He aha ʻo Tafamidis: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau kūikawā ʻo Tafamidis i hoʻolālā ʻia e hoʻolohi i ka holomua o kekahi mau maʻi puʻuwai a me nā maʻi nerve i hoʻokumu ʻia e nā waihona protein maʻamau ʻole. Hana kēia lāʻau lapaʻau ma ka hoʻopaʻa ʻana i kahi protein i kapa ʻia ʻo transthyretin, e pale ana iā ia mai ka wāwahi ʻana a me ka hana ʻana i nā puʻupuʻu pōʻino i loko o kou mau ʻōpū.

Inā ua kauoha kāu kauka iā tafamidis, ke hana nei ʻoe me kahi maʻi e pili ana i ke ʻano o kou kino e hana ai i kēia protein koʻikoʻi. ʻOiai he koʻikoʻi kēia mau maʻi, ʻo ka loaʻa ʻana o kahi koho lapaʻau kūpono hiki ke hāʻawi i ka manaʻolana a kōkua i ka mālama ʻana i kou maikaʻi o ke ola no nā wā lōʻihi.

He aha ʻo Tafamidis?

He mea hoʻopaʻa protein ʻo Tafamidis e pale ai i ka transthyretin mai ka wehe ʻana a me ka hōʻino ʻana i kou puʻuwai a me nā aʻalolo. E noʻonoʻo iā ia he mea hoʻopili molekala e mālama i kēia protein i kona ʻano kūpono a paʻa.

No ka papa o nā mea i kapa ʻia ʻo transthyretin stabilizers ka lāʻau lapaʻau, e lilo ana ia i ka lāʻau mua o kāna ʻano i ʻae ʻia no ka mālama ʻana i nā ʻano amyloidosis kikoʻī. Hana maoli kou ate i ka protein transthyretin, akā i kekahi poʻe, lilo kēia protein i mea paʻa ʻole a hana i nā waihona pōʻino i loko o nā ʻōpū.

Loaʻa ʻo Tafamidis i ʻelua ʻano: nā capsules maʻamau a me kahi mana hou, ʻoi aku ka ikaika i kapa ʻia ʻo tafamidis meglumine. Hana like nā mea ʻelua akā ʻokoʻa ka ikaika a me ke alapine ʻana o ka lāʻau.

No ke aha e hoʻohana ʻia ai ʻo Tafamidis?

Hoʻomaʻamaʻa ʻo Tafamidis i ʻelua mau maʻi nui: transthyretin amyloid cardiomyopathy a me ka hereditary transthyretin amyloidosis me ka polyneuropathy. Hoʻopili nā mea ʻelua i ka protein pilikia like akā pili i nā ʻāpana like ʻole o kou kino.

I ka transthyretin amyloid cardiomyopathy, waiho nui ka protein paʻa ʻole i loko o kou ʻiʻo puʻuwai, e paʻakikī a ʻaʻole hiki ke pauma i ke koko. Hiki i kēia maʻi ke hoʻoulu i ka pōkole o ka hanu, ka luhi, a me ka pehu ʻana i kou mau wāwae a me ka ʻōpū.

Hoʻopilikia nui ka amyloidosis transthyretin hoʻoilina me ka polyneuropathy i nā aʻa peripheral, e hoʻoulu ana i ka ʻeha, ka ʻūlū, a me ka nāwaliwali i kou mau lima a me nā wāwae. Hoʻoili ʻia kēia ʻano ma waena o nā ʻohana a hoʻomaka maʻamau i ka wā makua.

E hōʻoia kāu kauka i kāu maʻi ma o nā hoʻokolohua kikoʻī, me ka hoʻāʻo genetic a me nā scans puʻuwai kūikawā a i ʻole nā haʻawina nerve. He mea maʻamau kēia mau maʻi, e pili ana i kekahi mau tausani kānaka wale nō ma ka honua holoʻokoʻa, akā hiki iā lākou ke hoʻopilikia nui i kou ola i kēlā me kēia lā me ka ʻole o ka mālama kūpono.

