He aha ka Tofacitinib: Nā Hoʻohana, Nā Kumu, Nā Hopena ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Tofacitinib e kōkua ana i ka hoʻomaha ʻana i kāu ʻōnaehana pale ke hana nui. No ka papa o nā lāʻau i kapa ʻia ʻo JAK inhibitors kēia lāʻau lapaʻau waha, e hana ana ma ka ālai ʻana i kekahi mau protein e hoʻoulu ai i ka mumū i loko o kou kino.

Hiki ke kauoha ʻia ʻoe i ka tofacitinib inā loaʻa iā ʻoe nā maʻi e like me ka rheumatoid arthritis, psoriatic arthritis, a i ʻole ulcerative colitis. Ua hoʻolālā ʻia e kōkua i ka hōʻemi ʻana i ka ʻeha, ka pehu ʻana, a me nā hōʻailona ʻē aʻe ke hoʻouka hewa kāu ʻōnaehana pale i ka ʻiʻo olakino.

No ke aha e hoʻohana ʻia ai ka Tofacitinib?

Hoʻomaʻamaʻa ʻo Tofacitinib i kekahi mau maʻi autoimmune kahi e hana nui ai ka ʻōnaehana pale o kou kino. Ua ʻae ʻia ka lāʻau lapaʻau e ka FDA no ka rheumatoid arthritis, psoriatic arthritis, a me ulcerative colitis i nā pākeke.

No ka rheumatoid arthritis, kōkua ʻo tofacitinib i ka hōʻemi ʻana i ka ʻeha hui, ka ʻoʻoleʻo, a me ka pehu ʻana e hiki ke paʻakikī i nā hana i kēlā me kēia lā. Nui ka poʻe i ʻike i ka hoʻomaikaʻi ʻana o ko lākou ʻoʻoleʻo kakahiaka a hiki iā lākou ke neʻe me ka ʻoluʻolu i ka lā.

I ka psoriatic arthritis, ua manaʻo kēia lāʻau lapaʻau i ka mumū hui a me nā hōʻailona ʻili. Hiki iā ia ke kōkua i ka hōʻoluʻolu i nā hui ʻeha, pehu, ʻoiai e hoʻomaikaʻi ana i nā ʻili ʻili e hele pinepine ana me kēia maʻi.

No ka ulcerative colitis, hana ʻo tofacitinib e hōʻemi i ka mumū i loko o kou kolonā. Hiki i kēia ke kōkua i ka mālama ʻana i nā hōʻailona e like me nā neʻe ʻana o ka ʻōpū pinepine, ka ʻeha o ka ʻōpū, a me ke kahe ʻana e hoʻopilikia i kou maikaʻi o ke ola.

Pehea e hana ai ka Tofacitinib?

Hana ʻo Tofacitinib ma ka ālai ʻana i nā enzymes kikoʻī i kapa ʻia ʻo JAK proteins e hoʻouna ana i nā hōʻailona mumū i loko o kou kino. E noʻonoʻo i kēia mau protein ma ke ʻano he ʻelele e haʻi ana i kāu ʻōnaehana pale e hana i ka mumū.

I ka wā e hana nui ai kēia mau protein JAK, hiki iā lākou ke hoʻoulu i kāu ʻōnaehana pale e hoʻouka i nā ʻiʻo olakino e like me kou mau ami a i ʻole ke ala ʻai. Ma ka pale ʻana i kēia mau hōʻailona, ​​kōkua ka tofacitinib i ka hōʻemi ʻana i ka mumū e hoʻoulu ai i kāu mau hōʻailona.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia, ʻo ia hoʻi e kālele ana i nā ʻāpana kikoʻī o kāu ʻōnaehana pale ma mua o ka hoʻopaʻa ʻana i nā mea āpau. Eia naʻe, he lāʻau lapaʻau ikaika nō ia e pono ai ka nānā pono ʻana e kāu mea mālama ola.

Hiki iā ʻoe ke hoʻomaka e ʻike i nā hoʻomaikaʻi ʻana i kāu mau hōʻailona i loko o kekahi mau pule, ʻoiai hiki ke lawe i ʻekolu mahina e ʻike i nā pono piha. Pane ʻokoʻa nā kānaka a pau, no laila e hana kāu kauka me ʻoe e ʻimi i ke ala kūpono.

