He aha ka Trabectedin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau chemotherapy ikaika ka Trabectedin i hoʻohana ʻia e mālama i kekahi mau maʻi maʻi i holomua, ʻo ia hoʻi nā sarcomas ʻiʻo palupalu a me ka maʻi ʻaʻai ovarian. Hana kēia lāʻau lapaʻau ma ka hoʻopilikia ʻana i ka DNA o ke keena maʻi, e kōkua ana e hoʻolohi a hoʻōki paha i ka ulu ʻana o ka maʻi maʻi ke ʻaʻole i maikaʻi nā lāʻau lapaʻau ʻē aʻe.

Inā ua ʻōlelo kāu kauka i ka trabectedin, he mau nīnau paha kāu e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai. E hele kākou i nā mea a pau e pono ai ʻoe e ʻike e pili ana i kēia lāʻau lapaʻau ma nā huaʻōlelo maʻalahi a maʻalahi.

He aha ka Trabectedin?

He lāʻau chemotherapy ka Trabectedin i loaʻa mai kahi mea ola kai i kapa ʻia he sea squirt. Hāʻawi ʻia ma o ka IV (intravenous) infusion pololei i loko o kou kahe koko, e ʻae ana iā ia e hiki i nā keena maʻi maʻi ma kou kino.

No ka papa o nā lāʻau i kapa ʻia he alkylating agents kēia lāʻau lapaʻau, e hana ana ma ka hōʻino ʻana i ka DNA i loko o nā keena maʻi maʻi. Ke hiki ʻole i nā keena maʻi maʻi ke hoʻoponopono i kēia pōʻino, make lākou, e kōkua ana e hōʻemi i nā maʻi a i ʻole e hoʻolohi i ko lākou ulu ʻana.

Ua manaʻo ʻia ʻo Trabectedin he lāʻau lapaʻau maʻi maʻi kūikawā, ʻo ia hoʻi, hoʻohana pinepine ʻia ia i ka wā i hana ʻole ai nā lāʻau chemotherapy maʻamau ʻē aʻe. E noʻonoʻo pono kāu oncologist i kou kūlana kikoʻī ma mua o ka ʻōlelo ʻana i kēia lāʻau lapaʻau.

No ke aha i hoʻohana ʻia ai ka Trabectedin?

Hoʻohana nui ʻia ka Trabectedin e mālama i ʻelua ʻano maʻi maʻi i holomua. Hiki i kāu kauka ke ʻōlelo iā ia ke laha kou maʻi maʻi a i ʻole ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe.

ʻO nā kūlana nui i mālama ʻia me ka trabectedin e pili ana i ka sarcoma ʻiʻo palupalu holomua a me ka maʻi ʻaʻai ovarian hou. ʻO nā sarcomas ʻiʻo palupalu he mau maʻi maʻi e ulu ana i nā ʻiʻo, ka momona, nā kīʻaha koko, a i ʻole nā ʻiʻo kākoʻo ʻē aʻe ma kou kino.

No ka maʻi 'aʻai o ka ovaries, hoʻohana pinepine ʻia ka trabectedin ke hoʻi mai ka maʻi 'aʻai ma hope o nā lāʻau chemotherapy mua. Hoʻohui pinepine ʻia me kekahi lāʻau ʻē aʻe i kapa ʻia ʻo pegylated liposomal doxorubicin e hoʻomaikaʻi i ka pono o ka lapaʻau.

I kekahi mau hihia, hiki i nā kauka ke hoʻohana i ka trabectedin no nā ʻano maʻi 'aʻai ʻē aʻe ma ke ʻano he ʻāpana o nā hoʻokolohua lapaʻau a i ʻole ke kūpono ʻole nā lapaʻau maʻamau no kou kūlana.

Pehea e Hana ai ka Trabectedin?

Hana ka trabectedin ma ka komo ʻana i loko o nā pūnaewele maʻi 'aʻai a paʻa pono i ko lākou DNA. Kāohi kēia paʻa ʻana i nā pūnaewele maʻi 'aʻai mai ka kope pono ʻana i kā lākou mea genetic, pono lākou e hana i mea e mahele a hoʻonui ai.

