He aha ʻo Trastuzumab: Nā Hoʻohana, Nā Kumu, Nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Trastuzumab e kōkua i ka hakakā ʻana i kekahi mau ʻano maʻi umauma a me ka ʻōpū. He ʻano lapaʻau kūikawā ia i kapa ʻia he monoclonal antibody e hana ana ma ka pale ʻana i nā protein e kōkua i nā sela maʻi e ulu a laha.

Ua lilo kēia lāʻau lapaʻau i mea nui o ka mālama ʻana i ka maʻi maʻi no ka poʻe nona nā ʻōpū i nui loa ka protein i kapa ʻia ʻo HER2. Inā ʻoe a i ʻole kekahi āu e mālama nei e kū nei i kēia maʻi, hiki i ka hoʻomaopopo ʻana i ka hana ʻana o ka trastuzumab ke kōkua iā ʻoe e mākaukau no ka huakaʻi lapaʻau e hiki mai ana.

He aha ʻo Trastuzumab?

He antibody i hana ʻia i loko o ka hale hana ʻo Trastuzumab e hoʻohālike i ka ʻōnaehana pale o kou kino. Ua hoʻolālā ʻia e ʻimi a hoʻopili i nā sela maʻi i loaʻa nā pae kiʻekiʻe o kahi protein i kapa ʻia ʻo HER2 ma ko lākou ʻili.

E noʻonoʻo iā HER2 ma ke ʻano he hōʻailona e haʻi ana i nā sela maʻi e ulu wikiwiki. Ma kahi o 20 a 25 pakeneka o nā maʻi umauma a me kekahi mau maʻi ʻōpū i nui loa kēia protein. Ke hoʻopili ʻo trastuzumab i kēia mau protein HER2, ālai ia i nā hōʻailona ulu a kōkua i ka hoʻolohi ʻana a i ʻole ka hoʻōki ʻana i ka laha ʻana o ka maʻi.

Hāʻawi ʻia kēia lāʻau lapaʻau ma o ka laina IV pololei i loko o kou kahe koko. Hana pinepine ʻia ke kaʻina hana i loko o kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi maʻi kahi e hiki ai i nā poʻe loea mālama ola ke nānā pono iā ʻoe i ka wā o ka hoʻokomo ʻana.

No ke aha e hoʻohana ʻia ai ʻo Trastuzumab?

Hoʻomaʻamaʻa ʻo Trastuzumab i ka maʻi umauma HER2-positive a me ka maʻi ʻōpū HER2-positive. E hoʻāʻo kāu kauka i kāu mau sela maʻi e ʻike inā he kiʻekiʻe ko lākou o ka protein HER2 ma mua o ka ʻōlelo ʻana i kēia lapaʻau.

No ka maʻi umauma, hiki ke hoʻohana ʻia ʻo trastuzumab i nā kūlana like ʻole. Hiki ke hāʻawi ʻia ma mua o ke ʻoki ʻana e kōkua i ka hōʻemi ʻana i ka ʻōpū, e maʻalahi ai ka wehe ʻana. I kekahi manawa hoʻohana ʻia ma hope o ke ʻoki ʻana e kōkua i ka pale ʻana i ka maʻi mai ka hoʻi ʻana mai. I nā hihia i laha ai ka maʻi i nā ʻāpana ʻē aʻe o ke kino, hiki i ka trastuzumab ke kōkua i ka hoʻolohi ʻana i ka holomua.

I ka maʻi 'aʻai o ka ʻōpū, hui pū ʻia ka trastuzumab me nā lāʻau lapaʻau ʻē aʻe no ka maʻi 'aʻai ke laha a i ʻole ʻaʻole hiki ke wehe ʻia me ke ʻoki. ʻOi aku ka maikaʻi o ka hui pū ʻana ma mua o ka hoʻohana ʻana i hoʻokahi lāʻau lapaʻau wale nō.

