoholo inā kūpono ʻo sarilumab no kou kūlana kikoʻī e pili ana i kāu mau hōʻailona a me ka mōʻaukala olakino.

Pehea e hana ai ʻo Sarilumab?

Hana ʻo Sarilumab ma ka pale ʻana i nā mea hoʻokipa interleukin-6 i loko o kou kino. He ʻelele ʻo IL-6 e haʻi ana i kou ʻōnaehana pale e hana i ka mumū, ʻoiai ke pono ʻole.

Ke hoʻopili ʻo sarilumab i kēia mau mea hoʻokipa, pale ia iā IL-6 mai ka hoʻouna ʻana i nā hōʻailona mumū. Kōkua kēia i ka hōʻemi ʻana i ka pōʻino hui, ka ʻeha, a me ka pehu e pili ana me ka maʻi ʻaʻaʻa rheumatoid.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika iki i waena o nā lāʻau lapaʻau olaola. Ua ʻoi aku ka pahuhopu ma mua o nā steroid akā ua lawa ka ikaika e hoʻopilikia nui i kou ʻōnaehana pale. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā hoʻomaikaʻi ʻana i loko o 2-4 mau pule o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Pehea wau e lawe ai iā Sarilumab?

Hāʻawi ʻia ʻo Sarilumab ma ke ʻano he injection subcutaneous, ʻo ia hoʻi, hoʻokomo ʻoe iā ia i loko o ka ʻiʻo momona ma lalo pono o kou ʻili. ʻO ka mahele maʻamau he 200mg i kēlā me kēia pule ʻelua, akā hiki i kāu kauka ke hoʻomaka me 150mg inā loaʻa iā ʻoe kekahi mau maʻi olakino.

Hiki iā ʻoe ke hoʻokomo iā sarilumab i loko o kou ʻūhā, lima luna, a i ʻole ka ʻōpū. E hoʻololi i nā wahi injection i kēlā me kēia manawa e pale ai i ka huhū o ka ʻili. Pono ka lāʻau lapaʻau i ka mahana o ka lumi ke hoʻokomo ʻoe iā ia, no laila e lawe iā ia mai ka pahu hau 30-60 mau minuke ma mua.

ʻAʻole pono ʻoe e lawe iā sarilumab me ka meaʻai no ka mea ua hoʻokomo ʻia ma mua o ka ʻai ʻana. Eia naʻe, he mea nui e hoʻokomo iā ia i ka lā like i kēlā me kēia pule ʻelua e mālama i nā pae paʻa i kāu ʻōnaehana.

Na kāu mea mālama ola a i ʻole ke kahu e aʻo iā ʻoe pehea e hāʻawi ai iā ʻoe iho i ka injection. ʻIke ka hapa nui o nā kānaka he maʻalahi ia ma mua o ka mea i manaʻo ʻia, a maʻalahi nā peni i hoʻopiha mua ʻia i ke kaʻina hana.

Pehea ka lōʻihi e lawe ai au iā Sarilumab?

He lāʻau lapaʻau lōʻihi ʻo Sarilumab no ka maʻi ʻāʻī. Hoʻomau ka hapa nui o nā kānaka i ka lawe ʻana iā ia i ka wā e kōkua ana i kā lākou mau hōʻailona a ʻaʻole e hana ana i nā hopena ʻaoʻao koʻikoʻi.

E nānā kāu kauka i kāu pane ʻana i nā mahina mua e ʻike i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. Inā ʻoe e ʻike nei i ka hoʻomaikaʻi nui ʻana, e hoʻomau paha ʻoe me nā injections maʻamau.

Pono paha kekahi poʻe e lawe i ka sarilumab no nā makahiki e mālama i kā lākou kaohi hōʻailona. Eia naʻe, e loiloi mau kāu mea mālama ola i kāu lapaʻau e hōʻoia i ka mea maikaʻi loa iā ʻoe.

Mai hooki i ka lawe ʻana i ka sarilumab me ka ʻole e kamaʻilio mua me kāu kauka. Hiki ke hoʻi mai kāu mau hōʻailona inā e hooki koke ʻoe i ka lāʻau lapaʻau.

He aha nā hopena ʻaoʻao o Sarilumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka sarilumab ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i ʻike nā kānaka a pau iā lākou. ʻO ka hoʻomaopopo ʻana i ka mea e nānā ai hiki ke kōkua iā ʻoe e manaʻoʻiʻo i kāu lapaʻau.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Nā hopena ma ka pūnaewele injection e like me ka ʻulaʻula, ka pehu, a i ʻole ka ʻeha māmā
• Nā maʻi hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā poʻo e maʻamau ana he māmā a i ʻole
• Hoʻonui ʻia nā pae cholesterol, e nānā ʻia e kāu kauka
• Hoʻokiʻekiʻe ʻia nā enzymes ate, i ʻike ʻia ma o nā hoʻokolohua koko

