He aha ʻo Tafasitamab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i manaʻo ʻia ʻo Tafasitamab no kekahi mau ʻano maʻi maʻi koko. No ka papa o nā lāʻau i kapa ʻia he monoclonal antibodies kēia lāʻau, e hana ana e like me nā pōkā alakaʻi e ʻimi a hoʻouka i nā sela maʻi maʻi me ka waiho ʻana i nā sela olakino.

Inā ua kau ʻia ʻo Tafasitamab iā ʻoe a i ʻole kekahi āu e mālama nei, nui paha kāu mau nīnau e pili ana i ka mea e manaʻo ai. He holomua nui kēia lāʻau lapaʻau i ka mālama ʻana i nā maʻi maʻi koko, a ʻo ka hoʻomaopopo ʻana i ke ʻano o kāna hana hiki ke kōkua iā ʻoe e mākaukau no kāu huakaʻi lapaʻau.

He aha ʻo Tafasitamab?

He antibody i hana ʻia i loko o ka hale hana ʻo Tafasitamab e manaʻo ana i kahi protein kikoʻī i loaʻa ma kekahi mau sela maʻi maʻi. E noʻonoʻo iā ia he kī kūikawā e kūpono wale ana i nā laka i loaʻa ma nā sela maʻi maʻi, e kōkua ana i kāu ʻōnaehana pale e ʻike a luku i kēia mau sela ʻino me ka ʻoi aku ka maikaʻi.

Hāʻawi ʻia ka lāʻau lapaʻau ma o ka IV infusion, ʻo ia hoʻi, hāʻawi pololei ʻia i loko o kou kahe koko ma o ka vein. Hiki i kēia i ka lāʻau lapaʻau ke hele i kou kino e hiki i nā sela maʻi maʻi ma nā wahi a lākou e peʻe ai.

Ua ʻike ʻia ʻo Tafasitamab ma ka inoa inoa ʻo Monjuvi. Aia ka inoa kemika piha i ka

Ua hana ʻia ka lāʻau lapaʻau no nā mākua nona nā pūnaewele maʻi ʻaʻai e hōʻike ana i ka maikaʻi no kahi protein i kapa ʻia ʻo CD19. E hana kāu hui lapaʻau i nā hoʻokolohua kūikawā e hōʻoia i ka tafasitamab ke koho kūpono no kāu ʻano lymphoma.

Pehea e Hana ai ʻo Tafasitamab?

Hana ʻo Tafasitamab ma ka hoʻopili ʻana i kahi protein i kapa ʻia ʻo CD19 e noho ana ma luna o nā pūnaewele maʻi ʻaʻai. Ke hoʻopili ʻia, hōʻailona ia i kāu ʻōnaehana pale e hoʻouka a luku i kēia mau pūnaewele.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau maʻi ʻaʻai ikaika. He ikaika ia e kuhikuhi pono i nā pūnaewele maʻi ʻaʻai akā maʻamau ka liʻiliʻi o nā hopena ʻaoʻao koʻikoʻi ma mua o nā lāʻau chemotherapy kuʻuna.

Hana ka lāʻau lapaʻau ma nā ala nui ʻelua. ʻO ka mea mua, pale pololei ia i nā hōʻailona e kōkua ai i nā pūnaewele maʻi ʻaʻai e ola a hoʻonui. ʻO ka lua, hoʻolimalima ia i nā pūnaewele pale maoli o kou kino e hui pū i ke kaua e kūʻē i ka maʻi ʻaʻai.

Pehea e Lawe ai au i ka Tafasitamab?

Hāʻawi ʻia ʻo Tafasitamab ma o ka IV infusion wale nō ma kahi keʻena lapaʻau, no laila ʻaʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home. E mālama kāu hui mālama ola i nā hoʻomākaukau a me ka lawelawe ʻana nāu.

Ma mua o kēlā me kēia infusion, e loaʻa iā ʻoe nā lāʻau lapaʻau ma mua e kōkua ai e pale i nā hopena maʻi. Hiki i kēia mau mea ke komo i nā antihistamines, nā mea hoʻemi wela, a i ʻole nā steroids. E nānā pono kāu hui lapaʻau iā ʻoe i ka wā a ma hope o kēlā me kēia infusion.