Pehea e hana ai ʻo Tafamidis?

Hana ʻo Tafamidis ma ka hoʻopaʻa ʻana i ka protein transthyretin a mālama iā ia i ke kūpaʻa i loko o kou kahe koko. Pale kēia i ka protein mai ka haki ʻana a me ka hana ʻana i nā pūʻulu paʻa e hōʻino i kou mau ʻōkana.

Ma lalo o nā kūlana maʻamau, lawe ʻo transthyretin i nā hormones thyroid a me ka huaora A i loko o kou kino. Eia naʻe, i ka poʻe me ka amyloidosis, lilo kēia protein i mea paʻa ʻole a misfolds, e hana ana i nā waihona pōʻino i kapa ʻia ʻo amyloid fibrils.

Hana ka lāʻau lapaʻau e like me ka mea hoʻopaʻa molecular, e laka ana i ka protein i loko o kona ʻano kūpono. ʻAʻole kēia e hoʻohuli i ka pōʻino i loaʻa, akā hoʻolohi nui ia i ka hana ʻana o nā waihona protein hou, e kōkua ana i ka mālama ʻana i kāu hana ʻōkana i ka manawa.

Ua manaʻo ʻia ʻo Tafamidis he lāʻau lapaʻau ikaika me ka hana i manaʻo ʻia. ʻAʻole ia he lāʻau lapaʻau, akā hōʻike nā haʻawina lapaʻau hiki iā ia ke hoʻolohi nui i ka holomua o ka maʻi a hoʻomaikaʻi i nā helu ola ke hoʻomaka koke i ke kaʻina o ka maʻi.

Pehea e lawe ai au iā Tafamidis?

E lawe iā tafamidis e like me ke kauoha a kāu kauka, maʻamau i hoʻokahi manawa i ka lā me ka ʻole o ka meaʻai. ʻO ka maʻamau maʻamau he 20mg i kēlā me kēia lā (hoʻokahi capsule) a i ʻole 61mg i kēlā me kēia lā (ʻehā capsules), ma muli o kou kūlana kikoʻī a me ka formulation i kauoha ʻia.

Hiki iā ʻoe ke lawe i kēia lāʻau me ka wai, ka waiū, a i ʻole ka wai hua - ʻaʻole pili nui ka meaʻai i ke ʻano o ka lawe ʻana o kou kino iā ia. Eia naʻe, e hoʻāʻo e lawe iā ia i ka manawa like i kēlā me kēia lā e mālama i nā pae kūlike i loko o kou kahe koko.

E ale i nā capsules holoʻokoʻa me ka wehe ʻole ʻana, ka ʻoki ʻana, a i ʻole ka nau ʻana iā lākou. Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe, no ka mea, pono e komo pono ka lāʻau lapaʻau e hana pono.

E mālama i kāu lāʻau lapaʻau i ka lumi wela, mai ka makū a me ka wela. E mālama iā ia i loko o kāna pahu kumu me ka pūʻolo desiccant e pale ai i ka pōʻino o ka makū, hiki ke hoʻopilikia i ka mana o ka lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Tafamidis?

ʻO ka Tafamidis ka mea maʻamau he lapaʻau lōʻihi e pono ai ʻoe e hoʻomau mau e mālama i kāna mau hopena pale. No ka mea, hoʻolohi ia i ka holomua o ka maʻi ma mua o ka hoʻōla ʻana i ke kūlana, ʻo ka hoʻōki ʻana i ka lāʻau lapaʻau e ʻae i nā waihona protein ʻino e hoʻomau i ka hana.

E nānā kāu kauka i kāu pane ma o nā loiloi maʻamau, nā hoʻokolohua koko, a me nā haʻawina kiʻi. Kōkua kēia mau mea e loiloi inā e hoʻolohi pono ana ka lāʻau lapaʻau i ka holomua o kāu maʻi a inā pono e hoʻoponopono i ka dosis.