Na kāu oncologist e hoʻoholo i ka manawa maikaʻi loa a me ka hui pū ʻana o nā lāʻau lapaʻau e pili ana i kāu kūlana kikoʻī, ke olakino holoʻokoʻa, a me ke ʻano o ka pane ʻana o kāu maʻi 'aʻai i ka lāʻau lapaʻau.

Pehea e Hana ai ʻo Trastuzumab?

Hana ʻo Trastuzumab e like me ka missile alakaʻi e kuhikuhi ana i nā cell maʻi 'aʻai kikoʻī. Ua manaʻo ʻia he lāʻau lapaʻau maʻi 'aʻai ikaika waena e pololei loa i ke ʻano o kāna hoʻouka ʻana i ka maʻi 'aʻai.

Ke loaʻa i nā cell maʻi 'aʻai ka nui o ka protein HER2, loaʻa iā lākou nā hōʻailona mau e ulu a māhele wikiwiki. Pale ʻo Trastuzumab i kēia mau hōʻailona ma ka hoʻopili ʻana i nā protein HER2 ma ka ʻili o ka cell maʻi 'aʻai. Kāohi kēia hoʻopili ʻana i nā cell maʻi 'aʻai mai ka loaʻa ʻana o nā memo ulu e pono ai lākou.

Eia kekahi, kōkua ʻo trastuzumab i kāu ʻōnaehana pale e ʻike a hoʻouka i nā cell maʻi 'aʻai me ka ʻoi aku ka maikaʻi. Ke hoʻopili ka lāʻau lapaʻau i nā cell maʻi 'aʻai, hōʻailona ia iā lākou no ka luku ʻia e ka ʻōnaehana pale maoli o kou kino.

Hoʻopilikia pū ka lāʻau lapaʻau i ka hiki ʻole o ka cell maʻi 'aʻai ke hoʻoponopono iā ia iho a hana i nā kīʻaha koko hou e hānai ai i ka maʻi. ʻO kēia ala multi-pronged e hana ai ʻo trastuzumab i mea kūpono loa i nā maʻi 'aʻai HER2-positive.

Pehea wau e lawe ai iā Trastuzumab?

Hāʻawi mau ʻia ʻo Trastuzumab ma o ka IV infusion ma kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi 'aʻai. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha.

Ma mua o kāu lapaʻau mua ʻana, e loaʻa iā ʻoe nā lāʻau lapaʻau e kōkua ai i ka pale ʻana i nā hopena maʻi. Hiki i kēia mau mea ke komo i nā antihistamines a me ka acetaminophen. E hoʻomaka kāu hui mālama ola i ka infusion mālie a nānā pono iā ʻoe no nā hōʻailona o ka hopena.

Ma ka hoʻokomo mua ʻana, ma kahi o 90 mau minuke, a ʻo nā lapaʻau ma hope mai, ma kahi o 30 a 60 mau minuke. Hiki iā ʻoe ke noho ma kahi noho ʻoluʻolu i ka wā o ke kaʻina hana, a he nui ka poʻe e lawe mai i nā puke, nā papa, a i ʻole e noho pū nā lālā o ka ʻohana me lākou.

ʻAʻole pono ʻoe e pale i ka ʻai ʻana ma mua o kāu lapaʻau, akā ʻo ka ʻai ʻana i ka meaʻai māmā ma mua e hiki ke kōkua i ka pale ʻana i ka nausea. E inu nui i ka wai i nā lā ma mua o kāu hoʻokomo ʻana. E hāʻawi kāu hui mālama ola kino i nā ʻōlelo kikoʻī e pili ana i nā lāʻau lapaʻau āu e lawe ai a ʻaʻole paha e lawe ma mua o ka lapaʻau.

Pehea ka lōʻihi e lawe ai au i ka Trastuzumab?

Aia ka lōʻihi o ka lapaʻau trastuzumab i kāu kūlana kikoʻī a me ke ʻano o ka pane ʻana o kāu maʻi maʻi. Loaʻa ka lapaʻau i ka hapa nui o nā kānaka no hoʻokahi makahiki ke hoʻohana ʻia ma hope o ke ʻoki ʻana e pale i ka hoʻi ʻana mai o ka maʻi maʻi.