ʻAʻole pono ʻoe e hahai i nā palena meaʻai kūikawā me tafasitamab. Eia naʻe, he mea nui e noho hydrated ma mua a ma hope o kāu mau lāʻau lapaʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā alakaʻi kikoʻī e pili ana i ka ʻai a me ka inu ʻana i nā lā lapaʻau.

Pehea ka lōʻihi e lawe ai au i ka Tafasitamab?

ʻO ka papa lapaʻau maʻamau me tafasitamab e mau ana ma kahi o 12 mahina, ʻoiai hiki ke ʻokoʻa kēia ma muli o ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau. E pili ana kāu papa hana lapaʻau i nā infusions i kēlā me kēia mau pule i kēia manawa.

E nānā mau kāu kauka i kou holomua ma o nā hoʻokolohua koko a me nā kiʻi kiʻi. Kōkua kēia mau nānā ʻana e hoʻoholo inā e hana pono ana ka lapaʻau a inā pono e hana i nā hoʻoponopono.

Aia ka hoʻoholo e hoʻomau a hoʻōki paha i ka lapaʻau i nā mea he nui, me ka maikaʻi o ka pane ʻana o ka maʻi ʻaʻai, nā hopena ʻaoʻao āu e ʻike ai, a me kou olakino holoʻokoʻa. E hana pū kāu hui lapaʻau me ʻoe e hana i kēia mau hoʻoholo.

He aha nā hopena ʻaoʻao o Tafasitamab?

E like me nā lapaʻau maʻi ʻaʻai a pau, hiki i ka tafasitamab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi ana. Hiki i ka hoʻomaopopo ʻana i ka mea e manaʻo ai ke kōkua iā ʻoe e hoʻomākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu hui mālama ola.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka luhi, hiki ke loli mai ka luhi māmā a i ka pau ʻana o ka ikaika. Nui ka poʻe e ʻike pū i nā loli i kā lākou helu koko, e nānā pono ai kāu hui lapaʻau ma o nā hoʻokolohua koko maʻamau.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia:

• Luhi a me ka nāwaliwali
• Nā helu keʻokeʻo koko haʻahaʻa (e hoʻonui ana i ka pilikia o ka maʻi)
• Nā helu ʻulaʻula koko haʻahaʻa (anemia)
• Nā helu platelet haʻahaʻa (e pili ana i ka hoʻopaʻa ʻana o ke koko)
• Pāpaʻa
• Hoʻemi ʻia ka ʻai
• Ua
• Fiva

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao me ke kākoʻo olakino kūpono a me ka nānā ʻana. He ʻike ko kāu hui mālama ola i ke kōkua ʻana i nā maʻi ma o kēia mau pilikia.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau. Pono kēia mau mea i ka lāʻau lapaʻau koke a me nā maʻi koʻikoʻi, ke kahe nui ʻana o ke koko, a i ʻole nā hopena maʻi maʻi koʻikoʻi i ka wā o ka infusion.

Hiki i nā hopena ʻaoʻao laha akā koʻikoʻi ke komo:

• Nā maʻi nui ma muli o ka nāwaliwali o ka ʻōnaehana pale
• Tumor lysis syndrome (ka haki wikiwiki ʻana o nā pūnaewele maʻi ʻaʻai)
• Nā hopena maʻi āpau nui
• Progressive multifocal leukoencephalopathy (he maʻi lolo laha ʻole)
• Hoʻāla hou ʻia ʻo Hepatitis B i ka poʻe i loaʻa mua

E nānā pono kāu hui lapaʻau i kēia mau pilikia laha ʻole a e hana i nā hana e pale aku ai iā lākou i ka wā hiki. Mai kānalua e hōʻike i nā hōʻailona maʻamau ʻole, ʻaʻole hoʻi i ka liʻiliʻi o lākou.

ʻO wai ka mea pono ʻole e lawe iā Tafasitamab?

ʻAʻole kūpono ʻo Tafasitamab no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia nāu. Pono paha ka poʻe me kekahi mau maʻi a i ʻole nā kūlana olakino e pale i kēia lāʻau a i ʻole e pono ai ke nānā kūikawā.

ʻAʻole pono ʻoe e loaʻa iā tafasitamab inā ua loaʻa iā ʻoe kahi hopena maʻi āpau nui i kēia lāʻau a i ʻole kekahi o kāna mau mea i ka wā ma mua. E akahele nō hoʻi kāu kauka inā he moʻolelo kou o nā hopena maʻi āpau nui i nā antibodies monoclonal ʻē aʻe.