Pehea wau e lawe ai iā Tofacitinib?

E lawe i ka tofacitinib e like me ke kauoha a kāu kauka, maʻamau ʻelua i ka lā me ka ʻole o ka meaʻai. Hiki iā ʻoe ke lawe me ka waiū a i ʻole ka wai, a ʻaʻole koʻikoʻi ka manawa me nā meaʻai no ka absorption.

E ale i nā papa holoʻokoʻa me ka ʻole o ka ʻoki ʻana, ka wāwahi ʻana, a i ʻole ka nau ʻana iā lākou. Hoʻolālā ʻia ka formulation hoʻokuʻu lōʻihi e hoʻokuʻu mālie i ka lāʻau lapaʻau i ka lā, no laila hiki i ka hoʻololi ʻana i ka papa ke hoʻopilikia i ke ʻano o ka hana.

E hoʻāʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā e mālama i nā pae paʻa i loko o kou kahe koko. Hiki i ka hoʻonohonoho ʻana i nā mea hoʻomanaʻo kelepona ke kōkua iā ʻoe e hoʻokumu i kahi hana maʻamau, ʻoiai ke hoʻomaka mua ʻoe i ka lāʻau.

Inā pilikia ʻoe i ka ale ʻana i nā papa, e kamaʻilio me kāu kauka e pili ana i kāu mau koho. Hiki iā lākou ke hōʻike i nā ʻenehana e maʻalahi ai ka ale ʻana a i ʻole e kūkākūkā inā ʻo kēia lāʻau lapaʻau ka koho maikaʻi loa no ʻoe.

Pehea ka lōʻihi e lawe ai au iā Tofacitinib?

Lawe ka hapa nui o nā kānaka i ka tofacitinib ma ke ʻano he lapaʻau lōʻihi e mālama i ko lākou maʻi maʻi. E loiloi mau kāu kauka inā e kōkua mau ana ka lāʻau lapaʻau iā ʻoe a palekana.

E loaʻa paha iā ʻoe nā hoʻokolohua koko i kēlā me kēia mau mahina e nānā i kāu ʻōnaehana pale, ka hana o ke ake, a me ke olakino holoʻokoʻa. Kōkua kēia mau loiloi e hōʻoia i ka hana maikaʻi ʻana o ka lāʻau me ka ʻole o ka hopena ʻaoʻao e hopohopo ai.

Pono paha kekahi poʻe e hoʻomaha mai ka tofacitinib inā loaʻa iā lākou nā maʻi a i ʻole nā pilikia olakino ʻē aʻe. E alakaʻi kāu kauka iā ʻoe ma nā hoʻoponopono e pono ai e mālama iā ʻoe i ke olakino e like me ka hiki.

Mai hooki koke i ka lawe ʻana i ka tofacitinib me ka ʻole e kamaʻilio mua me kāu mea mālama ola. ʻO ka hooki ʻana i ka pōkole hiki ke hoʻi koke mai kāu mau hōʻailona, a makemake paha kāu kauka e hōʻemi mālie i kāu mahele.

He aha nā hopena ʻaoʻao o Tofacitinib?

E like me nā lāʻau lapaʻau a pau e pili ana i kāu ʻōnaehana pale, hiki i ka tofacitinib ke hana i nā hopena ʻaoʻao mai ka maʻalahi a i ka koʻikoʻi. ʻO ka hapa nui o nā kānaka e ʻae maikaʻi iā ia, akā ʻo ka ʻike i nā hopena hiki ke kōkua iā ʻoe e ʻike i ka mea e nānā ai.

ʻO nā hopena ʻaoʻao maʻamau e ʻike ai ka poʻe he nui, ʻo ia nā poʻo, ka maʻi maʻi, a me nā hōʻailona e like me ke anu. Hoʻomaikaʻi pinepine kēia mau mea i ka wā e hoʻoponopono ai kou kino i ka lāʻau i nā pule mua.