ʻO ka hapa nui o ka poʻe e pane maikaʻi i ka tafamidis e hoʻomau i ka lawe ʻana iā ia no nā makahiki. ʻOi aku ka maopopo o nā pōmaikaʻi o ka lāʻau lapaʻau i ka manawa, me nā haʻawina e hōʻike ana i nā ʻokoʻa nui loa i ka holomua o ka maʻi ma hope o 12 a 18 mau mahina o ka mālama mau.

Mai hooki i ka lawe ʻana i ka tafamidis me ka kūkākūkā ʻole ʻana me kāu kauka mua. ʻAʻole e hoʻokumu ka hoʻōki koke ʻana i nā hōʻailona haʻalele weliweli, akā e ʻae ia i kou kūlana e holomua wikiwiki ma mua o ka hoʻomau ʻana i ka lāʻau.

He aha nā hopena ʻaoʻao o Tafamidis?

ʻO ka hapa nui o ka poʻe e ʻae maikaʻi i ka tafamidis, me nā hopena ʻaoʻao he maʻalahi a hiki ke mālama ʻia. He palekana maikaʻi ka lāʻau lapaʻau i hoʻohālikelike ʻia me nā lāʻau lapaʻau ʻē aʻe no nā maʻi laha.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e hiki iā ʻoe ke ʻike:

• Nā pilikia digestive e like me ka nausea, ka maʻi maʻi, a i ʻole ka ʻoluʻolu o ka ʻōpū
• Nā ʻeha poʻo a i ʻole ka noʻonoʻo
• Luhi a i ʻole ka manaʻo e luhi pinepine ana ma mua o ka maʻamau
• Nā maʻi o ka ʻōnaehana hanu luna
• Nā maʻi o ka ʻōnaehana mimi

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā pule mua o ka mālama ʻana.

ʻOiai he mea maʻamau, hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e pono ai ka lāʻau lapaʻau koke:

• Nā hopena maʻi koʻikoʻi me ka ʻūlū, ka pehu, a i ʻole ka pilikia o ka hanu
• Ke kahe ʻana o ke koko a i ʻole ka ʻeha maʻamau
• ʻEha ʻōpū koʻikoʻi mau
• Nā hōʻailona o nā pilikia o ke ake e like me ka melemele o ka ʻili a i ʻole nā maka
• Nā hōʻailona puʻuwai koʻikoʻi a i ʻole e hōʻino ana

E kelepona koke i kāu kauka inā ʻike ʻoe i kekahi o kēia mau hopena ʻaoʻao koʻikoʻi. Hiki i ka hapa nui o nā kānaka ke hoʻomau i ka lawe ʻana iā tafamidis me ka nānā pono a me ke kākoʻo.

ʻO wai ka mea ʻaʻole pono e lawe iā Tafamidis?

ʻAʻole kūpono ʻo Tafamidis no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia no kāu kūlana kikoʻī. Pono nā kānaka me nā maʻi maʻi i ʻike ʻia iā tafamidis a i ʻole kekahi o kāna mau mea pono e pale i kēia lāʻau.

E mālama nui kāu kauka inā loaʻa iā ʻoe ka maʻi ate koʻikoʻi, no ka mea, ʻaʻole paha e hana pono kou kino i ka lāʻau. ʻOiai ʻaʻole e hoʻokaʻawale ʻakomi nā pilikia ate māmā iā ʻoe, pono paha lākou i nā hoʻoponopono ʻana i ka mahele a i ʻole ka nānā ʻana.

ʻAʻole pono nā wahine hāpai e lawe iā tafamidis, no ka mea, ʻaʻole i maopopo loa kāna hopena i nā pēpē e ulu ana. Inā ʻoe e hoʻolālā nei e hāpai a i ʻole e ʻike ʻoe e hāpai ana ʻoe i ka wā e lawe ana i kēia lāʻau, e kūkākūkā i nā koho ʻē aʻe me kāu kauka.