E nānā kūikawā kāu hui lapaʻau inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• Nā maʻi ikaika, ʻoi aku hoʻi nā maʻi bacteria, viral, a i ʻole fungal koʻikoʻi
• Moʻolelo o ka maʻi hepatitis B
• ʻO ka ʻōnaehana pale nāwaliwali loa
• Hāpai a i ʻole nā hoʻolālā e hāpai
• Hānai ʻana i ka umauma
• Nā koi lāʻau lapaʻau ola

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, hiki i kēia lāʻau ke hōʻeha i kāu pēpē e ulu ana. E kūkākūkā kāu hui mālama ola i nā ʻano hana pale hāpai palekana a me nā koho hoʻolālā ʻohana me ʻoe.

ʻO ka inoa inoa ʻo Tafasitamab

Kūʻai ʻia ʻo Tafasitamab ma lalo o ka inoa inoa ʻo Monjuvi ma ʻAmelika Hui Pū ʻIa. ʻO kēia inoa inoa ka mea āu e ʻike ai ma kāu mau papa hana lapaʻau a me nā pepa ʻinikua.

Hana ʻia ka lāʻau lapaʻau e MorphoSys a kūʻai ʻia ma ka hui pū ʻana me Incyte Corporation. I ka wā e kūkākūkā ana i kāu lapaʻau ʻana me nā hui ʻinikua a i ʻole nā mea mālama ola ʻē aʻe, pili nā inoa ʻelua (tafasitamab a me Monjuvi) i ka lāʻau lapaʻau hoʻokahi.

Nā Koho ʻē aʻe no Tafasitamab

Nui nā koho lapaʻau ʻē aʻe no ka lymphoma nui B-cell, akā pili ka koho maikaʻi loa i kāu kūlana kikoʻī. E noʻonoʻo kāu kauka i nā mea e like me kou olakino holoʻokoʻa, nā lapaʻau mua, a me ke ʻano o ka pane ʻana o kāu maʻi kanesa.

Hiki i nā lapaʻau ʻē aʻe ke komo i nā hui chemotherapy kuʻuna e like me R-CHOP a i ʻole nā lāʻau lapaʻau i manaʻo ʻia. ʻO ka lāʻau lapaʻau CAR T-cell e hōʻike ana i kahi koho holomua ʻē aʻe no kekahi poʻe maʻi, akā pono ia i nā kikowaena lapaʻau kūikawā.

Hiki i kekahi poʻe ke pōmaikaʻi mai nā hoʻokolohua lapaʻau e hoʻāʻo ana i nā lapaʻau hoʻokolohua hou. Hiki i kāu oncologist ke kōkua iā ʻoe e hoʻomaopopo inā kūpono kekahi mau haʻawina noiʻi no kou kūlana.

ʻOi aku ka maikaʻi o Tafasitamab ma mua o Rituximab?

ʻO Tafasitamab a me rituximab nā antibodies monoclonal i hoʻohana ʻia e mālama i nā maʻi kanesa koko, akā hana lākou ma nā ʻano like ʻole a hoʻohana ʻia i nā kūlana like ʻole. ʻAʻole maʻalahi ka hoʻohālikelike ʻana iā lākou no ka mea hoʻohana pinepine ʻia lākou i nā pae lapaʻau like ʻole.

Ua loaʻa ʻo Rituximab no ka lōʻihi a hoʻohana pinepine ʻia ma ke ʻano he ʻāpana o nā hui lapaʻau laina mua. Hoʻopaʻa ʻia ʻo Tafasitamab no nā kūlana i hoʻi mai ai ka maʻi kanesa a i ʻole ʻaʻole i pane maikaʻi i nā lapaʻau mua.

E koho kāu kauka i ka lāʻau lapaʻau kūpono loa e pili ana i kāu ʻano lymphoma kikoʻī, kāu mōʻaukala lapaʻau, a me kou olakino holoʻokoʻa. Ua hōʻoia ʻia nā lāʻau lapaʻau ʻelua i ka maikaʻi i kā lākou hoʻohana ʻana, a ʻo ke koho

Hiki ke hoʻohana palekana ʻia ʻo Tafasitamab i ka poʻe me ka maʻi puʻuwai, akā pono e hana pū kāu cardiologist a me ka oncologist e nānā pono iā ʻoe. ʻAʻole pili pololei ka lāʻau lapaʻau i ka ʻiʻo o ka puʻuwai, akā hiki i nā lāʻau lapaʻau maʻi maʻi ke hoʻopilikia i ke olakino cardiovascular.