Eia nā hopena ʻaoʻao pinepine e ʻike ai ʻoe:

• Nā maʻi hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā poʻo e maʻalahi a maʻalahi paha
• Ka maʻi maʻi a i ʻole nā loli i ka neʻe ʻana o ka ʻōpū
• Ke koko kiʻekiʻe
• Nausea a i ʻole ka ʻoluʻolu o ka ʻōpū

Hiki ke mālama ʻia kēia mau hopena maʻamau a emi pinepine i ka manawa. Eia naʻe, e haʻi i kāu kauka inā lilo kekahi o kēia mau hōʻailona i mea hoʻonāukiuki a ʻaʻole e hoʻomaikaʻi.

Pono nā hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke, ʻoiai ʻaʻole maʻamau lākou. No ka mea e pili ana ka tofacitinib i kāu ʻōnaehana pale, ʻoi aku ka nui o ka pilikia o ka hoʻomohala ʻana i nā maʻi.

E kelepona koke i kāu kauka inā ʻike ʻoe i kekahi o kēia mau hōʻailona e hopohopo nei:

• Ka wela, nā anu, a i ʻole nā hōʻailona e like me ka maʻi palū ʻaʻole e hoʻomaikaʻi
• Ka luhi a i ʻole ka nāwaliwali ʻano ʻē
• ʻO ke kuni mau a i ʻole nā pilikia hanu
• ʻO ka ʻeha a i ʻole ke kahe koko ʻano ʻē
• Nā loli ʻili e like me nā ʻōpala hou a i ʻole nā ʻeha
• ʻEha ʻōpū a i ʻole nā loli i nā hana ʻōpū

Hiki i kēia mau hōʻailona ke hōʻike i nā maʻi koʻikoʻi a i ʻole nā pilikia ʻē aʻe e pono ai ka loiloi a me ka mālama koke.

ʻO nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi e pili ana i nā ʻōpū koko, ʻoi aku hoʻi i nā māmā a i ʻole nā wāwae, a me kekahi mau ʻano maʻi ʻaʻai. E kūkākūkā kāu kauka i kēia mau pilikia me ʻoe a nānā i nā hōʻailona hōʻailona i ka wā o kāu mālama ʻana.

ʻO wai ka mea ʻaʻole pono e lawe iā Tofacitinib?

Pono kekahi poʻe e pale i ka tofacitinib ma muli o ka piʻi ʻana o nā pilikia koʻikoʻi. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe i ka tofacitinib inā he mau maʻi koʻikoʻi kāu e like me ka maʻi tuberculosis a i ʻole hepatitis B. Hiki i ka lāʻau lapaʻau ke hoʻonui i kēia mau maʻi ma ka hoʻopilikia ʻana i ka hiki o kāu ʻōnaehana pale e hakakā iā lākou.

ʻAʻole paha he mau moho maikaʻi nā poʻe me ka mōʻaukala o nā ʻōpū koko, nā pilikia o ka naʻau, a i ʻole kekahi mau maʻi ʻaʻai no ka tofacitinib. E kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i kēia mau pilikia hiki ke loaʻa no kāu kūlana.

Eia nā kūlana e pale maʻamau ai i kekahi mai ka lawe ʻana iā tofacitinib:

• ʻO ka maʻi tuberculosis a i ʻole nā maʻi koʻikoʻi ʻē aʻe
• Mōʻaukala o nā ʻōpū koko i nā māmā a i ʻole nā wāwae
• Nā pilikia ate koʻikoʻi
• Nā helu koko haʻahaʻa
• Hāpai a i ʻole ka hānai ʻana i ka waiū
• Nā lāʻau lapaʻau ola hou

E noʻonoʻo pū kāu kauka i kou makahiki, nā lāʻau lapaʻau ʻē aʻe, a me ke kūlana olakino holoʻokoʻa i ka wā e hoʻoholo ai inā kūpono ka tofacitinib iā ʻoe.

Inā ʻoe e hoʻolālā nei e hāpai a i ʻole e hānai ana i ka waiū, e kūkākūkā i kēia me kāu kauka. ʻAʻole maopopo loa nā hopena o ka tofacitinib i ka hāpai ʻana a me ka hānai ʻana, no laila ʻoi aku ka palekana o nā lāʻau lapaʻau ʻē aʻe.

Nā inoa inoa o Tofacitinib

Loaʻa ʻo Tofacitinib ma lalo o ka inoa inoa ʻo Xeljanz no nā papa hoʻokuʻu koke a me Xeljanz XR no nā papa hoʻokuʻu lōʻihi. Loaʻa i nā ʻano ʻelua ka mea hana like akā hoʻokuʻu ʻia ma nā ʻano like ʻole.