E noʻonoʻo e like me ka hoʻopaʻa ʻana i ka mīkini kope e hoʻohana ai nā pūnaewele maʻi 'aʻai e hana hou iā lākou iho. Ke hiki ʻole ke kope pono ʻia ka DNA, ʻike ka pūnaewele maʻi 'aʻai i kekahi mea hewa a pani mau.

Ua manaʻo ʻia kēia lāʻau lapaʻau he mea ikaika loa i ka honua chemotherapy. Ua hoʻolālā ʻia e kuhikuhi i nā pūnaewele e mahele wikiwiki ana, ʻo ia ke kumu e pono ai i ka maʻi 'aʻai akā hiki nō ke hoʻopilikia i kekahi mau pūnaewele olakino e mahele wikiwiki ana, e like me nā mea i loko o kou lauoho a i ʻole ka ʻōnaehana digestive.

ʻO ka lono maikaʻi, ʻoi aku ka koho ʻana o ka trabectedin no nā pūnaewele maʻi 'aʻai ma mua o kekahi mau lāʻau chemotherapy ʻē aʻe, e hōʻemi ana i nā hopena ʻaoʻao ʻoiai e pono ana i kāu maʻi 'aʻai.

Pehea e Lawe ai au i ka Trabectedin?

Hāʻawi mau ʻia ka Trabectedin ma ke ʻano he IV infusion ma kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi 'aʻai. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau ma ka home no ka mea pono ia i ka nānā pono ʻana e nā poʻe loea mālama ola.

Lawe maʻamau ka infusion ma kahi o 3 mau hola e hoʻopau ai. Ma mua o kāu lapaʻau, e loaʻa iā ʻoe nā lāʻau anti-nausea e kōkua ai i ka pale ʻana i ka ʻōpū, a e nānā kāu hui lapaʻau i kāu helu koko a me ka hana ate.

Loaʻa i ka hapa nui o nā kānaka ka trabectedin i hoʻokahi manawa i kēlā me kēia 3 pule, e hāʻawi ana i kou kino i ka manawa e ola ai ma waena o nā lapaʻau. E hoʻoholo kāu kauka i ka mahele pololei e pili ana i ka nui o kou kino, ke olakino holoʻokoʻa, a me ka maikaʻi o kou hoʻomanawanui ʻana i ka lāʻau.

Ma mua o kēlā me kēia hoʻokomo ʻana, e hōʻoia e ʻai i ka ʻai māmā a noho maikaʻi i ka wai. E pale i ka waiʻona no ka liʻiliʻi o 24 mau hola ma mua o ka lapaʻau ʻana, no ka mea, hiki i kēia ke hoʻokau i ke koʻikoʻi hou i kou ate i ka wā e hana ana i ka lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Trabectedin?

He ʻokoʻa nui ka lōʻihi o ka lapaʻau trabectedin mai kēlā kanaka i kēia kanaka. E nānā kāu oncologist i ka pane ʻana o kāu maʻi maʻi i ka lāʻau a me ka maikaʻi o kou kino e hoʻomanawanui ai.

Hiki i kekahi poʻe ke loaʻa ka trabectedin no nā mahina he nui, ʻoiai e hoʻomau ana kekahi i ka lapaʻau no hoʻokahi makahiki a ʻoi aku paha inā e hana maikaʻi ana a hiki ke mālama ʻia nā hopena ʻaoʻao. ʻO ke kī ka loaʻa ʻana o ke kaulike kūpono ma waena o ka hakakā ʻana i kāu maʻi maʻi a me ka mālama ʻana i kou maikaʻi o ke ola.

E nānā mau kāu kauka i kou holomua ma o nā hoʻokolohua koko, nā scans, a me nā hoʻokolohua kino. Inā pau kāu maʻi maʻi i ka pane ʻana i ka trabectedin a i ʻole inā paʻakikī loa nā hopena ʻaoʻao e mālama ai, hiki ke hoʻololi ʻia kāu hoʻolālā lapaʻau.

E hoʻomanaʻo ʻaʻole ʻo ka hoʻōki ʻana i ka trabectedin ke manaʻo nei e haʻalele i ka lapaʻau. Nui nā ala like ʻole i loaʻa i kāu hui oncology a e hana pū me ʻoe e ʻimi i ke ala maikaʻi loa i mua no kou kūlana kikoʻī.