Pono nā makuahine e hānai ana i ka waiū e pale aku iā tafamidis, no ka mea, ʻaʻole ʻike ʻia inā hele ka lāʻau i ka waiū umauma. Hiki i kāu kauka ke kōkua iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia inā ʻoe e hānai ana.

ʻO ka poʻe me ka maʻi kīkī koʻikoʻi e pono paha i nā hoʻoponopono ʻana i ka lāʻau, akā ʻaʻole pinepine nā pilikia kīkī māmā a i waena paha e pale i ka hoʻohana ʻana i ka tafamidis. E nānā mau kāu kauka i kāu hana kīkī i ka wā o ka mālama ʻana.

Nā inoa inoa o Tafamidis

Loaʻa ʻo Tafamidis ma lalo o nā inoa inoa nui ʻelua: Vyndaqel a me Vyndamax. Loaʻa i nā mea ʻelua ka mea hana like akā ʻokoʻa i kā lākou hana a me ka hoʻohana ʻana.

Aia i loko o Vyndaqel ka tafamidis meglumine a loaʻa i loko o nā capsules 20mg, i lawe ʻia i hoʻokahi manawa i ka lā. ʻO kēia ka mana mua i ʻae ʻia a ke hoʻomau nei i ka hoʻopaʻa ʻia ʻana no nā ʻano maʻi puʻuwai a me nā ʻano nerve o ka maʻi.

Aia i loko o Vyndamax ka tafamidis (me ka ʻole o ka meglumine) i loko o nā capsules 61mg, i lawe ʻia hoʻi i hoʻokahi manawa i ka lā. Ua like kēia hana hou me nā capsules Vyndaqel ʻehā a makemake pinepine ʻia no kāna papa hana maʻalahi.

He kūpono nā hōʻailona ʻelua - pili pinepine ke koho ma waena o lākou i ka makemake o kāu kauka, kāu ʻinikua, a me ka mea i ʻoi aku ka maʻalahi iā ʻoe ke lawe mau.

Nā koho ʻē aʻe o Tafamidis

I kēia manawa, he kakaikahi wale nō nā koho ʻē aʻe i ka tafamidis no ka mālama ʻana i ka transthyretin amyloidosis. ʻO ka laha ʻole o kēia mau maʻi ke ʻano o ka palena o nā koho lapaʻau, e hana ana i ka tafamidis i mea waiwai.

No ka hereditary transthyretin amyloidosis me ka polyneuropathy, ʻo patisiran a me inotersen nā therapies interference RNA e hana ʻokoʻa mai ka tafamidis. Hoʻemi kēia mau lāʻau i ka hana ʻana o ka protein transthyretin ma mua o ka hoʻopaʻa ʻana.

Hiki ke noʻonoʻo ʻia ka transplantation ate no kekahi poʻe me nā ʻano hereditary o ka maʻi, no ka mea, hana ka ate i ka hapa nui o ka protein pilikia. Eia naʻe, kūpono kēia ʻoki nui no nā maʻi i koho pono ʻia a ʻaʻole kōkua i nā hōʻailona e pili ana i ka puʻuwai.

No ka mālama ʻana i nā hōʻailona, ​​hiki i kāu kauka ke kuhikuhi i nā lāʻau lapaʻau e kōkua i ka puʻuwai, ka ʻeha o ke aʻalolo, a i ʻole nā ​​pilikia ʻē aʻe. Hana kēia mau lāʻau lapaʻau kākoʻo me ka tafamidis e hoʻomaikaʻi i kou ola.

Ke aʻo ʻia nei ka gene therapy a me nā lāʻau lapaʻau ʻē aʻe, akā ʻo tafamidis ka lāʻau lapaʻau mua i hōʻoia ʻia no ka hoʻolohi ʻana i ka holomua o ka maʻi i ka hapa nui o nā maʻi.

Ua ʻoi aku ka maikaʻi o Tafamidis ma mua o nā lāʻau lapaʻau ʻē aʻe?