Inā loaʻa iā ʻoe ka trastuzumab ma mua o ke ʻoki ʻana, hiki iā ʻoe ke loaʻa no kekahi mau mahina e kōkua i ka hōʻemi ʻana i ka maʻi. No ka maʻi maʻi holomua i laha, hoʻomau pinepine ka lapaʻau i ka wā e kōkua ana i ka mālama ʻana i ka maʻi a ke ʻae maikaʻi nei ʻoe.

E nānā kāu oncologist i kāu holomua ma o nā scans maʻamau, nā hoʻokolohua koko, a me nā loiloi. E loiloi lākou i ka maikaʻi o ka hana ʻana o ka lapaʻau a e nānā i nā hopena ʻaoʻao e pili ana, ʻoi aku ka pili ʻana i kāu hana puʻuwai.

Mai hooki i ka lawe ʻana i ka trastuzumab ma kāu iho, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi. E alakaʻi kāu hui mālama ola kino iā ʻoe ma nā hoʻoholo e pili ana i ka hoʻololi ʻana a i ʻole ka hoʻōki ʻana i ka lapaʻau e pili ana i kāu pane pilikino a me ke olakino holoʻokoʻa.

He aha nā hopena ʻaoʻao o Trastuzumab?

Hiki i ka Trastuzumab ke hana i nā hopena ʻaoʻao, akā nui ka poʻe e ʻae maikaʻi iā ia ma mua o ka chemotherapy kuʻuna. Hiki ke mālama ʻia nā hopena ʻaoʻao maʻamau me ka mālama kūpono a me ka nānā ʻana.

E hoʻomaka kākou me nā hopena ʻaoʻao āu e ʻike nui ai i ka wā o ka lapaʻau:

• Ka wela a me nā anu, ʻoiai i nā infusions mua
• Nā ʻeha poʻo e mau ana no hoʻokahi lā a ʻelua paha ma hope o ka lapaʻau
• Luhi e hiki ke loli mai ka luhi māmā a i ka manaʻo ua pau loa ka ikaika
• Nausea a me ka luaʻi i kekahi manawa, ʻoiai ʻoi aku ka māmā ma mua o ka chemotherapy
• Pāpaʻa e maikaʻi maʻamau ma waena o nā lapaʻau
• ʻEha ʻiʻo a me nā hono e like me nā hōʻailona e like me ka maʻi flu
• Pāpaʻa ʻili a i ʻole ka ʻūlū ʻana ma kahi i hoʻokomo ʻia ai a i ʻole ma nā wahi ʻē aʻe

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao i ka wā e hoʻoponopono ai kou kino i ka lāʻau, a hiki i kāu hui mālama ola ke hāʻawi i nā lapaʻau e kōkua i ka mālama pono ʻana iā lākou.

Aia kekahi mau hopena ʻaoʻao ʻaʻole maʻamau akā ʻoi aku ka koʻikoʻi e pono ai ka lāʻau lapaʻau koke:

• Nā pilikia o ka naʻau, me ka nāwaliwali o ka ʻiʻo o ka naʻau a i ʻole ka puʻuwai ʻole
• Nā hopena maʻi maʻi koʻikoʻi i ka wā o ka infusion, e hōʻeha ana i ka hanu a i ʻole ka pehu
• Nā pilikia o ka māmā e like me ka pōkole o ka hanu a i ʻole ka ʻūlū mau
• Nā maʻi koʻikoʻi ma muli o ka hana ʻōnaehana pale iho iho
• Nā koko koko e hiki ke hoʻoulu i ka pehu a i ʻole ka ʻeha i kou mau wāwae

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau hopena koʻikoʻi ma o nā hoʻokolohua naʻau maʻamau a me nā hana koko i kāu lapaʻau.

ʻO wai ka mea pono ʻole e lawe iā Trastuzumab?