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao maʻamau a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e koi ana i ka lāʻau lapaʻau koke:

• Nā maʻi koʻikoʻi e hiki ke hoʻoweliweli i ke ola
• Nā hopena maʻi koʻikoʻi me ka pilikia o ka hanu a i ʻole ka pehu
• Nā hāʻule nui i nā helu keʻokeʻo koko a i ʻole nā platelet
• Nā pilikia ate e hana ana i ka melemele o ka ʻili a i ʻole nā maka
• Ka lua o ka ʻōpū, ʻoiai he mea maʻamau loa kēia

ʻOiai ʻaʻole maʻamau kēia mau hopena ʻaoʻao koʻikoʻi, he mea nui e hoʻokaʻaʻike koke aku i kāu mea mālama ola inā ʻike ʻoe i nā hōʻailona e hopohopo nei.

ʻO wai ka mea pono ʻole e lawe iā Sarilumab?

ʻAʻole kūpono ʻo Sarilumab no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻO kekahi mau maʻi a i ʻole nā kūlana e hiki ke lilo i kēia lāʻau lapaʻau i mea weliweli.

ʻAʻole pono ʻoe e lawe iā sarilumab inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• Nā maʻi ikaika, me ka maʻi tuberculosis a i ʻole hepatitis B
• Maʻi ate koʻikoʻi a i ʻole nā enzyme ate kiʻekiʻe loa
• He haʻahaʻa loa ka helu o ke keʻokeʻo koko a i ʻole nā platelet
• Nā maʻi maʻi i ʻike ʻia iā sarilumab a i ʻole kekahi o kāna mau meaʻai
• Nā lāʻau lapaʻau ola i hoʻonohonoho ʻia i nā pule e hiki mai ana

E hoʻohana pū kāu kauka i ka mālama keu inā he moʻolelo kou o nā maʻi e hana hou ana, ke ʻoki ʻana i kēia manawa, a i ʻole nā maʻi ʻōnaehana pale ʻē aʻe.

Pono ka hāpai ʻana a me ka hānai ʻana i ka umauma i ka noʻonoʻo kūikawā. ʻOiai ʻaʻole i aʻo nui ʻia ʻo sarilumab i nā wahine hāpai, e kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia e hiki mai ana inā ʻoe e hoʻolālā nei e hāpai a i ʻole e kali ana.

Nā inoa inoa o Sarilumab

Hoʻolaha ʻia ʻo Sarilumab ma lalo o ka inoa inoa ʻo Kevzara ma ʻAmelika Hui Pū ʻIa a me ka hapa nui o nā ʻāina ʻē aʻe. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau lapaʻau.

Hana ʻia ʻo Kevzara e Sanofi a me Regeneron Pharmaceuticals. Hele mai ka lāʻau lapaʻau i nā peni i hoʻopiha mua ʻia a me nā syringes no ka injection ponoʻī maʻalahi ma ka home.

ʻAʻole like me kekahi mau lāʻau lapaʻau ʻē aʻe, ʻaʻohe mana generic o sarilumab i loaʻa i kēia manawa. ʻO ia hoʻi, ʻo Kevzara wale nō ke koho inā kau kāu kauka iā sarilumab.

Nā koho ʻē aʻe o Sarilumab

Inā ʻaʻole kūpono ʻo sarilumab iā ʻoe, hiki i kekahi mau lāʻau lapaʻau olaola ʻē aʻe ke mālama pono i ka maʻi rheumatoid arthritis. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe e pili ana i kāu mau pono kikoʻī a me ka moʻolelo olakino.

ʻO nā mea pale IL-6 ʻē aʻe e komo pū ana me tocilizumab (Actemra), e hana like ana me sarilumab akā hāʻawi ʻia ma ke ʻano he infusion a i ʻole injection. ʻO nā mea pale TNF e like me adalimumab (Humira) a i ʻole etanercept (Enbrel) e kuhikuhi ana i nā ala mumū like ʻole.

ʻO nā mea pale JAK e like me tofacitinib (Xeljanz) a i ʻole baricitinib (Olumiant) he mau lāʻau lapaʻau waha e maʻalahi ai kekahi poʻe e lawe. ʻO nā DMARD kuʻuna e like me methotrexate a i ʻole sulfasalazine he mau koho lapaʻau koʻikoʻi, ʻoiai no ka poʻe e hoʻomaka ana i ka mālama ʻana i ka arthritis.

E kōkua kāu mea mālama ola iā ʻoe e koho i ka koho maikaʻi loa e pili ana i kāu mau hōʻailona, ​​nā kūlana olakino ʻē aʻe, a me nā makemake lapaʻau.

Ua ʻoi aku ka maikaʻi o Sarilumab ma mua o Tocilizumab?