He aha nā hopena ʻaoʻao o ka Trabectedin?

E like me nā lāʻau chemotherapy a pau, hiki i ka trabectedin ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā ​​kānaka a pau e ʻike iā lākou ma ke ala like. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e hoʻomākaukau a ʻike i ka manawa e hoʻopili ai i kāu hui lapaʻau.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Ka luhi a me ka nāwaliwali e mau ana no kekahi mau lā ma hope o ka lapaʻau
• Ka luaʻi a me ka ninini ʻana, hiki ke mālama ʻia me nā lāʻau anti-nausea
• Ka helu haʻahaʻa o nā pūnaewele koko, hiki ke hoʻonui i ka pilikia o ka maʻi
• Nā loli hana ate, nānā ʻia ma o nā hoʻokolohua koko maʻamau
• ʻEha ʻiʻo a me nā hui
• Nalo o ka ʻai
• Ka lahilahi lauoho māmā (ʻoiai ʻaʻole maʻamau ka nalowale lauoho piha)

Hiki ke mālama ʻia kēia mau hopena maʻamau me ka mālama kākoʻo a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka papa hana lapaʻau.

ʻO nā hopena ʻaoʻao maʻamau ʻole akā ʻoi aku ka koʻikoʻi e koi i ka lāʻau lapaʻau koke. Aia kēia mau pilikia i nā pilikia ate koʻikoʻi, nā hāʻule nui i nā helu pūnaewele koko e hiki ke alakaʻi i nā maʻi koʻikoʻi, a me nā hopena maʻi maʻi koʻikoʻi i ka wā o ka hoʻokomo ʻana.

Hiki i kekahi poʻe ke ʻike i nā loli o ka puʻuwai, ka nāwaliwali ʻiʻo koʻikoʻi, a i ʻole nā pilikia o ka puʻupaʻa. ʻOiai ʻaʻole maʻamau kēia mau hopena koʻikoʻi, nānā pono kāu hui lapaʻau iā ʻoe e hopu i nā loli e pili ana i ka wā mua.

Inā ʻoe e ʻike i nā hōʻailona maʻamau ʻole e like me ka ʻeha o ka ʻōpū nui, ka pilikia o ka hanu ʻana, ka puʻuwai ʻole, a i ʻole nā hōʻailona o ka maʻi e like me ke kuni, e hoʻokaʻaʻike koke i kāu hui oncology.

ʻO wai ka mea pono ʻole e lawe iā Trabectedin?

ʻAʻole kūpono ʻo Trabectedin no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka ʻōlelo ʻana i kēia lapaʻau. Hiki i kekahi mau maʻi olakino a i ʻole nā lāʻau lapaʻau ke hana i ka trabectedin palekana ʻole a i ʻole ka liʻiliʻi o ka pono.

ʻAʻole pono ʻoe e loaʻa iā trabectedin inā loaʻa iā ʻoe ka maʻi ate koʻikoʻi, no ka mea, e hana ana kou ate i kēia lāʻau a hiki i nā pilikia ate e hōʻino. Pono nā kānaka me nā maʻi koʻikoʻi e kali a maʻemaʻe ka maʻi ma mua o ka hoʻomaka ʻana i ka lapaʻau.

E mālama nō kāu kauka inā he moʻolelo kou o nā pilikia o ka puʻuwai, ka maʻi kīkī, a i ʻole inā e lawe ana ʻoe i kekahi mau lāʻau lapaʻau e launa pū me ka trabectedin. Hiki i kekahi mau lāʻau lapaʻau ke hoʻopilikia i ke ʻano o kou kino e hana ai i ka lāʻau lapaʻau, e hiki ai ke ʻoi aku ka ʻona.

ʻAʻole hiki i nā wāhine hāpai ke loaʻa ka trabectedin no ka mea hiki iā ia ke hōʻino i ka pēpē e ulu ana. Inā he makahiki hānau keiki kāu, e kūkākūkā kāu hui lapaʻau i nā ʻano hana hoʻomalu hānau maikaʻi i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope.

ʻAʻole hoʻokahi wale nō makahiki e kāpae iā ʻoe mai ka mālama ʻana i ka trabectedin, akā pono paha nā mākua kahiko i ka nānā ʻana a i ʻole nā hoʻoponopono ʻana i ka mahele ma muli o ka maikaʻi o ka hana ʻana o ko lākou mau ʻōkana.