E hana paha kāu hui lapaʻau i nā hoʻokolohua hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a nānā iā ʻoe i ka wā o ka lāʻau lapaʻau. Inā he pilikia nui kou puʻuwai, hiki iā lākou ke hoʻoponopono i kāu papa hana lapaʻau a i ʻole e hāʻawi i nā ana pale puʻuwai hou.

He aha kaʻu e hana ai inā ua hala au i ka hoʻokomo ʻana o Tafasitamab?

No ka mea, hāʻawi ʻia ʻo tafasitamab ma kahi keʻena lapaʻau, hiki ke hala ka mahele ma muli o nā paio hoʻonohonoho a i ʻole nā pilikia olakino. E hoʻokaʻaʻike koke i kāu hui mālama ola inā pono ʻoe e hala a hoʻonohonoho hou i kahi manawa.

E kōkua kāu hui lapaʻau iā ʻoe e hoʻonohonoho hou i ka wā e palekana ai ke hana pēlā. Hiki iā lākou ke hoʻoponopono iki i kāu papa hana lapaʻau, akā he mea nui ʻaʻole e lele i nā mahele me ka ʻole o ke alakaʻi olakino, no ka mea, hiki i kēia ke hoʻopilikia i ka maikaʻi o kāu lāʻau lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Tafasitamab?

ʻO ka hoʻoholo e hooki i ka tafasitamab e pili ana i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi i ka lāʻau lapaʻau a me nā hopena ʻaoʻao āu e ʻike ai. Hoʻopau ka hapa nui o ka poʻe ma kahi o 12 mau mahina o ka lāʻau lapaʻau, akā hiki ke ʻokoʻa kēia.

E hoʻohana kāu kauka i nā scans maʻamau a me nā hoʻokolohua koko e nānā i kāu holomua. Inā nalowale ka maʻi maʻi a i ʻole ʻike ʻole ʻia, hiki iā ʻoe ke hoʻopau i ka papa hana lapaʻau i hoʻolālā ʻia. Inā loaʻa nā hopena ʻaoʻao koʻikoʻi, hiki i kāu kauka ke ʻōlelo e hooki koke a hoʻololi i kahi ala ʻokoʻa.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Tafasitamab?

Pono ʻoe e pale i nā lāʻau lapaʻau ola i ka wā e loaʻa ana iā tafasitamab no ka mea e pili ana ka lāʻau lapaʻau i kāu ʻōnaehana pale. Eia naʻe, palekana nā lāʻau lapaʻau ʻole (e like me ka pana flu) a ua ʻōlelo pinepine ʻia.

E hāʻawi ana kāu hui mālama ola i nā ʻōlelo kikoʻī e pili ana i nā lāʻau lapaʻau palekana i ka wā o kāu mālama ʻana. Hiki iā lākou ke ʻōlelo e loaʻa i kekahi mau lāʻau lapaʻau ma mua o ka hoʻomaka ʻana i ka tafasitamab a i ʻole ke kali ʻana a pau kāu mālama ʻana.

E Hoʻopilikia ʻo Tafasitamab i koʻu hiki ke hana a i ʻole ke kalaiwa?

Hiki i ka nui o nā kānaka ke hoʻomau i ka hana a me ke kalaiwa ʻana i ka wā e loaʻa ana ka tafasitamab, akā pono paha ʻoe e hana i kekahi mau hoʻoponopono. ʻO ka luhi kahi hopena ʻaoʻao maʻamau e pili ana i kou pae ikehu a me ka noʻonoʻo.

E hoʻolālā i kekahi maʻalahi i kāu papa manawa, ʻoiai i nā lā lapaʻau a me ka lā ma hope o nā infusions. Manaʻo kekahi poʻe e luhi no hoʻokahi a ʻelua paha lā ma hope o kēlā me kēia lapaʻau, ʻoiai ʻo nā mea ʻē aʻe e mālama i ko lākou pae ikehu maʻamau i ka wā o ka mālama ʻana.