Hele mai ʻo Xeljanz i nā papa 5mg āu e lawe ai i ʻelua manawa i ka lā. ʻO Xeljanz XR kahi papa hoʻokuʻu lōʻihi 11mg i lawe ʻia i hoʻokahi manawa i ka lā, a he mea maʻalahi kekahi poʻe.

Na kāu kauka e koho i ka formulation e hana maikaʻi loa no kou kūlana a me kou ola. He kūpono nā mana ʻelua ke lawe ʻia e like me ke kauoha.

Nā koho ʻē aʻe o Tofacitinib

Nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i nā kūlana like me tofacitinib, ʻoiai lākou e hana ma nā ʻano like ʻole. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ʻo tofacitinib iā ʻoe.

ʻO nā mea pale JAK ʻē aʻe me baricitinib (Olumiant) a me upadacitinib (Rinvoq). Hana like kēia mau lāʻau lapaʻau me tofacitinib akā loaʻa paha nā hopena ʻaoʻao like ʻole.

He kūpono nō hoʻi nā lāʻau lapaʻau biologic e like me adalimumab (Humira), etanercept (Enbrel), a me infliximab (Remicade) no nā kūlana autoimmune. Hāʻawi ʻia kēia mau mea ma ka injection a i ʻole ka infusion ma mua o nā papa waha.

He mea nui nā lāʻau lapaʻau hoʻololi maʻi maʻamau e like me methotrexate a me sulfasalazine. Ua hoʻohana ʻia kēia mau lāʻau lapaʻau no nā makahiki he nui a he kūpono paha ia ma muli o kou kūlana.

ʻOi aku ka maikaʻi o Tofacitinib ma mua o Methotrexate?

Hana ʻokoʻa ʻo Tofacitinib a me methotrexate a ʻaʻole pono e ʻoi aku ka maikaʻi a i ʻole ka ʻino ma mua o kekahi. ʻO ke koho maikaʻi loa e pili ana i kou kūlana, ka mōʻaukala olakino, a me nā makemake pilikino.

Ua hoʻohana ʻia ʻo Methotrexate no nā makahiki he nui a ʻo ia ka lāʻau lapaʻau mua e hoʻāʻo ai nā kauka no ka maʻi rheumatoid arthritis. Maʻamau ka maikaʻi a ʻoi aku ka liʻiliʻi ma mua o nā lāʻau lapaʻau hou e like me tofacitinib.

Hiki ke koho ʻia ʻo Tofacitinib inā ʻaʻole maikaʻi ka hana ʻana o ka methotrexate a i ʻole ke kumu o nā hopena ʻaoʻao e hoʻopilikia ai. Makemake kekahi poʻe e lawe i nā papa waha ma mua o nā injections e koi ai ka methotrexate i kekahi manawa.

E noʻonoʻo kāu kauka i nā mea e like me ke koʻikoʻi o kāu mau hōʻailona, ​​nā kūlana olakino ʻē aʻe āu, a me kāu mau pahuhopu lapaʻau i ke koho ʻana ma waena o kēia mau lāʻau.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Tofacitinib

He Palekana ʻo Tofacitinib no ka poʻe me ka maʻi puʻuwai?

Hiki i ka Tofacitinib ke hoʻonui i ka pilikia o nā pilikia o ka puʻuwai a me nā koko koko, ʻoiai i ka poʻe i loaʻa mua i ka maʻi puʻuwai a i ʻole nā ​​mea pilikia. E loiloi pono kāu kauka i kou olakino cardiovascular ma mua o ke kau ʻana i kēia lāʻau.

Inā he moʻolelo kou o ka puʻuwai, ka hahau ʻana, a i ʻole nā ​​koko koko, hiki i kāu kauka ke ʻōlelo aku i nā lāʻau lapaʻau ʻē aʻe. E nānā pū lākou iā ʻoe inā lawe ʻoe i ka tofacitinib, e nānā ana i nā hōʻailona o nā pilikia cardiovascular.