Nā inoa inoa o Trabectedin

Kūʻai ʻia ka Trabectedin ma lalo o ka inoa inoa ʻo Yondelis ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa a me ʻEulopa. ʻO kēia ka inoa maʻamau āu e ʻike ai ma kāu mau moʻolelo lapaʻau a me ka ʻike lāʻau lapaʻau.

Hiki i kekahi mau wahi ke loaʻa nā inoa inoa like ʻole a i ʻole nā mana generic, akā like ka mea hana. Hiki i kāu kauka lāʻau a i ʻole ka hui oncology ke wehewehe i ka hoʻohui kikoʻī āu e loaʻa nei.

I ke kūkākūkā ʻana i kāu mālama ʻana me nā mea lawelawe mālama ola like ʻole, he mea kōkua ke haʻi i ka inoa generic (trabectedin) a me ka inoa inoa (Yondelis) e pale aku i kekahi huikau.

Nā koho ʻē aʻe o Trabectedin

Inā ʻaʻole kūpono ka trabectedin iā ʻoe a i ʻole e pau ka hana ʻana, aia kekahi mau lāʻau lapaʻau ʻē aʻe. E noʻonoʻo kāu oncologist i kāu ʻano maʻi maʻi kikoʻī, nā lāʻau lapaʻau ma mua, a me ke olakino holoʻokoʻa i ke koho ʻana i ke koho maikaʻi loa.

No nā sarcomas ʻiʻo palupalu, hiki i nā koho ʻē aʻe ke komo i nā lāʻau chemotherapy ʻē aʻe e like me doxorubicin, ifosfamide, a i ʻole pazopanib. Ke hōʻike nei kekahi mau lāʻau lapaʻau i manaʻo ʻia a me nā lāʻau immunotherapy i ka hoʻohiki no kekahi mau ʻano sarcomas.

No ka maʻi 'aʻai o ka ʻōpū hua, hiki i nā koho ʻē aʻe ke komo i ka carboplatin, paclitaxel, topotecan, a i ʻole nā lāʻau hou e like me PARP inhibitors no nā maʻi me kekahi mau loli genetic. Hiki nō hoʻi i nā hoʻokolohua lapaʻau ke hāʻawi i ke komo ʻana i nā lāʻau lapaʻau.

ʻO ke kī, ʻo ia ka hana pili loa me kāu hui oncology e ʻimi i ke ala lapaʻau e hāʻawi ana i ka manawa maikaʻi loa e kāohi i kāu maʻi 'aʻai me ka mālama ʻana i kou maikaʻi o ke ola.

Ua ʻoi aku ka maikaʻi o Trabectedin ma mua o nā lāʻau chemotherapy ʻē aʻe?

ʻAʻole pono ʻo Trabectedin i

Ma mua o ka hoʻomaka ʻana i ka trabectedin, e hana kāu kauka i nā hoʻokolohua koko e nānā i ka maikaʻi o ka hana ʻana o kou ate. E hoʻomau ʻia kēia mau hoʻokolohua i ka wā o ka mālama ʻana e hopu koke i nā loli. Inā emi ka hana o kou ate, pono paha e hoʻoponopono ʻia kāu mahele a i ʻole pono e hoʻōki ʻia ka mālama ʻana.

ʻAʻole e hoʻokaʻawale ʻia ʻoe mai ka trabectedin inā he mau maʻi liʻiliʻi o ka hana ate, akā ʻo ia hoʻi e pono ʻoe i ka nānā ʻana a me nā mahele haʻahaʻa e mālama iā ʻoe.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Trabectedin?

He mea maʻamau loa ka overdose o ka Trabectedin no ka mea e hāʻawi ʻia e nā poʻe lapaʻau i aʻo ʻia i nā wahi i mālama ʻia. Eia naʻe, inā manaʻo ʻoe he hewa i kāu mālama ʻana, e ʻōlelo koke.