Hāʻawi ʻo Tafamidis i nā pono kūikawā ma ke ʻano he lāʻau lapaʻau waha mua i hōʻoia ʻia e hoʻolohi i ka holomua i ka transthyretin amyloidosis. No nā maʻi he nui, hāʻawi ia i kahi koho lapaʻau kūpono i maʻalahi ke mālama ma mua o nā mea ʻē aʻe e hiki ke hoʻokomo ʻia.

I ka hoʻohālikelike ʻana me patisiran a me inotersen, ʻoi aku ka liʻiliʻi o nā hopena ʻaoʻao koʻikoʻi o tafamidis a ʻaʻole pono e nānā mau ʻia no ka ʻona o ke ake a i ʻole nā ​​hoʻololi ʻana o ke koko. ʻO kēia ka mea e palekana ai i ka wā lōʻihi no nā poʻe he nui.

Hāʻawi ka formulation waha iā tafamidis i kahi pono kūpono ma mua o nā lāʻau lapaʻau injectable. Hiki iā ʻoe ke lawe ma ka home me ka ʻole e kipa i kahi keʻena lapaʻau, e maʻalahi ai ka mālama ʻana i ka lāʻau lapaʻau.

Eia naʻe, ʻo ka lāʻau lapaʻau

E nānā mau kāu kauka i ka hana o kou puʻuwai i ka wā e lawe ana ʻoe i ka tafamidis. ʻAʻole pinepine ka lāʻau lapaʻau e hoʻonui i nā maʻi puʻuwai ʻē aʻe a hiki ke kōkua i ka mālama ʻana i ka hana o ka puʻuwai ma ka pale ʻana i nā waihoʻoluʻu protein hou aʻe.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Tafamidis?

Inā lawe hewa ʻoe i ka tafamidis hou, e kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. ʻOiai ua kaupalena ʻia ka ʻike overdose ma muli o ka hou o ka lāʻau lapaʻau, he mea nui e loaʻa ke alakaʻi olakino.

Mai ho'āʻo e hoʻopōʻino iā ʻoe iho a i ʻole e lawe i nā lāʻau lapaʻau hou e kūʻē i ka overdose. E mālama i ka nui o ka lāʻau lapaʻau hou āu i lawe ai a me ka manawa, no ka mea, e kōkua kēia ʻike i nā mea mālama ola e hoʻoholo i ke ala maikaʻi loa o ka hana.

He aha kaʻu e hana ai inā hala wau i kahi mahele o Tafamidis?

Inā hala ʻoe i kahi mahele, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i hala a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i hala. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i nā mea hoʻomanaʻo kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua i ka mālama ʻana i ka mālama mau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Tafamidis?

Pono ʻoe e hooki i ka lawe ʻana i ka tafamidis ma lalo o ke alakaʻi a kāu kauka. No ka mea, he lapaʻau lōʻihi no kahi maʻi holomua, ʻaʻole maʻamau ka hooki ʻana ke ʻole ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi a i ʻole e loli nui kāu maʻi.

Hiki i kāu kauka ke noʻonoʻo e hooki inā loaʻa iā ʻoe nā pilikia olakino ʻē aʻe e hoʻopilikia ai i ka mālama ʻana, a i ʻole inā hōʻike ka nānā mau ʻana ʻaʻole e hāʻawi ka lāʻau lapaʻau i nā pōmaikaʻi i manaʻo ʻia no kāu kūlana.

Hiki iaʻu ke lawe i ka Tafamidis me nā lāʻau lapaʻau ʻē aʻe?

He kakaikahi nā pilina o Tafamidis me nā lāʻau ʻē aʻe, e hiki ai ke hoʻohana pū me ka hapa nui o nā lāʻau lapaʻau āu e pono ai no nā maʻi ʻē aʻe. Eia naʻe, e haʻi mau i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei.

E nānā kāu kauka i kāu papa inoa lāʻau lapaʻau piha e hōʻoia ʻaʻole he pilina pilikia. Pono paha kekahi mau lāʻau lapaʻau i nā hoʻoponopono manawa a i ʻole nā hoʻololi ʻana i ka mahele e hana maikaʻi me tafamidis.