E hōʻoia e haʻi i kāu kauka e pili ana i kekahi ʻeha o ka umauma, ka pōkole o ka hanu, a i ʻole ka pehu ʻana o ka wāwae i ka wā e lawe ana i ka tofacitinib. Hiki i kēia mau mea ke hōʻailona o nā pilikia puʻuwai a i ʻole ke kahe koko e pono ai ka nānā koke.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Tofacitinib?

Inā lawe hewa ʻoe i ka nui o ka tofacitinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻoi aku ka nui o nā maʻi.

Mai kali e ʻike inā maikaʻi ʻoe, no ka mea, ʻaʻole paha e ʻike koke ʻia kekahi mau hopena o ka overdose. Makemake paha kāu kauka e nānā pono iā ʻoe a i ʻole e hoʻoponopono i kāu hoʻolālā lapaʻau.

No ka pale ʻana i nā overdose ulia pōpilikia, e mālama i kāu lāʻau lapaʻau i loko o kāna pahu kumu me ka lepili maopopo. E noʻonoʻo e hoʻohana i kahi mea hoʻonohonoho pill inā ʻoe e lawe i nā lāʻau he nui, akā e nānā me kāu lāʻau lapaʻau e pili ana i ke ala maikaʻi loa e mālama ai i ka tofacitinib.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Tofacitinib?

Inā poina iā ʻoe kahi lāʻau, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu lāʻau i hoʻonohonoho ʻia e hiki mai ana. I kēlā hihia, e lele i ka lāʻau i poina a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua lāʻau i ka manawa hoʻokahi e hoʻoponopono ai i kahi lāʻau i poina, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. ʻAʻole e kōkua ka lawe ʻana i nā lāʻau hou aʻe iā ʻoe e ʻoi aku ka maikaʻi a ʻoi aku ka wikiwiki a hiki ke pilikia.

Inā poina pinepine ʻoe i nā lāʻau, e kamaʻilio me kāu kauka e pili ana i nā hoʻolālā e kōkua iā ʻoe e hoʻomanaʻo. Kōkua ka hoʻohana ʻana i nā lāʻau i ka mālama ʻana i nā pae paʻa o ka lāʻau i loko o kāu ʻōnaehana no nā hopena maikaʻi loa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Tofacitinib?

E hooki wale i ka lawe ʻana iā tofacitinib ke haʻi aku kāu kauka iā ʻoe he palekana ke hana pēlā. Pono ka hapa nui o nā kānaka me nā maʻi autoimmune maʻi i ka lāʻau lōʻihi e mālama i kā lākou mau hōʻailona ma lalo o ka mana.

E loiloi mau kāu kauka inā ke kōkua nei ʻo tofacitinib iā ʻoe a e nānā no nā hopena ʻaoʻao e pili ana. Hiki iā lākou ke hoʻoponopono i kāu lāʻau a i ʻole e hoʻololi i nā lāʻau inā pono, akā pono e hana mau ʻia kēia mau hoʻoholo.

Inā hopohopo ʻoe e pili ana i nā hopena ʻaoʻao a i ʻole manaʻo ʻoe ʻaʻole e hana ana ka lāʻau, e hoʻonohonoho i kahi manawa e kūkākūkā i kāu mau koho. Nui nā ala e hoʻoponopono ai i nā pilikia me ka ʻole e hooki loa i ka lāʻau.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Tofacitinib?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau maʻamau i ka wā e lawe ana iā tofacitinib, akā pono ʻoe e pale i nā lāʻau lapaʻau ola e like me ka lāʻau flu nasal a i ʻole ka lāʻau shingles. E kōkua kāu kauka iā ʻoe e hoʻolālā i ka papa manawa lāʻau lapaʻau palekana.

He mea nui loa ka noho ʻana i ka lā me nā lāʻau lapaʻau e like me ka pana flu makahiki a me ka lāʻau pneumonia, no ka mea, hiki i ka tofacitinib ke hoʻolilo iā ʻoe i mea maʻalahi i nā maʻi. Hiki i kēia mau lāʻau lapaʻau ke kōkua iā ʻoe e pale aku i nā maʻi koʻikoʻi.

E haʻi mau i nā mea mālama ola e lawe ana ʻoe iā tofacitinib ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau. Hiki iā lākou ke hōʻoia e loaʻa iā ʻoe ke ʻano kūpono a me ka manawa o nā immunizations no kou kūlana.