ʻO Sarilumab a me tocilizumab he mau mea pale IL-6, ʻo ia hoʻi, hana lākou ma nā ʻano like loa e hōʻemi i ka mumū. ʻO ka hoʻohālikelike ʻana iā lākou i ka pololei hiki ke paʻakikī no ka mea ʻaʻole i hoʻāʻo ʻia lākou i ke poʻo-i-ke-poʻo i nā haʻawina nui.

He mea maikaʻi loa nā lāʻau lapaʻau ʻelua no ka mālama ʻana i ka rheumatoid arthritis, a nui ka poʻe e hana maikaʻi me kekahi koho. ʻO ka koho pinepine e pili ana i nā mea hana e like me ke ʻano o ka hāʻawi ʻana i ka lāʻau lapaʻau a me kāu mau makemake pilikino.

Loaʻa wale ʻo Sarilumab ma ke ʻano he injection ponoʻī i kēlā me kēia pule ʻelua, ʻoiai hiki ke hāʻawi ʻia ʻo tocilizumab ma ke ʻano he infusion i kēlā me kēia ʻehā pule a i ʻole ka injection i kēlā me kēia pule. Makemake kekahi poʻe i ka maʻalahi o ka injection ponoʻī, ʻoiai makemake nā poʻe ʻē aʻe i ka liʻiliʻi o ka hoʻohana ʻana i nā infusions.

E noʻonoʻo kāu kauka i kāu kūlana kikoʻī, me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei a me nā hopena ʻaoʻao āu i ʻike ai, e kōkua e hoʻoholo i ke koho e hana maikaʻi ai iā ʻoe.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Sarilumab

He palekana anei ʻo Sarilumab no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana ʻia ʻo Sarilumab i ka poʻe me ka maʻi puʻuwai, akā pono ia i ka nānā pono ʻana. Hiki i ka lāʻau lapaʻau ke hoʻonui i nā pae cholesterol, hiki ke hoʻopilikia i kou pilikia cardiovascular.

E nānā mau kāu kauka i nā pae cholesterol a hiki ke kauoha i nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol inā pono. E nānā pū lākou i ke olakino o kou puʻuwai i ka wā o ka mālama ʻana.

Inā he maʻi puʻuwai koʻikoʻi kou a i ʻole nā pilikia puʻuwai i kēia manawa, e loiloi kāu mea mālama ola i nā pōmaikaʻi o ka sarilumab e kūʻē i nā pilikia hiki ke loaʻa. He mea nui ka kamaʻilio ʻana me kāu cardiologist a me rheumatologist.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Sarilumab?

Inā hoʻokomo hewa ʻoe i ka sarilumab ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole ke kikowaena mana ʻawaʻawa. Mai kali e ʻike inā e ulu ana nā hōʻailona.

Hiki i ka overdose o ka sarilumab ke hoʻonui i kou pilikia o nā maʻi koʻikoʻi a i ʻole nā hopena ʻē aʻe. Hiki i kāu kauka ke makemake e nānā pono iā ʻoe a i ʻole e hoʻoponopono i kāu papa hana lapaʻau.

No ka pale ʻana i nā overdose ulia pōpilikia, e nānā mau i kāu mahele ma mua o ka hoʻokomo ʻana a mai lawe i nā mahele keu e

Hiki i kāu mea mālama ola ke ʻōlelo e hooki i ka sarilumab inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, nā maʻi, a i ʻole inā komo kou maʻi i ke kala lōʻihi. E hana lākou i kahi hoʻolālā e nānā pono iā ʻoe i ka wā o nā loli lapaʻau.

Hiki i kekahi poʻe ke hōʻemi i kā lākou mahele a i ʻole e hoʻolōʻihi i ka manawa ma waena o nā injections ma mua o ka hooki ʻana. E hana kāu kauka me ʻoe e ʻimi i ke ala e mālama ai i kāu mau hōʻailona i kaohi ʻia me ka liʻiliʻi o ka lāʻau lapaʻau.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana i ka Sarilumab?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana i ka sarilumab, akā pono e pale ʻia nā lāʻau lapaʻau ola no ka mea hiki iā lākou ke hoʻoulu i nā maʻi i ka poʻe me nā ʻōnaehana pale i hoʻopaʻa ʻia.

E ʻōlelo kāu kauka e loaʻa i nā lāʻau lapaʻau koʻikoʻi e like me nā pana flu, nā lāʻau lapaʻau pneumonia, a me nā lāʻau lapaʻau COVID-19 ma mua o ka hoʻomaka ʻana i ka sarilumab. ʻOi aku ka maikaʻi o kēia mau lāʻau lapaʻau ke ʻole i hoʻopaʻa ʻia kāu ʻōnaehana pale.

E haʻi mau i kekahi mea mālama ola e hāʻawi ana iā ʻoe i nā lāʻau lapaʻau e lawe ana ʻoe i ka sarilumab. E hōʻoia lākou he palekana a kūpono nā lāʻau lapaʻau no kou kūlana.