ʻAʻole kūpono ʻo Trastuzumab no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. ʻAʻole hiki i nā poʻe me kekahi mau maʻi naʻau ke loaʻa i kēia lāʻau lapaʻau me ka palekana.

ʻAʻole pono ʻoe e loaʻa iā trastuzumab inā he maʻi maʻi koʻikoʻi ʻoe i ka lāʻau a i ʻole kekahi o kāna meaʻai. Pono ka poʻe me nā maʻi koʻikoʻi e kali a hiki i ka maʻemaʻe ʻana o ka maʻi ma mua o ka hoʻomaka ʻana i ka lapaʻau.

ʻO kekahi mau maʻi puʻuwai e hoʻoweliweli ai ka hoʻohana ʻana i ka trastuzumab. Aia kēia mau mea i ka maʻi puʻuwai nui, ka puʻuwai i loaʻa i kēia manawa, a i ʻole ka hana puʻuwai i hōʻemi nui ʻia. E hana kāu kauka i nā hoʻokolohua puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau e hōʻoia i ka ikaika o kou puʻuwai.

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, hiki i ka trastuzumab ke hōʻeha i ka pēpē e ulu ana a pono e pale ʻia. Pono nā wahine e hiki ke hāpai e hoʻohana i ka mana hānau kūpono i ka wā o ka lāʻau lapaʻau a no kekahi mau mahina ma hope.

ʻAʻole paha he mau moho maikaʻi nā poʻe me nā pilikia hanu nui a i ʻole ka maʻi māmā ikaika no kēia lāʻau lapaʻau. E loiloi kāu hui mālama ola i kou olakino holoʻokoʻa a kūkākūkā inā ʻoi aku ka maikaʻi ma mua o nā pilikia i kāu kūlana.

Nā inoa inoa o Trastuzumab

Loaʻa ka Trastuzumab ma lalo o nā inoa inoa like ʻole, ʻo Herceptin ka mea i ʻike nui ʻia. Ua hoʻohana maikaʻi ʻia kēia brand no nā makahiki he nui a he nui nā noiʻi e kākoʻo ana i kona pono.

Loaʻa i kēia manawa kekahi mau mana biosimilar, me Herzuma, Ontruzant, a me Trazimera. Ua like loa kēia mau mea me ka Herceptin kumu a hana like, akā hiki ke emi ke kumukūʻai.

Hiki i kāu ʻinikua a me ke kikowaena lapaʻau ke hoʻopili i ka brand āu e loaʻa ai. Ua hoʻāʻo ʻia nā mana i ʻae ʻia a hōʻike ʻia e hana pono i nā maʻi maʻi HER2-positive.

Mai hopohopo inā hoʻololi kāu kauka ma waena o nā inoa inoa like ʻole i ka wā o ka lāʻau lapaʻau. Noho like ka mea hana a me ka pono, a e hōʻoia kāu hui mālama ola e loaʻa iā ʻoe ka mana kūpono loa no kou kūlana.

Nā koho ʻē aʻe o Trastuzumab

Nui nā koho ʻē aʻe i ka trastuzumab no ka mālama ʻana i nā maʻi maʻi HER2-positive, akā e koho kāu kauka i ke koho maikaʻi loa e pili ana i kāu kūlana. Hana kēia mau koho ʻē aʻe ma nā ʻano like ʻole akā kuhikuhi i ka protein HER2 like.

He lāʻau lapaʻau ʻo Pertuzumab i manaʻo ʻia e HER2 a hoʻohana pinepine ʻia me ka trastuzumab. Ma ka hui pū ʻana, hiki iā lākou ke ʻoi aku ka maikaʻi ma mua o ka lāʻau hoʻokahi. Hoʻohana pinepine ʻia kēia hui ʻana no ka maʻi ʻaʻai umauma holomua a i ʻole ma mua o ke ʻoki ʻana.