Inā hāʻawi ʻia ka nui o ka trabectedin, e nānā pono kāu hui lapaʻau iā ʻoe no ka piʻi ʻana o nā hopena ʻaoʻao, ʻo ia hoʻi nā pilikia o ke ake a me nā helu koko haʻahaʻa loa. Hiki iā lākou ke hāʻawi iā ʻoe i nā lāʻau lapaʻau e kōkua i ka pale ʻana i kou mau ʻōpū a me ke kākoʻo ʻana i ka hoʻōla ʻana o kou kino.

ʻO ka nūhou maikaʻi, ua lawelawe ʻia ka trabectedin i nā haukapila a i ʻole nā ​​hale maʻi maʻi maʻi kahi e hiki ai i nā limahana lapaʻau ke pane koke i nā pilikia. Mai kānalua e nīnau i nā nīnau e pili ana i kāu mālama ʻana a i ʻole e hōʻike i nā hopohopo.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o ka Trabectedin?

Inā haʻalele ʻoe i kahi infusion trabectedin i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui oncology i ka hiki wawe e hoʻonohonoho hou. Mai ho'āʻo e hoʻoponopono i kahi mahele i haʻalele ʻia ma ka loaʻa ʻana o ka lāʻau hou ma hope.

E hoʻoholo kāu kauka i ka manawa maikaʻi loa no kāu mālama ʻana e pili ana i ka lōʻihi o ka hala ʻana mai kāu mahele hope loa a me ke ʻano o ka hoʻōla ʻana o kou kino. I kekahi manawa hiki i ka lohi pōkole ke kōkua inā e hana ana ʻoe me nā hopena ʻaoʻao.

ʻO ka haʻalele ʻana i hoʻokahi mālama ʻaʻole ia he manaʻo ua luku ʻia kāu hoʻolālā mālama maʻi maʻi. Hiki i kāu hui oncology ke hoʻoponopono i kāu papa manawa me ka mālama ʻana i ka pono o kāu hoʻolālā mālama holoʻokoʻa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Trabectedin?

Hiki iā ʻoe ke hooki i ka lawe ʻana i ka trabectedin ke hoʻoholo kāu kauka ʻaʻole ia he mea pono hou aʻe a i ʻole inā lilo nā hopena ʻaoʻao i mea paʻakikī loa e mālama. Pono e hana mau ʻia kēia hoʻoholo me kāu hui oncology.

ʻO nā kumu maʻamau e hooki ai, ʻo ia inā pau kāu maʻi maʻi i ka pane ʻana i ka lāʻau lapaʻau, inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā emi kou olakino holoʻokoʻa. I kekahi manawa ua hoʻolālā ʻia nā wā hoʻomaha lapaʻau e hāʻawi i kou kino i ka manawa e ola ai.

ʻO ka hooki ʻana i ka trabectedin ʻaʻole ia he manaʻo e hooki loa i ka lapaʻau maʻi maʻi. E loaʻa i kāu oncologist nā koho lapaʻau ʻē aʻe i mākaukau a e hana pū me ʻoe e hoʻololi mālie i ka pae aʻe o kāu mālama.

Hiki iaʻu ke kalaiwa ma hope o ka loaʻa ʻana o ka Trabectedin?

ʻO ka hapa nui o nā kānaka e luhi ma hope o ka hoʻokomo ʻana i ka trabectedin, no laila ʻoi aku ka maikaʻi e hoʻonohonoho i kekahi e kalaiwa iā ʻoe i ka home ma hope o ka lapaʻau. Hiki ke mau ka luhi no kekahi mau lā, e pili ana i kou hiki ke kalaiwa palekana.

Loaʻa kekahi poʻe i ka nausea a i ʻole ka ʻūlū ma hope o ka lapaʻau, hiki ke hoʻoweliweli i ke kalaiwa. E hoʻolālā e loaʻa i kahi lālā ʻohana a i ʻole hoaaloha e kōkua i ka lawe ʻana, ʻoi aku hoʻi no nā lapaʻau mua.

Ke maʻa ʻoe i ke ʻano o ka hopena o ka trabectedin iā ʻoe, e ʻike paha ʻoe hiki iā ʻoe ke kalaiwa hou i hoʻokahi a ʻelua paha lā ma hope o ka lapaʻau. E hoʻolohe i kou kino a mai kalaiwa inā luhi ʻoe, ʻūlū, a maikaʻi ʻole paha.