Hoʻohui ʻo T-DM1 (ado-trastuzumab emtansine) i ka trastuzumab me ka chemotherapy i loko o kahi lāʻau hoʻokahi. Mālama ʻia ia no ka poʻe i hoʻomau ka ulu ʻana o ka maʻi ʻaʻai me nā lāʻau lapaʻau ʻē aʻe i manaʻo ʻia e HER2.

No ka poʻe i hiki ʻole ke ʻae i nā infusions IV, aia kahi koho hou i kapa ʻia ʻo trastuzumab subcutaneous injection. Hāʻawi ʻia kēia mana ma ke ʻano he pana ma lalo o ka ʻili ma mua o ka IV, e wikiwiki a maʻalahi ka mālama ʻana.

E noʻonoʻo kāu oncologist i nā mea e like me ke kahua o kāu maʻi ʻaʻai, nā lāʻau lapaʻau i hala, ke olakino holoʻokoʻa, a me nā makemake pilikino i ka wā e ʻōlelo ai i ke ala maikaʻi loa no kāu mālama.

Ua ʻoi aku ka maikaʻi o Trastuzumab ma mua o Pertuzumab?

ʻAʻole nā mea hoʻokūkū maoli ʻo Trastuzumab a me pertuzumab - he mau hoa hana maoli lākou e hana maikaʻi i ka hui pū ʻana ma mua o kekahi. Hoʻopā nā lāʻau lapaʻau ʻelua i ka protein HER2, akā pili lākou i nā ʻāpana like ʻole o ia mea.

E noʻonoʻo iā HER2 me nā laka he nui, a loaʻa i kēlā me kēia lāʻau lapaʻau kahi kī i kahi laka ʻokoʻa. Ke hoʻohana ʻoe i ka trastuzumab a me ka pertuzumab i ka hui pū ʻana, ke laka nei ʻoe i nā hōʻailona ulu o ke keena maʻi ʻaʻai.

Hōʻike ka noiʻi ʻana i ka hui pū ʻana o kēia mau lāʻau lapaʻau ʻoi aku ka maikaʻi ma mua o ka hoʻohana ʻana i ka trastuzumab wale nō no ka poʻe he nui me ka maʻi ʻaʻai umauma HER2-positive. Ua lilo ke ala hui i ka mālama maʻamau no ka maʻi holomua a ke hoʻohana nui ʻia nei ma mua o ke ʻoki ʻana.

E hoʻoholo kāu kauka inā pono ʻoe i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua e pili ana i ke kahua o kāu maʻi ʻaʻai, ke olakino holoʻokoʻa, a me ka ikaika o kāu mālama ʻana. ʻO ka pahuhopu ka hāʻawi mau ʻana iā ʻoe i ka lāʻau lapaʻau maikaʻi loa i ka wā e mālama pono ai i nā hopena ʻaoʻao.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Trastuzumab

Nīnau 1. Ua palekana anei ʻo Trastuzumab no ka poʻe me ka maʻi puʻuwai?

Hiki i ka Trastuzumab ke hoʻopilikia i ka hana o ka puʻuwai, no laila pono e loiloi pono ʻia ka poʻe me ka maʻi puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau. E hana kāu kauka i nā hoʻokolohua puʻuwai, me kahi echocardiogram a i ʻole MUGA scan, e nānā i ka maikaʻi o ka hana ʻana o kou puʻuwai.

Inā he pilikia puʻuwai maʻalahi kāu, hiki nō paha iā ʻoe ke loaʻa iā trastuzumab me ka nānā pono. E nānā mau kāu hui mālama ola i ka hana o kou puʻuwai i ka wā o ka lāʻau a hiki ke hoʻoponopono a hoʻōki paha i ka lāʻau inā loaʻa nā pilikia.

ʻAʻole hiki i ka poʻe me ka maʻi puʻuwai koʻikoʻi, nā puʻuwai puʻuwai hou, a i ʻole ka hana puʻuwai i hōʻemi nui ʻia ke loaʻa palekana iā trastuzumab. Eia naʻe, e hana pū kāu oncologist a me ka cardiologist e ʻimi i ka hoʻolālā lapaʻau palekana a maikaʻi loa no kāu kūlana.

Nīnau 2. He aha kaʻu e hana ai inā ua hala au i kahi mahele o Trastuzumab?

E hoʻokaʻaʻike koke i kāu hui mālama ola inā ua hala ʻoe i kahi infusion trastuzumab i hoʻonohonoho ʻia. E kōkua lākou iā ʻoe e hoʻonohonoho hou i ka hiki wawe e mālama i ka pono o kāu lāʻau.

ʻAʻole e hōʻeha koke ka hala ʻana i kahi mahele, akā hiki ke hōʻemi i ka maikaʻi o ka lāʻau i ka hana ʻana i kāu maʻi maʻi. Ua hoʻolālā ʻia kāu papa hana lapaʻau e mālama i nā pae paʻa o ka lāʻau i loko o kāu ʻōnaehana.

Mai hoʻāʻo e

ʻO ka hapa nui o nā hopena infusion e hana ʻia i ka wā o ka mālama mua ʻana a hiki ke mālama ʻia ma ka hoʻolohi ʻana i ka helu infusion a i ʻole ka hāʻawi ʻana i nā lāʻau lapaʻau hou. E nānā pono kāu hui iā ʻoe a hiki ke hāʻawi iā ʻoe i nā lāʻau lapaʻau ma mua o nā infusions e hiki mai ana e pale i nā hopena.

ʻAʻole maʻamau nā hopena koʻikoʻi, akā ke hana lākou, hiki ke mālama ʻia me ka mālama olakino wikiwiki. Ua mākaukau mau kāu hui mālama ola e mālama i nā pilikia e kū mai ana i ka wā o ka mālama ʻana.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Trastuzumab?

Mai hooki i ka mālama ʻana iā trastuzumab iā ʻoe iho, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike i nā hopena ʻaoʻao. E hoʻoholo kāu oncologist i ka manawa e palekana ai a kūpono hoʻi e hooki ma muli o kāu hoʻolālā lapaʻau a me ke ʻano o kāu pane ʻana.

No ka mālama adjuvant (ma hope o ke ʻoki ʻana), hoʻopau ka hapa nui o nā kānaka ma kahi o hoʻokahi makahiki o ka mālama ʻana. Inā ʻoe e loaʻa ana iā trastuzumab no ka maʻi maʻi holomua, hoʻomau ka mālama ʻana i ka wā e kōkua ana i ka mālama ʻana i ka maʻi a ke ʻae maikaʻi nei ʻoe.

E loiloi mau kāu kauka i kāu holomua ma o nā scans, nā hoʻokolohua koko, a me nā hoʻokolohua kino. E kūkākūkā lākou i nā loli i kāu hoʻolālā lapaʻau a wehewehe i nā kumu ma hope o kā lākou ʻōlelo.

Q5. Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Trastuzumab?

Hiki iā ʻoe ke loaʻa ka hapa nui o nā lāʻau lapaʻau i ka wā e lawe ana iā trastuzumab, akā he mea nui ka manawa a me ke ʻano. Pono e pale ʻia nā lāʻau lapaʻau ola, ʻoiai ua palekana a paipai ʻia nā lāʻau lapaʻau i hoʻopau ʻia.

E kamaʻilio me kāu hui mālama ola ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau, me nā pana flu a i ʻole nā lāʻau lapaʻau COVID-19. Hiki iā lākou ke ʻōlelo i ka hoʻokaʻawale ʻana i nā lāʻau lapaʻau a puni kāu mau infusions trastuzumab no ka maikaʻi loa.

He mea nui ka noho ʻana i kēia manawa me nā lāʻau lapaʻau i ka wā o ka mālama ʻana i ka maʻi maʻi, no ka mea, hiki ke hoʻopaʻa ʻia kāu ʻōnaehana pale. E kōkua kāu hui lapaʻau iā ʻoe e hana i kahi papa hana lāʻau lapaʻau e hana pū me kāu hoʻolālā lapaʻau.